바톨린선의 선낭성 암종 2예

양숙영 ( Sook Young Vivian Yang ),이정원 ( Jeong Won Lee ),김우선 ( Woo Sun Kim ),정경란 ( Kyoung Lan Jung ),이선주 ( Sun Joo Lee ),이제호 ( Je Ho Lee ),배덕수 ( Duk Soo Bae ),김병기 ( Byoung Gie Kim ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6

Adenoid cystic carcinoma (ACC) of the Bartholin`s gland is a rare malignancy of the female genital tract and there have been 62 cases of ACC of the Bartholin`s gland in the Literature. We report two cases of ACC of the Bartholin`s. There is no consensus on optimal treatment of ACC of the Bartholin`s gland. Most commonly, wide Local excision and radical vulvectomy with or without Lymph node dissection, are performed. More Long-term follow up is recommended to evaluate optimal primary treatment and roles of radiotherapy and chemotherapy because ACC of the Bartholin`s gland recur and metastasize Long after primary treatment.

Ames test 결과와 QSAR를 이용한 변이원성예측치와의 비교

양숙영(Sook Young Yang),맹승희(Seung Hee Maeng),이종윤(Jong Yun Lee),이용묵(Yang Mook Lee),정호근(Ho Keun Chung),정해원(Hai Won Chung),유일재(Il Je Yu) 한국환경성돌연변이발암원학회 2000 한국환경성돌연변이·발암원학회지 Vol.20 No.1

Recently there is increasing interest in the use of structure activity relationships for predicting the biological activity of chemicals. The reasons for the interest include the decrease cost and time per chemical as compared with animal or cell system for identifying toxicological effects of chemicals and the reduction in the use of animals for toxicological testing. This study is to test the validity of the mutagenicity data generated from QSAR (Quantitative Structure Activity Relationship) program. Thirty chemicals, which had been evaluated by Ames test during 1997-1999, were assessed with TOPKAT QSAR mutagenicity prediction module. Among 30 chemicals experimented, 28 were negative and 2 were positive for Ames test. On the contrary, 23 chemicals showed the high confidence level indicating high prediction rate in mutagenicity evaluation, and 7 chemicals showed the low to moderate confidence level indicating low prediction in mutagenicity evaluation. Overall mutagenicity prediction rate was 77% (23/30). The prediction rates for non-mutagenic chemicals were 79% (22/28) and mutagenic chemicals were 50% (1/2). QSAR could be a useful tool in providing toxicological data for newly introduced chemicals or in furnishing data for MSDS or in determining the dose in toxicity testing for chemicals with no known toxicological data.

부추(Allium tuberosum R.)의 감마선 조사에 의한 휘발성 유기화합물의 성분 변화

한병재(Byung-Jae Han),양숙영(Sook-Young Yang),김준형(Jun-Hyoung Kim),심성례(Sung-Lye Shim),Rajendra Gyawali,이성진(Sung-Jin Lee),김경수(Kyong-Su Kim) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.4

본 연구에서는 감마선 조사에 의한 부추의 휘발성 유기화합물의 변화를 관찰하였다. 조사되지 않은 부추와 20 kGy의 선량으로 조사된 부추를 SDE방법으로 유기화합물을 추출한 후 정유를 GC/MS로 분석하였다. 비조사 시료와 조사시료에서 각각 56종, 54종의 화합물이 분리 동정되었으며, alcohol류, aldehyde류, ester류, ketone류, 함질소화합물과 함황화합물을 포함하고 있는 것이 확인되었다. 조사된 부추에 함유된 특징적인 휘발성 유기성분은 조사되지 않은 부추에서의 결과와 유사하였으나, 그 농도에 있어서는 눈에 띄는 차이를 보였다. 두 시료 모두에서 함황화합물이 다량 검출되어 주요 화합물임을 알 수 있었다. 성분들 중에서 다량의 dimethyl trisulfide와 methyl-(Z)-1-propenyl trisulfide가 함황화합물의 상대적 농도에 크게 기여하고 그 외 dimethyl disulfide, 3-ethyl-1,2-dithi-5-ene, methyl allyl disulfide와 (E)-2-hexanal도 휘발성 유기성분의 조성에 큰 비중을 차지하였다. 그 중 주된 화합물로 확인된 dimethyl trisulfide와 methyl-(Z)-propenyl trisulfide는 조사된 후 크게 감소된 것이 확인되었으며, 이외에도 (E)-2-hexanal과 3-ethyl-1,2-dithi-5-ene, diallyl trisulfide 역시 눈에 띄게 감소하였다. 이에 반하여 dimethyl disulfide는 조사 후 그 함량이 크게 증가하여 앞의 화합물들과는 다른 경향을 보였으며, 이외에도 diallyl sulfide와 allyl methyl sulfide, pyridine 등도 크게 증가하였다. Volatile compounds of γ-irradiated leeks (Aillum tuberosum R.) were isolated by simultaneous steam distillation and extraction method (SDE) and analyzed by gas chromatography/mass spectrometry (GC/MS) along with the non-irradiated sample. Leeks were irradiated at dose of 20 kGy and non-irradiated samples were considered as control sample. 56 and 54 compounds were identified in non-irradiated and irradiated samples, respectively. These components included the functional groups; alcohols, aldehydes, esters, ketones, N- and S-containing compounds. S-containing compounds such as dimethyl trisulfide, methyl-(Z)-1-pro-penyl trisulfide, dimethyl disulfide, 3-ethyl-1,2-dithi-5-ene and methyl allyl disulfide were the major compounds. Methyl-(Z)-1-propenyl trisulfide, diallyl trisulfide, (E)-2-hexanal and 3-ethyl-1,2-dithi-5-ene were clearly decreased by the γ-irradiation, but dimethyl disulfide, diallyl sulfide, allyl methyl sulfide and pyridine were increased by the γ-irradiation.

