급성전신발진농포증 환자의 임상 및 조직학적 분석

정인순 ( In Soon Jung ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee-bum Lee ),김성진 ( Seong-jin Kim ),이승철 ( Seung-chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.10

Background: Acute generalized exanthematous pustulosis (AGEP) is typically a medication-induced acute febrile eruption. Few large-scale studies have reported clinical data regarding AGEP in Korea. Objective: This study analyzed the clinical and histopathological features of AGEP in Koreans to identify recent trends in this context. Methods: This study retrospectively reviewed 31 patients with AGEP. Age, sex, clinical features, etiologies, laboratory findings, histopathological features, and treatment outcomes were obtained from patients’ medical records and photographs. Results: The mean age of onset was 43.6 years, and the male:female ratio was 2.1:1. All patients showed non-follicular tiny pustules and erythema. Fever was reported in 13 patients and neutrophilia in 17 patients. Medications were considered the most common etiological contributors. Twenty patients showed drug-induced AGEP, and 11 of 20 patients showed antibiotic-induced AGEP. Serum C-reactive protein and lactate dehydrogenase levels increased in 93.8% and 77.8% of the patients, respectively. Histopathologically, all patients showed subcorneal or intraepidermal pustules, followed by exocytosis and neutrophilic dermal infiltrate. Twenty-five patients improved within a mean period of 7.5 days after the onset of the skin rash. The percentage of women in the drug-induced AGEP group was significantly higher than that in the non-drug-induced AGEP group. Conclusion: This report describes a large-scale study that analyzed the clinical and histopathological features of AGEP in Koreans and seems to accurately reflect the recent trends in this context. Clinically, it is important to note that the percentage of women in the drug-induced AGEP group was higher than that in groups showing other etiologies of AGEP. (Korean J Dermatol 2018;56(10):594∼602)

생팥 및 삶은 팥의 열수 추출물의 유용 생리활성 평가

정인창(In-Chang Jung),이예슬(Ye-Seul Lee),강동균(Dong-Kyoon Kang),손호용(Ho-Yong Sohn) 동아시아식생활학회 2015 동아시아식생활학회지 Vol.25 No.3

Raw-red bean (RR) should be boiled in hot water, and only boiled-red bean (BR) has been used in the food industry. In the course of development of functional food using red- bean (Phaseolus radiatus L), hot- water extracts (HWEs) of RR and BR were prepared, respectively and their components and various biological activities were compared. The extraction yield at 100℃ of RR (16.2%) was higher than that of BR (14.8%), and contents of total polyphenols, total flavonoids and reducing sugars of HWE of RR were 2.5-fold, 2.1-fold and 1.5-fold higher than those of HWE of BR. In anti-oxidation activity assay, scavenging activities against DPPH anion and ABTS cation as well as reducing power of RR was higher than those of BR. The results suggest that the anti-oxidant compounds in red bean might be heat-liable or discarded during boiling in hot-water as a cooking drip. Unexpectedly, nitrite scavenging activity was stronger in HWE of BR than RR. In anti-microbial activity assay, HWE of RR (500 μg/disc) showed growth inhibition activity against gram-positive bacteria, whereas HWE of BR did not show any activity against any tested bacteria and fungi. Assay of in-vitro anti-diabetes and anti-thrombosis activities, which were previously reported in ethanol extract of red-bean, revealed that HWEs of RR and BR did not show significant activities against α-amylase, α-glucosidase, thrombin, prothrombin, or blood coagulation factors. Our results suggest that the anti-oxidation, anti-diabetes and anti-thrombosis activities of HWEs of RR and BR were lower than those of ethanol extracts of red bean, and bioactive substances in RR were destroyed during boiling or discarded after boiling. Further research on suitable boiling and re-use of cooking drip of red bean is necessary.

