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주산기 랫드 모체에서 Insulin-like Growth Factor System의 변동
진송군,박수현,조남표,강창원,Jin, Song-jun,Park, Soo-hyun,Cho, Nam-pyo,Kang, Chang-won 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.3
Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are important regulators on the development of maternal tissues during pregnancy. This study was performed to examine the relationship between maternal IGFs/IGFBPs system (i.e: IGF-I, II, their receptors, and IGFBPs) in pre- and post-partum rats. The liver and kidney are important organs for the synthesis of IGFs and IGFBPs in adults. The levels of materanal IGFs and IGFBPs in serum, liver, and kidney were examined at 14 and 21 days of gestation and at 3, 7, 11, and 14 days after birth. The expression of IGFs and their receptors mRNA was also examined in fetal and maternal rat liver, kidney. IGF-I concentrations in maternal serum and liver were decreased during pregnancy. However, IGF-I concentration in maternal kidney was increased, having maximal effect at 14 days of gestation. IGF-I concentrations were decreased in serum, liver, and kidney of postpartum rat, compared to control (p < 0.05). On the other hand, IGF-II concentrations in serum, liver, and kidney were increased during pregnancy (p<0.05) and gradually decreased to control level in postpartum period. The levels of IGFBP-3 and IGFBP-2 are expressed in serum, liver, and kidney. However, IGFBP-3 is mainly expressed in serum and liver, and IGFBP-2 in kidney. The levels of IGFBP-3 and IGFBP-2 in maternal serum were markedly decreased during pregnancy and gradually recovered to control level during postpartum period by western ligand blotting. However, there was no change of IGFBP-3 and IGFBP-2 levels by western immunoblotting. The levels of IGFBP-3 and IGFBP-2 in maternal liver and kidney also showed the same pattern of serum, although the main IGFBP is different. In normal rat serum, IGF-I 150 kDa and 50 kDa carrier proteins were detected. The level of IGF-I 150 kDa carrier proteins in pregnant rat was decreased compared to normal rat, but that of 50 kDa carrier proteins was increased. IGFBP-3 protease activity was identified in pregnant rat serum and maternal placenta, and it was inhibited by EDTA ($Ca^{2+}$ chelating agent) and aprotinin (serine proteinase inhibitor). Taken together, these results suggest that the changes of IGFs and IGFBPs in maternal rats are regulated by liver and kidney IGFs and their receptors mRNA during the pregnancy.
타액선 다형성 선종에서의 PLAG1과 CTNNB1 유전자 융합
김재진(Jae-Jin Kim),김은석(Eun-Seok Kim),고승오(Seung-O Ko),김효분(Hyo-Bun Kim),조남표(Nam-Pyo Cho) 대한구강악안면외과학회 2003 대한구강악안면외과학회지 Vol.29 No.4
The pleomorphic adenoma is the most common neoplasm involving both the major and minor salivary glands. It is a benign, slowgrowing tumor, but local recurrences can occur. The pleomorphic adenoma gene 1 (PLAG1), which is a novel zinc finger gene, is frequently activated by reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. This experimental study was preformed to observe the translocation patterns between PLAG1 gene and the three translocation partner genes. We also have analyzed the presence of PLAG1 transcripts by RT-PCR. CTNNB1/PLAG1 gene fusion was observed in three of nine pleomorphic adnomas. However, LIFR/PLAG1 and SII/PLAG1 gene fusions were not detectable. All of three gene fusions was not detectable in one Warthin’s tumor and three inflammatory salivary gland tissues. PLAG1 transcripts were expressed in all inflammatory salivary gland tissues and tumors except for three pleomorphic adenomas. Of particular one pleomorphic adenoma showing CTNNB1/PLAG1 gene fusion did not express PLAG1 transcipt. Our data indicate that gene fusion involving PLAG1 is a frequent event in pleomorphic adenoma, but correlation between gene fusion involving PLAG1 and PLAG1 transcription is not definite.
