유방암 조직의 Cox-2 발현

안민성(Min-Sung An),김상효(Sang-Hyo Kim),윤혜경(Hye-Kyoung Yoon),김운원(Woon-Won Kim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.6

Purpose: Cox-2 expression in breast carcinoma has been reported to be related to angiogenesis, lymph node metastasis and Her-2 expression. The aim of this study is to evaluate the clinicopathologic significance of Cox-2 expression in the invasive ductal carcinomas (IDC) and intraductal carcinomas (DCIS) of the breast. Methods: The materials were 353 IDC cases and 82 DCIS cases. Immunohistochemical stain for Cox-2 was interpreted as 1+ (weak & focal) and 2+ (diffuse), and the relationships between Cox-2 and ER, PR, Her-2, p53, Ki-67 and bcl-2 expressions were analyzed. Results: There was no significant difference of Cox-2 expression between IDC (148/353, 41.9%) and DCIS (38/82, 46.3%). Cox-2 (2+) expression was more frequent in low grade than intermediate and high grade IDC, but the difference was not significant statistically (P=0.0833), and there were no significant differences of Cox-2 expression according to age, tumor size, nuclear grade, lymph node metastasis in IDC and DCIS cases. In IDC cases, Cox-2 (1+ and 2+) expression showed positive relationships with p53 (+) and more than 10% of Ki-67 labeling index (P=0.0029, P=0.0015), and revealed tendencies of positive relationships with ER (+) and bcl-2 (+) (P=0.0750, P=0.0776). However, no significant relationship between Cox-2 and Her-2 expressions was recognized. In DCIS cases, Cox-2 (2+) expression rate was increased in cases showing negative for Her-2 (P=0.0092) and positive for bcl-2 (P=0.0486). Conclusion: Cox-2 expression seems to be involved in the development of breast carcinomas, but not related to the invasiveness. Cox-2 expression, especially 2+, in the DCIS cases suggest a possibility of less aggressive biological behavior.

장중첩증을 동반한 Peutz-Jeghers Syndrome

안민성(Min Sung An),김운원(Woon Won Kim),오상훈(Sang Hoon Oh),이난주(Nan Joo Lee) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.5

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease where the clinical manifestations are multiple harmatomatous gastrointestinal polyps and pigmentations of the skin. A harmatomatous polyp can develop at any part of the gastrointestinal tract, and the proximal small bowel is frequently involved. Intestinal obstruction, bleeding and intussusception, caused by GI polyps have been reported, which often require repeated surgery. A female patient presented with suffering of abdominal pain for two days duration. The patient was diagnosed with intussusception, and a resection and anastomosis of the small bowel was performed. The patient was treated for 15 days, and was discharged from the hospital without any particular complications. We report this case with a review of the literature.

현대 도예에 나타난 Installation에 대한 연구 비교 연구

원경환(Won, Kyung-Hwan),안민성(Ahn, Min-Sung) 한국조형디자인학회 2008 조형디자인연구 Vol.11 No.3

Installation Art is the art form of inducing the audience's participation by including the sense of sight, tactile sense, auditory sense, and sometimes the olfactory sensation in 3-dimensional space without remaining in the limitation of visual expression, escaping from the limitation of traditional art genre, which is divided into painting and sculpture, through expanding space of including choice and environment in diverse materials. The installation art has close relationship with a concept called ‘space.’ The installation, which was used in the whole space of exhibition, needs to allow the work to form one relationship rather than being separated from place. Here, the audience is emerged as an important role. An artist allows the audience to participate in the work, thereby leading to the accidental and unpredictable result. And, this can be seen to be the aim to cause the audience to have interest in the work and to provide the artist oneself with an opportunity that can be given inspiration. One of main characteristics in the work of installation art is what has ‘one-time attribute’ of coming to disappear with leaving just photos other records simultaneously with being withdrawal after a number of works had been installed for the fixed period. This is the plastic form that pursues the momentary behavior of escaping from the traditional art idea with saying that art needs to have perpetuity. Thus, in order to avoid a problem that is left just by these materials, the work is preserved by being permanently installed in a public place, or, the special attention is also paid to materials and techniques aiming to prevent damage, if possible. Meanwhile, since the start of the clay revolution centering on Peter Voulkos at the end of the 1950s, the modern art trend and modern ceramic art can be reminisced on one line. The installation art, which is recently showing the remarkable bullish trend in modern art, had natural influence upon modern ceramic art. And, this is possessing one genre in modern ceramic art in the contextual and methodological aspect. The modern ceramic art accepted a concept of modern sculpture, passed through more abundant experience, and arranged the firm position in the new ceramic-art aesthetics. The installation art arranged modern ceramists with the breakthrough of possibility for expression. As this is the sculpture of having the field base after passing through the form like performance, it is adding the motive power to development in ceramic art. Clay comes to have the semi-permanent property after passing through the process of plasticity. This is the part that can judge the possibility of ceramic art as the excellent art medium while supplementing a weak point in the installation art with saying of failing to have independence and permanence as the artistic work.

