직업성 질환 - 우정사업 종사자의 건강관리

장태원,Jang, Tae-Won 대한산업보건협회 2020 산업보건 Vol.386 No.-

형광기관지경의 미래

장태원,Jang, Tae-Won 대한기관식도과학회 2009 大韓氣管食道科學會誌 Vol.15 No.2

Lung cancer could be developed through a series of morphological changes from dysplasia to carcinoma in situ and then invasive cancer. However, precancerous lesions are generally a few cell layers thick and are detected only by chance. Autofluorescence bronchoscopy(AFB) is one of the newly developed diagnostic tools to detect the pre-cancerous lesions m the bronchial tissue. Several studies have shown that AFB improved the rate of detection of cancer and dysplastic lesions of the airway, especially those in intraepithelial stage. However, there were high rates of false positive with AFB, and it is also important to develop non-biopsy methods because of lack of accurate information of variable course of preneoplastic lesions regarding progression. So, many other technologies were developed, such as narrow band imaging(NBI), endobronchoscopic ultrasound, optical coherence tomography, and confocal fluorescence microendoscopy. Among the new machines, NBI is a new optical technology that can clearly visualize the microvascular structure m the mucosal layer. NBI seems to increase specificity without compromising sensitivity. In the future such techniques would make it possible to precisely study in detail the natural history of the premalignant epithelium.

직업성 질환I - 소방공무원의 건강관리

장태원,Jang, Tae-Won 대한산업보건협회 2020 산업보건 Vol.387 No.-

목재 부후균의 리그닌 분해효소 활성과 염료 화합물의 탈색

장태원,전상철,안태석,김규중,Jang, Tae-Won,Jun, Sang-Cheol,Ahn, Tae-Seok,Kim, Kyu-Joong 한국미생물학회 2006 미생물학회지 Vol.42 No.1

목재부후균은 리그닌 분해효소로 lignin peroxidase (LIP), Mn-peroxidase (MNP) 및 laccase를 생성하는데 균류에 따라 위의 효소중 하나 혹은 둘 이상의 효소를 분비하거나 전혀 생성하지 않는 균도 있다. 본 실험은 이러한 목재 부후균의 효소생성 양상과 몇 종의 염료화합물 탈색과의 상관관계를 조사하고자 하였다. 조사한 23종 36균주 중 MNP 생성균은 30균주였으며 LIP 혹은 laccase 생성균은 각각 11균주와 12균주였다. 또한 같은 종에서도 효소활성은 다양한 양상을 보여 주었다. 리그닌 분해효소 활성과 비교하여 염료 탈색 정도는 세 효소가 모두 분비되는 백색 부후균의 경우 염료 탈색율이 상대적으로 우수하였고 균주에 따라 차이가 있으나 MNP 활성만을 갖는 균주의 경우, poly R-478 polymeric dye 및 anthron-type dye 인 remazol brilliant blue R염료는 효소 활성도와 다소 유연관계를 보였으며 methylene blue, bromophenol blue및 congo red 염료는 위의 효소들과는 직접적인 관련이 없는 것으로 판단되었으며, 오히려 균사의 생장과 비례하여 탈색율을 나타냈다. LIP, MNP 및 laccase 효소활성이 거의 검출되지 않은 갈색 부후균에서는 bromophenol blue를 제외하고는 염료의 탈색이 10%미만 혹은 전혀 탈색이 되지 앓았다. Wood-rot fungi produce extracellular lignin-degrading enzymes, the best known of which are lignin peroxidase, Mn-peroxidase and laccase. In this experiment, some of them produced all of three enzymes. Many other wood-rot fungi produced one or two of those enzymes with various combinations. In this experiment, we tried to clarify the relationship between the pattern of enzyme production and degradative activity of several dye compounds. From the 36 strains of 23 species of wood-rot fungi, Mn-peroxidase activity was found in 30 strains of the fungi tested, whereas the activity of lignin peroxidase and laccase was detected in 11 strains and 12 strains of species, repectively, in Kirks low nitrogen media. In relation to the activity of lignin degrading enzymes and degradation of dye compounds, the white-rot fungi with three kinds of enzymes tested showed the best dye decolorizers. The fungi with Mn-peroxidase activity only decolorized poly R-478 and remazol brilliant blue R dye in proportion to the enzyme activity, while methylene blue, bromophenol blue and congo red dye were degraded in regardless of enzyme activity. Those dyes were degraded in relation to the growth rate of mycelium. Brown-rot fungi did not degrade all the dye compounds except bromophenol blue, in spite of moderate growth rate.

