내장형 제어 RISC코어를 위한 효율적인 랜덤 벡터 기능 검증 방법

양훈모,곽승호,이문기,Yang, Hun-Mo,Gwak, Seung-Ho,Lee, Mun-Gi 대한전자공학회 2001 電子工學會論文誌-SD (Semiconductor and devices) Vol.38 No.10

범용성이란 측면은 프로세서의 설계 과정 중 기능 검증의 중요도를 크게 부각시킨다. 따라서 본 논문은 기존 시뮬레이션 방법과 병행하여 기능 검증의 효율성을 높일 수 있는 효율적인 랜덤 벡터 기능 검증 방법을 제시한다. 본 기능 검증 방법은 내장형 제어 RISC 코어에 적합하며 실제 연세대학교와 삼성전자가 공동 개발한 32비트 프로세서인 CalmRISCTM-32의 코어 기능 검증에 적용하여 효율성을 확인한 바 있다. 본 기능 검증 방법은 클락 기반의 명령어 수준 시뮬레이터를 개발하여 이를 참조 모델로 삼고 랜덤 벡터로 이루어진 워크로드에 대해 HDL 시뮬레이션 결과와 비교함으로써 오류 검출을 수행하며 일반적인 테스트 벡터로써 발견하기 어려운 오류 유형을 보완하는 동시에 설계자에게 새로운 오류 유형의 기준을 제시하는 효과를 지닌다. Processors require both intensive and extensive functional verification in their design phase due to their general purpose. The proposed random vector verification method for embedded control RISC cores meets this goal by contributing assistance for conventional methods. The proposed method proved its effectiveness during the design of CalmRISCTM-32 developed by Yonsei Univ. and Samsung. It adopts a cycle-accurate instruction level simulator as a reference model, runs simulation in both the reference and the target HDL and reports errors if any difference is found between them. Consequently, it successfully covers errors designers easily pass over and establishes other new error check points.

현행 편입학제도는 중대한 결함이 많다

양훈모,Yang, Hun-Mo 한국대학교육협의회 1998 大學敎育 Vol.93 No.-

마이크로웨이브법에 의해 제조된 HAp 및 BCP 분말이 뼈모세포 및 파골세포의 활성에 미치는 영향

송호연,민영기,양훈모,맹주양,Song, Ho-Yeon,Min, Young-Ki,Yang, Hun-Mo,Mang, Joo-Yang 한국재료학회 2007 한국재료학회지 Vol.17 No.12

Hydroxyapatite (HAp) and biphasic calcium phosphate (BCP) nano powders were synthesized using the microwave-assisted synthesis process dependent on pH and microwave irradiation time. The average size of a powder was less than 100 nm in diameter. Through in-vitro cytotoxicity tests by an extract dilution method, the HAp and BCP nano powders have shown to be cytocompatible for L-929 fibroblast cells, osteoblastlike MG-63 cells and osteoclast-like Raw 264.7 cells. The activation of osteoblast was estimated by alkaline phosphatase (ALP) activity. When the HAp and BCP were treated to MG-63 cells, alkaline phosphatase activities increased on day 3, compared with those of the untreated cells. Also, the collagen fibers increased when the HAp and BCP powders suspension were treated to MG-63 cells, compared to those of the untreated cells. Quantitative alizarin red S mineralization assays showed a trend toward increasing mineralization in osteoblast cultured with powder suspension. In conclusion, hydroxyapatite and biphasic calcium phosphate appeared to be a bone graft substitute material with optimal biocompatibility and could be further applied to clinical use as an artificial bone graft substitute.

코로나바이러스감염증-19 사회적 거리두기 중 온열처치가 면역노화 억제에 미치는 효과

이승재 ( Seung-jea Lee ),양훈모 ( Hun-mo Yang ),김태욱 ( Tae-wook Kim ) 중앙대학교 학교체육연구소 2021 Asian Journal of Physical Education of Sport Scien Vol.9 No.1

