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윤성보,김대영 사단법인 한국동물생명공학회 2021 한국동물생명공학회지 Vol.36 No.4
Diabetic mellitus (DM) is a carbohydrate metabolic disorder that involves high blood sugar because insulin works abnormally. Type 2 diabetes accounts for most of them. However, diabetes treatments such as GLP-1 and DPP-4 inhibitors commonly caused side effects including gastrointestinal disorders. Grifola frondosa (G. frondosa) revealed various pharmacological effects in recent studies. It has a variety of anti-cancer polysaccharides through host-mediated mechanisms. D-fraction in G. frondosa has apoptotic effects, promoting myeloid cell proliferation and differentiation into granulocytes-macrophages. It has also been shown to reduce the survival rate of breast cancer cells. Though, no further study has been conducted on the specific effects of G. frondosa in the db/db mouse. Therefore, we would like to research the blood glucose improving effect of G. frondosa, a natural material, in type 2 diabetes model mouse, in this study. G. frondosa was administered to the disease model mouse (BKS.Cg-+Leprdb/+Leprdb/OlaHsd) for 8 weeks to monitor weight and blood glucose changes every week. And we evaluated anti-diabetes effects by checking biomarker changes shown through blood. Experiment did not show statistically significant weight differences, but control groups showed significantly higher weight gain than G. frondosa administered groups. We collected blood from the tail veins of the db/db mouse each week. As a result, the lowest blood sugar level was shown in the 500 mg/ kg group of G. frondosa. Glucose in the blood was examined with HBA1c, and 7.8% was shown in the 500 mg/kg administration group, lower than in other groups. These results suggest the potential improvements of diabetes in G. frondosa.
급성 심근경색증이 동반되지 않은 경도의 Troponin-I상승 환자의 예후 결정 요인
윤성보,이상학,정재헌,최승혁,이남호,박우정,오동진,임종윤,이광학 대한심장학회 2006 Korean Circulation Journal Vol.36 No.1
Background and Objectives:Although cardiac troponin I is widely used as a marker for myocardial infarction(MI), minor elevations of cardiac troponin I are also observed in other clinical situations. The prognostic factorsfor patients with these clinical features are not well established. The aim of this study was to discover the predictorsof mortality for the patients who had minor troponin elevations without acute MI. Subjects and Methods:Weenrolled consecutive 154 patients from the emergency department or inpatient units who had a peak troponin Ilevel greater than the lower limit of detectability (0.04 ng/mL), and the level was also less than the suggestive valueof MI (0.6 ng/mL). They were with chest pain or nonspecific symptoms of circulatory abnormality, but they lackedthe traditional features of acute MI. The endpoint was defined as death from all causes. The Cox proportionalhazard model was used to test the relationship between the clinical and biochemical variables and the outcomes.Results:During the follow-up period of 7.9±7.3 months, mortality occurred in 15 patients. Age, the creatinekinase myocardial isoform (CK-MB) level and the C-reactive protein (CRP) level as continuous variables hadsignificant correlations with the occurrence of death. After adjusting for any possible confounders in the multivariatemodel, these variables remained as independent predictors of mortality: age (HR 1.07, CI 1.02-1.14, p=0.012),CK-MB level (HR 1.61, CI 1.16-2.24, p=0.005), and CRP level (HR 1.01, CI 1.00-1.01, p=0.025). Conclusion:Integration of the CK-MB and CRP levels, as well as age, can be used for risk-stratification in the patients showingminor troponin I elevation for reasons other than acute MI. (Korean Circulation J 2006;36:60-65) 배경 및 목적:심근 troponin I는 심근경색증의 표지자로 광범위하게 이용되고 있으나, 그 외의 다른 조건에서 troponin이 경도로상승되기도 한다. 