정상성인에서 ALDH-I의 변이가 알콜의 정신운동성 수행과 주관적 평가에 미치는 영향

윤보현,윤진상,Yoon, Bo Hyun,Yoon, Jin Sang 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2

The purpose of this study was to evaluate the effects of alcohol on the psychomotor performance and subjective assessment in healthy Korean adults with acetaldehyde dehydrogenase I(ALDH-I) isozyme variance. A total of 20 male subjects, half with active ALDH-I and the other half with inactive ALDH-I, were selected through both a self-reporting questionnaire examining alcohol sensitivity and the Higuchi's ethanol patch test detecting ALDH-I deficiency. In a doule-blind, placebo-controlled cross-over design, each subject consumed four doses of alcohol(0.25, 0.5, 0.75, 1.0g/kg) and placebo on five separate occasions at weekly intervals, Treatment order was fully balanced using a $5{\times}5$ Latin square, Psychomotor performance tests[coritical flicker fusion threshold(CFF) and choice reaction time(CRT)] and self-estimate questionnaires were conducted at baseline and at time points of 20, 40, 60, 90, 120, 150, 180 minutes after consuming the test drug for 20 minutes, Blood alcohol concentrations(BACs) using breath analyzer were measured at baseline and at time points of 10, 20, 30, 40, 50, 60, 75, 90, 105, 120, 150, 180 minutes after drinking, The BACs and the mean changes in the psychomotor performances and subjective assessments from pre-alcohol baseline, were compared between the two groups. The findings were summarized as follows : 1) BACs were tended to be higher in the inactive group than the active in all of the four alcohol doses. However significant group differences were only after the 0.5g/kg dose of alcohol. 2) The inactive group showed significant impairment in CFFT at most time points alter 0.75 and 1.0g/kg doses of alcohol. 3) In CRT, total reaction time(TRT) significantly prolonged in the inactive group than the active group at 20 minutes after 0.25 and 1.0g/kg doses of alcohol and at 40, 60, 90 minutes alter 0.75g/kg dose of alcohol. In the inactive group, recognition time component significantly increased at 20, 60, 90 minutes after 1.0g/kg dose of alcohol, while movement time component significantly increased at 40, 60 minutes after 0.75g/kg dose of alcohol. 4) Subjective evaluation of the effect of alcohol revealed that physical and mental conditions as well as a self-estimate of the effects of alcohol on performance were significantly worse in the inactive group than the active at some time points alter all of the lour alcohol doses, wihch were more pronounced after 0.75 and 1.0g/kg doses of alcohol. 5) Most of the group differences mentioned above, still remained statistically significant after BAC was entered as a covariate, These findings demonstrated that the alcohol sensitivity is higher in individuals with inactive ALDH-I than those with active ALDH-I both on the subjective assessments and the objective psychomotor performances. Furthermore, these results suggest thai the alcohol sensitivity may be determined by acetaldehyde concentration rather than BAC per se. In future studies, after more accurate genotyping for ALDH-I, the relationships between BAC, acetaldehyde concentration and alcohol sensitivities should be clearly defined. ALDH-I 활성군과 비활성군에서 음주후 정신운동성 수행 및 주관적 평가에 미치는 영향을 비교하였다. 사교적 음주에 상응하는 4종류의 알콜(0.25, 0.5, 0.75, 1.0g/kg)을 투여한 결과 비활성군이 활성군에 비해 보다 부정적인 평가를 하였다. 이는 특히 고용량의 알콜(0.75 및 1.0g/kg)을 투여시 분명하였다. 이러한 결과는 비활성군이 활성군에 비해 알콜에 대한 민감성이 주관적인 판단과 객관적인 수행에서 모두 더 높다는 사실을 반영한다.