구강 편평세포암종의 예후평가에 관한 병리조직학적, 유세포분석적 및 임상적 매개변수들의 비교연구
조남표,류선열 전남대학교 치과대학 1993 전남치대논문집 Vol.5 No.1
A series of 26 patients with primary oral squamous cell carcinoma(SCC) who were treated from 1988 to 1993 at Chonbuk National University Hospital, were evaluated by flow cytometry, immunohistochemical analysis of p53 and PCNA, new malignancy grading system, and the TNM classification. Our purpose in this study was to determine the prognostic value of the above parameters and their correlation. Abnormal DNA content (aneuploidy) was identified in 15(58%) of the 26 neoplasms. Abnormal DNA content correlated highly with the tumor size and clinical stage (classified by the TNM classification proposed by the American Joint Committee on Cancer). Positive immunohistochemical detection of p53, a nuclear protein involved in the development of numerous human tumors, was accomplished in 21(81%) of 26 primary SCC and in 3 of 11 nonneoplastic epithelial hyperplasia. Positive immunohistochemical detection of PCNA, polymerase delta accessory protein, was accomplished in all primary SCC and nonneoplastic epithelial hyperplasia. The differences of p53- and PCNA-labeled index between primary SCC and nonneoplastic epithelial hyperplasia were statistically sign ificant (P<0.05). Histologic mean malignancy score of the primary SCC was 14.2. But the histopathologic mean malignancy score had no prognostic value except for the significant difference of population means of invasion pattern and invasion stage between aneuploid and diploid groups of SCC.
구강편평세포암종의 유세포분석적 DNA측정을 위한 이중 매개변수법의 적용
백병주,조남표,김재곤,주훈,김수야 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2
A series of 31 patients with primary oral squamous cell carcinoma (SCC) who were treated at Chonbuk National university Hospital during the years 1991-1995,were evaluated by dual parameter analysis in flow cytometric DNA measurement,Bryne's malignancy grading system,and the TNM classification.The aims of the present study were to discover that previously undetected aneuploid clones could be detected by dual parameter analysis and to determine the prognostic value of the above parameters. 1.Using dual parameter analysis of cytokenratin and DNA on disintegrated paraffin-embedded samples,aneuploid clones which were undetected by regular single parameter DNA analysis could be found among the cytokenratin-selected cells. DNA aneuploidy from parafin-embedded samples were 15 cases compared with 10 cases using conventional DNA analysis. 2.The portion of aneuploid tumors showed slightly higher clinical stage tumor size than the portion of diploid tumors, but the difference was not significant.The portion of DNA aneuploid tumors showed significantly higher mean mitosis and total malignancy scores than the portion of DNA diploid tumors. 3.The majority of the patients presented with clinical stage Ⅲ and Ⅳ lesions showed showed significantly higher mean total malignancy scores as compared to those with clinical stage Ⅰ and Ⅱ. 4.Histopatholgic mean total malignancy score of the 31 cases was 12.7.Among the histologic parameters,mean mitosis score was correlated to the status of DNA ploidy and total malignancy score were correlated to the DNA ploidy and clinical staging.
Immunopotentiator(OK-432)가 마우스 淋巴節 組織學的 變化에 미치는 影響
崔三任,趙南杓,宋熹鍾,文俊一,崔湖烈,金象皓 의과학연구소 1988 全北醫大論文集 Vol.12 No.3
To investigate the mechanism of action of the OK-432 as a immunopotentiator, morphological studies of the lymph nodes were carried out in mice. OK-432 was administered intravenously in single(0.1 KE/100 g body weight) or sequential(0.01, 0.025, and 0.05KE/100 g body weight for succesive 3 days) doses to mice sensitized with sheep erythrocytes(SRBC) and nonsenstized mice. One, 3,5,7, and 10 days after OK-432 administration, histological and histochemical examinations were performed by H&E, methylgreen pyronin(MGP), and reticulin stains. The results were as follows: 1. In control group(treated with SRBC only), follicular structures of primary lymph follicles with indistinct germinal center were partially disrupted. The parafollicular area consisted mostly of pyrninophilic cells. 2. In OK-432 administered group, especially in sequentially administered group, secondary lymph follicles with distinct germinal center were developed. 3. In OK-432 administered group, and the development of secondary lymph follicles with enlarged and prominent germinal center were noted in the sequentially-administered groups. According to these results, immunopotentiator OK-432 affected not only parafollicular area of the T-cell area, but also germinal center of the B-cell area. This suggest that OK-432 may potentiate the humoral immunity as well as the cellmediated immunity.