Anthracofibrosis의 결핵활동성 지표로서 혈청 IL-2 $sR{\alpha}$, IFN-${\gamma}$, 그리고 TBGL(tuberculous glycolipid) antibody 측정의 의의

정도영,차영주,이병준,정혜령,이상훈,신종욱,김재열,박인원,최병휘,Jeong, Do Young,Cha, Young Joo,Lee, Byoung Jun,Jung, Hye Ryung,Lee, Sang Hun,Shin, Jong Wook,Kim, Jae-Yeol,Park, In Won,Choi, Byoung Whui 대한결핵및호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.55 No.3

연구배경 : 기관지내시경에서 관찰되는 anthracofibrosis가 활동성결핵과 연관이 있다는 보고가 있으나, 관찰 당시에 결핵의 활동성 여부가 확실하지 않아서 항결핵치료 시행여부를 결정하기 어려운 경우가 있다. 본 연구에서는 결핵의 활동성과 연관이 높은 IL-2 $sR{\alpha}$, IFN-${\gamma}$의 혈청 농도와 결핵의 혈청진단방법인 TBGL 항체의 농도가 anthracofibrosis 환자에서 결핵의 활동성 여부를 진단하는데 도움이 되는지를 알아보고자 하였다. 방 법 : 건강한 자원자(16명), 활동성결핵으로 진단되어 투약하기 직전의 환자(22명), 활동성결핵으로 진단되고 6개월간 항결핵제 투여를 마친 환자(13명), 그리고 anthracofibrosis 환자(15명)에서 혈청을 채취한 뒤, IL-2 $sR{\alpha}$, IFN-${\gamma}$ 그리고 TBGL 항체의 농도를 ELISA 방법으로 측정하였다. 결 과 : 건강한 자원자, 결핵치료전 환자, 결핵치료후 환자, 그리고 anthracofibrosis 환자의 IL-2 $sR{\alpha}$는 각각 $640{\pm}174$, $1,611{\pm}2,423$, $953{\pm}562$, $863{\pm}401$ pg/ml, IFN-${\gamma}$의 농도는 각각 0, $8.16{\pm}17.34$, $0.70{\pm}2.53$, $2.33{\pm}6.67$ pg/ml, 그리고 TBGL 항체 농도는 각각 $0.83{\pm}0.80$, $5.91{\pm}6.71$, $6.86{\pm}6.85$, $3.22{\pm}2.59$ U/ml였다. TBGL 항체 농도만이 건강한 자원자에서 다른 군에 비해 낮았을 뿐(p<0.05) IL-2 $sR{\alpha}$와 IFN-${\gamma}$ 농도는 네 군 사이에 차이가 없었다. Anthracofibrosis 환자 중에서 나중에 활동성 결핵으로 진단된 6명과 나머지 9명 사이에서도 상기한 지표의 농도 차이는 관찰되지 않았다. 결 론 : 1) Anthracofibrosis 환자의 40%에서 활동성 결핵이 동반되었다. 2) 혈청 IL-2 $sR{\alpha}$, IFN-${\gamma}$ 그리고 TBGL 항체 농도는 anthracofibrosis에서 결핵의 활동성 지표로 유용하지 않았다. 3) 혈청 TBGL 항체 농도는 건강한 자원자와 나머지 군 사이에 유의한 차이를 보였다. Background : Anthracofibrosis, a descriptive term for multiple black pigmentation with fibrosis on bronchoscopic examination, has a close relationship with active tuberculosis (TB). However, TB activity is determined in the later stage by the TB culture results in some cases of anthracofibrosis. Therefore, it is necessary to identify early markers of TB activity in anthracofibrosis. There have been several reports investigating the serum levels of IL-2 $sR{\alpha}$, IFN-${\gamma}$ and TBGL antibody for the evaluation of TB activity. In the present study, we tried to measure the above mentioned serologic markers for the evaluation of TB activity in patients with anthracofibrosis. Methods : Anthracofibrosis was defined when there was deep pigmentation (in more than two lobar bronchi) and fibrotic stenosis of the bronchi on bronchoscopic examination. The serum of patients with anthracofibrosis was collected and stored under refrigeration before the start of anti-TB medication. The serum of healthy volunteers (N=16), patients with active TB prior to (N=22), and after (N=13), 6 month-medication was also collected and stored. Serum IL-2 $sR{\alpha}$, IFN-${\gamma}$ were measured with ELISA kit (R&D system, USA) and serum TBGL antibody was measured with TBGL EIA kit (Kyowa Inc, Japan). Results : Serum levels of IL-2 $sR{\alpha}$ in healthy volunteers, active TB patients before and after medication, and patients with anthracofibrosis were $640{\pm}174$, $1,611{\pm}2,423$, $953{\pm}562$, and $863{\pm}401$ pg/ml, respectively. The Serum IFN-${\gamma}$ levels were 0, $8.16{\pm}17.34$, $0.70{\pm}2.53$, and $2.33{\pm}6.67$ pg/ml, and TBGL antibody levels were $0.83{\pm}0.80$, $5.91{\pm}6.71$, $6.86{\pm}6.85$, and $3.22{\pm}2.59$ U/ml, respectively. The serum level of TBGL antibody was lower than of other groups (p<0.05). There was no significant difference of serum IL-2 $sR{\alpha}$ and IFN-${\gamma}$ levels among the four groups. Conclusion : The serum levels of IL-2 $sR{\alpha}$, IFN-${\gamma}$ and TBGL antibody were not useful in the evaluation of TB activity in patients with anthracofibrosis. More useful ways need to be developed for the differentiation of active TB in patients with anthracofibrosis.