벤처기업 경영자 특성이 경영성과에 미치는 영향에 관한 연구;대덕연구개발특구를 중심으로

윤보현,박준병,Yoon, Bo-Hyun,Park, Joon-Byoung 한국벤처창업학회 2007 벤처창업연구 Vol.2 No.3

Current researches have been proceed on CEO's Characteristics of venture business because the CEO has considered as one of the important factors for the success of venture business. But prior research on the performance of venture business has produced inconsistently in terms of CEO's characteristics. The purpose of this study is to develop a comprehensive model for the relation between the performance and a type of CEO's characteristics by a growth process of venture business, which is the main subject of analysis in venture business. Also, this study analyzes various CEO's characteristics and the effects for performance of venture business which are in the Daedeok valley. To achieve the purpose of this research, an empirical study by using research model and hypotheses including the general characteristics of venture business and CEO's demographic characteristics has been presented as a research method for relation analysis. The principal findings of the research and its significance are summarized as follows: First, it was found that there is a significant different in the performance of CEO's behavioral characteristics by the scale, type and growing step of organization for venture business. Second, it was found that there is not a significant between an academic career, management experience, foundation experience for business and related working experience of venture CEO and the performance, but there os a partially significant difference in CEO's behavioral characteristics. Third, it was found that there is a partially significant difference between CEO's behavioral characteristics of venture business and the performance by the general characteristics of organization for venture business and demographic characteristics. In conclusion, in spite of the insufficient research for venture business in Daedeok, the implications of theses findings and contributions made by this research is to confirm the characteristics factor of CEO for venture business and general characteristics of organization for venture business by multidisciplinary side. In addition, the findings provide the basis for the analyzing of managerial strong point and weak point referred to supporting system for venture business. Finally, the findings of this study suggest that the results should be a useful data for groping a solution for upbringing plans in terms of a long-term point of view.

산과적 출혈의 처치에 있어서 경피적 혈관색전술의 이용

윤보현(Bo Hyun Yoon),김미하(Mi Ha Kim),신희철(Hee Chul Syn),문정빈(Jeong Bin Moon),전종관(Jong Kwan Jun),오수영(Soo Young Oh),박중신(Joong Shin Park),김석현(Seok Hyun Kim),이택상(Taek Sang Lee),정진욱(Jin Wook Chung),박재형(Jae Hyung 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.7

목적 : 고식적 방법으로 해결되지 않는 산과적 출혈의 처치에 있어 경피적 혈관 색전술의 임상적 효용성을 규명하기 위하여 이 연구를 시행하였다. 연구 방법 : 1992년 2월부터 1999년 3월까지 서울대학교병원에서 임신과 연관된 출혈로 경피적 혈관색전술을 시행받은 20명을 대상으로 하였다. 의무기록을 검토하여 시술 전후의 임상적 상황, 수혈량 및 추정 실혈량, 시술의 성공여부, 시술 소요시간, 시술과 관련된 합병증 및 시술 이후의 경과 등을 조사하였다. 결과 : 다양한 원인에 의한 출혈로 색전술이 시행된 총 20례중 18례에서 성공적인 지혈이 이루어졌다. 이 중 한 례는 두 차례에 걸친 시술이 필요하였으며, 두 경우에서는 색전술 이후 재발된 출혈로 수술적 치료가 불가피하였다. 시술에 걸린 평균 소요시간은 약 96.4 50.1분이었고 시술 이후 평균 입원일수는 10.4 7.7일 이었다. 시술과 관련된 합병증은 일시적인 하지 및 둔부의 감각이상과 허혈로 인한 하복부 동통 등이었으며 대부분 곧 소실되었고 그 외 심각한 합병증은 확인되지 않았다. 2례에서는 색전술 후 임신이 되어 성공적으로 분만하였다. 결론 : 종래의 고식적 방법에 의하여 지혈되지 않는 산과적 출혈의 치료에 경피적 혈관색전술이 매우 안전하고 효과적인 방법임을 확인하였다. Objective : To investigate whether emergency selective arterial embolization may serve as a safe and effective alternative treatment in the management of intractable pregnancy-associated hemorrhage. Methods : Between February 1992 and March 1999, 20 patients at Seoul National University Hospital underwent angiographic embolization to control obstetrical hemorrhage. In all cases, hemostatic embolization was performed because of intractable hemorrhage unresponsive to conservative management. All available hospital records were reviewed and detailed to collect adequate clinical data such as specific leading complication, clinical status, estimated blood loss and blood replacement requirements, length of procedure, used emboli, complications associated with the procedure, and its results. Results : We have experienced the successful embolization in 18 of 20 patients of pregnancy-related hemorrhage from the different causes. One of these successful cases required two embolization attempts. Two of these patients needed surgical treatment because of rebleeding after the embolization. The mean length of the time for the procedure was 96.4±50.1 minutes (range; 50-260 min.). The average length of hospitalization was 10.4±7.7 days (range; 1-36 days). No major complication related to the embolization was found. Two women became pregnant after embolization. Conclusion : This study indicates that angiographic embolization is a safe and effective method for the control of pregnancy-related hemorrhagic complications unresponsive to conservative management and that it allows maintenance of reproductive ability.

