사립체 질환: 새로운 위대한 모방자가 될 것인가?

김영한,안석민,서영준,윤종형,배은주,이홍진,Kim, Young Han,Ahn, Seok Min,Seo, Young Jun,Yoon, Jong Hyung,Bae, Eun Ju,Lee, Hong Jin 대한유전성대사질환학회 2016 대한유전성대사질환학회지 Vol.16 No.3

Mitochondrial disease is a group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for the cell. Diagnosis of mitochondrial disease is difficult, subtle, and has many problems. It is more likely to miss the diagnosis of mitochondrial disease, especially in borderline cases where the symptoms of the disease are not severe. In this regard, urine organic acid analysis is noninvasive and can increase the sensitivity and specificity through repeated load test with few changes according to the specimen. And, It is considered to be suitable as a screening test for mitochondrial diseases because it has a great advantage of distinguishing from organic aciduria, urea cycle disorder and fatty acid oxidation disorder which may have similar symptoms. The purpose of this study was to investigate the clinical features and age distribution of mitochondrial diseases diagnosed by organic acid analysis and to establish the policy of diagnosis and treatment based on this study.

연소 유동장의 PIV 가시화 측정과 제반 문제들

김영한,윤영빈,정인석,Kim, Young-Han,Yoon, Young-Bin,Jeung, In-Seuk 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.4

PIV(Particle Image Velocimetry) is a recently developed technique for visualizing the fluid velocity fields. Because it has several advantages over the LDV(Laser Doppler Velocimetry), it became one of the most popular diagnostic tools in spite of its short history. However, its application to combustion is restricted by some problems such as flame illumination, scattered light refraction, particle density variation due to heat release, the combined effect of abrupt change in particle density and fluid velocity on flame contour, and thermophoresis which is particle lagging due to temperature gradient. These problems are expected to be originated from the non-continuous characteristics of flames and the limitations of particle dynamics. In the present study, these problems were considered for the visualization of the instantaneous coaxial hydrogen diffusion flame. And the instantaneous flame contour was detected using particle density difference. The visualized diffusion flame velocity field shows its turbulent and meandering nature. It was also observed that the flame is located inside the outer shear layer and flame geometry is largely influenced by the vorticity.

Neonatal Onset Isovaleric Acidemia with Novel Mutation

김영한,배은주,박형두,이홍진,Kim, Young Han,Bae, Eun Ju,Park, Hyung-Doo,Lee, Hong Jin The Korea Society of Inherited Metabolic Disease 2016 대한유전성대사질환학회지 Vol.16 No.1

Isovaleric acidemia is autosomal-recessively inherited and an inborn error of metabolism caused by abnormal leucine metabolism due to the genetic defect of IVD (Isovaleryl-CoA dehydrogenase). IVD corresponds to mitochondrial matrix enzyme that acts on converting isovaleryl-CoA into 3-methylcrotonyl-CoA in the leucine catabolism. The IVD gene is located at Chromosome 15q14-q15, particularly between base pair 40,405,485 and base pair 40,435,948. It consists of 12 exons and has been reported to cause over 50 diseases so far. We conducted IVD gene test on the patient with acute isovaleric acidemia and confirmed a new type of mutation for the first time. As a result of analyzing the IVD gene sequence, we found out that c.129T>G(p.Asn43Lys) and c.1033A>G(p.Asn345Asp) mutations exist as heterozygosity at Exon 1 and Exon 10 respectively, novel mutation.

LCFQ ( Linear Clock Fair Queueing ) 알고리즘의 설계와 성능 분석

김영한,이재용,Kim, Young-Han,Lee, Jae-Yong 대한전자공학회 1999 전자공학회논문지SC (System and control) Vol.s36 No.1