데이타 배열을 사용하는 병렬 프로그램에서 그레인 크기를 이용한 데이타 선인출 기법

정인범(In-Bum Jung),이준원(Joon-Won Lee) 한국정보과학회 2000 정보과학회논문지 : 시스템 및 이론 Vol.27 No.1

데이타 선인출 방법은 데이타 참조와 프로세서 계산의 중첩을 이용하여 주메모리 접근 지연시간을 줄여주는 효과적인 방법이다. 그러나 선인출된 데이타가 캐쉬 메모리에 있는 다른 유용한 데이타들을 대체시키거나 또한 선인출된 데이타가 사용되지 않는 무익한 선인출일 경우 프로그램의 성능은 저하된다. 이러한 현상은 향후 사용되는 데이타들에 대한 정확한 예측이 부족하므로 발생된다. 병렬 프로그램이 계산을 위하여 데이타 배열들을 사용할 때 그레인 크기는 향후 사용되는 데이타 지역의 범위를 나타내므로 데이타 선인출을 위한 유용한 정보이다. 이런 정보를 기반으로 본 논문에서는 병렬 프로그램의 그레인 크기를 이용한 새로운 데이타 선인출 방법을 제안한다. 모의시험에서 제안된 선인출 방법은 기존의 선인출 방법들보다 버스 트랜잭션을 감소시킬 뿐만 아니라 유용한 선인출의 증가로 시험된 병렬 프로그램들의 성능을 향상시킨다. The data prefetching scheme is an effective technique to reduce the main memory access latency by exploiting the overlap of processor computations with data accesses. However, if the prefetched data replicate the useful existing data in the cache memory and they are not being used in computations. performances of programs are aggravated. This phenomenon results from the lack of correct predictions for data being used in the future. When parallel programs exploit the data arrays for computations, the grain size is useful information for data prefetching scheme because it implies the range of data using in computations. Based on this information, we suggest a new data prefetching scheme exploited by the grain size of the parallel program. Simulation results show that the suggested prefetching scheme improves the performance of the simulated parallel programs due to the reduction of bus transactions as well as useful prefetching operations.

자연개념의 관점에서 본 사회생태학적 건축의 이해

정인아(Jung In-A),김흥만(Kim Heung-Man),이인희(Lee In-Hee) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.5

This study is an attempt to understand architecture linking between nature and society focused on the concept of nature in social ecology advocated by Murray Bookchin in 1960s. Social ecology firmly opposes to the position of environmental fascism which insists that ecological crisis’s reason is human because it detests human. So Bookchin proposes new concept of nature to prevent from a partial point of view about nature and he aims to ecological society by ecological dialectic. Meanwhile contemporary ecological buildings have been tried to build for overcoming the dichotomous relations. But it has shared the conceptual properties appearing in various ecological thoughts and theories. It can also give confusion to architectural decisions. Because of this reason, we need to understand architecture being between nature and society. With this study, we will expect ecological society both consisting of social-ecological building in having potential abilities and interacting nature with society.

분화 유도된 근육줄기세포의 내막증식 억제 효과

정인목(In Mok Jung),한소리(So Rhee Han),최금희(Keum Hee Choi),권유진(Yujin Kwon),이태승(Taeseung Lee),민승기(Seung-Kee Min),박양진(Yang Jin Park),정중기(Jung Kee Chung),하종원(Jongwon Ha),김상준(Sang Joon Kim) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.6

Purpose: Although progenitor cells may contribute to intimal hyperplasia (IH) after arterial injury, positive contribution of IH is variable with type of injury or cells. This study was designed to examine whether differentiated muscle derived stem cells (MDSC) attenuate IH in rat. Methods: MDSCs were retrieved using preplate techniques from rat calf muscle and MDSCs (preplate 6th culture fraction, pp6) were exposed to VEGF (50 ng/㎖) for endothelial differentiation prior to injection. Male rats were divided into two groups (cell treated vs. control) and underwent carotid balloon injury with 2-Fr catheter. The virus containing Green fluorescent protein (GFP) gene was transfected into cells for monitoring. Cells (5×10?) were indwelled into carotid artery for 30 minutes after injury and then blood flow was restored. Arteries were harvested at various intervals (1, 2 and 4 weeks) after injury. The intima to media thickness ratio (IMTR) was calculated with morphometric analysis. Results: Endothelial surface markers such as VE-CADHERIN were strongly expressed on differentiated MDSCs. At 4 weeks after injury, IH was predominantly observed in control group compared to cell treated group. The intensity of GFP was strongly observed at 1 week and declined at 4 weeks in carotid artery wall at MDSC group. CD31(+) endothelial cells were observed at MDSC group compared to control. The mean IMTR in cell treated groups were significantly lower than control at 2 weeks (P=0.005) and 4 weeks (P≤0.001). Conclusion: Our study demonstrates that MDSCs therapy promotes re-endothelialization and leads to attenuation of IH after balloon injury in rat.

