심한 호중구 감소증을 보인 X-관련성 범저감마글로불린혈중 1례

이경연 ( Kyoung Yeon Lee ),이동규 ( Dong Kyu Lee ),박준은 ( Jun Eun Park ),이재호 ( Jae Ho Lee ),이명익 ( Myung Ik Lee ) 대한소아알레르기호흡기학회 2002 소아알레르기 및 호흡기학회지 Vol.12 No.4

저자들은 폐렴치료 중 1개월 이상 심한 호중구 감소증이 지속되었던, 유전자 분석으로 확진된 XLA 환아를 경험하였기에 문헌고찰과 함께 보고하며, 만성 혹은 반복되는 감염의 증상과 함께 호중구 감소증이 나타날 때 XLA를 포함한 면역결핍질환을 의심하는 것이 필요하다고 사료된다. X-linked agammaglobulinemia(XLA) is characterized by markedly reduced number of B lymphocytes, panhypogammaglobulinemia, recurrent bacterial infections in the first few years of life because of genetic defect for Bruton`s tyrosine kinase at Xq22 region. A

한국 소아 천식 환자의 보호자 삶의 질에 대한 설문 개발 및 유용성 평가를 위한 다기관 공동 연구

차재국(Jae Kook Cha),오재원(Jae Won Oh),홍수종(Soo Jong Hong),이혜란(Hae Ran Lee),이명익(Myung Ik Lee),김규언(Kyu Earn Kim),이준성(Joon Sung Lee),이하백(Ha Baik Lee),이상일(Sang Il Lee) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.3

N/A Background: and objective: Asthma is the most common chronic disease among children. Thus, when children have asthma, it can have a significant impact on health-related quality of life, not only for children, but also for parents and family. We developed to measure asthma- specific quality of life in caregivers of children with asthma age 7~17 years and evaluated the measurement properties of the questionnaire. Materials and method: The questionnaire of caregivers of children with asthma include 13 items in two areas(activity limitation-4 items, emotional function-9 items) and the response options for each item are on a 5-point scale where 1 indicates maximum impairement and 5 indicates no impairement. Results are expressed as the mean score for overall quality of life as well as for each of the domains. At follow-up visit, we asked caregivers whether they had experienced any change in their overall quality of life related to their children's asthma since the previous visit. They responded on a 11-point scale from -5(a very great deal worse) to 0(no change) to +5(a very great deal better). We recruited 195 caregivers of children with asthma from thirty-three general hospitals and evaluated the measurement properties of the questionnaire. Result: The questionnaire of caregivers of children with asthma showed excellent responsiveness in changed group, but the change in score of stable and changed group has no difference. It was reproducible in subjects who are stable. There was no longitudinal and cross- sectional correlations between caregiver's questionnaire score and the child's asthma status, while cross-sectional correlations were found between caregiver's questionnaire score and PEFR Conclusion The questionnaire of caregivers of children with asthma is simple and easy to use, and is applicable.

한국 호아 천식 환자의 삶의 질에 대한 설문 개발 및 유용성 평가를 위한 다기관 공동 연구

차재국(Jae Kook Cha),오재원(Jae Won Oh),홍수종(Soo Jong Hong),이혜란(Hae Ran Lee),이명익(Myung Ik Lee),김규언(Kyu Earn Kim),이준성(Joon Sung Lee),이하백(Ha Baik Lee),이상일(Sang Il Lee) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.3

