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양석철 ( Seok Chul Yang ) 대한내과학회 2008 대한내과학회지 Vol.75 No.4
Despite therapeutic advances with minimally invasive surgical techniques, improved radiotherapy dosing with 3-dimensional planning, new chemotherapy agents and targeted therapies including epidermal growth factor receptor tyrosine kinase inhibitor, monoclonal antibody and anti-angiogenesis agents, the 5-year overall survival for lung cancer has remained relatively poor, mainly because by the time a diagnosis is made, lung cancer is often well advanced and treatment options are limited. The majority of lung cancer cases are diagnosed in a late stage, when nonspecific symptoms such as cough, dyspnea, and hemoptysis are present. Advances in early diagnostic and treatment options have the potential to manage lung cancer. The diagnostic approach to lung cancer may be divided into two problems; first, establishing the diagnosis and second, accuracy of staging. Bronchoscopy is now being used increasingly in the investigation and management of a wide spectrum of malignant, infectious, inflammatory, and other diseases or pathology of the lungs. There have been recently advances in bronchoscopic diagnosis of lung cancer; autofluorescence bronchoscopy, endobronchial ultrasound, and electromagnetic navigation bronchoscopy. Autofluorescene bronchoscopy exploits the inherent fluorescence property of cancerous tissue and improves detection of premalignant lesions not seen with white light bronchoscopy. Endobronchial ultrasound utilizes a flexible ultrasound probe to image and biopsy lesions and lymph nodes beyond the wall of the bronchus. Electromagnetic navigation bronchoscopy combines virtual bronchoscopy, three-demensional CT images, and a steerable probe to help navigate a bronchoscope to a particular peripheral lung lesion or lymph node. The purpose of this review is to describe current bronchoscopic advances in diagnosis and staging of lung cancer. (Korean J Med 75:398-406, 2008)
비소세포 폐암에서 Cyclooxygenase-2와 Polo-Like Kinase-1의 상관관계
이규화 ( Kyu Hwa Lee ),양석철 ( Seok Chul Yang ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.4
Background: Elevated expression of cyclooxygenase-2 (COX-2) and Polo-like kinase-1 (PLK-1) is observed in a wide variety of cancers. Augmented expression of COX-2 and enhanced production of prostaglandin E2 (PGE2) are associated with increased tumor cell survival and malignancy; COX-2 has been implicated in the control of human non-small cell lung carcinoma (NSCLC) cell growth. PLK-1 siRNA induced the cell death of lung cancer cells and the systemic administration of PLK-1 siRNA/atelocollagen complex inhibited the growth of lung cancer in a liver metastatic murine model. COX-2 and PLK-1 are involved in proliferation and in cell cycle regulation, and there is a significant correlation between their interaction in prostate carcinoma. Methods: In this study, we investigated the pattern of COX-2 and PLK-1 expression in NSCLC, after treatment with IL-1β, COX-2 inhibitor and PLK-1 siRNA. Results: Expression of PLK-1 was decreased in A549 COX-2 sense cells, and was increased in A549 COX-2 anti-sense cells. Knock out of PLK-1 expression by PLK-1 siRNA augmented COX-2 expression in A549 and NCl-H157 cells. When A549 and NCI-H157 cells were treated with COX-2 inhibitor on a dose-dependent basis, PLK-1 and COX-2 were reduced. However, when the expression of COX-2 was induced by IL-1β, the production of PLK-1 decreased. Conclusion: These results demonstrate that COX-2 and PLK-1 are regulated and inhibited by each other in NSCLC, and suggest that these proteins have a reverse relationship in NSCLC.
내과계 중환자들의 예후 판정에 었어서 제 7병일 APACHE III 점수의 임상적 유용성
김미옥,윤수미,박은주,손장원,양석철,윤호주,신동호,박성수,Kim, Mi-Ok,Yun, Soo-Mi,Park, Eun-Joo,Sohn, Jang-Won,Yang, Seok-Chul,Yoon, Ho-Joo,Shin, Dong-Ho,Park, Sung-Soo 대한결핵및호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.2
