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윤정훈,안철민,이두연,조철호,김도영,손희영 대한내과학회 1987 대한내과학회지 Vol.33 No.1
Benign solitary schwannoma of the chest wall is rare disease. A 46-year old female patient was admitted to our hospital for the abnormal shadow on the chest roentgenogram. Chest X-ray and CT scan revealed a mass on the left lateral chest wall, Oh left lateral thoracotomy, this mass was turned out to be a hens egg sized mass of the inner chest wall. The mass was excised with ease. Histological section revealed a typical neurilemmoma. A brief rveiw of the literatures is given.
윤정훈,최종훈,Yoon, Jung-Hoon,Choj, Jong-Hoon 대한안면통증구강내과학회 2000 Journal of Oral Medicine and Pain Vol.25 No.4
Oral mucositis or stomatitis produced by stomatotoxic chemotherapy and/or radiation therapy are painful, restrict oral intake and, importantly, act as sites of secondary infection and potals of entry for the endogenous oral microflora often leading to bacteremias or sepsis. A number of clinical observations and studies of animal model suggests a pathophysiological complexity in the development of mucositis. The condition appears to represent a sequential interaction of the oral mucosal cells and tissues, pro-inflammatory cytokines, and local environmental factors in the mouth. This article discussed and reviewed biological process of the mucositis and, the role of cytokines as initiators and amplifiers of the process. The recognition that the pathophysiology of mucositis is a multifactorial process has presented opportunities for intervention based upon biological attenuation.
변연성 발육성 치아종 : A Case of Peripheral Developing Odontoma
윤정훈,임경수,손홍범 조선대학교 구강생물학연구소 2003 Oral Biology Research (Oral Biol Res) Vol.27 No.1
A peripheral odontoma is a relatively rare lesion and is thought to represent the soft tissue counterpart of the central or intraosseous odontoma. Although several odontogenic tumors can occur peripherally, only a few cases of peripheral odontomas involving the gingival tissues have been reported. No earlier stage of peripheral odontoma or peripheral developing odontoma has been described. Here, we report a case of a peripheral developing odontoma occurring in the gingiva of a 4-rear-old Korean boy. Microscopic sections showed several nodules of developing rudimentary tooth germ-like structures in the gingival tissue. It seems likely that this case arise from remnants of the dental lamina located in the gingiva, since the clinical and histologic presentation lends support to the peripheral origin of this tumor.
Adult Solitary Myofibroma of the Mandible Mimicking a Periapical Lesion
윤정훈 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.5
Myofibroma is a benign tumor composed of fibroblasts and myofibroblasts, occasionally occurring most commonly as a solitary lesion of soft tissue, skin, or bone in children younger than 3 years of age. Solitary lesion of myofibroma is exceedingly rare in adult jaws. This report describes a rare case of myofibroma in the mandible that occurred in a 41-year-old Korean woman.
윤정훈 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.5
Myofibroma is a benign tumor composed of fibroblasts and myofibroblasts, occasionally occurring most commonly as a solitary lesion of soft tissue, skin, or bone in children younger than 3 years of age. Solitary lesion of myofibroma is exceedingly rare in adult jaws. This report describes a rare case of myofibroma in the mandible that occurred in a 41-year-old Korean woman.
5'-Nitro-Indirubinoxime이 타액선 암세포의 제1형 교원질 부착 및 이동에 미치는 영향
윤정훈,안상건 대한구강악안면병리학회 2009 대한구강악안면병리학회지 Vol.33 No.6
We have previously shown that 5’-nitro-indirubinoxime (5’-NIO) has potent anti-tumor effect in various human cancer cells. But the potential anti-invasive effect of 5’-NIO in salivary gland cancer has not been studied yet. The goal of this study is to evaluate the effect of 5'-NIO on salivary gland adenocarcinoma SGT cell adhesion and migration to Type I collagen treatment. Western blot, adhesion and migration assay were performed to evaluate the impacts of 5’-NIO on the expression of MMP-2/-9 and its upstream signaling molecules after treatment of type І collagen. SGT cell adhesion to type I collagen is significantly suppressed by 5’-NIO. 5’-NIO decreased expression of β1 integrin, phosphorylation of FAK, MMP-2/ -9 compared with type I collagen treatment. In addition, 5’-NIO inhibited the migration of SGT cells treated with type I collagen. These results suggest that 5’-NIO could effectively inhibit the invasion and migration of human SGT cells by downregulating the expression of β1 integrin and MMP-2/-9 and phosphorylation of FAK, Akt, and Erk. Adhesion and migration to type I collagen of SGT cells can be influenced through 5’-NIO.
개화성 백악-골 이형성증 : 다발성 외상성 골 낭과 동반한 증례
윤정훈,안상건,김수관 대한구강악안면병리학회 2005 대한구강악안면병리학회지 Vol.29 No.1
Florid cemento-osseous dyspl잃ia with concommitant traumatic bone cyst is uncommon condition. We report a case of florid cemento 。,sseous dysplasia involving four quadrants of the jaws and associated with large cystic lesion of the mandible misdiagnosed as a multiple odontogenic keratocysts in a 37-year-old Korean woman. Histological examination revealed unencapsulated fibroblastic proliferation with formation of bone and cementum, showing different developmental stages, and cys디c lesions resembling a traumatic bone cyst.