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      • KCI등재

        Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer

        안상현,심홍진,김광민,김보라,Bang Hui-Jae,Do Hyejin,Lee Hyang-Rae,Kim Youngwan 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.2

        We aimed to review whether pretreatment inflammatory markers reflect the short- and long-term outcomes of patients with colon cancer, rectal cancer, colon and rectal cancers, and metastatic colorectal cancer (CRC). We found that pretreatment complete blood count and blood chemistry tests reflect short-term and long-term oncological outcomes in patients with CRC. Specifically, in patients with colon cancer, hypoalbuminemia was associated with worse postoperative morbidity, mortality, and inferior survival. In patients with rectal cancer, elevated neutrophil-lymphocyte ratio (NLR) and thrombocytosis were associated with postoperative complications, poor overall survival (OS), and disease-free survival (DFS). A high C-reactive protein/albumin ratio (CAR) was associated with poor OS and DFS. In patients with metastatic CRC, increased NLR and platelet-lymphocyte ratio (PLR) were associated with poor OS, DFS, and progression-free survival (PFS). In addition, high CAR and a low albumin/globulin ratio on blood chemistry tests were associated with poor OS and PFS. Although universal cut-off values were not available, various types of pretreatment laboratory markers could be utilized as adjuncts to predict prognosis in patients with CRC.

      • KCI등재후보

        明의 제2차 紅夷砲 구매와 관련된 두 문서: 「報效始末疏」와 「貢銃效忠疏」

        안상현 서울대학교 규장각한국학연구원 2011 규장각 Vol.39 No.-

        The detailed commentary translations of the Loyalty Report and the Cannon Report into Korean are provided, These reports describe the facts that the government of the Ming dynasty bought culverin cannons from the Portuguese in Macao. The Loyalty Report was written in 15th day of the ninth month in 1628 by senate of Portuguese in Macao, and was submitted to the Ming dynastic government in the 17th day of the first month of 1630. The latter or the Cannon Report was written by João Rodrigues and submitted along with The Loyalty Report. The former insists that the residence of Portuguese in Macao should be legalized under the law of the Ming dynasty, and also that the newly-rising Netherlands should be excluded by the government of the Ming dynasty. The latter describes in detail the itinerary of the Portuguese military delegate from Macao to Beijing. The Cannon Report briefed with comments by Han Lin describes the whereabouts of Teixeira and Rodrigues after meeting the ambassador Chong. According to the description, Teixeria and others died in Dengzhou battle with rebellions during the Wuqiao rebellion of 1631 to 1632, and Rodrigues desperately escaped from Dengzhou and finally returned back to Macao to die a few month later. Thus, even if the ambassador Chong’s proposal to learn the production method of both culverine and niter through Rodrigues had been accepted by the Choson government, the proposal could not be carried out.

      • KCI등재

        Genistein의 Endocannabinoid system (ECS) 활성 유도를 통한 피부염 손상 회복 효과

        안상현,서일복,김기봉 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.1

        Objectives: After inducing dermatitis in 6-week-old mice, we tried to find out the effects of recovery in the damaged skin by administering genistein and palmitoylethanolamide (PEA) Methods: The 6-week-old mice were divided into the control group (Ctrl), dermatitis causing group (AcDE), genistein-administered group after the onset of dermatitis (GsT), and PEA-administered group after the onset of dermatitis (PEAT). Seven mice were assigned to each group. Changes in the skin barrier were observed after three days of administration following the onset of dermatitis. Results: In the GsT and PEAT, there was less skin damage compared to the AcDE, and the lowest skin damage showed in the GsT. The intensity of CB1 and CB2 expression was increased by 64% (CB1) and 39% (CB2) in the GsT, and 38% (CB1) and 28% (CB2) in the PEAT compared to the AcDE. The E-catherin positive reaction was decreased in the AcDE, while the E-catherin positive reaction was increased in the GsT (76%) and PEAT (34%). The p-JNK positive reaction was increased in the AcDE, while the p-JNK positive reaction was decreased in the GsT (60%) and PEAT (39%). Toxic Hepatopathy was not observed in the liver tissue of Genistein administered 3OGsT, and PEA administered 3OPEAT. Conclusions: Genistein has recovery effect on dermatitis damage through active induction of the endocannabin system (ECS). 목적: 6주된 생쥐에서 피부염 유발한 후 genistein과 palmitoylethanolamide (PEA)를 투여하여 피부염 손상 회복 효과를 알아보고자 하였다. 방법: 6주된 생쥐를 대조군 (Ctrl), 피부염 유발군 (AcDE), 피부염 유발 후 genistein 투여군 (GsT), 피부염 유발 후 PEA 투여군 (PEAT)으로 나누었다. 각 군에 7마리씩 배정하였다. 피부염 유발 후 투약 3일 후 피부 장벽의 변화를 관찰하였다. 결과: GsT과 PEAT에서는 AcDE에 비해 적은 피부 손상을 보였으며, GsT이 제일 낮은 피부손상을 보였다. CB1와 CB2 발현의 intensity는 AcDE에 비해 GsT (64%, 39%)와 PEAT (38%, 28%)는 증가하였다. E-cadherin 양성반응은 AcDE에서 감소한 반면 GsT (76%)와 PEAT (34%)는 증가하였다. p-JNK 양성반응은 AcDE에서 증가하였고, GsT (60%)와 PEAT (39%)는 감소하였다. Genistein이 투여된 3OGsT와 PEA가 투여된 3OPEAT의 간조직에서 간독성이 관찰되지 않았다결론: Genistein이 Endocannabinoid system (ECS) 활성 유도를 통하여 피부염 손상 회복 효과가 있음을 확인하였다.