종합 서비스망에서, 트랙픽을 발생시키는 각각의 플로우에 대하여 QoS(Quality of Service)를 적절하게 제공하기위해서는 호스트와 라우터에 자원 예약뿐만 아니라 효율적인 트랙픽 스케쥴링이 채택되어야 한다. 본 논문에서는 가상시간이 선형적으로 증가하는 새로운 페어 큐잉 알고리즘에 제안한다. 본 논문에서 제안된 알고리즘은 각 플로우에 대하여 기존의 SCFQ(Self-Clocked Fair Queneing) 알고리즘과 유사한 구현 복잡성을 갖으면서 더 감소된 최대 지연와 평균 지연시간을 제공하고 공평성 측면에서도 개선됨을 보여준다. 또한 자신에게 할당된 대역폭보다 더 많은 트랙픽을 발생시키는 플로우에 의해 다른 플로우는 영향을 받지 않도록하는 독립성 특성 또한 SCFQ보다 더 좋은 성능을 보인다. 본 논문에서는 제안된 알고리즘에 대한 공평성을 증명했고, 최대지연과 평균지연시간에 대한 시뮬레이션 결과를 나타냈다. In order to provide appropriate Quality of Service(QoS) guarantee to each traffic flow in intergrated service networks, an efficient traffic scheduling algorithm as well as resource reservation must be adopted in host and transit routers. In this paper, a new efficient fair queueing algorithm which adopts a linearly increasing virtual time is presented. The proposed algorithm is fair and the maximum and mean delay guaranteed of each flow are less than those of the SCFQ(self clocked fair queueing) algorithm which is one of the most promising traffic scheduling algorithm, while providing low implementation complexity as the SCFQ scheme. And, it has the better isolation provided than SCFQ, which means that each flow is much less influenced by the violating traffic flows provided its allocated bandwidth gurantee. The fairness of the proposed algorithm is proved and simulation results of maximum and mean delay presented.

주강계 저열팽창 주조합금의 열팽창 계수와 경도에 미치는 Mo , V 첨가의 영향

김영한,윤의박,문병문,홍영명 ( Young Han Kim,Eui Park Yoon,Byoung Moon Moon,Young Myung Hong ) 한국주조공학회 1998 한국주조공학회지 Vol.18 No.5

For enhancing the mechanical properties of LTE (low thermal expansion) cast steel, systematic researches have been carried out. The effects of alloying elements such as vanadium, molybdenum and carbon on the hardness and linear thermal expansion coefficient were investigated. In the range of 0.5∼2.3 wt% carbon, addition of 1.73 wt% carbon caused hardness increase due to the formation of eutectic carbide having high hardness but over the range of 1.73 wt% carbon, hardness was decreased. Thermal expansion coefficient increases with carbon contents. In the LTE cast steel containing 0.6 wt% carbon, hardness increased up to 1.96 wt% vanadium addition. But over the range of 1.96 wt% vanadium hardness was decreased by coarse eutectic carbide. Thermal expansion coefficient of LTE cast steel containing 0.6 wt%carbon moderately increased with increasing vanadium contents. There was no significant variation of hardness and thermal expansion coefficient according to molybdenum content in LTE cast steel. (Received June 29, 1998)

열처리에 의한 도재용 Ni-Cr합금 표면의 변화에 관한 연구

김영한,이선형,양재호,정헌영,Kim, Young-Han,Lee, Sun-Hyung,Yang, Jae-Ho,Jung, Heon-Young 대한치과보철학회 1989 대한치과보철학회지 Vol.27 No.2

The purposes of this study were to analyze the microstructural and compositional changes of metal surfaces following different conditions of preoxidizing heat treatment, to investigate the composition of metal oxides, and to evaluate the effect of preoxidation and removal of surface oxides on microstructure and diffusion profiles. The techniques of EDAX (energy-dispersive analysis of x-ray), ESCA (electron spectroscopy for chemical analysis), and EPMA (electron probe micro analysis) were used, along with SEM (scanning electron microscopy). The obtained results were as follows : 1. A surface of the specimen became rough and the amount of the metal oxides increased with increasing the heat treatment time and temperature and the partial pressure of oxygen. 2. At an air pressure of 28' vacuum, the higher the temperature and the longer the time of preoxidation, the higher Ni concentration was detected. 3. Cr concentration in the specimen heat treated with air was higher than that of with vacuum. 4. The oxides in the specimens were mainly composed of Ni and Cr oxides. On the globular growth particles, significant rises in Al concentration of Rexillium III and Ti concentration of Verabond were noted. 5. Atomic diffusion occurred at the ceramic-metal interface, furthermore the amount of the flux was increased with preoxidation heat treatment.

