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이영순,김종배,정재영,정석권,이건우,Lee Yong Soon,Kim Jong Bae,Chung Jae Young,Chung Suk Kwon,Lee Kweon Woo,Shin Kwang Soon 대한수의사회 1983 대한수의사회지 Vol.19 No.1
Aeromonas punctata subgroup caviae and Plesiomonas shigelloides were isolated and identified from the lesion of ulcer disease of crusion carp in Ban Wol storing reservoir, the kyungki-do province.
마우스에 있어서의 Tyzzer병(病) 감염방어기구(感染防禦機構)
이영순,이장락,Lee, Yong Soon,Lee, Jang Nak 대한수의학회 1980 大韓獸醫學會誌 Vol.20 No.1
1. In adult ICR-SLC mice, significant increase in the occurrence of the Tyzzer's disease was noted when the reticuloendothelial system was blockaded with the carbon particles. The most suitable bloakading time was 2 hours before inoculating Tyzzer's organisms, the route was intraperitoneal and the dose was 3mg/body. 2. Survival rate of the experimental group ICR-SLC suckling mice receiving BCG ($3{\times}10^8$) 6 days prior to intraperitoneal inoculation of Tyzzer's organisms was 80 percent, but the control group was 17%. 3. In comparing the survival rate of the nude/nude mice with the nude/+ mice, the former congenitally thymus deficient mice are 11 percent, but the latter are 67 percent.
이영순,강경선,신동진,김형욱,조재진,김배환,남기환,서광원,Lee, Yong-Soon,Kang, Kyung-Sun,Shin, Dong-Jin,Kim, Hyoung-Ook,Cho, Jae-Jin,Kim, Bae-Hwan,Nam, Ki-Hoan,Seo, Kwang-Won 한국독성학회 1992 Toxicological Research Vol.8 No.2
SKI 2053R and SKI 2053R-human serum albumin(HSA) mixture were examined for their antigenicity in Hartley guinea pigs as well as C57BL/6 mice in comparison with distilled water (DW), HSA and DW-HSA conjugate. Several antigenicity tests, including acitive systemic anaphylaxis(ASA), passive systemic anaphylaxis (PSA), passive cutaneous anaphylaxis (PCA) and indirect hamagglutination test (IHA), were performed according to the Established Regulations of National Institute of Safety Research. The results were as follows: 1. When guinea pigs were sensitized with SKI2053R or SKI2053R-HSA emulsified with complete Freund's adjuvant(CFA), these animals showed negative reactions in ASA and PSA. 2.No blue spot was observed on the back skin of guinea pigs in the PCA test. 3. Sera from guinea pigs revealed a negative reaction in IHA. 4.Guinea pigs were sensitized by HSA emulsified with CFA as a positive control, and these animals showed positive reactions in ASA, PSA, PCA, and IHA. As shown above, SKI2053R was considered to possess neither antigenic, nor haptenic properties, and confirmed not to have the haemagglutinating activity.
이영순,조재진,강경선,김배환,남기환,서광원,강성근,임윤규,허강준,Lee, Yong-soon,Cho, Jae-jin,Kang, Kyung-sun,Kim, Bae-hwan,Nam, Ki-hoan,Seo, Kwang-won,Kang, Seong-keun,Lim, Yun-kyu,Heo, Kang-jun 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.3
This study was performed for assessing carcinogenicity of Folpet using medium-term carcinogenicity bioassay. Sprague-Dawley rats aged six weeks divided into four grout's and were initially given an intraperitoneal injection of diethylnirosamine at 200mg/kg body weight. Two weeks later, group 1(negative control) was treated with basal diet. A Folpet was given per oral administration to group 2(100 ppm) and goup 3(1,000 ppm). Group 4 was fed on water containing 0.05% phenobarbital sodium as a promtor for six weeks. At three weeks after beginning of the experiment, partial hepatectomy was performed in all rats. The tumor-promoting effects were examined by the numbers and areas per $cm^2$ of induced glutathion S-tranferase placetal form(GST-P) positive foci in liver, and silver stained nucleolar organizer regions(AgNORs) which have recently introduced as one of the indicators for the cell proliferative activity. As the results, Folpet didn't have tumor-promoting effects on GST-P positive foci developement and AgNORs during promoting stage after initiation, whereas phenobarbital sodium treatment group showed promoting effect. It was concluded that Folpet didn't have promoting effect at 500, 1,000 ppm using this midium-term carcinogenicity bioassay model.
