Mechanisms of Macromolecular Interactions Mediated by Protein Intrinsic Disorder

홍성현,최상민,김령현,고준석 한국분자세포생물학회 2020 Molecules and cells Vol.43 No.11

Intrinsically disordered proteins or regions (IDPs or IDRs) are widespread in the eukaryotic proteome. Although lacking stable three-dimensional structures in the free forms, IDRs perform critical functions in various cellular processes. Accordingly, mutations and altered expression of IDRs are associated with many pathological conditions. Hence, it is of great importance to understand at the molecular level how IDRs interact with their binding partners. In particular, discovering the unique interaction features of IDRs originating from their dynamic nature may reveal uncharted regulatory mechanisms of specific biological processes. Here we discuss the mechanisms of the macromolecular interactions mediated by IDRs and present the relevant cellular processes including transcription, cell cycle progression, signaling, and nucleocytoplasmic transport. Of special interest is the multivalent binding nature of IDRs driving assembly of multicomponent macromolecular complexes. Integrating the previous theoretical and experimental investigations, we suggest that such IDR-driven multiprotein complexes can function as versatile allosteric switches to process diverse cellular signals. Finally, we discuss the future challenges and potential medical applications of the IDR research.

펄스통전가열에 의한 텅스텐 탄화물의 제조

홍성현,김현진 한국입자에어로졸학회 2009 Particle and Aerosol Research Vol.5 No.4

Tungsten carbide powder was fabricated with carbothermal reaction by pulsed electric current flowing in compact of tunsten oxide and carbon. The mixed powder of tunsten oxide and carbon was ball-milled into ultrafine powders. The mixed powder of tungsten oxide and carbon was put into carbon mold and heat-treated at 1050~1200℃ by pulsed electric current flowing. The formation of tungsten carbide powder could be achieved by heat treatment at 1200℃ for 10 minitues. Key words : Tungsten carbide, Tungsten oxide, Carbothermal reaction, Pulsed electric current, Powder

[교회가 청년에게] 어두운 세력엔 빛 썩은 곳엔 소금을

홍성현 새가정사 1989 새가정 Vol.- No.-

Facile bulk scale synthesis process of nano bentonite used as drilling mud

홍성현,김수영 한국공업화학회 2021 한국공업화학회 연구논문 초록집 Vol.2021 No.0

동해안 무속장단 변주유형의 운영 –굿거리장단을 중심으로

홍성현 한국공연문화학회 2020 공연문화연구 Vol.0 No.40

본고는 동해안 무속에서 사용하는 굿거리장단의 변주유형의 운영을 연구한 논문이다. 동해안 별신굿 예능보유자였던 故김용택의 굿거리장단 연주가 다른 장르에서 보았던 굿거리장단과 색다르게 다가왔고 그 요인을 찾기 위해 그가 연주할 때 사용하는 변주유형과 연주기법들을 살펴보았다. 동해안 무속 굿거리장단은 여타 다른 장르에서 연주되는 굿거리장단의 유형과 기법보다 다양한 변주유형이 존재하며 독특한 형태의 기법들을 사용하고 있다. 이 같은 다양한 변주유형과 독특한 연주기법이 실제 연주에 반영되어 즉흥적인 변주가 이루어지고 있다. This study is about the variation types, techniques and live performance of the East Sea Coast Shamanism Gutgury rhythm. This study looks over the East Sea Coast Byeolsingut entertainment holder, Kim Yongtaek’s variation and performance types to find the factors for the difference between his Gutguri rhythm performance and Gutguri rhythm performed from other genres. East Sea Coast Shamanism Gutguri rhythms have more variable types than itself from other genres, and use unique techniques. This paper is a study on how these variation types and unique techniques are used in live performance to manage impromptu variation rhythms.

강수지표를 이용한 우리나라 강수량의 시간적인 특성 변화

홍성현,김영규,이원현,정은성,Hong, Seong-Hyun,Kim, Young-Gyu,Lee, Won-Hyun,Chung, Eun-Sung 한국수자원학회 2012 한국수자원학회논문집 Vol.45 No.4

