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정화진(Hwa Jin Jung),조윤주(Yoon Joo Choi),원장원(Chang Won Won),서영록(Young Rok Seo) 한국환경성돌연변이발암원학회 2006 한국환경성돌연변이·발암원학회지 Vol.26 No.2
The reactive oxygen species (ROS) caused the damage of macro molecules, many degenerative disease and cancer, which was produced in process of the aerotropic metabolic pathway as well as in response to the various genotoxic stresses. Recently, redox systems including the number of antioxidant proteins such as catalase, glutathione peroxidase, heam-containing peroxidase, peroxiredoxin and superoxide dismutase (SOD) has been reported to have chemopreventive effects. Antioxidant proteins has been known to have the activity directly removing ROS and affecting the protein-protein interaction and cell signaling to induce the cellular responses. We need to understand the mechanism of antioxidants prevent DNA damage from oxidative stresses for researching the cancer prevention and providing the development of cancer therapeutic drug.
Multiplex SSR마커를 이용한 느타리(Pleurotus ostreatus) 품종 판별
최종인,정화진,나경숙,오민지,김민근,류재산,Choi, Jong In,Jung, Hwa Jin,Na, Kyeong sook,Oh, Min-Ji,Kim, Min-Keun,Ryu, Jae-San 한국버섯학회 2021 한국버섯학회지 Vol.19 No.1
느타리 품종구분을 위한 마커의 개발을 위하여 곤지7호의 어버이 일핵 균사중의 하나인 MT07156-97의 전체 유전자 염기서열을 바탕으로 제작한 251개의 SSR 프라이머를 제작하였다. 우선적으로 수한1호, 곤지7호, 흑타리 품종에 다형성 여부를 관찰하여 20개의 SSR을 선발하고, 이를 10개 품종에 적용하였다. 단일의 프라이머로는 일부 품종이 구분되지 않았으므로, 선발된 프라이머 간의 다양한 조합(multiplex 방식)을 적용한 결과 모든 품종을 판별할 수 있는 분자마커 다형성을 보인 프라이머 "166+115" 조합을 선발하였다. 별도로 프라이머 115와 166가 만들어 낸 산술적인 유전자좌(loci) 31개보다 12개 많은 40개의 유전자좌가 증폭되어 다양한 품종에 특이적인 분자마커를 제공할 수 있었다. 개발된 분자마커는 종균의 품질관리, 품종의 판별, 신품종 보호에 활용될 수 있을 것이다. To develop a method for the differentiation of Pleurotus ostratus cultivars, the multiplex-simple sequence repeat (SSR) primer set based on the SSRs obtained from whole genomic DNA sequence analysis was designed with two polymerase chain reaction (PCR) primer sets. These SSR primer sets were employed to distinguish 10 cultivars and strains. Twenty polymorphic markers were selected based on the genotyping results. PCR with each primer produced 1-4 distinct bands ranging in size from 150 to 350 bp, which was within the expected range. However, since a sole SSR marker was unable to detect polymorphisms in every cultivar, multiplex PCRs with composite PCR primer sets were employed. The multiplex primer, "166+115," completely discriminated 12 cultivars and strains with 40 loci, which were 12 more than the simple arithmetic addition of each locus of the primers 115 and 166. These results might be useful to provide an efficient method for the differentiation of P. ostreatus cultivars with separate PCRs for the quality control of spawn and protection of breeders' rights.
포름알데히드로 세리신 정착 후 정련에 의한 실크 생사의 반숙 정련
박건용,박창혁,정화진,이미연,이정주,박두경,Park, Geon Yong,Park, Chang Hyouck,Jeong, Hwa Jin,Lee, Mi Yeon,Lee, Jung Ju,Park, Du Keong 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.5
To obtain the half-degummed silk yarns of 5~10% degumming losses, raw silk yarns were degummed with alkaline detergent after fixing sericin with formaldehyde. Adding above 5 g/l acetic acid or tartaric acid in 1% and 5% formaldehyde fixing baths created a lot of sericin loss during degumming with 3 g/l alkaline detergent and 2 g/l sodium carbonate after fixing sericin due to alkaline hydrolysis of sericin cross-linkage. When sericin was degummed with 3 g/l alkaline detergent after fixing with 0.1% formaldehyde at $40^{\circ}C$ or $60^{\circ}C$ for 15 min, the degumming temperature necessary to obtain satisfactory half-degumming was $70{\sim}80^{\circ}C$. Also, fixing sericin at $60^{\circ}C$ resulted in stronger sericin fixation than fixing at $40^{\circ}C$. However, the softener of cationic surfactant added in sericin fixing baths did not prevent the attachment of degummed silk yarns. Approximately 6.5% degumming loss was obtained when sericin was degummed at $85^{\circ}C$ for 30 min with 3 g/l alkaline detergent after fixing with 0.1% formaldehyde at $80^{\circ}C$ for 15 min and 30 min, and in case of adding 2 g/l acetic acid in fixing baths the half-degummed silk yarns of about 10% degumming losses, which were severely attached to each other, were obtained.
