http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
새로운 심근관류 영상 화합물로서 99mTc - Ethyl - 3 - Isocyanobutyrate의 합성 , 표지 및 체내동태에 대한 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),임상무(Sang Moo Lim),이경한(Kyung Han Lee),정재민(Jae Min Jeong),조정혁(Jung Hyuck Cho),오승준(Seung Joon Oh),정수욱(Soo Wook Chung) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2
N/A Technetium labeled isonitrile analogues are widely used as myocardial perfusion imaging agents. We synthesized and characterized a new isonitrile compound, ethyl 3-isocyanobutyrate (EIB). Proton and 13C NMR spectroscopy and thin layer chromatography with a C18 coat was performed. EIB was easily labeled with 99mTcO4-with sodium dithionite. The labeling efficiency measured by RP-HPLC was over 95%. The labeled product was stable with dilution in normal saline and with prolonged incubation at room temperature. There was no formation of secondary products or free 99mTcO4. In vivo kinetics study of Tc-99m(I) labeled EIB in rabbits showed adequate myocardial uptake, good contrast against lung background, and relatively rapid liver clearance. The heart to lung ratio was over 2.5 and the heart to liver ratio was approximately from 0.4 to 5 at 60 minutes post injection. Hepatic clearance of Tc-99m-MIBI was faster (t1/2,=6 minutes) than that of Tc-99m-MIBI. In vivo kinetics observed in dog was similar to that in rabbit but there was faster gallbladder filling, and thus lower liver background. SPECT imaging of the canine myocardium showed favorable imaging characteristics. However, biodistribution in mice demonstrated a myocardial % injected dose/organ of less than 0.1%. This was thought to be due to interspecies difference in plasma esterase activity. In human plasma, Tc-99m(I) labeled EIB was stable for at least 2 hours, without production of secondary products by HPLC. We conclude that ethyl 3-isocyanobutyrate may be a potential new myocardial perfusion imaging agent and deserves further investigation as to its usefulness for clinical use.
두뇌혈류영상용 방사성의약품인 Ethylcystein Dimer ( ECD ) 의 합성과 99mTc 표지 및 뇌단일광자단층영상 구성
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),이경한(Kyung Han Lee),정재민(Jae Min Jeong),곽철은(Cheol Eun Kwark),조정혁(Jung Hyuck Cho),정수욱(Soo Wook Chung) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.2
N/A Et.hylcystein dimer(ECD) was synthesized by dimerization of L-thiazo1idine-4-carboxylic acid in liquid ammania with sodium metal and successive esterification in ethanolic solution of hydrogen chlorde. The purified product was labeled with Tc in the presence of sodium glucarate(pH=5.6) and stannous chloride. Best result was obtained from the preparation consisting of O.lmg ECD, 40 ul of 0.4M sodium glucarate (pH=5.6), and 20 ug of stannous chloride. The labeling efficiency was 90% with previous condition. The labeled 99mTc-ECD was stable at least for 3 hours in PBS(pH 7.4) at roorn temperature. About. 10mCi of 99mTc-ECD was inject.ed to normal volunteer, and SPECT image of brain was obtained by triple head camera 10 minutes after inectian. The image showed similar distribution of radioact.ivity in brain with that of HMPAO image.
뇌혈류 영상용 방사성의약품 PRODD의 99mTc 표지 및 생체내분포
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),정재민(Jae Min Jeong),조정혁(Jung Hyuck Cho),오승준(Seung Joon Oh),정수욱(Soo Wook Chung) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.3
N/A Tc-99m labeled PnAO(propylene amine oxime) derivatives have been widely studied as brain perfusion agents. We synthesized and characterized a PnAO derivative, (RR/SS/meso)-4,8-diaza- 3,9,dimethylundecane-2,l0-dione bisoxime(PRODD). Proton-NMR spectroscopy and thin layer chromatography(silence gel) were performed for its characterization PRODD was 1abeled with Tc- 99m using stannous chloride as reducing agent. The labeling efficiency was determined to be about 85%. Brain uptakes of 4.16±0.42 %ID/g and 3.24±0.13 %ID/g were found after l0min and 30min after intravenous injection. Brain-to-blood ratios were 1.17 and 0.75 at 10 and 30 minutes, which were lower than 1.3 and 1.9 of the ratios with commercial Tc-99m-HMPAO. Autoradiographs of rat brain sections showed the gray matter to white matter ratios of 1.13±0.10 at 30 min after intravenous injection, which was lower than 1.94±0.19 of commercial Tc-99m-HMPAO. With the above findings, we concluded that the lipophilic Tc-99m-PRODD complex was able to cross the blood-brain barrier, however the complex showed lower uptake than Tc-99m-HMPAO in mouse or rat brains. We Could suggest possibility that PRODD could be used as another Tc-99m chelator.