Doppler초음파를 이용한 발육지연태아의 흉부하강대동맥 혈류속도파형의 양상

윤보현 ( Bo Hyun Yoon ),이필량 ( Pyl Ryang Lee ),김승협 ( Seung Hyup Kim ),신희철 ( Hee Chul Shin ),김승욱 ( Syng Wook Kim ) 대한주산의학회 1990 大韓周産醫學會雜誌 Vol.1 No.1

A real time sector scanner with a pulsed Doppler transducer was used to study and compare the blood flow velocity wavefroms of fetal descending thoracic aorta in 97 normal pregnancies and 50 cases of fetal growth retardation with 170 and 67 examinations, respectively. All pregnancies were in the third trimester. In both groups, A / B ratio, resistance index, and pulsatility index remained unchanged with increasing gestational age. In growth reatarded pregnancies, there were singnificant increases in A / B ratio, pulsatility index, and resistance index, and significant decrease in end diastolic velocity compared to those in normal pregnancies(p<0.05), reflecting increased peripheral vascular resistance. In the 8 distressed fetuses, Doppler findings were more pathological than those in the fetuses without distress. This method may be of value in the evaluation of fetal well-being in risk pregnancies by giving an early sign of hemodynamic changes in developing hypoxia.

한국 주식시장에서의 대안 인덱스투자전략 연구

윤보현 ( Bo Hyun Yoon ),최영민 ( Young Min Choi ) 한국파생상품학회(구 한국선물학회) 2014 선물연구 Vol.22 No.2

본 연구는 주식시장의 시가총액 비중 시장 인덱스의 위험 대비 수익률 관점의 비효율을 지적하며 등장한 다양한 대안적인 인덱스 투자전략을 한국 주식시장에 적용하여 실증 분석한다. 대안 인덱스 투자전략이란 인덱스를 구성하는 종목의 비중 계산을 시가총액 비중이 아닌 재무제표를 이용하거나, 평균-분산 최적화 결과를 이용하는 등의 방법을 이용하는 것으로 한국 주식시장에서 포트폴리오를 구성하여 수익률을 측정한 결과, 시장 인덱스보다 위험 대비 수익률의 효율성이 증대함을 확인하였다. 또한 대안인덱스의 초과수익률은 Fama-French의 3요인 분석 결과 시장요인 및 기업규모요인 그리고 가치요인의 세 가지 요인으로 설명이 가능한 것으로 나타났다. 하지만, 이 사실이 대안 인덱스의 유용성을 해친다고 할 수는 없다. Fama-French의 기업규모요인이나 가치요인은 매수/매도 포지션으로 이루어져있고, 포트폴리오 재구성 시 높은 수준의 시장충격이 발생할 가능성이 높기 때문이다. 본 연구는 이러한 측면에서 대안 인덱스가 100% 매수 포지션으로만 이루어져 있고 회전율도 높지 않기 때문에 기업규모요인이나 가치요인을 실질적으로 투자가능하게 만들어주는 순기능이 존재할 수 있음을 제시하였다. There have been several studies of alternative equity index strategies which suggest better investment opportunities with higher risk adjusted return pointing out empirical evidence of inefficient risk-return trade-off implied in the market-cap weighted index. Commercial products based on these strategies, regarded as passive equity strategies, become more popular in the U.S. and European stock markets. We investigates whether these strategies are also valid in Korean stock market and our empirical results add support to their efficacy. From Fama-French 3-factor analysis, we find that the excess return of alternative equity index is attributed to market, size and value factors and it does not show a significantly positive alpha. Even without positive alpha, however, these strategies are valuable to investors in the sense that they offer opportunities to fully exploit size and value premium with long-only portfolios. The advantage of these strategies is more straightforward recalling the fact that rebalancing of Fama-French factor portfolios involves short-sale and high turnover.