N/A Background:and object: Traditional asthma outcome measures such as symptoms, spirometry. And medication requirements usually provide valuable information about the asthmatic status but they rarely capture the functional impairments. Thus, many clinicians are increasingly recognizing the importance of an assessment of health-related quality of life(HRQL) as an outcome measure in asthma. We developed a questionnaire to measure asthma-specific quality of life in Korean children and evaluated the measurement properties. Materials and methods : The questionnaire for children with asthma included 14 items in three domains (symptoms-6 items, activity limitation-4 items, and emotional function-4 items) and the response options for each item were on a 5-point scale where 1 indicated maximum impairment and 5 indicated no impairment. Results were expressed as the mean score for overall quality of life as well as for each of the domains. At #follow-up clinic visit, patients completed global assessment of change related to their symptoms, activities and emotions. We recruited children (7-17 years of age) with asthma from thirty-three general hospitals. Results Data from 214 patients(144 boys and 70 girls) who completed the questionnaire were analyzed. The mean age was 10.0 years and the disease severity consisted of mild intermittent (26.6%), mild persistent(36.0%), moderate persistent(32.2%), and severe persistent (3.3%). The questionnaire for children with asthma showed a high index of responsiveness, reproducibility, and both longitudinal and cross-sectional correlations with the conventional asthma indices and with the questionnaire score. But there was no relationship between changes in questionnaire score of the domain of emotional function and changes in FEV1 or PEFR. Conclusion: The questionnaire of children is straight forword, and easy to apply.

한국인 영아사망의 사인 분석

서경 ( Kyung Seo ),이명익 ( Myung Ik Lee ),홍영진 ( Young Jin Hong ),한영자 ( Young Ja Han ),도세록 ( Se Rok Doh ) 대한주산의학회 2001 Perinatology Vol.12 No.3

Mycoplasma pneumoniae 폐렴의 임상적 고찰

이은경(Eun Kyung Lee),홍영진(Young Jin Hong),이명익(Myung Ik Lee),안돈희(Don Hee Ahn),손근찬(Keun Chan Sohn) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1993 소아알레르기 및 호흡기학회지 Vol.3 No.2

N/A A clinical study was made on 261 cases of Mycoplasma pneumoniae pneumonia from January 1985 to June 1992. Those patients were composed of 220 in-patients and 41 out-patients. The results were as follows. 1. Annual distribution showed increased incidence in 1990 and seasonal distribution showed increased incidence in spring and autumn. 2. Out of 261 cases, 147 cases were male, 114 cases were female and high incidence was in the age of 1 to 6 years (75.5%). Male to female ratio was 1.4:1. 3. The cases which had allergic history were 53 cases. Bronchial asthma were 22 cases and atopic dermatitis were 11 cases. 4. Sinusitis was the most common concomitant disease. 5. Cough was the most common chief complaint (93.5%) and duration was less than 7 days on initial visit (48.1%). 6. The most common auscultatory finding was coarse breathing sound (180 cases, 69%) and then followed by rale and wheezing. 7. Leukocyte counts in peripheral blood were most common in the range of 5,001-10,000/㎣ (53.1%). Erythrocyte sedimentation rate were in the range of 10-19㎜/hr. Positive CRP cases were 86 cases (36.3%). 8. Radiologic finding of pulmonary infiltration was the most common in right lower lobe.

제대 혈청 IgE 치 ( Ultra RIA ) 에 대한 고찰

강진섭(Jin Seop Kang),고재욱(Jae Wook Ko),홍영진(Young Jin Hong),안돈희(Don Hee Ahn),이명익(Myung Ik Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1995 소아알레르기 및 호흡기학회지 Vol.5 No.1

N/A The objectives of this report is to evaluate and determine the normal level of cord serum IgE which is regarded as one of successful parameters , predicting the development of atopic disease in neonate. Forty mothers who were admitted to NMC for the purpose of fullterm delivery and their newborns were investigated. We had titrated cord serum IgE levels by new method , IgE Ultra RIA, and also checked maternal serum IgE by IgE RIA method. Additionally, allergic and smoking histories of mothers and informations of neonate were taken for comparison of cord serum IgE levels . The following results were obtained. 1. The median value of cord serum IgE measured by Ultra RIA method was 0.22(range : 0.11-2.19) IU/ml and that of maternal serum IgE by RIA method was 59.5(range 6-448) IU/ml. 2. There was no significant correlation between log10 value of maternal and cord serum IgE. 3. According to the sex and birth weight, there was no significant differences of cord serum IgE levels. 4. According to birth order , cord serum IgE levels of first babies showed significantly higher than those of others. 5. According to allergic family history and maternal smoking history , there was no significant difference of cord serum IgE levels .

