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Helicobacter pylori에 감염된 십이지장궤양 환자의 벽세포수 및 산분비영역과 위산분비능과의 관계
정인식(In Sik Chung),박두호(Doo Ho Park),최상욱(Sang wook Choi),양영상(Young Sang Yang),최명규(Myung Kyu Choi),김성수(Sung Soo Kim),채현석(Hiun Suk Chae),김상우(Sang Woo Kim),최종영(Jong Young Choi) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
N/A Background/Aims: Convincing evidence now exists that Helicobacter pylori (H. pylori) has a pathogenic role in the development of active chronic gastritis and duodenal ulcer (DU). Unlike H. pylori-induced gastritis, the pathophysiology of H. pylori-induced DU is not clearly defined. It has been known that the patients with DU disease tend to secrete acid more than the controls do. To secrete acid more, the density of parietal cells should be increased and/or the oxyntic gland area of gastric mucosa should be well preserved. The present study aims to identify which of the two mechanisms is more relevant to hyperacidity in H. pylori-infected DU patients. Methods: we examined the acid output (basal and pentagastrin-stimulated), the oxyntic area by Congo red chromoscopy, and the number of parietal cells per unit area of the oxyntic gland in H. pylori-infected 20 DU patients and 20 non-ulcer subjects. Results: Basal acid output of DU patients was about 5-fold higher than that of controls (32.3 +- 17.9 vs. 6.1 +- 5.6 mmol/hr, P<0.001). The maximal acid output and peak acid output of DU patients were also approximately 3-fold higher than those of controls, respectively (59.7 +- 29.8 vs. 18.8 +- 18.9 mmol/hr, P=0.001; 73.9 +- 40.1 vs. 23.7 +- 20.6 mmol/hr, P=0.001). Fasting serum gastrin concentration was not significantly different between DU patients and controls. There was a significant difference in the width of oxyntic area between DU patients and controls (P<0.001). Eighty five percent of oxyntic area in DU patients was closed type, whereas 85 % of controls was open type. In DU patients, although the parietal cell density seemed to be higher than that of controls (579 +- 197 vs. 477 +- 204/mm ), the difference was not statistically significant. Peak acid output was well correlated with width of oxyntic area(r=0.568, P=0.002). Conclusions: H. pylori-infected duodenal ulcer patients have hyperacidity owing to rather well-preserved oxyntic area than density of parietal cells. (Korean J Gastroenterol 1997;29:591-600)
Helicobacter pylori에 감염된 십이지장궤양과 비궤양성 소화불량에서 ABO 혈액형과 HLA의 연관
채현석(Hiun Suk Chae),김태규(Tai Gyu Kim),한훈(Hoon Han),김성수(Sung Soo Kim),최규용(Kyu Yong Choi),정인식(In Sik Chung),차상복(Sang Bok Cha),박두호(Doo Ho Park),김부성(Boo Sung Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5
N/A Background/Aims: It has been known that genetic factors, for example, blood group, non-secretor and HLA system, are associated with duodenal ulcer and that Helicobacter pylori infection is the major cause of peptic ulcer. However, Helicobacter pylori is also found in non-ulcer dyspepsia and asyrnptomatic patients without ulcer formation. But, it is still not known regarding what kind of genetic factors have an effect on ulcer formation at the time of Helicobacter pylori infection. This study was performed to make clear wbich genetic factors are re1ated with duodenal ulcers among Koreans, and what kind of genetic factors could influence on the ulcer formation in the patients with Helicobacter pylori infection according to ABO blood groups and HLA antigen.'