선별검사 목적으로 시행된 관상동맥 CT의 석회수치에 따른 임상경과 관찰

정인현 ( In Hyun Jung ),김정순 ( Jeong Soon Kim ),남효정 ( Hyo Jung Nam ),김희성 ( Hee Sung Kim ),김홍규 ( Hong Kyu Kim ),박덕우 ( Duk Woo Park ),이승환 ( Seung Whan Lee ),김영학 ( Young Hak Kim ),이철환 ( Cheol Whan Lee ),김재중 대한내과학회 2010 대한내과학회지 Vol.78 No.4

Background/Aims: In general, multidetector computed tomography (MDCT) is not recommended as a screening tool for asymptomatic individuals. However, the programs for general health evaluation at several hospitals in Korea include MDCT to detect cardiac disease. The objectives of this study were to evaluate the clinical outcomes of asymptomatic individuals according to the coronary artery calcium score (CACS) obtained from screening MDCT and to assess the eligibility of risk stratification in the NCEP-ATP III guidelines for predicting a significant stenosis on MDCT. Methods: We reviewed the medical records of 845 asymptomatic subjects (age 53±9 years, 67% men) who underwent MDCT as part of a general health evaluation at Asan Medical Center, Seoul, Korea, from January to December 2008. Results: Atherosclerotic plaques were identified in 332 (39.3%) subjects. Sixty (7.1%) individuals had significant stenosis (≥50% diameter stenosis). The prevalence of significant stenosis was higher in the group that had more than a 10% risk of coronary heart disease (CHD) at 10 years (p<0.05). Among the patients with occult coronary artery disease (CAD), 28 received coronary angiography, which resulted in 20 revascularizations (17 percutaneous interventions and three bypass surgeries) and eight medical treatments. In patients with significant narrowing, the CACS cutoff value for predicting coronary revascularization was 111.0 (AUC=0.87, 95% confidence interval; 0.76~0.97; sensitivity 80.0%, specificity 92.1%). Conclusions: According to the NCEP-ATP III guidelines, the prevalence of occult CAD on MDCT was significantly higher in the group with a 10% or higher risk for CHD at 10 years. A CACS≥110 was associated with a significantly higher rate of coronary revascularization in asymptomatic patients with significant stenosis on MDCT. (Korean J Med 78:466-476, 2010)

자궁근종 환자의 수술 전후 혈중 렙틴의 농도 변화

정인국 ( In Kook Jung ),김기형 ( Ki Hyung Kim ),나용진 ( Yong Jin Na ),이규섭 ( Kyu Sup Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.8

Objective: To investigate possible relationship between uterine leiomyoma and serum leptin levels, we compared serum leptin levels between women with uterine leiomyoma and women without leiomyoma, and then investigate the effects of hysterectomy on serum leptin levels. Methods: Serum leptin levels were measured before (day-1) and after (day+5) surgery for 32 women with uterine leiomyoma and were measured when they visit our health promotion center for 32 normal women. We compared serum leptin levels between two groups, and then we analyzed perioperative changes of serum leptin levels in women with uterine leiomyoma. Pearson correlation test was performed between pre-/postoperative leptin ratio and resected uterine weight to investigate whether the changes of serum leptin levels are directly related with resection of leiomyoma. Results: In women with uterine leiomyoma, serum leptin levels were lower compared with normal group (7.41±4.31ng/㎖ vs. 17.56±8.65ng/㎖) (P<0.05). Postoperative serum leptin levels were decresed than preoperative serum leptin levels (6.07±2.98ng/㎖ vs. 7.41±4.31ng/㎖) (P<0.05). Pearson correlation coefficient between pre-/postoperative leptin ratio and resected uterine weight showed no statistical significance. Conclusion: Serum leptin levels were lower in women with uterine leiomyoma. And serum leptin levels were more decreased after hysterectomy. There were significant postoperative decrease in serum leptin levels but the result between pre-/postoperative leptin ratio and resected uterine weight revealed no direct correlation. It seems that lower serum leptin levels maybe due to postoperative stress and neuroendocrinological response rather than myoma itself. In conclusion, further investigation is needed for clinical use of serum leptin levels as a serum marker after conservative treatment of uterine leiomyoma.

성인 두부백선의 임상 및 진균학적 분석(61증례, 1990∼2018)

정인순 ( In Soon Jung ),류건욱 ( Geon Wook Ryu ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.1

Background: Tinea capitis, a superficial dermatomycosis, is caused by a dermatophyte infection on the scalp and hair. Recently, the number of adult patients with tinea capitis have been increasing; therefore, the clinical and mycological features of tinea capitis may be different from those of previous reports. However, only a few studies on adult tinea capitis have been conducted in Korea. Objective: This study aimed to analyze the clinical and mycological features of Korean adult patients with tinea capitis. Methods: A retrospective review of 61 adult patients with tinea capitis was conducted. Clinical features including age, sex, clinical type, and treatment outcome were obtained from medical records and images. The mycological features, including the result of KOH smear and fungal culture, were also analyzed. Results: The mean onset age was 61.3 years, and the male-to-female ratio was 1:4.1. Two patients (3.3%) had a family history of developing the same symptoms, and 17 (27.9%) had a history of close contact with animals. The most predilection site was the vertex, followed by the frontal and parietal areas. Microsporum canis was cultured in 66.7% patients, and Trichophyton rubrum was cultured in 28.6% patients. The number of adult patients with tinea capitis has been increasing constantly. The proportion of patients infected by T. rubrum has been increasing since 2000. Of the 51 patients who received treatments, 42 showed improvements. No significant difference was observed between patients treated with terbinafine and itraconazole. Conclusion: This is the large-scale study that analyzed the clinical and mycological features of Korean adult patients with tinea capitis. (Korean J Dermatol 2020;58(1):1∼6)

