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곽재환,인진경,이미성,최은화,이희순,홍진태,윤여표,이수재,서승용,서영거,정재경 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.12
Concise total synthesis of obovatol (1) was achieved from the commercially available eugenol (5) via linear 4 steps in 40% overall yield. The key features of the synthesis involve the chemoselective orthobromination of phenol in the presence of isolated double bond and the efficient Cu-catalyzed Ullmann coupling of two aromatic moieties for the diaryl ether skeleton.
Jung-Eun Yang,인진경,Mi-Sung Lee,곽재환,이희순,이수재,강한영,서영거,정재경 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.8
An efficient Pictet-Spengler type reaction of N,O-acetal TMS ethers for the practical synthesis of 1-substituted tetrahydroquinolines, medicinally important alkaloids, has been accomplished. To demonstrate the versatility of this novel procedure, the total synthesis of calycotomine, a representative 1-hydroxymethyl substituted tetrahydroisoquinoline, is also described.
Synthesis and Anti-platelet Activity of Obovatol Derivatives
곽재환,정재경,이슬기,박은석,인진경,송지호,김영진,최남송,이희순,윤여표,홍진태,곽영신,민경훈 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7
Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.