헬리코박터 파이로리의 병원성 단백질, CagA에 대한 분자 독성학적 측면에서의 고찰
김병주(Byung J. Kim),정화진(Hwa Jin Jung),황지나(Jee Na Hwang),강석하(Seok Ha Kang),오세진(Se-Jin Oh),서영록(Young Rok Seo) 한국독성학회 2004 Toxicological Research Vol.20 No.3
Helicobacter pylori (H. pylori) infects more than half of the people in the world as a major<br/> microbe to cause most of gastric diseases. Recently, cytotoxin associated-antigen A (CagA) is believed as<br/> one of the most important virulence factors of H. pylori. Molecular toxicological pathway of CagA is necessary<br/> to investigate for understanding the pathological and toxicological aspects of H. pylori, since this virulence<br/> protein harasses intercellular processes of host cells to get profit for the survival of H. pylori. CagA is<br/> coded from cag pathogenicity island (cag PAI) and translocated into host cells by Type 4 secretion system<br/> (TFSS). Tyrosine phosphorylation of CagA targets Src homology 2-containing phosphotyrosine phosphatase<br/> (SHP-2) to form a CagA-SHP-2 complex. This complex depends on the similarity of sequence<br/> between EPIYA motif and Src homology 2 domain (SH2 domain) of CagA. The generation of growth factors<br/> is an essential role of CagA in protecting and healing gastric mucosa for the survival of H. pylori. On<br/> the other hand, the activation of IL-8 by CagA induces neutrophils generating inflammation and free radicals.<br/> Indeed, free radicals are well known carcinogen to induce DNA damage. In addition, the transduction<br/> of mitogen-activation signal by CagA is one of the interesting features to understand how to cause cancer.<br/> The relationship between cancer and inflammation with CagA was mainly discussed in this review.
박상원 ( Sang Won Park ),이재웅 ( Jae Woong Lee ),이진호 ( Jin Ho Lee ),하인혁 ( In Hyuk Ha ),변장훈 ( Jang Hoon Byun ),정범환 ( Bum Hwan Jung ),정화진 ( Hwa Jin Jung ),이인희 ( In Hee Lee ),김민정 ( Min Jeong Kim ),김은지 ( Eun J 한방재활의학과학회 2016 한방재활의학과학회지 Vol.26 No.1
Objectives Despite the increasing use of Ja-ha-guh (Hominis-placenta ) pharmacopuncture in rehabilitative medicine field, its standard compound has yet to be investigated. The purpose of this study is to provide standardization for future studies and increase satisfaction of patients by utilizing standard pharmacopuncture. Methods Alanine and leucine were selected as potential standard compounds. LC/MS was used to devise an analytic method. This analytic method was subject to validation. According to validation guideline of Korea Food and Drug Administration, the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy were measured. With this analysis, 3 lots of Ja-ha-guh pharmacopuncture were analyzed. Results Because the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy meet criteria of the guideline, the analytic method was validated. It was found that Ja-ha-guh pharmacopuncture contained 211.02±7.28 ug/ml of alanine and 372.03±7.58 ug/ml of leucine. Conclusions Both alanine and leucine appear to be suitable standard compounds. These results are likely to contribute to further standardization of Ja-ha-guh for medical use. (J Korean Med Rehab 2016;26(1):33-40)
유옥철 ( Ok Cheol Yu ),최성률 ( Sung Ryul Choi ),주환수 ( Hwan Soo Joo ),한창 ( Chang Han ),문혜연 ( Hye Yeon Moon ),정화진 ( Hwa Jin Jung ),정찬헌 ( Chan Hun Jung ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.6
Objectives : It is necessary to manage herbal medicines based on effectiveness by comparing the efficacy of herbal medicines by region. In this study, we compared anti-oxidative activity and marker compounds of Eucommiae Cortex by regional groups. Methods : Eucommiae Cortex grown and harvested in Gangjin, Sancheong, Yeongwol, Jangsu, and Jecheon were used. Eucommiae Cortex was extracted in distilled water at 100℃ for 3 hours, and filtered. filtered. Extract samples were freeze-dried at -80℃. Comparison of anti-oxidant activity in Eucommiae Cortex samples from regional groups was measured in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline- 6-sulphonic acid) (ABTS) free radical scavenging, and ferric reducing antioxidant power (FRAP) between regional groups of Eucommiae Cortex. In addition, high-performance liquid chromatography (HPLC) analysis was conducted to compare pinoresinol diglucoside concentration by regional groups. Results : HPLC analysis found that pinoresinol diglucoside concentration, widely known as the marker compound of Eucommiae Cortex, was the highest in Gangwon Yeongwol. There was a significant difference in anti-oxidative activity of Eucommiae Cortex between regional groups as discovered in DPPH, ABTS and FRAP assays. DPPH free radical scavenging was the highest in Jeonbuk Jangsu. ABTS free radical scavenging was the highest in Jeonbuk Jangsu and Chungbuck Jecheon. FRAP was the highest in Jeonbuk Jangsu. Conclusions : Although pinoresinol diglucoside concentration was high, anti-oxidative activity was not proportionately high. Pinoresinol diglucoside concentration was the highest in Gangwon Yeongwol. Anti-oxidative activity was the highest in Jeonbuk Jangsu.
다양한 환경변이원의 분자독성학적 메커니즘 연구에 있어서 항종양 인자 p53의 중요성 고찰
정화진,류재천,서영록 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.3
The study of p53 tumor suppressor protein is one of most important subjects to an environmental toxicology as well as in cancer biology Generally, p53 has been known to Involve the cell cycle regulation and apoptosis by the activation of its target genes such as p2l and bax in a number of cellular stress responses In addition, associations of p53 with cellular proteins presumably reflect the involvement of p53 in critical cellular processes such as DNA repair The complex formation of p53 and exogenous proteins such as viral or cellular proteins has been shown in many cases to play important roles in carcinogenic processes against environmental mutagen Recently the disruption of p53 protein by oxidative stress has been also reported to have relevance to carcinogenesis These findings suggested that the maintaining of stability and functional activity of p53 protein was also important aspect to play as a tumor suppressor protein Therefore, the detection of functional status of p53 proteins might be an effective biomarker for the cancer and human diseases under the environmental toxicologic carcinogen.