흉부 X-Ray 검사실에서 Auto Voice Device의 유용성과 방사선사의 편의성에 관한 고찰

정인아(In-A Jung),이동희(Dong-Hee Lee),이민우(Min-Woo Lee),김순배(Sun-Bae Kim) 대한영상의학기술학회 2012 대한영상의학기술학회 논문지 Vol.2012 No.-

목적: 음성안내가 많은 흉부 X-ray 검사실에서 사용할 Auto voice device를 제작하여 장비의 유용성과 이에 따른 방사선사의 업무 편의성에 대해 알아보고자 하였다. 대상 및 방법: 2012년 01월 09일 부터 02월 24일에 걸쳐 방사선사 87명에게 검사방법과 장비사용법이 담긴 동영상을 보여준 후 연구목적과 취지를 설명하고 협조를 요청하여 설문 지를 배부하여 분석하였다. 방사선사의 일반적 특성은 성별은 남성이 58명(67.7%)으로 9 명(33.3%)인 여성의 약 2배이고, 평균연령은 36(35.89±7.90)세이며, 근무기간은 13(13.41±7.54)년, 검사건수는 300~399건이 41명(28.7%)으로 가장 많은 비중을 차지했 다. 조사결과 분석은 방사선사의 검사에 대한 일반적 견해와 개선사항과 장비의 질에 대한 견해를 파악하기 위해 빈도와 백분율을 산출하고, 검사장비도입의 효과 및 효능의 통계적 처리는 SPSS를 이용하여 일원배치 분산분석(ANOVA)을 하였다. 결과: 설문조사 결과 연령과 근무기간에 따른 Auto voice device의 유용성은 유의확률이 0.05 이상으로 모두 통계적으로 유의하지 않아 상관관계가 적은 것으로 나타났다. 그러나 검사건수에 따른 검사자의 피로도 감소는 유의확률 0.000 (p<0.01)으로 매우 유의한 결과를 얻었고, 검사건수에 따른 업무의 편의성도 유의확률 0.001 (p<0.01)으로 매우 유의하다는 결과가 나왔다. 결론: Auto voice device를 사용함으로써 업무의 편의성 증가와 목의 피로도 감소는 매우 높은 평가를 얻었다. 하지만 장비를 조작하는 시간이 추가됨에 따라서 전체적인 검사시간은 단축되지 않았고, 호흡조절도 장비를 사용하는 것과 육성을 사용하는 것을 비교하였을 때크게 다르지 않았다. 향후 개선사항들을 토대로 장비의 음질 개선과 언어의 다양화, 자막기 능을 추가하여 현재 장비의 업그레이드를 진행 중이며, 더 발전된 Auto voice device로 방사선사의 업무에 보다 더 효율을 줄 것으로 기대한다. Purpose: This study investigated usefulness of the device and its work convenience for radiologic technologist by making auto voice device used at chest X-ray lab where many voice guidance is made. Materials and Methods: The subjects are 87 radiologic technologists and they were asked to see video clip where how to use the device and method of applying to examination was introduced during the period from Jan. 9, 2012 to Feb. 24, 2012. Since then, study purpose was explained to ask for cooperation. For general characteristics of the subjects, the gender is 58 males (67.7%); 29 females (33.3%) - male is double female. Average age is 36 (35.89±7.90). Working period is 13 (13.41±7.54) years. As for number of examination by radiologic technologist, 41 radiologic technologists (28.7%) did 300-399 cases each person. To show general opinion of the subjects about examination, and opinion about improvements and quality of device, percentage was used. Effect and efficiency of using Auto voice device was analyzed using ANOVA through statistical processing by SPSS. Results: For reduction of fatigue in radiologic technologist s throat according to number of examination, p-value 0.000 (p<0.01) - this is very significant result. For work convenience according to number of examination, p-value 0.000 (p<0.01) -this is also very significant result. Conclusion: Using auto voice device brought increase of work convenience and reduction of fatigue in throat. But whole time for examination was not saved because maneuvering device requires additional time. In controlling breathing, there is no much difference between using device and human voice. It is expected that if auto voice device is improved in sound quality, variety in provided language etc. through this study results, this device would be more useful for work of radiologic technologists in the future.

