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미노클린 첨부제의 구강점막 독성 및 치은조직내에서의 생분해에 관한 연구
임병무,김형섭,한상섭,이호일,채현석,Rim, Byung-Moo,Kim, Hyung-Seop,Han, Sang-Sup,Lee, Ho-Il,Chae, Hyun-Sok 대한치주과학회 1994 Journal of Periodontal & Implant Science Vol.24 No.2
Minocline Strip(MS), a local drug delivery developed as a controlling means for microoragnisms in gingival wound and periodontitis, was implanted in the gingiva of experimental animals. The toxic effects and biodegradation of MS were studied in respect to pathological changes induced in gingival tissue. The experimental animals treated with MS had not showed significant difference in symptom, body weights, feed and water intake, and blood analysis throughout 150 days of experimental period, but revealed significantly increased values of total WBC counts and AST (SGOT) on the 7th day, compared with controls. The treated animals revealed petechial hemorrhage and severe edema accompanying degeneration and necrosis of damaged muscle fibers around the surgical wound, but no local inflammatory reaction and concerned lesions were found. The implanted MS became encapsulated by thin connective tissue, and its size and color diminished gradually according to the experimental term. The MS-like material appeared in the nearby lymphatics on the 110th day. The implated MS remained as fine granular particles or disappeared on the 130th day, and the decrease of its volume and density were variable depending on each individual. These results indicate that long-term implantation of MS may not produce inflammation or toxic effects, and eventually lead to complete biodegradation.
원발성간임의 (原發性肝癌) 초음파상에 (超音波像) 관한 연구
박경남(Kyung Nam Park),이창홍(Chang Hong Lee),기춘석(Choon Suk Kee),최웅환(Oung Whan Choi),이동후(Dontg Hoo Lee),이호채(Ho Chae Lee),김순길(Soon Gill Kim),민영일(Young Il Min) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.1
N/A The gray- cale ultrasonographic app arances of histopathologically proven primary hepatoma in 61 patients were evaluated retrospectively. Our study has revealed four different ultrsonographic patterns of primary hepatoma: echogenic(39.4%), sonolucent(8.2%), mixed(31.0%) and diffuse parenchymal distortion(21.3%). Of 61 primary hepatoma examined, 19 cases exhibited encapsulation. Predominantly, the marginal Contour of mass was irregular rather than smooth. Most of cases represented downward convexity of the lower edge of the liver. Both of hump and marginal irregularity on the hepatic surface were exhibited in 54.1% and 59.0% respectively. Ultrasonography makes it possible to demonstrate not only the extrinsic compression of the vascularity by the tumor mass on intrahepatic vessels, inferior vena cava, and abdominal aorta, but also extrahepatic biliary obstruction. While 40.9% of cases were found to have a cites, splenomegaly was noticed in 31.1% In fact, ultrasonography is a useful screening method for imaging primry hepatorna with pecial regard of its noninva siveness and easy application to assess the nature and extent of the lesions.
난치성 복수에 대한 복수 초여과 및 복강내 재주입법의 장기 치료효과
이호채,기춘석 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1
Management of ascites, which is caused by liver cirrhosis or other hepatic disease, can be very difficult if it is refractory to drug therapy. Diuretics, even when effective, may cause metabolic or ionic derangements. Repeated abodominal paracentesis may result in hypotension, renal functional impairement and loss of albumin. LeVeen shunt, a devise to drain ascitic fluid into vein, has its lmited use because of some serious complications, such as pulmonary edema, heart failure, gastrointestinal bleeding and DIC. Alternatively there have been trials in which tapped ascitic fluids were ultrafiltered and the unfiltered proteins were retruned back into the peritoneal cavity. These studies however were conducted withsmall number of cases in short term periods. Therefore the present study was designed to evaluate the longterm therapeutic effect of ascitic ultrafiltration and peritoneal reinfusin on 392 patients with 912 procedures for about 9 years. Ascitic fluid was tapped through 15 gauge needle and was continuously led to an artificial hollowfiber kidney with cuprophan semipermeable membrane and ultrafiltered by a blood pump. The unfiltered macro-molecular solution containing most of the proteins was returned back into the peritoneal cavity through another 15 gauge needle. Nine hundred and twelve procedures were performed on 392 patients during the period of 9 years. The results were as followings; 1) Approximately 5300cc of ascites was ultrafiltered for an average of 3.85 hours. 2) There were no significant changes in blood pressure and heart rate before, during and after the procedures. 3) There were no significant changes in creatinine clearance and serum electrolytes before and after the procedures. 4) Serum albumin level increased from mean value of 2.51±0.5 gm/dl to 3.06±0.52gm/dl on the 3rd day after ultrafiltration (P<0.01). 5) The mean interval of ultrafiltration required in patients with liver cirrhosis was 28.0 days and n malignant ascites, 18.7 days, respectively. 6) Compared with 30 cirrhotic patients treated conventionally, 52 similar patients treated with intermit ultrafiltration lived longer, 5.1±3.2 v.s 11.2±.5 months, p<0.05. 7) There was minor complication such as abdominal pain, muscle cramping, dizziness, chest tightness and ascites leakage, but serious complications were not observed. In conclusion, ascitic ultrafiltration and peritoneal reinfusion is thought to be an effective method in controlling refractory ascites and reducing morbidity and mortality of cirrhotic patients.