.. Methods: The duodenal ulcer patients (36), non-ulcer dyspepsia (19) and norraal healthy controls (103) were included in this study. Helicobacter pylori infection was detected with phenol red spray method in vivo which was confirmed with Warthin-Starry silver stain. HLA antigen expression (HLA-A,B) of peripheral blood T lymphocytes was studied with microlymphocytotoxicity teclmique. Results: Tbe frequency of HLA-A 33 was higher in duodenal ulcer patients (l4/36, 38.9%) compared with the control group (21/103, 20.4%). On the contrary, no difference in HLA-B has been shown between duodenal ulcer patients and controls. Among patients with Helicobacter pylori infection, blood group 0 was significant1y more frequent in patients with duodenal ulcers (21/36, 58.3%) than in non-ulcer dyspepsia (5/19, 26.3%). In patients with HLA-A 33, blood group 0 was significantly more frequent in duodenal ulcer patients (7/)4, 50%) than in non-ulcer dyspepsia patients (0/7, 0%). Conclusions: In Helicobacter pylori-infected patients, HLA-A 33 is related with duodenal ulcers and the patients with both blood group 0 and HI.A-A 33 are more likely to have duodeual ulcers than those with HLA-A 33 and without blood groop O. (Korean J Gastrnenterol 1996; 28:623 - 631)
Helicobacter pylori에 감염된 생쥐에서 위염에 대한 위산의 역할
김성수 ( Sung Soo Kim ),이여민 ( Yeo Min Lee ),김형근 ( Hyung Keun Kim ),김진일 ( Jin Il Kim ),채현석 ( Hiun Suk Chae ),정인식 ( In Sik Chung ),박두호 ( Doo Ho Park ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.6
목적: 위산이 H. pylori 감염에 의한 위염 진행을 억제할 수 있는지 알아보고자 대상 및 방법: C57BL/6 생쥐 28마리에 H. pylori (SS1 균주)를 감염시켰다. 7마리씩 4군으로 나누어 I군은 처치 없이 관찰하고, II군은 위투여(sham injection), III군은 펜타가스트린 125μg/kg, IV군은 펜타가스트린 250μg/kg을 일주일에 3회 피하 주사하여, 7개월 후 위 점막 pH를 측정하고, 위 점막의 H. pylori 군집도, 호중구 활성도, 만성 염증, 위선 위축의 변화를 관찰하였다. 결과: H. pylori 군집도는 체부와 전정부 모두 군 간에 차이가 없었다. 호중 구 활성도는 체부에서 타군에 비해 IV군이 현저히 낮았으며(I군, 1.71; II군, 1.0; III군, 2.71; IV군, 0.29, p<0.05), 전정 부에서는 군 간에 차이가 없었다. 만성 염증 세포의 침윤정도는 체부에서 III군에 비해 IV군이 현저히 낮았으나(1.86 vs. 1.0, p<0.05), 전정부에서는 군 간에 차이가 없었다. 위축 정도는 군 간에 통계적인 차이가 없었다. 대상 위 점막의 평균산도 3.2를 기준으로 고위산분비군과 저위산분비군으로 나누어 비교했을 때 체부에서 고위산분비군은 저위산분비군에 비해 H. pylori 군집도(1.4 vs. 2.4; P=0.04), 호중구 활성도(0.9 vs. 2.3; p=0.018) 및 만성 염증 세포의 침윤 정도(1.2 vs. 1.8; p=0.011) 모두 유의하게 낮았다. 결론: 위산은 위내 H. pylori에 의한 위염 확산을 억제하는 데 중요한 역할을 하는 것으로 생각한다. Background/Aims: This study was designed to investigate the role of gastric acid in the extent of H. pylori-induced gastritis. Methods: Twenty eight mice were innoculated with live H. pylori. They were allocated into four groups. Mice in group I received no treatment, group II mice were treated with sham injection, group III received 125μg/kg body weight of pentagastrin, while group IV received 250μg/kg body weight of pentagastrin subcutaneously three times a week. After 7 months, the mucosal pH, H. pylori density, neutrophils and monocytes infiltration, and the degree of atrophy were assessed in the stomach. Results: In the gastric body, the densities of H. pylori were not different among groups. The degree of neutrophil infiltration was significantly lower in group IV compared to other groups (p<0.05). The degree of monocyte infiltration was also significantly lower in group IV than group III (p<0.05). In the gastric antrum, there was no significant difference of the H. pylori density, neutrophil and monocyte infiltration, and degree of atrophy among the groups. The mice with the gastric mucosal pH lower than mean of 3.2 had significant lower level of H. pylori density (1.4 vs. 2.4, p=0.04), and infiltration of neutrophils (0.9 vs. 2.3, p=0.018), and monocytes (1.2 vs. 1.8; p=0.011) than the those with mucosal pH above 3.2 in the body of stomach. Conclusions: Gastric acid plays a role in suppressing the proximal propagation of H. pylori-induced gastritis to the body of stomach. (Korean J Gastroenterol 2007;50:363-369)