소아기관지천식에 대한 Ketotifen(Zaditen^(�))의 예방효과

이명익,손근찬 최신의학사 1988 最新醫學 Vol.31 No.6

당뇨병교실 피교육자들의 질문양상에 대한 고찰

이명익,유형준,김두만,성상규,송금오,이금자,감규상 대한당뇨병학회 1987 Diabetes and Metabolism Journal Vol.11 No.1

신생아, 영아 및 소아 발열 환아에 있어서 CRP, 백혈구수, 혈침치, 중성구 및 질병분포의 비교 관찰

안돈희,조병래,이명익,손근찬 대한감염학회 1988 감염 Vol.20 No.3

We studied total 413 cases of febrile neonates, infants and children, which were divided into 232 cases of CRP positive group and 181 cases of CRP negative group, and compared ESR, WBC, polymorphonuclear leucocyte count, band form neutrophil and disease distribution in both group. We concluded that CRP is important and may be valuable screening test for the detection of bacterial infection in febrile and infectious neonates, infants and children.

최근 2년간의 소아과 입원환자의 세균배양에서 분리된 균과 그 감수성에 관하여

서수정,홍영진,이명익,김순화,안돈희 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

저자들은 1990년 7월부터 1992년 6월까지 만 2년간 국립의료원 소아과 입원환자로부터 분리, 도정한 병원균주 765주를 대상으로 균종의 분포와 항균제 감수성을 조사하였고, 1985년과 1986년에 분리된 병원균주와 비교 분석한 결과요약은 다음과 같다. 1. 각 검체에서 배양된 균주는 소변 배양에서 333주(40.8%)로 가장 많았으며, 다음으로 기타 배양(화농, 제대, 안, 기도 분비물, 척수액)106주, 인후부 배양 90주, 기도 삽입 튜브 배양 90주, 혈액 배양 33주, 대변 배양 33주 순이었으나 인후부 배양, 기도 삽입 큐브 배양, 혈액 배양 및 기타 배양에서는 S. aureus가 가장 많이 분리되었으며, 소변 배양에서는 E.coli, 대변 배양에서는 Salmonella가 많았다. 2. 그람양성균 중에는 S. aureus, Enterococcus, Streptococcus 순으로 많았으며, 그람음성균 중에는 E. coli, K. pneumoniae, Enterobacter, Acinetobacter 순으로 5년전과 같았다. 3. S. aureus는 Cep, Meth, Amk에 각각 75%, 56%, 71%의 감수성을 보였으니 5년전에 비해 감소하였고 다른 항균제에 대해서도 보두 감소하는 경향이었다. 그리고 질병과 연관된 혈액과 농 배양에서 분리한 S. aureus는 C데에 각각 86%, 88%, Meth에 각각 71%, 88%의 감수성을 보여 전체 평균보다 높았다. 4. Streptococcus는 Amp에 83%, CM에 96%, P두에 67%로 5년전에 비해 증가하는 경향이었다. 5. Enterococcus는 Amp에 83%의 감수성을 보여 5년전보더 감소하는 경향이었고, 그 외 CM, Pen, Tc에 낮은 감수성을 보였다. 6. E. coli는 Amk, Ct에 매우 높은 감수성을 보였으며, Amp, CM, To에는 점차 감소하는 경향을 보였다. 7. K. pneumoniae에는 Amk에 매우 높은 감수성을 보였고, GM, KM, To에는 55%의 감수성을 보였고 5년전과 유사하였다. 8. Enterobacter spp.는 Amk에 89%, GM, KM, To, Ct에 48~65%의 감수성을 보였으며 5년전에 비해 모두 감소하였다.Acinetobacter spp.는 Amk에 74%, GM, KM, To에 46%의 감수성을 보였으며 5년전과 큰 차이가 없었다. 9. Pseudomonas spp.는 Amk, Ca GM, To에 대해서는 5년전에 비해 증가하는 경향이었으며, Amp, Cep, CM, Tc에는 감수성균이 극히 드물었다. 그리고 Cfb에는 67% 감수성을 보였다. 10. Proteus spp.는 Amk, Ct에 매우 높은 감수성을 보였으며, Ca, C데, GM, To에 45~75%의 감수성을 보였으며 5년전에 비해 감소하였다. 11. Salmonella는 Amp, CM, Tc에는 5년전에 비해 현저히 감소하여 56%, 63%, 25%의 감수성을 보였다. 12. H. influenzae는 Amp, Ca에 63%, Tc에 75%로 5년전에 비해 감소하였고, Amk, C데, CM, GM, KM, To, Ct에 높은 감수성을 보였다. 13. 