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DNCB로 유발된 생쥐의 알레르기접촉피부염에 갈근승기탕(葛根承氣湯)이 미치는 영향
임태형,박혜선,Lim, Tae-Hyung,Park, Hye-Sun 사상체질의학회 2015 사상체질의학회지 Vol.27 No.2
Objectives The aim of this study was to investigate the effects of GalGunSeungGi-Tang (GST) on allergic contact dermatitis (ACD) induced by 2,4-dintrochlorobenzone (DNCB) Methods In this study, The changes of body weight, ear weight, ear thickness, spleen weight, dorsum skin thickness, symptom score by eyesight, histological finding, proliferation rates of splenocyte in vitro and in vivo are investigated to check effects of GST. The mice are divided into four group; Normal (naive mice), Control (DW administered), GST-L (GST 500mg/Kg/day administered), GST-H (GST 1,000mg/Kg/day administered). Results GST inhibited weight of ear significantly (P < 0.05) and also thickness (P < 0.01). In addition, There are significant decrease in thickness of dorsum skin and proliferation rates of splenocyte in vivo in GST administered group. Finally, GST reduced symptom score and hyperkeratosis, hyperpigmentation, increase of granulocyte and parakeratosis in histological finding. Conclusions These results suggest that GST can decrease symptoms of ACD.
청상방풍탕(淸上防風湯)의 아토피성 알레르기 반응(反應) 조절(調節) 효과(效果)
임태형,박은정,이해자,한경훈,나원경,진경선,Lim, Tae-Hyung,Park, Eun-Jung,Lee, Hai-Ja,Han, Kyeung-Hoon,Na, Won-Kyeung,Jin, Kyong-Son 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.2
Objective : To demonstrate of regulatory effect of atopic allergic regulation by Chungsangbangpoong-Tang(CBT), This experiment was studied. Methods : The author investigated a possible effect of CBT on cytokines production using human T cell line (MOLT-4) or human mast cell line (HMC-1). In addition, the author investigated whether CBT has inhitory effects on compound 48/80- induced histamine release from rat peritoneal mast cells (RPMC) and compound 48/80-induced ear swelling in ICR mice. Results : CBT (0.01 mg/ml)-containing medium in stimulated culture supernatants significantly increased IL-2 secretion compared with untreated MOLT-4, whereas CBT (0.01-1.0 mg/ml)-containing medium in stimulated culture supernatants significantly decreased IL-4 secretion compared with untreated MOLT-4. Significant reduced levels of IL -6 and $TNF-{\alpha}$ were observed in the HMC-l with CBT (P<0.05). CBT did not inhibit the histamine release from the RPMC but inhibit ear swelling response. Conclusion : These results suggest that CBT contributes to the treatment of atopic allergic reactions, such as atopic dermatitis and that its action may be due to regulation of cytokine production.