      • 천상열차분야지도에 나타난 고려시대 피휘와 천문도의 기원

        안상현 한국우주과학회 2009 한국우주과학회보 Vol.18 No.2

        조선 태조 4년(1395년)에 제작된 천상열차분야지도는 그 원본이 고구려에서 기원된 것으로 알려져 있다. 그러나 이 천문도의 원석을 조사한 결과 고려 태조 王建에 대한 避諱가 적용된 별자리가 있음을 알게 되었다. 이것은 천상열차분야지도의 원본이 고구려가 아닌 고려에서 기원했음을 의미한다. 이에 따라 천상열차분야지도의 고구려 기원설에 대한 연구의 역사를 재점검함으로써 그 학설의 근거가 잘못된 단정에 기인함을 알아냈고, 기존 학설에 대한 전면적인 재검토를 하게 되었다. 이 논문에서는 조선은 물론이고 일본과 중국의 다양한 천문도들과 조선의 보천가, 천문류초, 누주통의 등의 문헌, 그리고 고려사, 조선왕조실록, 승정원일기 등의 역사 기록을 전면적으로 조사하여 이러한 避諱의 양상을 파악하였다. 그 결과 천상열차분야지도의 원본 성도는 고려시대의 작품일 가능성이 크다는 결론에 도달하였다.

      • KCI등재

        신법보천가(新法步天歌) 연구

        안상현 한국우주과학회 2009 Journal of Astronomy and Space Sciences Vol.26 No.4

        We investigated ‘Song of the Sky Pacers, Adopted to the New Methods’ (ÿ˜Ø), the latest version of Joseon’s ‘Song of the Sky Pacers’ (˜Ø). Due to the influence of new knowledge on Chinese asterisms imported from the Ching dynasty, ‘Song of the Sky Pacers with New Star-Charts’ was written in the eighteenth century. However, the disagreement between song and star-charts was causing confusion in practical applications such as Joseon’s national examination for selecting astronomers. In order to improve this situation, Royal Observatory of the Joseon dynasty (núš) published ‘Song of the Sky Pacers, Adopted to the New Methods’ based upon star-charts and song in the Sequel of I-Hsiang-K’ao-ch’eng (Œaéúx0A). The New Song was edited by a middle-class professional astronomer Yi Jun-yang (¯–]), and corrected by a nobleman Nam Byeong-gil (¢"Ø). We establish a brief biography of Yi Junyang. The New Song preserves the genuine characteristics of previous Joseon’s Song including the format of title of each lunar mansion and description on the location of the Milky Way in the asterisms. The description of the Milky Way was newly written based on the data in volume 31 and 32 of the Sequel of I-Hsiang-K’ao-ch’eng.

      • KCI등재

        능동 응용의 특성을 고려한 능동 노드 구조

        안상현,김경춘,손선경,손승원 한국정보과학회 2002 정보과학회논문지 : 정보통신 Vol.32 No.2

        The active network is a new networking approach to allow new protocols to be developed easily by solving the limitation of the existing protocol development procedure and the long protocol standardization process. So far many research institutes and universities have proposed active node architectures and active packet formats, but still there are some problems needed to be solved. One of them is the active packet format and the routing approach which consider the requirements of various active applications. Therefore, in this paper, we figure out the requirements of various active applications and design four types of active packet formats that reflect these requirements and propose routing schemes appropriate for these characteristics. Also we propose an active node architecture which reflect these requirements. 능동 네트워크는 기존 프로토콜 개발 방식이 가지는 새로운 프로토콜의 수용 능력에 있어서의 한계와, 장시간의 표준화 작업 등의 문제를 해결하기 위해 등장한 새로운 네트워킹 방식이다. 지금까지 많은 연구소와 대학에서 능동 노드의 구조와 능동 패킷의 형식을 제안해 왔으나, 현재까지 제안된 능동 네트워크에서 고려되지 못한 문제들이 여전히 남아 있다. 그중의 하나가 서로 다른 능동 응용들의 요구사항에 따라 특성화되는 능동 패킷과 라우팅 방법에 대한 것이다. 따라서 본 논문에서는 다양한 능동 응용들의 요구사항에 따른 능동 패킷의 기능을 파악해서 이를 반영한 능동 패킷의 종류를 네 가지로 구분하고, 각 특성에 맞는 라우팅 방법을 제안한다. 또한 이들 사항을 반영한 능동 노드 구조도 제시하였다.

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