연구배경 : 중환자의 예후를 계량화 하려는 채점 체계 중 APACHE III 체계는 중환자실 제1병일 접수는 물론 일 갱선점수도 중환자의 예후를 예측할 수 있는 것으로 알려져 왔다. 평균 재원일이 외국과 비교하여 3-4배의 차이가 나는 점을 감안하면, 일 갱신점수는 예후를 판정하는 지표로서 경제적 효율성이 떨어진다. 이에 제7병일(평균 중간 재원일)의 APACHE III 점수의 임상적 유용성에 관해 알아 보고자 하였다. 방 법 : 1997년 6월부터 1998년 4월까지 한양대학교 구리병원 내파계 중환자실에 입원한 241명의 제1병일과 7병일 APACHE III 점수를 조사하여 생존군과 비생존군 간의 차이를 분석하였다. 결 과 : 전체 환자 수는 241명으로 이 중 사망자가 65명으로 26.6%의 사망률을 나타내었으며 평균 재원일 수는 $10.3{\pm}13.8$일이였다. 제1병일 APACHE III 점수는 $59.7{\pm}30.9$, 제7병일 APACHE III 점수는, $37.9{\pm}27.7$점이였다. 제1병일과 제7병일 APACHE III 점수는 생존군과 비생존군에서 $49.9{\pm}23.8$, $86.3{\pm}32.3$점, $30.1{\pm}18.5$, $81.1{\pm}30.4$점으로 유의한 차이를 보였다(P<0.0001, P<0.0001). APACHE III 점수가 사망률에 미치는 영향을 알아보기 위하여 로지스틱 회귀분석을 시행한 결과 제1병일과 제7병영일의 비차비(odds ratio)는 각각 1.0507, 1.0779로 유의한 결과를 나타내었다(P<0.0001). 결 론 : 이상의 결과로서 제1병일 APACHE III 점수 뿐 아니라 제7병일 점수 또한 사망률 예측과 입원 후 치료 경과에 의해 변화된 예후를 평가하기에 유용한 척도임을 알 수 있었다. 평균 중간 재원일인 제7병일 APACHE III 점수는 일 갱선점수가 경제적으로 물적, 인적 비용이 많이 드는 상황에서 비용효과면에서 임상의에게 도움을 줄 수 있다고 판단된다. Background : Most current research using prognostic scoring systems in critically ill patients have focused on prediction using the first intensive care unit (ICU) day data or daily updated data. Usually the mean ICU length of stay in Korea is longer than in the western world. Consequently, a more cost-effective and practical prognostic parameter is required. The principal aim of this study was to assess the prognostic value of the seventh day(7th day : the average mean ICU length of stay) APACHE III score in a medical intensive care unit. Methods : 241 medical ICU patients from July 1997 to April 1998 were enrolled. The 1st and 7th scores were measured by using the APACHE III scoring system and compared between survivors and non-survivors. Logistic regression analysis was performed to determine the relationship between the $1^{st}$ and $7^{th}$ APACHE III scores and the mortality risk. Results : 1 )The mean length of stay in the ICU was $10.3{\pm}13.8$ days. 2)The mean $1^{st}$ and $7^{th}$ day APACHE III scores were $59.7{\pm}30.9$ and $37.9{\pm}27.7$. 3) The mean $1^{st}$ day APACHE III score was significantly lower in survivors than in non- survivors($49.9{\pm}23.8$ vs $86.3{\pm}32.3$, P<0.0001). 4)The mean $7^{th}$ day APACHE III score was significantly lower in survivors than in non- survivors($30.1{\pm}18.5$ vs $80.1{\pm}30.4$, P<0.0001). 5)The odds ratios among the $1^{st}$ and $7^{th}$ day APACHE III scores and the mortality rate were 1.0507 and 1.0779 respectively. Conclusion : These results suggest that the seventh day APACHE III score is as useful in predicting the outcome as is such like the first day APACHE III score. Therefore, in comparison to the daily APACHE III score, measuring the $1^{st}$ and $7^{th}$ day APACHE III scores are also useful for predicting the prognosis of critically ill patients in terms of cost-effectiveness. It is suggested that the $7^{th}$ day APACHE III score is useful for predicting the clinical outcome.
Surfactant Protein A , B 와 C 유전자 발현의 Circadian Rhythm에 관한 실험적 연구
손장원(Jang Won Sohn),양석철(Seok Chul Yang),윤호주(Ho Joo Yoon),신동호(Dong Ho Shin),박성수(Sung Soo Park),김정미(Chung Mi Kim) 대한내과학회 2001 대한내과학회지 Vol.60 No.6
Background : All organisms have developed an internal timing system capable of reacting to and anticipating environmental stimuli with a program of appropriately timed metabolic, physiologic, and behavioral events. The alveolar epithelial type II cell of mammalian lung synthesizes, stores, and secretes a lipoprotein pulmonary surfactant, which functions to stabilize alveoli at low lung volumes. Methods : The authors investigated the diurnal variation of surfactant protein A, B and C mRNA accumulation. The diurnal variation on gene expression of surfactant protein A, B and C were analysed using filter hybridization at 9 AM, 4 PM and 11 PM. Lung SP-A protein content was determined by double sandwich ELISA assay using a polyclonal antiserum raised in rabbits against purified rat SP-A. Results : 1. The accumulation of SP-A mRNA at 4 PM was significantly decreased 23.5% compared to the value at 9 AM (p<0.05). 2. The accumulation of SP-B mRNA at 4 PM and 11 PM was decreased by 15.1% and 5.7%, respectively, compared to the value at 9 AM (p=0.07, p=0.69). 3. The accumulation of SP-C mRNA at 4 PM and 11 PM was decreased by 6.8% and 7.7%, respectively, compared to the value at 9 AM (p=0.38, p=0.57). 4. Total lung SP-A content at 4 PM and 11 PM was increased by 5.3% and 15.9%, respectively, compared to the value at 9 AM (p=0.64, p=0.47). Conclusion : These findings represent diurnal variation of surfactant proteins mRNA expression in vivo. This results suggested the diurnal variation of hydrophilic surfactant protein rather than hydrophobic surfactant proteins.(Korean J Med 60:547-554, 2001)
1996년 춘계학술대회 학술퀴즈 : 다발성 임파절 이상증을 동반한 비대칭적 폐 간질성 병변
이경상 ( Kyung Sang Lee ),양석철 ( Suck Chul Yang ),윤호주 ( Ho Joo Yoon ),신동호 ( Dong Ho Shin ),박성수 ( Sung Soo Park ),이정희 ( Jung Hee Lee ),김혁 ( Hyuk Kim ),최요원 ( Yo Won Choi ),전석철 ( Seok Chol Jeon ) 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.4