본 연구에서는 과거에서부터 기록된 우리나라 65개의 관측소들을 대상으로 강수량 데이터를사용하여 강수빈도와 극한 지표들을 산출해 냄으로써, 지표에 따라 지역별 분포를 살펴보고 시공간적인 증 감율에 대한 결과를 제시하였다. 그 결과를 시계열로 도시함으로 쉽게 파악할 수 있지만경향이 뚜렷하게 나타나지 않는 경우에는 통계적 방법인 Mann-Kendall 경향성 분석을 실시하여 이에 대해 파악하였다. 더불어 FARD를 이용하여 100년과 200년의 빈도확률강수량을 산정하고 이를 비교하였다. 강우특성을 크게 Amount, Extreme, Frequency로 분류하고 각각의 지수를 강우량 지수(Rainfall Index for Amount), 강우극치 지수(Rainfall Index for Extremes), 강우빈도 지수(Rainfall Index for Frequency)로 정의하고 RIA, RIE, RIF를 산술평균하여 홍수에 대한 종합적인 강우 위험도를 나타내는 평균 강우지수(Average Rainfall Index, ARI)를 산정하였다. 그 결과 과거에 비해 최근 10년간 강우량의 정량적인 평가 특성은 양적으로 22.3%, 극치사상 발생측면은 26.2%, 빈도측면은 5.1% 증가하였음을 확인 할 수 있었다. 본연구의 결과는 최근 우리나라 기후변화 경향을 구체적으로 제시하고 있으므로 기후변화 대비 적응 연구의 기초 자료로 활용될 수 있다. This study suggests the results of temporal and spatial variations for rainfall data in the Korean Peninsula. We got the index of the rainfall amount, frequency and extreme indices from 65 weather stations. The results could be easily understood by drawing the graph, and the Mann-Kendall trend analysis was also used to determine the tendency (up & downward/no trend) of rainfall and temperature where the trend could not be clear. Moreover, by using the FARD, frequency probability rainfalls could be calculated for 100 and 200 years and then compared each other value through the moment method, maximum likelihood method and probability weighted moments. The Average Rainfall Index (ARI) which is meant comprehensive rainfalls risk for the flood could be obtained from calculating an arithmetic mean of the RI for Amount (RIA), RI for Extreme (RIE), and RI for Frequency (RIF) and as well as the characteristics of rainfalls have been mainly classified into Amount, Extremes, and Frequency. As a result, these each Average Rainfall Indices could be increased respectively into 22.3%, 26.2%, and 5.1% for a recent decade. Since this study showed the recent climate change trend in detail, it will be useful data for the research of climate change adaptation.

BPSG막의 Flow 특성

홍성현,이종무,송성해 한국세라믹학회 1989 한국세라믹학회지 Vol.26 No.3

Effects of annealing temperature, time, and atmospehre on the flow characteristics of Atmospheric Pressure Chemical Vapor Deposition-borophosphosilicate glass were investigated. Stable step coverage can be obtained by annealing the BPSG film at 90$0^{\circ}C$ for 30 minutes in N2 atmosphere, but further heat treatment isnot effective. Flow characteristics of the BPSG film was better in steam atmosphere than in N2 atmosphere, and the factors which cause it were analyzed. The concentration of boron in the BPSG film was measured pretty accurately by FTIR spectrum. Boron content in the BPSG film was reduced by annealing treatment. The decrement of boron was greater in steam atmosphere than in the N2 atmosphere. Also it was found from the FTIR spectroscopic analysis that PH3 inhibited the oxidation of B2H6.

분말고속도공구강 JYPS-23에서 열처리조건에 따른 3점 굽힘피로특성

홍성현,배종수,김용진 한국분말야금학회 2000 한국분말재료학회지 (KPMI) Vol.7 No.3

The effect of tempering temperature on the three point bending fatigue behavior of a P/M high speed steel JYPS-23 (1.28% C, 4.20% Cr, 6.40% W, 5.00% Mo, 3.10% V, bal. Fe) was investigated. The number of cycles to failure of the specimen austenitized at $1175^{\circ}C$ drastically increased with increasing tempering temperature. As tempering temperature increased from 500 to $620^{\circ}C$, the volume fraction and average size of carbides (MC or M6C) did not significantly changed, while hardness decreased drastically. The reduced hardness is due to the softening of matrix, which increased the resistance of the fatigue crack propagation. For a practical application, powder compacting test were also conducted with the P/M high speed steel punches tempered at 500, 580, and $620^{\circ}C$. The number of compacting cycles to failure of the punches also increased with increasing tempering temperature.

열화학적 방법에 의한 초미립 TiC-15%Co 분말의 합성

홍성현,탁영우,김병기 한국분말야금학회 2003 한국분말재료학회지 (KPMI) Vol.10 No.4

Ultrafine TiC-15%Co powders were synthesized by a thermochemical process, including spray drying, calcination, and carbothermal reaction. Ti-Co oxide powders were prepared by spray drying of aqueous solution of titanium chloride and $Ti(OH)_2$ slurry, both containing cobalt nitrate, fellowed by calcination. The oxide powders were mixed with carbon powder to reduce and carburize at 1100~125$0^{\circ}C$ under argon or hydrogen atmosphere. Ultrafine TiC particles were formed by carbothermal reaction at 1200~125$0^{\circ}C$, which is significantly lower than the formation temperature (~1$700^{\circ}C$) of TiC particles prepared by conventional method. The oxygen content of TiC-15%Co powder synthesized under hydrogen atmosphere was lower than that synthesized under argon, suggesting that hydrogen accelerates the reduction rate of Ti-Co oxides. The size of TiC-15%Co powder was evaluated by FE-SEM and TEM and Identified to be smaller than 300 nm.

Synthesis of a Ti–Cr–V alloy by pulsed current assisted reaction

홍성현,송명엽 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.4

Preparations of a Ti–Cr–V alloy were tried by applying pulsed electric current through compacted mixtures of TiO2, V2O5, Cr2O3 and C, and of TiH2, Cr and V after ball-milling into fine powder. TGA and DTA curves for a mixture of TiO2, V2O5, Cr2O3 and C showed that weight decreased up to about 1423 K. The Ti–Cr–V alloy could not be prepared from a mixture of TiO2, V2O5, Cr2O3 and C. However, from a mixture of TiH2, Cr and V, the Ti–Cr–V alloy formed together with phases of Cr1.93Ti1.07, Ti or C.