고성능 프로세서를 위한 카운터 기반의 캐시 교체 알고리즘

정도영,이용석,Jung, Do Young,Lee, Yong Surk 대한전자공학회 2013 전자공학회논문지 Vol.50 No.6

캐시 메모리의 성능에 큰 영향을 미치는 요소 중 하나인 캐시 교체 알고리즘 중에서 가장 최적의 성능을 가지는 알고리즘은 LRU알고리즘이다. LRU알고리즘은 데이터의 temporal locality특성이 강한 프로그램에서 좋은 성능을 보여주지만, 그렇지 않은 프로그램에서는 많은 캐시 미스를 발생시킨다. 본 논문에서는 LRU알고리즘의 이러한 단점을 개선하기 위한 새로운 카운터 기반 교체 알고리즘인 DCR(Dynamic Counter based Replacement) 알고리즘을 제안한다. 본 논문에서는 캐시에 저장된 이후로 교체되기 전까지 다시 사용되지 않는 데이터인 zero reuse line의 발생 추이를 관찰함으로써 프로그램의 temporal locality 특성이 시간에 따라 동적으로 변화함을 보였다. 그리고 이에 착안하여 제안하는 DCR 알고리즘은 주기적으로 zero reuse line의 수를 카운트하여 프로그램의 temporal locality 변화에 대응할 수 있도록 하였다. DCR 알고리즘은 기존의 LRU알고리즘과 비교하여 최대 2.7%, 평균 0.47%의 미스율 감소를 보였다. Replacement policy is one of the key factors determining the effectiveness of a cache. The LRU replacement policy has remained the standard for caches for many years. However, the traditional LRU has ineffective performance in zero-reuse line intensive workloads, although it performs well in high temporal locality workloads. To address this problem, We propose a new replacement policy; DCR(Dynamic Counter based Replacement) policy. A temporal locality of workload dynamically changes across time and DCR policy is based on the detection of these changing. DCR policy improves cache miss rate over a traditional LRU policy, by as much as 2.7% at maximum and 0.47% at average.

투입산출표를 이용한 한국 농림어업의 고용구조와 고용유발효과 변화추이 분석

정도영 ( Do Young Jung ),장지용 ( Ji Yong Jang ),박재운 ( Jae Un Park ) 한국축산경영학회 2010 농업경영정책연구 Vol.37 No.2

확률적 재고모형을 이용한 적정 안전재고수준 결정에 관한 연구

정도영(Jung Do Young),박상혁(Park Sang Hyuk),한승헌(Han Seung Heon) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10

정상인에서 수동적인 뻗은다리올림 시 생체되먹임 장치의 압력과 허리골반 움직임의 상관관계

정도영(Do-young Jung) 한국전문물리치료학회 2018 한국전문물리치료학회지 Vol.25 No.3

Background: Passive straight leg raising (PSLR) is the common clinical test to measure of hamstring muscle length. Hip flexion angle contributes to change the lumbopelvic rotation during PSLR. Pressure biofeedback unit (PBU) is commonly used to detect lumbopelvic movement during lower limb movements. Thus, there may be the relationship between pressure of PBU and lumbopelvic motion during PSLR. Objects: The objective of this study was to determine the relationship between pressure of PBU and lumbopelvic motion during PSLR. Methods: Thirty two subjects participated in this study. A three-dimensional motion analysis system were used to measure the lumbopelvic angle during PSLR, while recording the pressure of PBU according to angle of PSLR by 10 degree increments. Pearson product moment correlations and linear regression analysis were used to describe the relationship between variables. Results: The results showed that there was a significant relationship between the lumbopelvic and angle of PSLR (Pearson’s r=.83, p<.05), between the pressure of PBU and angle of PSLR (Pearson’s r=.75, p<.05), and between lumbopelvic motion and pressure of PUB (Pearson’s r=.83, p<.05). Linear regression equation using lumbopevic angle as an independent factor was as follows: Pressure of PBU = 47.35 + (2.55 × angle of lumbopelvic motion) (R 2 =.69, p<.05). Conclusion: Results of the present study indicate that pressure of PBU can be used to indirectly detect the amounts of lumbobevic motion during muscle length test or stretching of hamstring.