도재전장주조관의 순측 치경부 변연 적합도에 관한 주사전자현미경적 연구

김영한,이선형,Kim, Young-Han,Lee, Sun-Hyung 대한치과보철학회 1985 대한치과보철학회지 Vol.23 No.1

The purpose of this study was to evaluate the marginal fitness of collarless metal-ceramic crown formed with direct lift technique using wax compared with metal-ceramic crown with metal butt margin. Twenty crowns, ten were collarless metal-ceramic crowns and ten were metal-ceramic crowns with metal butt margins, were made and cemented on epoxy resin dies, and their marginal openings were measured on scanning electron microphotographic prints at x200 magnification. The results were as follows; 1. In the case of collarless metal-ceramic crowns, the mean marginal opeining was $43.78{\pm}17.67{\mu}m$, the mean maximum marginal opening was $52.81{\pm}19.81{\mu}m$, and the mean minimum marginal opening was $34.99{\pm}16.58{\mu}m$. 2. In the case of metal-ceramic crowns with metal butt margins, the mean marginal opening was $47.62{\pm}25.55{\mu}m$, the mean maximum marginal opening was $61.90{\pm}24.39{\mu}m$, and the mean minimum marginal opening was $34.86{\pm}24.92{\mu}m$. 3. There was no significant difference between two types of crowns at the 99% confidence level. 4. The marginal fitness of collarless metal-ceramic crown formed with direct lift technique using wax was clinically acceptable.

영상분석을 통한 KL-3 엔진 노즐목 삭마 경향 분석

김영한(Young-Han Kim),박성진(Sung-Jin park),류철성(Chul-Sung Ryu),김용욱(Yong-Woo Kim),한상엽(Sang-Yeop Han),김병훈(Byung-Hun Kim) 한국연소학회 2003 KOSCOSYMPOSIUM논문집 Vol.- No.-

ℓ₁-최적제어를 이용한 컨테이너 크레인의 운전

김영한(Young Han Kim),장상목(Sang Mok Chang) 한국항해항만학회 2005 한국항해항만학회지 Vol.29 No.5

컨테이너 크레인의 제어방법에 관한 기존 연구는 피제어 변수의 최종목표치의 오차를 최소화하는 목적함수를 사용하여 제어계산을 하였기 때문에 계산에서 얻어진 입력은 실제 운전에 적합하지 않은 과도한 변화를 가지게 되었다. 본 연구에서는 컨테이너 크레인의 비선형 모델을 사용하여 4차 Chevyshev 함수로 근사한 제어입력을 계산하는 새로운 제어계산 방법을 제안하였다. 제어 목적식은 편차의 절대치의 합을 최소화하도록 구성하였고 최적화 계산에는 심플렉스 알고리듬을 활용하였다. 본 제안의 제어방법으로 계산된 제어 입력과 출력을 기존의 제어방식으로 계산된 결과와 비교하여 본 제안의 제어방식의 결과가 기존 제어방식에 비해 안정된 컨테이너 크레인 운전성능을 보였다. The existing control techniques for the operation of a container crane satisfy the terminal condition of controlled variables, but the outcome of input computation is inadequate for the operation of the crane due to heavy movement of inputs. In this study, a new control technique employing a nonlinear model of the crane is proposed to compute the inputs approximated with the 4th-order Chevyshev function. The control objective of sum of absolute deviations is minimized, and the optimization is conducted with the simplex algorithm. The inputs and outputs computed from the proposed technique were compared with the results of the previous study to show that they give more stable crane operation than the existing control technique.

축소(Ⅰ) 수정형 엔진의 연소 시험

김영한(Young-Han Kim),김용욱(Yong-Wook Kim),이재룡(Jae-Yong Lee),문일윤(Il-Yoon Moon),고영성(Young-Sung Ko),이수용(Soo-Yong Lee) 한국항공우주연구원 2002 항공우주기술 Vol.1 No.1