Pentacam으로 측정한 정상 한국인에서 각막 전후면의 구면수차
임태형,이종락,최기용,조범진,Tae Hyung Lim,MD,Jong Rak Lee,MD,Kee Yong Choi,MD,Beom Jin Cho,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.6
Purpose: To evaluate the spherical aberrations of the anterior and posterior surfaces of normal corneas using Pentacam in a Korean sample population and determine their ranges and changes with age. Methods: We used Pentacam (Oculus Inc.,Germany) to measure the anterior and posterior corneal spherical aberrations of 240 eyes in 240 patients with normal corneas who visited our clinic. The means and ranges of spherical aberrations and their changes with age were determined. We examined both eyes of 90 patients to confirm the inter-ocular symmetry in spherical aberration. Results: The mean age of the 240 patients (M:F=103:137) was 49.8 years (range: 20-79), and the mean spherical aberrations of the anterior and posterior surfaces of the cornea were 0.230±0.078 μm, and -0.04±0.021 μm, respectively. The mean total corneal spherical aberration was 0.19±0.087 μm. There were no differences between males and females, and inter-ocular symmetry was observed in all tested patients. There was a tendency for the values of anterior, posterior and total corneal spherical aberration to increase with age. Ranges of spherical aberrations were from -0.177 μm to 0.423 μm in the anterior cornea, from -0.083 μm to 0.034 μm in the posterior cornea, and from -0.238 μm to 0.410 μm in the total cornea. Conclusions: In a Korean population, the mean total corneal spherical aberration was 0.19 μm, which was shown to increase with age. Some patients were shown to have an extreme value. Based on these results, a preoperative analysis for corneal spherical aberration may be helpful when selecting aspheric intraocular lenses. J Korean Ophthalmol Soc 2010;51(6):816-821
하태형 ( Tae Hyung Ha ),임병화 ( Byung Hwa Lim ) 한국금융공학회 2015 금융공학연구 Vol.14 No.1
본 논문은 국내 채권수익률 자료로부터 다요인 CIR 모형의 이자율 기간구조를 추정하였다. 10년 만기 국고채 수익률의 공시가 시작된 2000년 12월부터 2013년 7월까지의 월간 자료를 활용하였고 유한표본으로 구성된 자료추정의 적합성을 확보하기 위해 칼만필터 방법과 준최우추정법을 동시에 적용하였다. 추정 결과, 다요인 CIR 모형이 국내 채권 시장의 이자율 기간구조를 잘 설명할 수 있다는 사실을 밝혔다. 구체적으로, 단기자료의 경우 2요인 모형과 3요인 모형이 특별한 차이가 없었던 반면 장기자료에서는 3요인 모형의 시장 이자율 기간구조의 설명력이 가장 높았다. 이는 국내 이자율 기간구조 추정에 있어 기간구조의 성질이 뚜렷한 장기채권이 포함된 자료일수록 다요인 모형 추정이 필요함을 의미하며 실제 3요인 CIR 모형의 각 요인은 단기이자율 수준, 장기이자율 수준, 그리고 기간구조의 변동성을 설명할 수 있었다. 본 논문은 다요인 CIR 모형이 국내 채권시장의 이자율 기간구조를 잘 반영할 수 있다는 사실을 입증하여 국내 채권의 평가뿐만 아니라 이자율 파생상품의 투자 분석 기법의 범위를 넓혔다는 데에 의의가 있다. We investigate multi-factor CIR model of the term structure of the interest rate in Korea bond market. To capture the dynamics of the term structure, we consider up to three factors and apply the Kalman filter method and quasi-maximum likelihood estimation for a monthly date set from Dec. 2000 to Jul. 2013, which includes the government bonds with maturity 10 years. As a result, the multi-factor model performs well to show the feature of the term structure of interest rate. Especially, three factor model performs best for the bonds with long maturity. We verify that three factors represent short-term interest rate, long-term interest, and the volatility of the term structure.
지주막하출혈 수술 이후 발생한 이명을 소양인 흉격열증으로 진단한 치험 1례
임태형,박혜선,Lim, Tae-Hyung,Park, Hye-Sun 사상체질의학회 2016 사상체질의학회지 Vol.28 No.2
Objectives This case study reports patient diagnosed as Soyangin Hyunggyeok yeoljeung with tinnitus, headache and sleep discomfort after Subarachnoid Hemorrhage(SAH) had treated with HyungBangSabaek-San.Methods The patient suffering from tinnitus, sleep discomfort had taken HyungBangSabaek-San from the first to the end three times a day. We measure tinnitus by Tinnitus Handicap Inventory(THI) and observe symptoms change using Visual Anlaogue Scale(VAS).Results The symptoms had been steadily decreased and quality of life had increased also. Headache and constipation had been improved in a week and tinnitus and chest discomfort had decreased next week. At last, patient complained symptoms slightly.Conclusions HyungBangSabaek-San a is treatment of Soyangin Hyunggyeok yeoljeung and may be considered as a treatment of tinnitus.