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미성숙 랫드 자궁비대반응시험을 이용한 DEHA의 내분비계 장애작용 평가
박기대,한범석,정자영,오재호,조완섭,조민정,최미나,김성준,김승희,Park, Ki-Dae,Han, Beom-Seok,Jeong, Ja-Young,Oh, Jae-Ho,Cho, Wan-Seob,Cho, Min-Jeong,Choi, Mi-Na,Kim, Sung-Joon,Kim, Seung-Hee 한국환경보건학회 2007 한국환경보건학회지 Vol.33 No.5
This study was aimed to investigate the estrogenic activity of Di-(2-ethylhexyl) adipate (DEHA) using immatured type uterotrophic assay. SD rats were treated with DEHA (40, 200, 1000mg/kg/day), estradiol-3-benzoate (EB) $(1{\mu}g/kg/day)$ as positive control on the assay. In immatured-type uterotrophic assay, relative organ weights of kidney and reproductive organs such as ovary at high-dose group were significantly increased compared to those of vehicle control group. DEHA did not influence the levels of serum FSH and LH, and uterine morphological changes such as luminal epithelial height, myometrial thickness and numbers of uterine gland, and BrdU indices. In these results, there was no significant variation by DEHA treatment, suggesting that DEHA appears not to be a endocrine disrupter with estrogenic activity.
중기 다장기 발암성시험법을 이용한 플라스틱 가소제의 전암단계 병변에 미치는 영향
한범석(Beom Seok Han),박기대(Ki Dae Park),조완섭(Wan Seob Cho),송창용(Chang Yong Song),조현무(Hyun Mo Cho),김철규(Cheul Kyu Kim),최미나(Mina Choi),성낙원(Nak Won Seong),이여진(Yeo Jin Lee),오상연(Sang Yeun Oh),정자영(Jayoung Jeong),김 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
This study was conducted to assess the modifying effects of diisodecyl phthalate (DIDP) and diethylhexyl phthalate (DEHP) in the rat medium-term multi-organ bioassay using five different carcinogens. Seventy five, 6-week-old, male F344 rats were divided into four groups. Animals were sacrificed at week 12. To evaluate modifying effects of preneoplastic lesions of DIDP and DEHP, we measured glutathione S transferase placental form (GST-P) and 5-bromodeoxyuridine (BrdU) expression level in liver, numbers of aberrant crypt foci (ACF) in colon and performed histopathological observation. The body weights of rats given 12,000 ppm DEHP and 8,000 ppm DIDP were significantly decreased compared to those of control group. Relative liver and kidney weights of rats given DIDP were significantly increased compared to those of control group in a dose dependent manner. There was no significance of GST-P positive foci and BrdU labeling indices in liver and numbers of ACF in colon among each group. Although hyperplasia of urinary bladder of rat given DEHP were significantly increased compared to that of control group, there were no significant changes of preneoplastic lesions on all organs of rats given DIDP. These results indicate that DIDP has no modifying effect on preneoplastic lesions in all organs.
김형섭 ( Hyung Sub Kim ),김용순 ( Yong Soon Kim ),임채형 ( Chae Hyung Lim ),곽승준 ( Seung Jun Kwack ),조영래 ( Young Rae Cho ),강미선 ( Mi Sun Kang ),오재호 ( Jae Ho Oh ),조완섭 ( Wan Seob Cho ),한범석 ( Bum Seok Han ),김승희 ( S 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
To compare the responsiveness of nephrotoxicity parameters, mercuric chloride(HgCl2) was administered intraperitoneally at the doses of 0.2, 0.6 and 1.0 mg / kg for different exposure periods(1, 3 and 7 days) using F344N rats. We compared several parameters resulted from animal study(body weight change, organ weight), clinical pathological(serum and urine chemistry), histopathological study and toxicogenomic study. Animal body weight significantly decreased and kidney weight(relative) increased in a dose-dependent manner. Serum chemistry analysis showed that BUN and creatinine were relatively one of nephrotoxicity biomarkers against HgCl2 and serum chemistry analysis was more sensitive than urine analysis. In the histopathological study, dose and time-dependency was clearly observed. Cellular swelling was observed in the low dose(0.2 mg / kg) group(1 day treatment) and focal inflammation including cellular swelling was observed in the high dose group. In the DNA microarray analysis, gene expression profiles were analysed in the 1-day and 3-days treatment group. Taken together, the responsiveness of individual parameter(body weight change, organ weight, clinical pathology, histopathology and DNA microarray) was different. This study suggests that these considerations should be involved in the analysis of toxicity study data as well as toxicogenomic study could provide a useful information to reduce the number of experimental animals used in the repeated toxicity study.
김형섭 ( Hyung Sub Kim ),김용순 ( Yong Soon Kim ),임채형 ( Chae Hyung Lim ),곽승준 ( Seung Jun Kwack ),조영래 ( Young Rae Cho ),강미선 ( Mi Sun Kang ),오재호 ( Jae Ho Oh ),조완섭 ( Wan Seob Cho ),한범석 ( Bum Seok Han ),김승희 ( S 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
To compare the responsiveness of nephrotoxicity parameters, mercuric chloride(HgCl2) was administered intraperitoneally at the doses of 0.2, 0.6 and 1.0 mg / kg for different exposure periods(1, 3 and 7 days) using F344N rats. We compared several parameters resulted from animal study(body weight change, organ weight), clinical pathological(serum and urine chemistry), histopathological study and toxicogenomic study. Animal body weight significantly decreased and kidney weight(relative) increased in a dose-dependent manner. Serum chemistry analysis showed that BUN and creatinine were relatively one of nephrotoxicity biomarkers against HgCl2 and serum chemistry analysis was more sensitive than urine analysis. In the histopathological study, dose and time-dependency was clearly observed. Cellular swelling was observed in the low dose(0.2 mg / kg) group(1 day treatment) and focal inflammation including cellular swelling was observed in the high dose group. In the DNA microarray analysis, gene expression profiles were analysed in the 1-day and 3-days treatment group. Taken together, the responsiveness of individual parameter(body weight change, organ weight, clinical pathology, histopathology and DNA microarray) was different. This study suggests that these considerations should be involved in the analysis of toxicity study data as well as toxicogenomic study could provide a useful information to reduce the number of experimental animals used in the repeated toxicity study.
랫드에서 계피유래활성물질(CB-PH)의 경구투여에 의한 4주간 반복투여독성 시험
조현무(Hyun-Mu Jo),성낙원(Nak-Won Seong),제정환(Jung Hwan Che),박기대(Ki Dae Park),남기택(Ki Taek Nam),조완섭(Wan-Seob Cho),한범석(Beom Seok Han),양기화(Ki Hwa Yang),김방현(Bang Hyun Kim),이국경(Kook Kyung Lee),김형진(Hyoung-Chin Kim 한국독성학회 2003 Toxicological Research Vol.19 No.4
Although 'Cinnamon' has been widely used for the food and biophamacy in the world, it's toxicity was not screened completely. Major component of 'cinnamon' is CB-OH and CB-PH. CBPH has been reported to have antimutagenic effect. To investigate the toxicity of 2- o-Benzoylcinnamaldehyde (CB-PH), repeated dose (4 weeks) oral toxicity test performed in SD rats. Results of repeated dose oral toxicity tests for 4 weeks (CB-PH; 500, 1000, 2000 mg/kg/day) suggested that the CB-PH treated group showed no significant toxicological findings with body weights, organ weights, hematological and histopathological findings. Therefore, these data indicated that the maximum tolerated dose of CB-PH was 2000 mg above/kg/day in the rats.