선박조립분야에 있어 고속용접 현황 및 전망

장태원,문종현,윤동렬,Jang Tae-Won,Moon Jong-Hyun,Yoon Dong-Ryeol 대한용접접합학회 2004 대한용접·접합학회지 Vol.22 No.6

《 노걸대 박통사연구 》

장태원(Tae Won Jang) 영남중국어문학회 1988 중국어문학 Vol.14 No.1

N/A

느티나무 잎 에틸아세테이트 분획물 및 열수 추출물의 항산화 및 산화 적 DNA 손상 억제 활성

장태원 ( Tae-won Jang ),박재호 ( Jae-ho Park ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.3

Reactive oxygen species (ROS) has been played a critical role in damage of DNA. Recently, many effort is focusing to develop the natural antioxidants for controlling ROS. Zelkova serrata, Ulmaceae, is close as plants which are planted in front of Korea villages. Although Zelkova serrata is familiar with Koreans, those of antioxidant activities and protective effects on oxidative DNA damage haven’t studied. We demonstrated antioxidant activities and inhibitory effects on oxidative DNA damage of Leaf from Zelkova serrata with ethyl acetate fractions (EA) and hot water extracts (HW). Between the extracts, EA showed higher activities in 1,1-diphenyl-2-picryl-hydrazyl, 2,2``-azino-bis[3- ethylbenzthiazoline- 6-sulphonic acid radical scavenging, Fe2+ chelating and reducing power than HW. Also, those of total phenolic content are 56.63 and 51.61 mg/g respectively. In addition, φX- 174 RF I plasmid DNA cleavage assay for inhibitory effect by oxidative DNA damage was both EA and HW has significant protective effect on oxidative DNA damage. The results suggested that leaf from Zelkova serrata with ethyl acetate fractions and hot water extracts have surpassing potential as natural resources with antioxidant and inhibitory effect on oxidative DNA damage.

從結果補語到完成貌的演變

장태원(Tae Won Jang) 언어과학회 2002 언어과학연구 Vol.23 No.-

The purpose of this study is to refute Zhao`s claim that LE(了) has been brought about from LAI(來) through the state of weakening in "verbness," and to present the results of corpus analyses from the Tang Dynasty to the modern Chinese texts. Although LAI has the meaning of change and development, it has its own system of development and it is different from LE. In Present-Day Chinese Marker LE that denotes a perfective aspect has originated from LIAO(了) through the latter`s verbness being weakened.

複句中的 "着"的語法功能

장태원(Tae Won Jang) 언어과학회 2002 언어과학연구 Vol.22 No.-

This study has analyzed the grammatical functions of ZHE in the following five complex structures by assuming that ZHE is a continuous aspect marker and NI is a phase marker: (1) the grammatical functions of the structure "V1 + ZHE + (NP) + V2 + (NP)", (2) the grammatical functions and pragmatic senses of ZHE in a continuous aspect, (3) the grammatical functions of ZHE in a comparative structure, (4) the grammatical functions of ZHE in an imperative structure, (5) the pragmatic senses of ZHE-NI.

괴화와 괴각 에틸아세테이트 분획물의 항산화 및 산화적 DNA 손상 억제 활성

장태원 ( Tae Won Jang ),김예랑 ( Ye Rang Kim ),이승현 ( Sung Hyeon Lee ),김도완 ( Do Wan Kim ),박재호 ( Jae Ho Park ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.2

Objectives : In this study, we demonstrated the antioxidant activities and the inhibitory effect on oxidative DNA damage of ethyl acetate fractions extracted from Sophorae Flos and Sophorae fructus. Methods : Sophorae Flos and Sophorae fructus were extracted with methanol(MeOH) and divided to Petroleum ether, Ethyl acetate(EtOAC) and Water fraction. The antioxidant activities were conducted by the 1,1-diphenyl-2-picryl hydrazyl(DPPH) radical, 2, 2``-Azine-bis(3-ethylbenzothiazoline-6 sulfonic acid) diammonium salt(ABTS) radical scavenging assay, Fe2+ chelating assay and Reducing power assay. The inhibitory effect of DNA damage were characterized on φX-174 RF I plasmid DNA cleavage assay. In addition, we analyzed the Total phenol contents and the Vitamin C contents of Sophorae Flos and Sophorae fructus. Results : The results of DPPH were 92.71% and 94.72%, ABTS were 87.16% and 62.44%, and Fe2+ chelating were 95.81% and 85.11% at 200㎍/㎖of Sophorae Flos and Sophorae fructus respectively. The Sophorae Flos showed stronger effect than Sophorae fructus in Reducing Power assay. Total phenol content was 111.77 ㎎/g and 122.54 ㎎/g, and Vitamin C content was 2.59 ㎎/g and 3.03 ㎎/g. Also both Sophorae Flos and Sophorae fructus have inhibitory antioxidant effect on φX-174 RF I plasmid DNA cleavage assay. Conclusions : Over all, this study suggests that Sophorae Flos and Sophorae fructus can be used as not only effective antioxidant but also natural medicine.