이사무 노구치의 작품에 관한 연구

원경환(Won, kyung-hwan),안민성(Ahn, min-sung) 한국조형디자인학회 2009 조형디자인연구 Vol.12 No.3

The purpose of this study is to examine the relationship between Isamu Noguchi's (1904 ∼1988) works and Japan's traditional characteristics. This can be done by trying to analyze his ceramic sculpture made in Japan, in which when this modern sculptor was immersed in seeking for his identity. The analysis will include and be compared to the formative characteristics in typically environmental sculptures that brought motif from Japanese traditional garden. Noguchi pursued a way to the sculpture that has an abstract quality, as well as a social relationship while concentrating on nature and a human being. He aimed to create sculptural environment for human activities as the actual place that art and society are connected, by introducing sculpture to the daily life. Isamu Noguchi's perspective of modern art was disciplined in Paris Studio of the sculptor Constantin Brancusi (1876〜1957), and was lively-integrated space by combining with the experience on Japan's traditional garden. The forms (what is geometrical and what is organic, what is traditional and what is modern), which are diversely shown in Noguchi's works, are maintaining the dialectical tension between oppositive propensities (what is spiritual and what is scientific, what is ideal and what is practical). Its reason can be found in Noguchi's personal experience and his individual history. These are composed of opposite elements such as his childhood in Japan and his adolescence in America, and the et tic difference that he felt simultaneously between his American mother and Japanese father. Ceramic work became the medium he explores his identity. Through ceramic work in Japan, Noguchi tried to establish his identity by experiencing combination of nature and abstraction and by pursuing connection with Japan. In order to seek for cultural identity in Japan, Noguchi maintained his characteristic of modernism, while utilizing elements in Japan's traditional aesthetics. Noguchi's continuous effort for exploring identity was shown as the uniquely formative characteristic in his work, and brought about expansion in sphere of modern sculpture as a pioneer of new environmental art.

소형 이동 로봇의 사람 추적 성능 개선을 위한 휠 오도메트리 기반 실시간 보정에 관한 연구

박재훈(Jaehun Park),안민성(Min Sung Ahn),한재권(Jeakweon Han) 한국로봇학회(논문지) 2022 로봇학회 논문지 Vol.17 No.2

Oncologic Outcomes and Risk Factors for Recurrence after Tumor-specific Mesorectal Excision of Rectal Cancer: 782 Cases

김삼희,배기범,Jung Min Kim,Jae-Ho Shin,안민성,Tae Geun Ha,Sung Mok Ryu,Kwang Hee Kim,Tae Hyeon Kim,최창수,Jin Yong Shin,Minkyung Oh,Seung Hun Baek,Kwan Hee Hong 대한대장항문학회 2012 Annals of Coloproctolgy Vol.28 No.2

Purpose: The aim of this study was to analyze the oncologic outcomes and the risk factors for recurrence after a tumor-specific mesorectal excision (TSME) of resectable rectal cancer in a single institution. Methods: A total of 782 patients who underwent a TSME for resectable rectal cancer between February 1995 and December 2005 were enrolled retrospectively. Oncologic outcomes included 5-year cancer-specific survival and its affecting factors,as well as risk factors for local and systemic recurrence. Results: The 5-year cancer-specific survival rate was 77.53% with a mean follow-up period of 61 ± 31 months. The overall local and systemic recurrence rates were 9.2% and 21.1%, respectively. The risk factors for local recurrence were pN stage (P = 0.015), positive distal resection margin, and positive circumferential resection margin (P < 0.001). The risk factors for systemic recurrence were pN stage (P < 0.001) and preoperative carcinoembryonic antigen level (P = 0.005). The prognostic factors for cancer-specific survival were pT stage (P < 0.001), pN stage (P < 0.001), positive distal resection margin (P =0.005), and positive circumferential resection margin (P = 0.016). Conclusion: The oncologic outcomes in our institution after a TSME for patients with resectable rectal cancer were similar to those reported in other recent studies, and we established the risk factors that could be crucial for the planning of treatment and follow-up.