조기양막파수 산모에서 중합효소 연쇄반응 기법을 이용한 양수내 Ureaplasma urealyticum 의 검출과 양수내 염증성 반응 및 주산기 예후와의 연관성

윤보현(Bo Hyun Yoon),이희선(Hee Sun Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6

연구 목적 : 만삭전 조기양막파수 산모의 양수에서 중합효소 연쇄반응 (polymerase chain reaction, PCR) 기법을 이용하여 Ureaplasma urealyticum이 검출된 산모의 혈액 및 양수내 염증성 반응과 주산기 예후를 알아보고자 하였다. 연구 대상 및 방법 : 임신 36주 이전에 분만진통을 동반하지 않는 조기양막파수로 진단되어 양수천자술이 시행된 단태임신 산모 131명을 대상으로 하였다. 양수의 일반 미생물 및 mycoplasma 배양검사와 U urealyticum에 대한 시발체 (primer)를 이용한 PCR을 시행하였다. 양수배양 검사 및 U urealyticum에 대한 PCR 결과에 따라 산모를 양수배양 음성이며 U urealyticum에 대한 PCR결과는 음성인 군 (제 1군, n=84), 양수배양은 음성이나 U urealyticum PCR결과는 양성군 (제 2군, n=12), PCR결과에 관계없이 양수배양이 양성인 군 (제 3군, n=35)으로 분류하였다. 산모와 양수내 염증성 반응을 알아보기 위해 산모 혈액내 C 반응성 단백 농도와 산모 혈액 및 양수내 백혈구 수를 측정하였다. 결과 : 1) 양수배양에서 세균이 검출된 경우는 26.7% (35/131)였으며, U urealyticum은 18.3% (24/131)에서 검출되었다. U urealyticum에 대한 PCR은 26.7% (35/131)에서 양성이었다. 2) 양수내 백혈구 수는 배양음성 PCR 양성군 (제 2군)에서 배양음성 PCR음성군 (제 1군)에 비해 유의하게 증가되어 있었으며, 배양양성군 (제 3군)과는 유의한 차이가 없었다 (median 169 [1-2,295] cells/㎣ vs median 1 [0-7,956] cells/㎣, p<0.001; median 169 [1-2,295] cells/㎣ vs median 270 [0-13,248] cells/㎣). 3) 산모 혈액내 백혈구 수 및 C 반응성 단백의 농도는 배양음성 PCR음성군 (제 1군)과 배양음성 PCR양성군 (제 2군)간에 유의한 차이가 없었다 (백혈구 수: median 8,500 [1,300-19,500] cells/㎣ vs median 10,600 [4,000-21,400] cells/㎣; C 반응성 단백: median 0.2 [0-10.0] ㎎/㎗ vs median 0.4 [0-5.0] ㎎/㎗). 4) 제대염의 빈도는 배양음성 PCR양성군 (제 2군)에서 배양음성 PCR음성군 (제 1군)에 비해 유의하게 높았으나 (24.6%[15/61] vs 71.4%[5/7], p=0.02), 배양양성군 (제 3군)과는 유의한 차이가 없었다. 5) 신생아 패혈증과 폐렴을 합한 선천성 감염성 이환률 및 기관지폐 이형성증의 발생빈도가 배양음성 PCR양성군 (제 2군)에서 배양음성 PCR음성군 (제 1군)에 비해 유의하게 높았다 (선천성 감염성 이환: 11.4% [9/79] vs 36.4% [4/11]; 기관지폐 이형성증: 2.5% [2/79] vs 27.3% [3/11], p<0.05). 결론 : PCR을 이용하여 양수 내에서 U urealyticum이 검출된 만삭전 조기양막파수 산모에서 양수내 염증성 반응이 증가되고 불량한 주산기 예후를 보임을 확인하였다. Objective : The aim of this study was 1) to determine the clinical significance of isolation of Ureaplasma urealyticum (U urealyticum) by polymerase chain reaction (PCR) in amniotic fluid and 2) to identify the association of positive result of