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OMC-2010 추출물이 마우스의 비장세포 cytokine 생성에 미치는 영향
배기상 ( Gi Sang Bae ),박경철 ( Kyoung Chel Park ),최선복 ( Sun Bok Choi ),조일주 ( Il Joo Jo ),서상완 ( Sang Wan Seo ),김종진 ( Jong Jin Kim ),신용국 ( Yong Kook Shin ),김민선 ( Min Sun Kim ),박규환 ( Kyu Hwan Park ),김현식 ( Hyu 대한본초학회 2012 大韓本草學會誌 Vol.27 No.5
Objective : This study was performed to estimate the effects of OMC-2010 extract on cytokine production in mouse spleen cells. Methods : Mouse spleen cells were pre-treated with ethanol and water extract of OMC-2010 for 1 h, then stimulated with lipopolysaccharide (LPS, 1 μg/ml) for 48 h. Then the cells were harvested for real-time reverse transcription polymerase chain reaction to detect cytokines. Results : OMC-2010 ethanol extract significantly inhibited the LPS-induced interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-5 mRNA expressions, but not shown such changes in IL-6, IL-4, IL-13. OMC-2010 water extract significantly inhibited the LPS-induced TNF-alpha, and IL-5 mRNA expressions, but not shown such changes in IL-1beta, IL-6, IL-4, IL-13. Conclusions : Theses results could suggest that both ethanol and water OMC-2010 extract could inhibit the TNF-alpha and IL-5 mRNA expression.
조항주(Hang Joo Cho),황인용(In Yong Whang),김지일(Ji Il Kim),안창혁(Chang Hyuck Ahn),김정수(Jeong Soo Kim),유승진(Seung Jin Yoo),임근우(Keun Woo Lim) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.2
Purpose: We wanted to evaluate the value of intravenous contrast enhanced abdomen-pelvis computed tomography (CT) for diagnosing acute appendicitis and we wanted to determine which patients groups will benefit from preoperative CT. Methods: Between January and June 2006, the medical records of 354 patients who had clinically suspected acute appendicitis were retrospectively reviewed. Appendectomy was performed in 260 patients and CT was conducted in 108 patients of the 260 patients. The 5㎜ slice CT scans were evaluated for the presence of appendicitis. The sensitivity, specificity and accuracy of CT were calculated. The negative appendectomy rate (NAR) was compared between the patients with CT scans and those without CT scans. Furthermore, the patients were classified into the children and adults groups and the male and female groups and the differences of the NARs were analyzed for each group. Results: The sensitivity, specificity and accuracy were 95%, 93% and 94%, respectively. The NAR was lower for the patients with a CT scan (12%) compared to 27% for those patients without CT scans (P=0.002). The difference of the NAR between the preoperative CT group and the without CT group was statistically significant for the female (P=0.004) and adult groups (P=0.012) (14% vs 36%, 11% vs 26%, respectively). Conclusion: Preoperative intravenous contrast enhanced abdomen-pelvis CT was effective in reducing the negative appendectomy rate in patients who were suspected of having acute appendicitis. Especially, the adults and women benefit more from CT scanning and they had a significantly lower negative appendectomy rate than the children and men, respectively.
주원균(Won-Kyun Joo),김용(Yong Kim),조은일(Eun-Il Cho),맹성현(Sung-Hyoun Myaeng) 한국정보과학회 1998 한국정보과학회 학술발표논문집 Vol.25 No.2Ⅲ
인터넷이 그 규모 및 정보의 내용에서의 대형화를 지향하면서, 분산환경에서 사용자들의 정보에 대한 요구가 날로 증가하고 있고, 이를 만족시킬 수 있는 전 단계로 정보 수집이라는 것이 새로운 문제로 떠오르고 있다. 이에 에이전트를 기반으로 구성된 분산 디지털 도서관상에서 웹 정보 서비스를 제공하기 위한 로봇 에이전트를 설계 · 구현하였다. 구현된 로봇은 JAVA 와 RMI 를 기반으로 에이전트화를 통해 분산 환경 구조를 갖추고 있으며, 멀티 쓰레드와 로봇 제어 알고리즘을 통해 정보의 수집 및 관리에 있어서 로봇의 신뢰도를 향상시켰고, DBMS 와 에이전트의 연계를 통한 대용량 처리 기능과 관리자의 관리의 편리성을 도모하기 위해 자동화 기능을 갖추었으며, 로봇과 관련되어 발생할 수 있는 부하를 최소화 할 수 있도록 하였다.
지르칼로이-4 산화가속화 현상에 대한 수소화물 석출과 산화막 건전성의 영향
金龍秀,金東主,金善其,趙一濟,李英雨 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.12
The roles of the hydride precipitation and integrity of the oxide layer in the accelerated corrosion of Zircaloy-4 are investigated by determining the critical ratio of P_H2/P_H20 using TGA(Thermo-Gravimetric Apparatus) and studying the effect of hydride precipitation on the oxidation kinetics. Under hydrogen-water mixture environment hydriding reaction takes place much faster than the oxidation reaction at early stage and soon later growing oxide begins to retard the hydriding reaction and completely prevent from the hydriding in the second stage. It turns out that even in this stage the oxidation rate is enhanced with increasing P_H2/P_H20 ratio. In the final stage, the oxide breakdown occurs, thus, massive hydriding takes place again. Intermittent weight gain measurements using autoclaves also confirm these results.
한국인 및 중국 한족 정신분열병 환자의 5-HT2A 수용체 유전자 -1438A/G 다형성
이장호,이광철,이승부,오용인,최영근,조아랑,정주호,장환일 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1
Objectives : The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population. Methods : A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Resthction Fragment Length Polymorphism (RFLP). Results : There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G Poly-morphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics. Conclusion : These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.