정치섭,조정혁,안창준 청주대학교 산업과학연구소 1999 産業科學硏究 Vol.17 No.1
We have studied the linear and nonlinear optical properties of the Langmuir(L) films of polyamic acid alkyl amin salt in which the nonlinear optic (NLO) chromophore (triphnylamino-(p-nitrophnyl)-ethylene group) was substituted as a side chain by using Brewster angle microscope(BAM) and second harmonic generation (SHG) technique. The collapse point in a π-A isotherm is generally defined as the surface pressure where the monolayers are riding on top of each other and disordered multilayers are being formed. But in this experiment using BAM and SHG, suprisingly the collapse was not found at the collapse point but found near the surface pressure where the liquid condensed(LC)-liquid expended(LE) phase transition occur.
Reaction Mechanism of α-Diethylaminoacetophenone with Potassium Cyanide and Ammonium Carbonate (1)
Kwon, Soon-Kyung,Shin, Dae-Hyun,Cho, Jung-Hyuck 충남대학교 자연과학연구소 1978 學術硏究誌 Vol.5 No.2
α-Diethylaminoacetophenone을 50% alcohol 용액에서 potassium cyanide, ammonium carbonate와 반응시키면 5-phenylhydantoin이 생성된다. 이 반응의 반응 메카니즘, 특히 α-diethylaminoacetophenone group이 분리되는 step을 연구했다. GC/MS System을 이용하여 분석한 결과 ethylbenzoate가 생성되는 것으로 보아 α-diethylaminoacetophenone은 hydantoin-ring 형성전에 알칼리 분해되어 benzaldehyde로 될 것으로 사료된다.
벤조디아제핀 수용체 영상용 양전자 방출 핵종 표지 플루마제닐 유도체 [F-18](3-(2-Fluoro)flumazenil의 합성과 생체 내 분포
장영수,이숙자,강삼식,홍성현,이명철,이동수,정준기,정재민,조정혁 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.6
Purpose: Radiotracers that bind to the central benzodiazepine receptor are useful for the investigation of various neurological and psychiatric diseases. [C-11]Flumazenil, a benzodiazepine antagonist, is the most widely used radioligand for central benzodiazepine receptor imaging by PET. We synthesized 3-(2-[F- 18]fluoro)flumazenil, a new fluorine-18 (t1/2=110 min) labeled analogue of benzodiazepine receptor imaging agent, and evaluated in vivo for biodistribution in mice. Materials and Methods: Flumazenil (Ro 15-1788) was synthesized by a modification of the reported method. Precursor of 3-(2-[F-18]fluoro)flumazenil, the tosylated flumazenil derivative was prepared by the tosylation of the ethyl ester by ditosylethane. [F-18] labeling of tosyl substitued flumazenil precursor was performed by adding F-18 ion at 85℃ in the hot cell for 20 min. The reaction mixture was trapped by C18 cartridge, washed with 10% ethanol, and eluted by 40% ethanol. Bidistribution in mice was determined after intravenous injection Results: The total chemical yield of tosylated flumazenil derivative was ∼40%. The efficiency of labeling 3-(2-[F-18]fluoro)flumazenil was 66% with a total synthesis time of 50 min. Brain uptakes of 3-(2-[F-18]fluoro)flumazenil at 10, 30, 60 min after injection, were 2.5±0.37, 2.2±0.26, 2.1±0.11 and blood activities were 3.7±0.43, 3.3±0.07, 3.3±0.09%ID/g, respectively. Conclusion: We synthesized a tosylated flumazenil derivative which was successfully labeled with no-carrier-added F-18 by nucleophilic substitution.