PCR for U urealyticum with maternal and intraamniotic inflammatory response in patients with preterm premature rupture of membrane (PROM). Methods : Amniocentesis was done in 131 patients with preterm PROM during the period from January, 1994 to January, 1998. Amniotic fluid was cultured for bacteria and mycoplasmas. PCR with primer for U urealyticum was performed. Patients were divided three groups according to the results of amniotic fluid culture and PCR for U urealyticum: those with a negative amniotic fluid culture and negative PCR (group 1, n=84), those with a negative amniotic fluid culture but positive PCR (group 2, n=12) and those with a positive amniotic fluid culture (group 3, n=35). Results : 1) U urealyticum was isolated in 18.3% (24/131) by conventional culture method and in 26.7% (35/131) by PCR. 2) Patients with a negative amniotic fluid culture but positive PCR for U urealyticum (group 2) had significantly higher amniotic fluid white blood cell (WBC) count and higher rate of funisitis than those with a negative amniotic fluid culture and negative PCR (group 1) (amniotic fluid WBC: median 169 [1-2,295] cells/㎣ vs median 1 [0-7,956] cells/㎣ p<.001; funisitis: 71.4%[5/7] vs 24.6%[15/61], p=0.02). 3) Patients with a negative culture but positive PCR for U urealyticum (group 2) had higher rate of congenital infectious morbidity and bronchopulmonary dysplasia in their babies than those with a negative culture and negative PCR (group 1) (congenital infectious morbidity: 36.4% [4/11] vs 11.4% [9/79]; bronchopulmonary dysplasia: 27.3% [3/11] vs 2.5%[2/79], p<0.05 for each). 4) No significant differences in perinatal outcome were observed between patients with a negative culture but positive PCR (group 2) and those with a positive amniotic fluid culture (group 3). Conclusion : Isolation of U urealyticum by PCR in amniotic fluid is associated with an intense intraamniotic inflammatory response and adverse perinatal outcomes in patients with preterm premature rupture of membranes.