본 연구의 목적은 온열처치(반신침수, 42±0.5℃, 60분, 5분 간격)가 중년 폐경기 비만 여성(연령; 52.24±3.92세, 신장; 160.2±3.67cm, 체중; 62.34±5.13kg, 체지방율; 33.54±4.12%)의 면역노화 억제에 미치는 효과를 확인하는 것이다. 온열처치 전 후 심부체온, 림프구와 호중구의 수준을 비교하였으며, 연구 결과는 다음과 같다. 온열처치를 적용한 결과 심부체온은 유의하게 증가하였다(***p<0.001). 운동면역학 측면에서 중요한 림프구 수준도 온열처치 이후 유의하게 증가하였다(**p<0.01). 또한 면역노화와 관련성이 높은 호중구 역시 유의하게 증가하였다(**p<0.01). 결론적으로 온열처치는 심부체온을 상승시킴으로써 면역노화를 억제시키는데 효과가 나타난다는 사실을 확인하였다. 나아가 감염성 질환에 대한 저항력도 증가할 수 있을 것으로 판단된다. 차후 면역노화에 대한 억제력을 유발시키는 최적의 심부체온 범위와 자극에 대한 연구의 필요성을 제안한다. The purpose of this study was to undergo thermotherapy (half-body immersion, 42±0.5℃, 60 minutes, 5 minutes intervals) in middle-aged menopausal obese women (age; 52.24±3.92 years, height; 160.2±3.67cm, weight; 62.34±5.13kg, %body fat; 33.54±4.12%) on the suppression of immunosenescence. Pre and Post thermotherapy, the levels of tympanic temperature (Tty), lymphocytes, and neutrophil were compared. The results of the study are as follows, Tty was significantly increased (***p<0.001). Lymphocytes and neutrophils levels were significantly increased after thermotherapy (**p<0.01). In conclusion, thermotherapy is effective in suppressing immunosenescence by raising core temperature. Furthermore, it is believed that resistance to infectious diseases can be increased. Therefore, we propose the necessity of research on the optimal range of core temperature to immunosenescence.

PMMA를 이용한 다공질 β-TCP 골충진제 제조 및 생체적합성 평가

송호연,윤민호,김영희,민영기,양훈모,이병택,Song, Ho-Yeon,Youn, Min-Ho,Kim, Young-Hee,Min, Young-Ki,Yang, Hun-Mo,Lee, Byong-Taek 한국재료학회 2007 한국재료학회지 Vol.17 No.6

Porous ${\beta}-tricalcium$ phosphate $({\beta}-TCP)$ bioceramic was fabricated by pressureless sintering using commercial HAp and different volume percentages of PMMA powders (30-60 vol.%). The range of spherical pore size was about $200-250\;{\mu}m$ in diameter. By increasing the PMMA content, the number of pores and their morphology were dramatically changed as well as decreased the material properties. In case of using 60 vol.% PMMA content, network-type pores were found, due to the necking of the PMMA powders. The values of relative density, elastic modulus, bending strength and hardness of the 60 vol.% PMMA content sample, sintered at $1500^{\circ}C$, were about 46%, 22.2 GPa, 5MPa and 182 Hv respectively. Human osteoblast-like MG-63 cells and osteoclast-like Raw 264.7 cells were well grown and fully covered all of the porous ${\beta}-TCP$ bodies sintered at $1500^{\circ}C$.

식품 알러지 연구를 위한 생체 모델에 있어서 Chemokine의 역할

이정범(Jeong-Beom Lee),양훈모(Hun-Mo Yang),민영기(Young-Ki Min),서형석(Hyung-Seok Seo) 한국생활환경학회 2009 한국생활환경학회지 Vol.16 No.6

To clarify the role of chemokine on eosinophil infiltration to gut of ovalbumin (OVA) sensitized rat when challenged with OVA (food allergy model) we made an experiment. For immunohistochemistry, 5 ?m cryostat-sections were made from the snap-frozen tissue (small intestine) and stained with chromotrope 2R and hematoxylin for eosinophil stain. The number of eosinophils was represented as the average in ten fields at ×400 magnification. In addition, reverse transcription polymerase chain reaction (RT-PCR) and southern blotting were performed to evaluate expression of regulated on activation, normal T cell expressed, and secreted (RANTES) in gut. A marked edema of villi and eosinophil infiltration to the lamina propria was only seen and peaked at 6 h in OVA sensitized mice after the oral challenge with OVA. Furthermore, analysis of RT-PCR and southern blotting demonstrated that RANTES mRNA expression was induced an antigen-specific manner and the expression peaked at 3 h and 6 h and declined thereafter, which is well matched with time course of eosinophil infiltration. Taken together, as in bronchial mucosa and skin, RANTES might play an important role on eosinophil recruitment to the gut site of food allergy in the rats.

Design of Interface Bridge in IP-based SOC

Hwi-Sung Jung(정휘성),Hun-Mo Yang(양훈모),Moon-Key Lee(이문기) 대한전자공학회 2001 대한전자공학회 학술대회 Vol.2001 No.6

대식세포가 β-tricalcium Phosphate 뼈이식제의 생분해에 미치는 영향

김영희,변인선,오익현,민영기,양훈모,이병택,송호연,Kim, Young-Hee,Jyoti, Anirban,Byun, In-Sun,Oh, Ik-Hyun,Min, Young-Ki,Yang, Hun-Mo,Lee, Byong-Taek,Song, Ho-Yeon 한국세라믹학회 2008 한국세라믹학회지 Vol.45 No.10

