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귀밑샘에 생긴 다형선종의 수술적 치료로써의 제한적 국소절제술
이형석,김준식,김남균,이경석,이윤정,Yi, Hyung-Suk,Kim, Jun-Sik,Kim, Nam-Gyun,Lee, Kyung-Suk,Lee, Yoon-Jung 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4
Purpose: Pleomorphic adenoma is the most common benign neoplasm in parotid gland. Superficial parotidectomy was usually used to remove the pleomorphic adenoma. But, this method has to remove tumor with normal parotid tissue. Authors did lumpectomy to remove pleomorphic adenoma in parotid gland, because pleomorphic adenoma is wrapped in a capsule as it grows. The purpose of this study is to evaluate the efficacy of lumpectomy as a treatment of pleomorphic adenoma in parotid gland. Method: From 2002 to 2008, 8 patients underwent the lumpectomy of the pleomorphic adenoma in parotid gland. Occurrence of the complications and recurrance were evaluated. Result: Patients were followed-up for a mean 45 months. There were no recurrance or no complication after lumpectomy. Conclusion: Authors suggest that the lumpectomy lead to decrese complications, recurrane and can be used as a procedure for the resection of pleomorphic adenoma in parotid gland.
Tail model의 기계적 이질통에 대한 전침 자극의 효과 및 교감신경계의 관여기전
이형석,민병일,황병길,박동석,이순걸,Lee, Hyung-suk,Min, Byung-il,Hwang, Byung-gil,Park, Dong-suk,Lee, Soon-geul 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1
Objective : This study was intended to investigate the analgesic effects of electroacupuncture(EA) on mechanical allodynia according to the frequency and intensity of EA. Also to know if mechanical allodynia and the analgesic effects of EA is related to the sympathetci nervous system and/or the purinergic system. Methods : mechanical allodynia-induced rats were produced by resecting S1-S2 nerve. The zusanli(ST36) was used for acupoint and the rats were divided into 4 groups. Each group was given different stimuli[low frequency low intensity-EA(LFLI-EA), low frequency high intensity-EA(LFHI-EA), high frequency low intensity-EA(LFHI-EA), high frequency high intensity-EA(HFHI-EA)]. Futhermore, to make sympathectomy6-OHDA and phentolamine were administered intraperitonially and the concentration of norepinephrine(NE) were measured. As a ATP blocker, suramin was applied for this study. Results : Comparing to control group, each of the 4 groups(LFLI-EA, LFHI-EA, HFLI-EA, HFHI-EA) showed a significant reduction of response frequency of mechanical allodynia. LFHI-EA was more effective than that of LFLI-EA. The LFHI-EA group also had longer lasting effects from the stimulation than the other groups. Sympathectomy didn't show any reduction of response frequency of mechanical allodynia.(Each n=6, n=4). Nor did both sympathectomy and ATP block. The response frequency wasn't reduced by sympathectomy or by sympathectomy and ATP block, but was significantly reduced with LFHI-EA Conclusions : These results suggest that EA has a significant analgesic effect on mechanical allodynia which has no connection with NE and/or ATP.
일측성 광대뼈골절 환자에서 수평계와 자를 이용한 변위 교정의 간단한 파악법
이형석,이경석,김준식,김남균,Yi, Hyung-Suk,Lee, Kyung-Suk,Kim, Jun-Sik,Kim, Nam-Gyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.2
Purpose: The zygoma is a key element which composes the facial contour. Zygomatic fracture induces facial asymmetry. We use radiologic evaluation or inspections mainly for identification of symmetry after reduction depressed zygomatic fracture. But the disadvantages of such methods are time-consuming and complicated process. So we tried to develop a new testing method with a ruler and a level. Methods: In unilateral depressed zygomatic fracture patient, parallel to the patient's head to make sure lay horizontaly. Put the leg of a ruler on the malar eminence so that it is at the same distance from the facial midline. Then take the level of malar eminence as put the level above the ruler. This process was performed before and after the reduction. Results: We were able to fix with plate and screw after checking the results of reduction fast and easily. Good results were obtained at post-operative radiologic evaluation. Conclusion: We can easily get the ruler and level around life. This method is not only simple but also shorttime process compared with other method-radiologic evaluation or inspection. And the operator can explain the results to the patients easily and objectively. Authors obtained the good results with this new method, and would introduce it for another method of identifying the result of reduction in depressed zygomatic fractures.