위장관 ; 한국인에서 위저선용종과 결장암의 상관관계: 16년간 후향적 고찰
황선미 ( Sun Mee Hwang ),김병욱 ( Byung Wook Kim ),채현석 ( Hiun Suk Chae ),이보인 ( Bo In Lee ),최황 ( Hwang Choi ),지정선 ( Jeong Seon Ji ),최규용 ( Kyu Yong Choi ),정인식 ( In Sik Chung ),맹이소 ( Lee So Maeng ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.1
Background/Aims: There is an ongoing debate on the relationship between gastric fundic gland polyps and increased incidence of colorectal neoplasia in Caucasians. However, there was no report on the relationship between gastric fundic gland polyp and colorectal neoplasia in Korea. The aim of this study was to identify the characteristics of gastric fundic gland polyps and whether a relationship exists between fundic gland polyps and colorectal neoplasia in Korean population. Methods: Persons who underwent an esophagogastroduodenoscopy and colonoscopy from 1992 to 2007 at the Health Promotion Center of Incheon St. Mary`s Hospital, The Catholic University of Korea were reviewed retrospectively. The relationship between gastric fundic gland polyps and colorectal neoplasia were analyzed. Results: Among 22,451 subjects, fundic gland polyps were found in 328 subjects (1.5%). Fundic gland polyps were more common in women than in men (odds ratio of 6.25; 95% CI of 4.68-8.34). The odds ratios for colorectal neoplasia in all subjects with gastric fundic gland polyps were 0.56 (95% CI of 0.33-0.95) and men who were 50 years of age or older had an odds ratio of 2.81 (95% CI of 1.03-7.66) as compared to the control group. However, age and sex-adjusted odds ratios for all gastric fundic gland polyps were 0.73 (95% CI of 0.42-1.26), for men 1.78 (95% CI of 0.80-3.98), and for women 0.37 (95% CI of 0.16-0.87). Conclusions: Surveillance colonoscopy in patients with fundic gland polyps can be performed in the same manner as general population in Korea. (Korean J Gastroenterol 2011;58:20-24)
Helicobacter pylori 감염 위상피세포에서 Rosiglitazone이 세포성장과 p27 및 Skp2 발현에 미치는 영향
김성수 ( Sung Soo Kim ),조영석 ( Young Seok Cho ),김형근 ( Hyung Keun Kim ),신옥란 ( Ok Ran Shin ),채현석 ( Hiun Suk Chae ),최명규 ( Myung Gyu Choi ),정인식 ( In Sik Chung ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.4
Peroxisome proliferator-activated receptorγ (PPARγ)는 핵 수용체로 PPARγ 배위자는 세포주기 조절인자와 세포자멸사에 관련된 인자의 발현에 영향을 미쳐 악성 종양의 성장을 억제할 수 있다. H. pylori 감염에 의한 위샘암의 발생은 위상피세포 증식과 세포자멸사의 불균형이 관여한다. 이에 저자들은 H. pylori 감염 위상피세포에서 rosiglitazone이 세포 성장에 미치는 영향과 p27 단백과 Skp2 단백 발현에 미치는 영향을 보고자 하였다. 대상 및 방법: 위상피세포주인 AGS 세포에 H. pylori를 감염시킨 후 PPARγ 발현은 Western blot을 이용하여 측정하였다. Rosiglitazone을 처리한 후 H. pylori 감염 AGS 세포의 생존율을 측정하였다. H. pylori를 감염시킨 AGS 세포에서 rosiglitazone을 처리한 후 p27 단백과 Skp2 단백 발현은 Western blot을 이용하여 측정하였다. 결과: H. pylori 감염 AGS 세포에서 PPARγ 발현이 증가하였다. Rosiglitazone 처리는 H. pylori 감염 AGS 세포성장을 용량 및 시간 의존적으로 억제하였다. Rosiglitazone은 H. pylori 감염 AGS 세포에서 용량 및 시간 의존적으로 p27 단백 발현을 증가시켰고 Skp2 단백 발현을 감소시켰다. 결론: Rosiglitazone은 H. pylori 감염 AGS 세포의 성장을 억제하였다. 또한 p27 단백 발현을 증가시켰고, 이는 p27 단백분해에 관여하는 Skp2 단백 발현의 감소와 연관이 있었다. 