Various calcium phosphate bioceramics are distinguished by their excellent biocompatibility and osteoconductivity. Especially, the exceptional biodegradability of $\beta$-TCP makes it a bone graft substitute of choice in many clinical applications. The activation of osteoclasts, differentiated from macrophage precursor cells, trigger a cell-mediated resorption mechanism that renders $\beta$-TCP biodegradable. Based on this evidence, we studied the biodegradation process of granular-type $\beta$-TCP bone graft substitute through in vitro and in vivo studies. Raw 264.7 cells treated with RANKL and M-CSF differentiated into osteoclasts with macrophage-like properties, as observed with TRAP stain. These osteoclasts were cultured with $\beta$-TCP nano powders synthesized by microwave-assisted process. We confirmed the phagocytosis of osteoclasts by observing $\beta$-TCP particles in their phagosomes via electron microscopy. No damage to the osteoclasts during phagocytosis was observed, nor did the $\beta$-TCP powders show any sign of cytotoxicity. We also observed the histological changes in subcutaneous tissues of rats implanted with granule-type $\beta$-TCP synthesized by fibrous monolithic process. The $\beta$-TCP bone graft substitute was well surrounded with fibrous tissue, and 4 months after implantation, 60% of its mass had been biodegraded. Also, histological findings via H&E stain showed a higher level of infiltration of lymphocytes as well as macrophages around the granule-type $\beta$-TCP. From the results, we have concluded that macrophages play an important role in the biodegradation process of $\beta$-TCP bone graft substitutes.

카페인섭취가 신장성 운동 중 대퇴근 통증 감소에 미치는 효과

김태욱(Tae-Wook Kim),이정범(Jeong-Beom Lee),신영오(Young-Ho Shin),양훈모(Hun-Mo Yang),민영기(Young-Ki Min),서형석(Hyung-Seok Seo) 한국생활환경학회 2009 한국생활환경학회지 Vol.16 No.6

The purpose of this research was to determine what effect the consumption of caffeine has on alleviating muscular pain induced by repeated eccentric contraction during exercise. For this, 17 male and female college students with no prior exercise experience who do not habitually consume caffeine classified control group (male=1, female=8, age=22.67±1.15 yrs, height=165.03±5.66 ㎝, body mass=57.62±6.40 ㎏, BMI=21.48±1.60 ㎏ㆍm?²) and the experimental group with 3 ㎎ㆍ㎏?1 caffeine ingestion (male=2, female=6, age=21.20±1.40 yrs, height=165.74±5.53 ㎝, body mass=58.95±5.70 ㎏, BMI=21.67±1.81 ㎏ㆍm?²). Both carried out backward walking at a 85-88 steps per minute rhythm on a treadmill with a ?15% elevation at a speed of 3 ㎞ㆍh?1 for 30 minutes under 32±0.3℃ temperature and 33.93±0.53% humidity. The energy consumed by each of the subjects was approximately 5-7.9 ㎉ㆍmin?1 varying by different physical traits. To determine the effect of caffeine in reducing muscular pain, the changes in body mass and myoglobin levels Pre and Post the experiment were comparatively analyzed, along with the record of the perception of quadriceps muscle pain level taken every 5 minutes. The results are as follows. First, there were no statistically significant reductions in body mass between the groups (p=.709). This data suggests that an increase in sweating volume was not stimulated, and as a result side effects such as an increase in temperature, or dehydration did not occur in experimental group. Secondly, the perception of quadriceps muscle pain level in the experimental group came out low (p=.003) and is noteworthy. As a result, the potential for caffeine to prevent or reduce DOMS (delay onset muscle soreness) was proven valid. Thirdly, there were no statistically significant increase in blood myoglobin levels between the groups (p=.624). By the results of the experiment, indicate that caffeine is effective in reducing both sensual pain as well as the physiological deterioration of the muscles.

4주간의 반복적인 온열 부하가 Adipoinsular axis에 미치는 영향

김태욱(Tae-Wook Kim),이정범(Jeong-Beom Lee),양훈모(Hun-Mo Yang),민영기(Young-Ki Min),서형석(Hyung-Seok Seo) 한국생활환경학회 2012 한국생활환경학회지 Vol.19 No.6

This study was performed to identify the adipoinsular axis response, which is closely related to energy balance and obesity, for subjects (10 males, age, 23.17±2.58yrs; height, 173.16±3.28cm; weight, 67.68 ± 5.23 kg, body fat, 21.34 ± 3.52%; muscle mass, 20.40 ± 3.58 kg) which consisted of human who experienced thermal loading regularly for four weeks (half bath in hot water, 43oC, 12 times, 30min/day, RTL). According to results of the present study, RTL inhibited expression of insulin significantly and the level of leptin was also reduced significantly due to a chain reaction of adipoinsular axis. Though waist size was reduced significantly, levels of free fatty acid and mean whole body sweat loss volume showed significant increase. In conclusion, RTL contributed to inhibiting expressions of insulin and leptin. And, it was demonstrated that the overall response of adipoinsular axis was reduced according to this inhibition.