요로 감염시 소변 배양에서 자란 균은 E. coli, K. pneumoniae, Enterococcus 순으로 많았으며, E. coli의 감수성은 전체 세균배양의 감수성과 비슷한 양상을 보였으며 K.pneumoniae는 Amk, Ct에 전체 세균배양의 감수성과 비슷하며, C데, GM, To에는 전체 세균배양의 감수서보다 높았다. Enterococcus는 Amp에 94%로 가장 높은 감수성을 보아며 전체 세균배양의 감수성 83%보다 높았다. Antimicrobial susceptibility of 765 strains isolated during the period of 1990 through 1992 from pediatric department of National Medical Center were studied. The isolated strains and antimicrobial susceptibility were compared with those in 1985 and 1986. The results were as follows; 1) the most frequently isolated strains from various specimens were S.aureus from throat, blood, intubation tip and others, E.coli from urine and Salmonella from stool. 2) Hightly frequent isolates of Gram positive organsim were S.aureus, Enterococcus and Streptococcus. In Gram negative organism, the most frequently isolated species were E.coli, K.pneumoniae, Enterobacter and Acinetobacter were isolated in the decreasing orer. Relatively similar patterns of isolation of each species were observed in 1985 and 1986. 3) Over 70% of S. aureus strains were susceptible to cephalothin and amikacin. Its susceptibility to methicillin was decreased from 63% in 1986 to 56% in 1991. The isolated strains from blood and pus related to disease were more susceptible to methicillin as 71% and 88% than others. 4) Streptococcus ws highly susceptible to chlormphenicol as 96% susceptibility. Its susceptibility to ampicillin was 83% and to penicillin G was 67%. 5) Enterococcus was less susceptible to chloramphenicol, Penicillin G and tetracycline. Its susceptibility to ampicillin was decreased from 100% in 1986 to 883% in 1991. 6) E.coli was highly susceptible to amikacin and cefotaxime. Its susceptibilities to ampicillin, chloramphenicol and tobramycin were decreased. 7) K.pneumoniae was highly susceptibe to amikacin as 96% susceptibility. Its suscetibilities to gentaimicin, kanamycin and tobramycin were 55%. 8) Pseudomons spp. was more susceptible to amikacin, carbenicillin, gentamicin and tobramycin in 1991 in comparison with those in 1986. 9) Over 94% of Salmonella strains were susceptible to amikacin, gentamicin, tobramycin and cefotaxima. Its susceptibility to ampicillin was decreased from 100% in 1986 to 56% in 1991 and to chloramphenicol was decreased form 100% in 1985 to 63% in 1991. 10) Over 88% of H.influenzae strains were usceptible to amikacin, cephalothin, chloramphenicol, gentamicin, knamycin, tobramycin and cefotaxime. Its susceptibilities to ampicillin and carbenicillin were decreased from 100% in 1985 to 63% in 1991. 11) The most frequently isolated species from urine related to urinary tract infection were E.coli, K.pneumoniae, Enterococcus and Enterobacter were isolated in the decreasing order. Antimicrobial susceptibility of E. coli was similar in comparison with those from total specimens. K.pneumoniae was more susceptible to cephalothin, gentamicin and tobramycin than those from total specimens. Enterococcus was more susceptible to ampicillin as 94% susceptibility in comparison with 83% from total specimens.