살균성, Phenylthionocarbamate 유도체들의 정량적인 구조와 독성과의 관계

성낙도(Nack-Do Sung),양숙영(Sook-Young Yang),박관용(Kwaun-Yong Park) 충남대학교 농업과학연구소 2001 Korean Journal of Agricultural Science Vol.28 No.1

새로운 제초성 N-phenyl-3,4-dimethylphthalimide 유도체의 정량적인 구조와 독성과의 관계 (QSTR)

성낙도(Nack-Do Sung),양숙영(Sook-Young Yang),강학식(Hak-Sik Kang) 한국농약과학회 2002 농약과학회지 Vol.6 No.1

Quantitative structure-toxicity relationships (QSTRs) between various physicochemical parameters of substituents in new herbicidal N-phenyl-3,4-dimethylphthalimide derivatives and their discriminate score (DS) for chronic and acute toxicities against mouse and rat evaluated using TOPKAT calculation were discussed quantitatively. From the basis on the findings, it was shown that carcinogenicities of female was higher than that of male and mouse had higher tendency than rat. The STR analyses results of Hansch-Fujita type equations suggested that mouse (female & male) and rat male except rat female are dependent on LUMO energy commonly in carcinogenicity. The selective carcinogenicity factor of two species between male mouse and female mouse is dependent on optimal value (ca. (L)<SUB>opt.</SUB>=5.0Å) for length of R₂-substituent mainly. According to Free-Wilson approach, in the case of rat male, alkyl and aryl substituents were superior and in the other case, contribution of fluoro group substituents were superior to chronic toxicity.

비교 분자장 분석 (CoMFA) 방법에 따른 1-(5-methyl-3-phenylisoxazolin-5-yl)methoxy-2-chloro-4-fluoro-benzene 유도체들의 Protox 저해 활성에 관한 이해

성낙도(Nack-Do Sung),송종환(Jong-Hwan Song),양숙영(Sook-Young Yang),박경용(Kyeng-Yong Park) 한국농약과학회 2004 농약과학회지 Vol.8 No.3

Three dimensional quantitative structure-activity relationships (3D-QSAR) studies for the protox inhibition activities against roat and shoot of rice plant (Orysa sativa L.) and barnyardgrass (Echinochloa crus-galli) by a series of new A=3,4,5,6-tetrahydrophthalimino, B=3-chloro-4,5,6,7-tetrahydro-2H-indazolyl and C=3,4-dimethylmaleirnino group, and R-group substituted on the phenyl ring in 1-(5-methyl-3-phenylisoxazolin-5-yl)methoxy-2-chloro-4-fluorobenzene derivatives were performed using comparative molecular field analyses (CoMFA) methodology with Gasteiger-Huckel charge. Four CoMFA models for the protox inhibition activities against root and shoot of the two plants were generated using 46 molecules as training set and the predictive ability of the each models was evaluated against a test set of 8 molecules. And the statistical results of these models with combination (SIH) of standard field, indicator field and H-bond field showed the best predictability of the protox inhibition activities based on the cross-validated value r²<SUB>cv</SUB>. (q²=0.635~0.924), conventional coefficient (r² <SUB>ncv</SUB>.=0.928~0.977) and PRESS value (0.091~0.156), respectively. The activities exhibited a strong correlation with steric (74.3~87.4%), electrostatic (10.10~18.5%) and hydrophobic (1.l0~8.30%) factors of the molecules. The steric feature of molecule may be an important factor for the activities. We founded that an novel selective and higher protox inhibitors between the two plants may be designed by modification of X-subsitutents for barnyardgrass based upon the results obtained from CoMFA analyses.