이러한 p27 단백 발현 증가가 H. pylori 감염에서 세포 전환율에 미치는 영향과 위암 발생과의 연관성에 대해서는 추후 많은 연구가 필요할 것으로 보인다. Background/Aims: Ligands for peroxisome proliferator-activated receptorγ (PPARγ), a member of the ligand-activated nuclear receptor superfamily, exhibit anti-tumoral effects and are associated with de novo synthesis of proteins involved in regulating the cell cycle and cell survival/death. Helicobacter pylori (H. pylori) is an etiologic agent for gastric adenocarcinoma, and raises the cell turnover of gastric epithelium. The aim of this study was to investigate the effect of PPARγ ligand rosiglitazone on the cell proliferation and the expressions of p27 and Skp2 protein in H. pylori infected gastric epithelial cells. Methods: We examined the expression of PPARγ by Western blot in H. pylori infected AGS human gastric epithelial cells. The effect of rosiglitazone on the survival of H. pylori infected AGS cells was assessed by cell viability assay. After the treatment of rosiglitazone in H. pylori infected AGS cells, the expressions of p27 and Skp2 were assessed by Western blot. Results: The expression of PPARγ protein was increased in H. pylori infected AGS cells. Cell growth was inhibited and decreased in dose-and time-dependent manner in H. pylori infected AGS cells treated with rosiglitazone. A decrease in Skp2 expression and a reciprocal increase in p27 expression were found in dose- and time-dependent manner in H. pylori infected AGS cells treated with rosiglitazone. Conclusions: Rosiglitazone inhibited the growth of H. pylori infected AGS cells. Rosiglitazone attenuated Skp2 expression, thereby promoting p27 accumulation in H. pylori infected human gastric epithelial cells. Further studies will be needed to find the effects of accumulation on cell turnover in H. pylori infection and the role in the H. pylori-associated gastric carcinogenesis. (Korean J Gastroenterol 2010;55:225-231)
열화상 카메라를 이용한 LED 투광등 방열특성에 관한 연구
이중섭(Chung seob Yi),정인국(In guk Jeong),서정세(Jeong se Suh),정민채(Min chae Jeong) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
In the recent times, with the feature of low-power and eco-friendly, use of LED(Light Emitting Diode) is increasing. For resolving the problem of radiant heat which is the most important design factor when develop the LED, the distribution of temperature on LED lamp was observed by thermal image camera. As the result, steady state was achieved after about 70min since the LED had turned on and it could be confirmed to excellent cooling performance as the maximum temperature is blow 55℃ Also distributions of temperature according to installed angle was investigated.
이중섭(Chung seob Yi),윤지훈(Ji hun Yun),정인국(In guk Jeong),서정세(Jeong se Suh),정민채(Min chae Jeong) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
In the recent times, with the feature of low-power and eco-friendly, use of LED(Light Emitting Diode) is increasing. For resolving the problem of radiant heat which is the most important design factor when develop the LED, the distribution of temperature on LED lamp was observed by thermal image camera. As the result, steady state was achieved after about 120min since the LED had turned on and it could be confirmed to excellent cooling performance as the maximum temperature is blow 60℃ Also distributions of temperature according to installed angle was investigated.
1996년도 제35차 대한소화기학회 추계학술대회 / 일반연제 : 위장관 ; 비궤양성소화불량환자에서 위배출시간지연과 자율신경기능실조의 임상적 의의
박수헌,김진일,나종순,채현석,김재광,한준열,최규용,정인식,정규원,선희식,박두호,손형선 ( Soo Heon Park,Jin Il Kim,Jon Soon Na,Hiun Suk Chae,Jae Kwang Kim,Jun Yul Han,Kyu Yong Choi,In Sik Chung,Kyu Won Chung,Hee Sik Sun,Doo Ho Park,Hyung Su 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1