한국형 노인우울검사(Korean Form of Geriatric Depression Scale;KGDS) 표준화 연구

정인과(In-Kwa Jung),곽동일(Dong-Il Kwak),조숙행(Sook-Haeng Joe),이현수(Hyeon-Soo Lee) 대한노인정신의학회 1997 노인정신의학 Vol.1 No.1

본 연구는 한국형 노인우울검사(KGDS)에 대한 표준화 연구로, 예비 연구에서 제기되었던 문항 내용 및 길이, 표집의 문제를 개선하여 최종적으로 30문항을 확정한 후 신뢰도와 타당도를 검증하였다. 연구대상은 60세 이상의 노인 450명으로, 우울환자 군은 129명(남자 28명, 여자 119명)이었고 대조군은 321명(남자 276명, 여자 194)이었다. KGDS의 신뢰도를 검증한 결과, Cronbach의 계수는 .88, 반분신뢰도는 .79, GDS와의 상관은 .87로서 만족스러운 수준이었고 두 집단의 평균의 차이를 검증해본 결과 α=.001 수준에서 유의하였다(환자군 평균 17.82(10.52), 대조군 평균 10.52(5.12), t=12.07). KGDS의 구성타당도와 내적 구조를 파악하기 위해 실시한 요인분석에서는 정서적 불편감(Emotional discomfort), 비관적 사고 및 불행감(Negative thinking and Unhappiness feeling), 신체적 약화 및 기력쇠퇴(Physical weakening and decreased vitality), 인지기능 저하(Cognitive dysfunction), 사회적 관심과 활동저하(Decreased social interest and activity) 등 총 5개의 구성요인이 밝혀졌고 총 설명변량은 53.72%였다. 마지막으로 KGDS의 판별력과 최적 절단점수를 확인하기 위해 판별분석 및 민감도, 특이도의 지표를 구하여 본 결과 전체판별률은 75%이었고 최적 절단점수는 14점이 제안되었으며 고전적인 백분위점수분포를 추가적으로 고려하여 14∼18점 사이는 경계선수준 및 경도의 우울증, 19∼21점 사이는 중등도의 우울증, 22점 이상은 심도의 우울증으로 분류할수 있을 것으로 기대되었다. 결론적으로, 기존의 노인 우울검사(GDS)의 낮은 진단 변별력을 개선시키고자 새로이 만든 한국형 노인우울검사(KGDS)는 기존 검사에 비해 진단변별력이 10% 가량 향상되었을 뿐 아니라 신뢰도, 타당도도 만족스러운 수준을 보여 노인우울 진단용 검사로 유용하게 쓰일 수 있을 것으로 여겨진다. This study was aimed to standardize the Korean Geriatric Depression Scale (KGDS). In order to slove the unsatisfied discriminating power of Geriatric Depression Scale (GDS:Yesavage et al. 1983) presented in Korean studies, the authors made KGDs. The preliminary KGDS was costructed of 40 items selected from GDS, BDI, SDS, MMPI-D, CES-S and had satisfied reliability and validity, but had some problems in item contents, number of times, and sampling. Thus by correcting these problems, the authors made new KGDS of 30 item, and tested the reliability and validity of the final version of KGDS. The values of Cronbach's α and Split-half reliability were .88 and .79 respectively, and correlational coefficent with GDS was .87. The differences of means was signified at α=.001 level (patients group mean=17.82 (10.52), control group mean=10.52 (5.12), t=12.07). On factor anlaysis, 5 factors in KGDS were extracted. They were labeled Emotional discomfort (factor 1), Negative thinking and Unhappinesss feeling (factor 2), Physical weakening and decreased vitality (factor 3), Cognitive dysfunction (factor 4), Decreased social interest and activity (factor 5), which represent depressive features of the elderly in thought, emotional, cognitive, physical, social aspects. The total percentage of variance of 5 factors was 53.72%. The result of discriminatin anlaysis showed that hit ratio of KGDS was 75%, and the score of 14 was suggested as the optimal cutoff score. Additionally, by use percentile score distribution of control group (normal) subjects, each of the score of 14-18, 19-21, over 22 suggested borderline or mild depression, moderate depression, severe depression, respectively. Conclusively, the final version of KGDS not only improved diagnostic discriminatory power approxtimately 10% than GDS, but also showed satisfiable reliability and validity. So the KGDS could be a useful tool for evaluaion of elderly depression.