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Detection and Characterization of Extracellular Phospholipase $A_2$ Activity in Human Amniotic Fluid
백석환,이승호,장현욱,Baek, Suk-Hwan,Lee, Seung-Ho,Chang, Hyeun-Wook 생화학분자생물학회 1992 한국생화학회지 Vol.25 No.3
사람의 양수 중에서 처음으로 세포외성 phospholipase $A_2$ 활성이 있음을 확언하였으며, 출산에 있어서 중요한 prostaglandin의 전구체인 arachidonic acid 제공에 중요한 역활을 할 것이라고 생각된다. 본 효소는 지금까지 보고된 group I이나 group II phospholipase $A_2$와 계변 활성제의 영향이나 monoclonal antibody와의 반응성에서 다른 특성을 갖는 효소로 추정되었으며, 또한 적어도 2종류의 phospholipase $A_2$의 활성이 존재함에 시사되어 금후 더욱 구체적인 검토를 행하여 단백화학적 특성을 규명할 필요가 있다. Extracellular phospholipase $A_2$ activity has been identified in human amniotic fluid. This enzyme required $Ca^{2+}$ ion and exhibited bimodal pH optimum at pH 7.0 and 9.0. The phospholipase hydrolyzed 1-acyl-2-[1-$^{14}C$]arachidonoylphosphatidylethanolamine to form only [$^{14}C$]arachidonic acid indicating that the enzyme had phospholipase "$A_2$" activity. Ionic and non-ionic detergents caused loss of enzymatic activity. This phospholipase $A_2$ was recognized, in part, by a monoclonal antibody raised against phospholipase $A_2$ from human synovial fluid. This finding suggests that our enzyme is an another type of an extracellular phospholipase $A_2$ which may not belong to the 14 KDa group II phospholipase $A_2$ family.
사람 양수 중의 세포외성 Phospholipase A2 특성
백석환,이승호,장현욱 ( Suk Hwan Baek,Seung Ho Lee,Hyeun Wook Chang ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.3
Extracellular phospholipase A₂ activity has been identified in human amniotic fluid. This enzyme required Ca^(2+) ion and exhibited bimodal pH optimum at pH 7.0 and 9.0. The phospholipase hydrolyzed 1-acyl-2-[1-^(14)C]arachidonoylphosphatidylethanolamine to form only [^(14)C]arachidonic acid indicating that the enzyme had phospholipase $quot;A₂$quot; activity. Ionic and non-ionic detergents caused loss of enzymatic activity. This phospholipase A₂ was recognized, in part, by a monoclonal antibody raised against phospholipase A₂ from human synovial fluid. This finding suggests that our enzyme is an another type of an extracellular phospholipase A₂ which may not belong to the 14 KDa group II phospholipase A₂ family. v
손윤희,조현정,장현욱,손건호,남경수,Shon Yun-Hee,Cho Hyun-Jung,Chang Hyeun-Wook,Son Kun-Ho,Nam Kyung-Soo 한국생명과학회 2006 생명과학회지 Vol.16 No.3
Six fractions of Salvia miltiorrhiza were tested for their chemopreventive potentials using biochemical markers of carcinogenesis such as quinone reductase (QR), glutathione S-transferase (GST) and glutathione (GSH). Seventy percentage of EtOH extract was potent inducer of QR activity in Hepa1c1c7 murine hepatoma cells. GST activity was increased about 1.4-fold with EtOAc extract at concentration of 50 ${\mu}g/ml$. GSH levels were significantly increased with $H_2O$ extract, 70% EtOH extract and water extract at concentration of 50 ${\mu}g/ml$ (p<0.005). From these results, 70% EtOH extract (250 mg/kg) was intragastrically administered to ICR mice for 14 days. QR, GST and GSH levels were significantly increased with the 70% EtOH treatment. These studies suggest that the 70% EtOH extract of S. miltiorrhiza could be considered as a potential agent for cancer chemoprevention. 본 연구는 단삼 분획추출물로부터 in vitro와 in vivo상에서 QR과 GST의 활성 유도와 GSH의 함량변화를 지표로 암예방 효과를 측정하였다. Hepalcla7 세포에 대한 in vitro상에서의 실험결과 QR 활성 유도율은 70% EtOH 추출물 50 ${\mu}g/ml$ 처리군에서 2.5배로 가장 높은 유도율을 나타내었고, GST 활성 측정은 EtOAc추출물 50 ${\mu}g/ml$농도에서 1.4배의 유도율을 나타내었다. GSH 생성변화를 살펴본 결과에서는 $H_2O$추출물, 70% EtOH 추출물 그리고 water layer 추출물 50 ${\mu}g/ml$ 농도에서 높은 생성율을 나타내었다. 이상의 결과에서 QR활성과 GSH 함량변화에서 높은 증가효과를 나타낸 70% EtOH 추출물을 관류법으로 마우스에 투여하여 in vivo 상에서의 QR과 GST의 활성 변화와 GSH 함량을 측정한 결과 QR, GST활성과 GSH함량이 250 mg 투여시 각각 1.7배 및 1.5배의 활성 증가와 1.4배 함량증가를 측정할 수 있었음으로 70% EtOH추출물은 암예방효과가 가장 높은 것으로 생각된다.
양주혜,나민균,장현욱,Yang, Ju-Hye,Na, Min-Kyun,Chang, Hyeun-Wook 대한약학회 2011 약학회지 Vol.55 No.4
We investigated the effects of butanol fraction of Asterias amurensis (BFA) on the anti-allergic activity. BFA inhibited both cyclooxygenase-2 dependent prostaglandin $D_2$ and 5-lipoxygenase dependent leukotriene $C_4$ generation in a concentration-dependent manner with $IC_{50}$ values of 174.6 and 22.2 ${\mu}g$/ml, respectively. In addition, BFA also inhibited the degranulation in a dose dependent manner. Furthermore, oral administration of BFA inhibited IgE-mediated passive cutaneous anaphylaxis in mice. These results suggested that BFA may be useful in regulating mast cell-mediated allergic diseases.