한편 이런 임상 조건에서 troponin이 상승했을 경우 예후 결정 요인은 잘 알려져 있지 않다. 본 연구는 troponin이 경도로 상승되었으나 심근경색증이 동반되지 않은 환자에서 사망률의 예측 요인을 알아보기 위해 계획되었다.방 법:응급실과 입원 환자 중 측정된 troponin 최고 농도가 측정 가능 최소 농도(0.04 ng/mL)보다 크고 일반적 심근경색증 진단 농도(0.06 ng/mL) 보다 작은 154명을 연속적으로 포함하였다. 환자들이 흉통 혹은 순환기계 이상을 시사하는 비특이적인 증상이 있으나 심근경색증의 전통적인 양상을 보이지 않는 경우를 대상으로 하였다. 종말점은 모든원인에 의한 사망으로 하였다. 임상적 변수, 생화학적 변수와 추적 결과와의 관계를 평가하기 위해 Cox proportionalhazard model을 사용하였다. 결 과: 7.9±7.2개월 동안의 추적 기간 동안 15명이 사망하였다. 연속형 변수로 표시한 연령, CK-MB, CRP 농도가 사망에 대해 의미있는 상관 관계를 보였다. 다변수 모델에서 분석 한 결과 이 변수들 모두 사망에 대한 독립적인 예측 요인임 을 알 수 있었다: 연령(HR 1.07, CI 1.02-1.14, p=0.012), CK-MB(HR 1.61, CI 1.16-2.24, p=0.005), CRP 농도(HR 1.01, CI 1.00-1.01, p=0.025). 결 론: Troponin이 경도로 상승하였으나 급성 심근경색증이 없는 환자에서 연령, CK-MB, CRP 농도에 대한 종합적 평가가 환자의 위험도 예측에 이용될 수 있을 것으로 보인다.
Active Molecular Chitosan alleviate Bleomycin-induced Acute Pulmonary Inflammation in Mice
윤성보,강동훈,최지선,김대영 한국키틴키토산학회 2019 한국키틴키토산학회지 Vol.24 No.3
Generally acute pulmonary inflammation is triggered by damage to alveolar epithelial cells due to the pollutants, viral infection, allergens and toxic substances. The active molecular chitosan (AMC, 5~8 kDa) is known to have non-toxic, bio-degradable, and biological activities including anti-tumor, anti-viral, and anti-inflammatory activities. The purpose of this study was to observe AMC’s preclinical efficacy to acute pulmonary inflammation and evaluate the therapeutic effect of a bleomycin (BLM) induced mouse model using AMC, a final product made by the hydrolysis of chitosan. Our experiments were conducted using male C57BL/ 6 mouse and BLM (5 mg/kg) was injected once with the intratracheal instillation (IT) method to induce pulmonary inflammation. Each group was conducted with prednisolone (PDS, 6.5 mg/kg) or AMC (100 mg/kg and 200 mg/kg, respectively) for 10 days with oral gavage. The relative lung weight measurements, histological findings in lung tissue specimens and cell counts through bronchoalveolar lavage fluid (BALF) were performed to determine the anti-inflammatory effects of AMC. The AMC treated groups with BLM induction had a decreased tendency of inflammation on our experiments. A dose of 100 mg/kg AMC induce group showed that similar aspect with control group on histological results. In addition, the lymphocyte rate appeared a noticeable on this group. The degree of lymphocyte was remarkably lower. It was inferred that inflammatory improvement in the AMC treated group. We confirmed that the BLM-induced lung disease model that progressed inflammation was inhibited by AMC. Furthermore, AMC performs an anti-inflammation function and has the possibility of use for the treatment of inflammatory disease.
18세 남자 환자에서 좌주간지 혈전이 동반된 급성 심근 경색
윤성보 ( Seong Bo Yoon ),이상학 ( Sang Hak Lee ),박광혁 ( Kwang Hyuk Park ),한권우 ( Kweon Woo Han ),정재헌 ( Jae Hun Jung ),최승혁 ( Seung Hyuk Choi ),이남호 ( Nam Ho Lee ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
Acute myocardial infarction in the adolescence is unusual. Moreover, the prevalence of left main coronary artery stenosis is rare in this population. We describe a case of acute ST elevation myocardial infarction in an 18 year-old male. He did not have history of congenital heart disease or other traditional risk factors for premature coronary disease. He was mildy overweight and showed normal laboratory tests except low high-density lipoprotein cholesterol level and modestly elevated plasma homocysteine level. Coronary angiography revealed totally occluded left anterior descending artery and thrombus at the bifurcation of left main coronary artery. He underwent emergency coronary stenting at distal left main coronary artery and proximal left anterior descending artery. He was discharged without in-hospital cardiac event. (Korean J Med 69:S807-S811, 2005)