안정된 면과 폼 롤러 위에서 한 발 들기 자세 시 초음파를 이용한 복근들의 두께 양상 비교

정도영 ( Do Young Jung ),고은경 ( Eun Kyung Koh ),김수정 ( Su Jeong Kim ),권오윤 ( Oh Yun Kwon ) 한국운동역학회 2010 한국운동역학회지 Vol.20 No.4

The purpose of this study was to compare the thickness of the abdominal muscles during single leg holding exercise (SLH) in a hooked lying position on stable surface and on a foam roller. Healthy twenty subjects who had no medical history of lower extremity or lower back pain were recruited for this study. Muscle thickness of transverse abdominis(TrA), internal oblique (IO), and external oblique (EO) was recorded using real-time ultrasonography during SLH. Paired t-test with Bonferroni adjustment was used to compare the muscles thickness during SLH on stable surface and on a foam roller. The result showed that TrA and IO muscle demonstrated greater thickness during SLH on foam roller than those on the stable surface. This finding suggests that SLH on an unstable foam roller is more effective to increase thicknesses of TrA and IO muscles than stable surface.

불균일한 공극길이에서의 스위치드 리럭턴스 모터 토오크 특성

정도영(Jung Do-Young),이상호(Lee Sang-Ho),오흥석(Oh Hong-Seok) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.7

중학생의 안전실천과 인지실패가 안전사고에 미치는 영향

정도영(Jung, Do-Young),이승호(Lee, Sung-Hou) 한국산학기술학회 2013 한국산학기술학회논문지 Vol.14 No.8

본 연구는 중학생의 안전실천과 인지실패의 정도를 알아보고, 이 들이 안전사고에 미치는 영향을 알아보기 위한 것이다. 연구대상자는 총 292명이며 2012년 11월 5일부터 11월 25일까지 설문조사하여 자료를 수집하였다. 연구 도구는 SPSS win17.0을 사용하였고, 평균과 표준편차, Paired t-test, 피어슨 상관계수를 이용하였다. 대상자의 안전실 천과 인지실패는 부(-)의 상관을 나타냈으며 안전에 대한 실천정도가 높은 대상자가 사고인지 실패율이 낮았다. 또한 안전사고 경험이 적게 나타났다. 그와 반대로 안전에 대한 인지실패가 높은 대상자는 안전사고 경험이 높게 나타났 다. 따라서 안전실천과 인지실패의 정도를 지속적으로 파악하여 안전사고 예방에 대한 방안을 마련하기 위한 연구가 필요하다. 또한 연구의 범위를 확대함으로써 학교현장에 다양한 안전사고 예방 교육프로그램을 적용하여 안전의식 함 양과 안전실천의 일반화가 이루어져야 한다. This study was investigate to impact on safety accidents occurrence for the safety practices of middle school students learn the extent of the failure. A total of 292 patients and it survey data were collected from 5 November 2012 to 11 May 25 of research subjects. Research tools were used SPSS win17.0, the mean and standard deviation, Paired t-test, Pearson's correlation coefficient was used. Safey practice and cognitive failure of subjects was related to negative correlation and according as safety practices was higher, cognitive failure was low. According as safety practices and cognitive failure was low, Safety incidents experienced was high. Therefore, by applying safety practices and cognitive failure degree, it need to for research to come up with ways for the prevention of safety accidents. Besides, A variety of safety and accident prevention training programs by expanding the scope of the study in school, it should be done generalization of safety awareness, cultivate and Safety practice.

주산기 암컷 백서의 태아에 방사선피폭에 따른 선천성기형 발생 시 셀레늄과 엽산 혼합물의 방사선 방호효과

정도영(Do-Young Jung),최형석(Hyung-Seok Choi),김장오(Jang-Oh Kim),신지혜(Ji-Hye Shin),김주희(Joo-Hee Kim),박경진(Gyeong-Jin Park),민병인(Byung-In Min) 대한방사선과학회(구 대한방사선기술학회) 2018 방사선기술과학 Vol.41 No.2

This study is a search for radiation protection effects of radiation exposure on the organogenic period during the prenatal period, which is known to be the most likely to have congenital malformations by radiation exposure. To study the radiation protection for the mixture of selenium that is strong antioxidant and folic acid that is essential vitamin for DNA synthesis, 2 Gy of radiation was irradiated to pregnant female rats. then, after 14 days of fetal birth, observing blood components, SOD(Superoxide Dismutase), histological changes and external malformations. There was a significant protective effect to reduce blood cell damage(p<0.05) in the irradiation group after selenium and folic acid mixture were administered than irradiation group, and the activation of SOD which is antioxidant enzymes was increased. In addition, confirmed the effect of suppressing the expression of apoptosis of small intestinal cells and the re-duction of cerebral cortex layer reduction by radiation. thus, it was confirmed that the congenital malformations were re-duced as a result of these protective effects. Based on these results, selenium and folic acid mixture may reduce the in-cidence of congenital malformations, and it will reduce the damage of the fetus caused by the exposure of the organo-genic period due to accidents.

IEEE 802.11 기반의 멀티채널 멀티라디오 무선 메쉬 네트워크에서 인접 라디오간의 간섭문제 연구

정도영(Do Young Jung),김용규(Yong Gyu Kim),마중수(Joong Soo Ma) 한국통신학회 2010 한국통신학회 학술대회논문집 Vol.2010 No.11