배플을 적용한 Cargo용 연료탱크 내부의 슬로싱 저감 연구

윤보현(Bo-Hyun Yoon),윤준규(Jun-Kyu Yoon),임종한(Jong-Han Lim) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회지 Vol.34 No.8

귀농 유입요인과 지역상황적 특성이 귀농만족도와 삶의 질에 미치는 영향요인 연구

윤보현(Bo-hyun Yoon),윤학로(Hak-ro Yoon) 한국문화경제학회 2024 문화경제연구 Vol.27 No.1

본 연구는 귀농 유입요인과 지역상황적 특성이 귀농만족도에 미치는 영향을 살펴보 고, 귀농만족도와 삶의 질간의 영향관계를 검증하였다. 또한 귀농만족도와 삶의 질에 미치는 영향에 있어서 SNS활용특성의 조절효과를 실증하고자 하였다. 현재 농촌에 정 착하여 살고 있는 귀농⋅귀촌인을 대상으로 2023년 10월 22일부터 1개월간 설문지 400부를 배포하여 350(87.5%)부를 회수하였고, 분석에 적합하지 않은 불성실 응답자 의 설문지 20부(6%)를 제외한 총 330부(94%)의 설문지를 분석에 이용하였다. 본 연구 는 SPSS 22.0을 사용하여 요인분석, 신뢰도분석, 다중회귀분석 등을 실시하였다. 실증분석결과 귀농 유입요인과 지역상황적 특성은 귀농만족도에 정(+)의 영향을 미치고 있 었으며, 귀농만족도는 삶의 질에 정(+)의 영향을 미치는 것을 검증하였다. SNS활용특성은 귀농만 족도와 삶의 질에 정(+)의 영향을 미치고 있었으나 조절효과는 없는 것으로 나타났다. 이러한 연 구결과는 귀농만족도와 삶의 질간의 영향관계를 실증하고, SNS활용특성이 귀농만족도와 삶의 질간의 조절효과를 검증함으로써 귀농만족도에 대한 연구를 더욱 풍부하게 하였다. 또한 귀농 ⋅귀촌인의 안정적 농촌 정착을 위하여 기존의 영농관련 정책에서 벗어나 개인의 행복증 진과 자아성찰을 위한 관심과 관련정책의 필요성을 제시함으로써 실무적 의의가 있다. The purpose of this study was to examine the effects of factors and regional situational characteristics on return to farming satisfaction, verify the relationship between return to farming satisfaction and quality of life, and demonstrate the moderating effect of SNS utilization characteristics in the relationship between return to farming satisfaction and quality of life. As a result of the analysis, it was verified that the factors of the return to farming inflow and regional situational characteristics had a positive (+) effect on the satisfaction of returning to farming, and that the satisfaction of returning to farming had a positive (+) effect on the quality of life. The characteristics of SNS use had a positive (+) effect on the satisfaction of returning to farming and the quality of life, but there was no moderating effect

호흡음주측정에서 Alco-Sensor Ⅳ와 Lion Alcolmeter SD-400P의 비교

윤보현(Bo-Hyun Yoon),정명섭(Myung-Sub Jung),표경식(Kyung-Sik Pyo),임채식(Chae-Sig Lim),이병회(Byung-Hoi Lee),박용현(Yong-Hyun Park) 한국중독정신의학회 1999 중독정신의학 Vol.3 No.1

Objectives:The aim of this study was to evaluate the interreliabilities and reproducibilities of two breathanalyzers which commonly used in clinical settings, research fields, and legal purposes including roadside testing. Methods:Thirty-four healthy male volunteers were examined through 30, 60, 90, 120, 150 and 180 minutes after 20 minutes’ intake of one of the two doses of alcohol (0.5 and 0.75 g/kg of body weight) on separate occasions. Two kinds of breathanalyzers [Alco- Sensor Ⅳ (Intoximeters, Inc., USA;Alco-Sensor) and Lion Alcolmeter SD-400P (Lion Laboratories plc, UK;SD-400P)] were used to measure the breath alcohol concentrations (BrAC). Duplicate breath samples at each time point were used to determine the repeatabilities of the breathanalyzers. Results:Mean values of two breathanalyzers at each time point were not statistically different. Although there were not significant, the values obtained from SD-400P were tended to slightly higher than those of Alco-Sensor. Inter-reliabilities of Alco-Sensor and SD-400P at 0.5 and 0.75 g/kg of body weight were very high[r=0.972 (p〈.001);r= 0.938 (p〈.001), respectively]. Test-retest reliabilities of Alco-Sensor and SD- 400P were also very high[r=0.976 (p〈.001); r=0.984 (p〈.001), respectively]. Conclusion:The two breathanalyzers can be used as highly reliable instruments in all kinds of fields including roadside testing. Although further studies concerning the accuracy and precision of the breath-alcohol measurements in Koreans should be done, it suggests that these instruments may be easily and safely used as evidential breath testing.

콘크리트의 내화학성에 관한 실험적 연구(Ⅱ)

윤보현(Yoon, Bo Hyun),김제원(Kim, Jae Won),설광욱(Seol, Gwang Wook),김명재(Kim, Myoung Jae),부척량(Boo, Cheong Yang) 한국콘크리트학회 1997 콘크리트학회논문집 Vol.9 No.1