가족성 아밀로이드성 말초신경병증 1예

양우석,서민정,권유석,유현정,노숙영,백소아 대한근전도전기진단의학회 2003 대한근전도 전기진단의학회지 Vol.5 No.2

살균성, Phenylthionocarbamate 유도체들의 정량적인 구조와 독성과의 관계

성낙도,양숙영,박관용 충남대학교 농업과학연구소 2001 농업과학연구 Vol.28 No.1

아직까지 시도된 바 없는 살균성 phenylthionocarbamate 유도체들의 phenyl-치환기가 변화함에 따라 TOPKAT 계산으로 예측된 다양한 급성 및 만성 독성값에 미치는 정량적인 분자구조와 독성과의 관계 (QSTRs)를 검토한 결과는 다음과 같다. (1) 기질분자의 구조변화에 따른 독성치와 그의 판별점수 (D.S.)에 기초하여 분자 중 특정부분(FRAGMENT)이 양 (+)의 값으로 독성에 기여하는 대체적인 순서는 Aro, C=C, -O-, -NH- 및 할로겐 (X) 원자의 순이었다. (2) 대부분의 화합물들은 매우 높은 돌연변이와 발암성이 예측되었으며 특히, 치환기의 위치에 관계없이 fluoro-치환체는 B₂상수에 따른 입체효과 ((B₂)_(opt)=1.54Å)에 의하여 모두 100% 돌연변이를 발현한 반면에 trifluoromethyl-치환체는 돌연변이 발현 가능성이 전혀 없었다. (3) 가장 높은 독성 발현조건은 phenyl-치환기에 대한 소정의 적정값으로 돌연변이성에는 (B₂)_(opt)=1.54Å, 발암성에는 수컷 rat와 mouse는 (R)_(opt)=0.16 및 (π)_(opt)=0.16 그리고 rat는 경구독성은 LD_(50)(εLUMO)_(opt)=-0.52e.v, chronic LOAEL; (B₃)_(opt)=1.54Å, 어독성은 LC_(50);(log P)_(opt)=4.25 및 물벼룩에 대한 독성은 EC_(50),(σ)_(opt)=0.68를 나타내는 경우이었다. (4) 돌연변이성에는 할로겐 중 fluoro-기를 위시하여 nitro 및 methyl-기 등의 순서로 기여하였고 phenyl 고리 상, 치환기의 위치와 전자수수관계에는 대체로 무관한 경향을 나타내었다. The authors attempted to derive a comprehensive quantitative structure-toxicity relationships (QSTRs) between various physicochemical parameters of phenyl substituents in fungicidal phenylthionocarbamate derivatives and toxicity evaluated using TOPKAT calculation On the basis of this approach we made preditions for toxicity values for not yet tested substances with respect to these systems The results suggested that the optimal values. (B_(2))_(opt)=l.54_(A)(Ames mutagnicity). (R)_(opt)=0.l6 (car-cinogemcity of male rat). (π)_(opt)=0.16 (carcinogenicity of male mouse). (εLUMO)_(opt)=-0.52 ev (LD of rat oral). (B_(3)opt =l54_(A)(chronic LOAEL), (logP)_(opt) =425(LC_(50) of Fathead minnow) and (σ)_(opt)=-0.68(EC_(50) of Daphnia magna) of phenyl substituents were strongly correlated with the acute and chronic toxicities

갑상선중독증환자의 응급제왕절개술시 경막외마취 1예보고

강성희,장태호,김세환,김경한,양숙영 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.6

Hyperthyroidism is usually caused by multinodular diffuse enlargement of the gland in Graves disease and can be associated with pregnancy. Ideally, appropriate medical therapy establishes a euthyroid state prior to anesthesia. However, if emergency surgery becomes necessary in an unprepared patient, the anesthesiologist must avoid situations that may exacerbate the disease and should prevent thyroid storm during perianesthetic period. In this case, a 26 years old female with poorly controlled thyrotoxicosis was scheduled for emergency Cesarean-section. The patient was successfully managed by epidural anesthesia and discharged uneventfully at the 9th postoperative day.