Anti-protozoal efficacy of Agrimonia pilosa ethanol extract against Toxoplasma gondii
이형석(Hyung-Suk Lee),김옥진(Okjin Kim) 한국예방수의학회 2022 예방수의학회지 Vol.46 No.1
Toxoplasmosis, caused by Toxoplasma gondii (Tg), is one of the most prevalent zoonotic diseases worldwide. Currently, safe and efficient therapeutic options for this disease are still being developed, and are urgently needed. Agrimonia pilosa (A. pilosa) is a rosaceous plant, and widely distributed in Asia. The bioactive compounds in A. pilosa Ledeb include flavonoid, triterpenoids, and isocoumarin, and have been reported to show many pharmacological effects including anti-inflammatory, antioxidant, and antibacterial activities.The aim of this study was to determine Anti-protozoal efficacy of Agrimonia pilosa ethanol extract (APE) against Toxoplasma gondii (Tg). In this study, APE was examined and screened for anti-Tg activity. Seventy percent ethanol was used for herbal extraction. For anti-Tg activity screening, in vitro study with APE using tachyzoit of Tg RH strain infected HeLa cells were performed. Also, in vivo anti- Tg study using the mouse infection model was conducted. As the results, the selectivity of APE was 3.35, which was higher than Sulfadiazine selectivity (2.08). Also, we performed in vivo animal study to evaluate the anti-Tg activity of APE with mouse model. As the results, Anti-toxoplasma activity of the APE was as high as sulfadiazine. These results demonstrate that it can be successfully cured against Tg infection with APE. It could be a promising native herb treatment for the prevention of Tg infection.
뇌졸중 환자에서 배우자 사이에 뇌혈관 질환의 위험요인 일치성이 있는가?
이형석(Hyung-Suk Lee),고영채(Youngchai Ko),백신혜(Shin-Hye Baek),신경섭(Kyeong Seob Shin),김지선(Ji-Sun Kim),한현정(Hyun Jeong Han),신동익(Dong-Ick Shin) 한국콘텐츠학회 2011 한국콘텐츠학회논문지 Vol.11 No.5
혈관 질환 위험인자의 가족력은 이미 잘 알려져 있으며 최근 심혈관 질환의 위험인자를 대상으로 한 연구에서는 가족력 뿐 만 아니라 배우자간의 위험인자 일치성이 있다고 밝혔다. 이는 혈관 질환 위험인자에서의 가족력은 유전적인 이유뿐 만이 아니라 환경적 요인으로 인해서도 발생한 다는 것을 암시한다. 그러나 뇌졸중이 발생한 환자에서 그 배우자간 위험인자의 일치성을 알아본 연구는 없었다. 이 연구는 본 연구를 진행하기 앞서 시행한 연구로서 뇌졸중으로 입원했던 환자를 대상으로 위험인자간의 관련성을 조사해서 그 경향성을 파악하고자 하였는데 고혈압의 유무(p=0.025)와 경동맥 내막-중막 두께(r=0.479, p=0.001)에서 의미있는 연관성을 보였으나 나이를 보정하는 경우 의미가 없는 것으로 드러났다. 일반 인구 대상이거나 심혈관질환자가 대상이었던 종전의 연구 결과와는 다른 결과였다. 의미 있는 경향성을 보인 위험인자에 대해서 추후 보다 큰 규모의 연구가 필요할 것이다. Familial concordance of vascular risk factors is well understood and there are many studies about inter-spouse concordance of the risk factors for coronary heart disease. However, there are no studies for inter-spousal relation of the risk factors in cerebrovascular disease patients. We analysed inter-spouse correlation of cerebrovascular risk factors in patients admitted our hospital due to stroke and their spouses. There was statistically significant inter-spouse concordance in the presence of hypertension(p=0.025) and carotid IMT(r=0.479, p=0.001). However, the further age-adjusted analysis revealed no significant result. Differently from the results of previous studie,, the present study shows no significant spousal concordance. Althought there are tendencies of spousal concordance in some risk factors, the age is major determinant.