이영순,강경선,신동진,조재진,김형욱,김배환,임윤규,Lee, Yong-Soon,Kang, Kyung-Sun,Shin, Dong-Jin,Cho, Jae-Jin,Kim, Hyoung-Ook,Kim, Bae-Hwan,Lim, Yoon-Kyu 한국독성학회 1992 Toxicological Research Vol.8 No.2
A subacute toxicity study of cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R) was carried out to obtain information on its toxicological profiles, and to determine the maximum tolerated dose in beagle dogs. Four groups of beagle dogs (2M and 2F per group, 0,0.5,1.0,2.0mg/kg/day)were given 15 i.v. injections of SKI 2053R. In order to compare the toxic effects of SKI 2053R with those of cisplatin, one group was treated with cisplatin(0.7mg/kg/day)according to the same treatment schedule. The dosing schedule was divided into 3 courses of 5 consecutive days with 23-day dose-free intervals between each course. After completion of the treatments, remaining dogs were necropsied under established guidelines. Three of four dogs in the high dose group and one of four dogs in the middle dose group treated with SKI 2053R died of hypovolemic shock secondary to hemorrhagic and ulcerative enterocolitis. No toxicity-related mortality occurred in the low dose group of SKI 2053R. No survivor was observed in the group of cisplatin. Clinical signs including vomiting, diarrhea, anorexia and loss body weight were apparent in dogs given either cisplatin or high and middle doses of SKI 2053R. Severe thrombocytopenia and leukocytopenia were observed in the high dose group of SKI 2053R and cisplatin-treatment group, while toxicities as bone marrow suppression were reversible. The significant elevation of serum ALP values in group of SKI 2053R(2.0 mg/kg/day and 1.0mg/kg/day) and cisplatin(0.7mg/kg/day)was observed. Slight proteinuria waa observed in high and middle dose level groups of SKI 2053R. In histopathological examinations, pathological alterations of liver, kidney and spleen were noted dose-dependantly in dogs treated with SKI 2053R, and there was no overt sign of toxicity in low dose group of SKI 2053R. Compared to SKI 2053R, more severe durg-related toxicities occurred in dogs treated with cisplatin. It waw estimated that maximum tolerated dose of SKI 2053R in this treatment schedule was 0.5~0.7mg/kg/day. In conclusion, overall toxic potential of SKI 2053R was approximately 3 times lower than that of cisplatin with respect of lethality.
이영순,Lee Yong-Soon 대한수의사회 1983 대한수의사회지 Vol.19 No.2
A total of 110 adult dogs (12pet dogs, 27 stray dogs, 71 other dogs collected from were examined for Brucella canis infection, and 11cases ($10\%$) were found to have Seoul areal high titered agglutinin. Especially, the positive titer (1 : 160
개의 평골근육종(平滑筋肉腫) 2예(例)에 관한 미세형태학적관찰(微細形態學的觀察)
이영순,임창형,Lee, Yong-soon,Lim, Chang-hyeong 대한수의학회 1984 大韓獸醫學會誌 Vol.24 No.1
Undifferentiated leiomyosarcomas were encountered in two dogs, and an ultrastructural study was carried out. The results of this study were summarized as follows; 1. The nuclei of mosts tumor cells showed bilobate appearance. 2. Most cells of the tumors had not a distinct basement membrane. 3. Most cells of the tumors had a degenerative rough endoplasmic reticulum. 4. Intercellular matrix contained some amounts of collagen. 5. Attachment areas between tumor cells were not apparent, but a few tight junction were clearly seen. 6. Myofibrils were present in bipolor end area.
Beagle dog 에서 DA-3030 ( G-CSF ) 의 정맥내 4 주간 반복투여 독성
이영순(Yong Soon Lee),조재진(Jae Jin Cho),남기환(Ki Hoan Nam),서광원(Kwang Won Seo),강성근(Sung Keun Kang),박재학(Jae Hak Park),김원배(Won Bae Kim) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.3
This study was performed to determine the toxic effect of DA-3030(granulocyte-colony stimulating factor, G-CSF) in beagle dogs. DA-3030(G-CSF) was injected intravenously at doses of 115㎍/㎏/day, 11.5 ㎍/㎏/day and 1.15 ㎍/㎏/day seven days per week for 28 days. After completion of the treatments, the dog were necropsied. The number of dead animal was zero in all groups. No specific clinical sign was found, either. In hematological results, WBC was significantly increased dose-dependently in treated groups. In histopathological findings, megakaryocyte and rubricyte were found in the liver and spleen at the dose of 115㎍/㎏/day. Therefore, we could find the extramedullary hematopoiesis was increased. Megaka yocyte and rubricyte were increased in bone marrow, too. In conclusion, those signs were estimated the pharmacological effect of DA-3030(G-CSF). According to the results, non toxic dose of DA-3030(G-CSF) was higher than 115㎍/㎏/day