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구강 편평세포암종의 예후평가에 관한 병리조직학적, 유세포분석적 및 임상적 매개변수들의 비교연구
조남표,류선열 전남대학교 치과대학 1993 전남치대논문집 Vol.5 No.1
A series of 26 patients with primary oral squamous cell carcinoma(SCC) who were treated from 1988 to 1993 at Chonbuk National University Hospital, were evaluated by flow cytometry, immunohistochemical analysis of p53 and PCNA, new malignancy grading system, and the TNM classification. Our purpose in this study was to determine the prognostic value of the above parameters and their correlation. Abnormal DNA content (aneuploidy) was identified in 15(58%) of the 26 neoplasms. Abnormal DNA content correlated highly with the tumor size and clinical stage (classified by the TNM classification proposed by the American Joint Committee on Cancer). Positive immunohistochemical detection of p53, a nuclear protein involved in the development of numerous human tumors, was accomplished in 21(81%) of 26 primary SCC and in 3 of 11 nonneoplastic epithelial hyperplasia. Positive immunohistochemical detection of PCNA, polymerase delta accessory protein, was accomplished in all primary SCC and nonneoplastic epithelial hyperplasia. The differences of p53- and PCNA-labeled index between primary SCC and nonneoplastic epithelial hyperplasia were statistically sign ificant (P<0.05). Histologic mean malignancy score of the primary SCC was 14.2. But the histopathologic mean malignancy score had no prognostic value except for the significant difference of population means of invasion pattern and invasion stage between aneuploid and diploid groups of SCC.