하시모토 갑상선염을 동반한 유두상 갑상선암의 임상병리학적 특징

강상현,하태권,박하경,이홍태,신재호,안민성,김광희,배기범,김태현,최창수,김진수<SUP>1<.SUP>,김기훈<SUP>1<.SUP>,김운원<SUP>1<.SUP>,김상효,Sang Hyun Kang,Tae Kwun Ha,Ha Kyoung Park,Hong Tae Lee,Jae Ho Shin,Min Sung Ahn,Kwang Hee Kim,Ki Beom Bae,Ta 대한갑상선-내분비외과학회 2013 The Koreran journal of Endocrine Surgery Vol.13 No.1

Purpose: Hashimoto's thyroiditis (HT) is an important cause of hypothyroidism caused by autoimmune chronic lymphocytic thyroiditis. In order to attain a better understanding for use in treatment of papillary thyroid carcinoma (PTC) coexisting with HT, we conducted an analysis of the clinicopathologic features, as well as the importance of HT as a prognostic factor. Methods: In this retrospective study, we analyzed 341 patients who were histopathologically diagnosed with PTC following surgery. Results: PTC coexisting with HT was observed in 19.6% (67 patients) of all PTC patients. A statistically significant gender difference was observed in the group with HT (two male vs. 65 female), with a higher positive rate of anti-thyroglobulin antibody and smaller tumor size, compared to the PTC group without HT. When tumor size increased, a lower coexistence rate of HT was observed. No significant differences were observed in multifocality, cervical lymph node (LN) metastasis, coexistence of benign nodule, and extent of LN dissection. However, frequency of extrathyroidal extension was significantly lower and total thyroidectomy rate was higher in the group with HT. TNM stage and AMES stage were similar in both groups; frequency of high MACIS score showed a significant decrease in the group with HT. The recurrence rate and disease-free survival in patients with PTC were not significantly affected by coexistence of HT. Conclusion: We found a significant relationship with gender, extrathyroidal extension, and tumor size in PTC coexisting with HT. However, no significant differences in recurrence rate and disease-free survival were observed between groups. Therefore, coexistence in PTC could not be applicable as a prognostic factor of PTC.

유두상 갑상선암에서 최소 갑상선외 침범의 예후인자로서의 유용성

이민재,하태권,박하경,이홍태,신재호,안민성,김광희,배기범,김태현,최창수,김상효,Min Jae Lee,Tae Kwun Ha,Ha Kyoung Park,Hong Tae Lee,Jae Ho Shin,Min Sung An,Kwang Hee Kim,Ki Beom Bae,Tae Hyeon Kim,Chang Soo Choi,and Sang Hyo Kim 대한갑상선-내분비외과학회 2012 The Koreran journal of Endocrine Surgery Vol.12 No.2

Oncologic safety of self-expanded metal stent insertion as a bridge to elective surgery in malignant colorectal obstruction

Se Hui Oh(오세휘),Nak Jun Choi(최낙준),Sang Hyuk Seo(서상혁),Min Sung An(안민성),Kwang Hee Kim(김광희),Ki Beom Bae(배기범),Jin Won Hwang(황진원),Sang Heon Lee(이상헌),Ji Hyun Kim(김지현),Sam Ryong Jee(지삼룡),Mi Seon Kang(강미선),Kwa 대한종양외과학회 2016 Korean Journal of Clinical Oncology Vol.12 No.1

Purpose: Colorectal obstruction develops most frequently by carcinoma, and 7%–30% of these colorectal carcinomas are acute cases. The oncologic safety of self-expanding metal stent (SEMS) insertion as a bridge to surgery has not yet been established. Thus, we investigated the oncologic safety of SEMS insertion as a bridge to surgery in patients with obstructive colorectal cancer. Methods: This retrospective had 56 patients enrolled requiring emergency management for obstructive colorectal cancer at stage II or III, who had undergone curative surgery between July 2008 and June 2011. These subjects were divided into two groups: patients who had undergone emergency surgery without SEMS insertion (non-stent group) and those who had undergone elective surgery after preoperative decompression with SEMS insertion (stent group). The two groups were compared for clinicopathologic characteristics, postoperative complications, and survival rate. Results: Enterostomy was performed in 25 patients (100.0%) in the non-stent group and 1 patient (3.2%) in the stent group; laparoscopic surgery was carried out in 7 patients (28.0%) in the non-stent group and 19 patients (61.29%) in the stent group, each showing statistically significant differences. There was no statistically significant difference in postoperative complications and 5-year disease-free survival rate (72% vs. 74.19%, P=0.87, respectively). Conclusion: In treatment of malignant colorectal obstruction, elective operation after stent insertion had similar oncologic outcomes compared with emergency operation. Preoperative stent insertion not only lowers the incidence of enterostomy but also makes laparoscopic surgery possible, thereby enhancing patients’ quality of life. Therefore, preoperative stent insertion is a useful method that may replace emergency surgery in treatment of malignant colorectal obstruction.

Cosmetic outcomes and patients’ satisfaction of oncoplastic surgery in Korean patient with breast cancer

Sumin Ha(하수민),Tae Hyun Kim(김태현),Anbok Lee(이안복),Kyung-Do Byun(변경도),Jae Woong Han(한재웅),Min Sung Ahn(안민성),Kwang Hee Kim(김광희),Ki Beom Bae(배기범),Ha Kyoung Park(박하경),Jae Ho Shin(신재호),Sang Hyuk Seo(서상혁) 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.2

Purpose: Oncoplastic surgery (OPS) has emerged as the latest ideal surgery in treatment of breast cancer. The purpose of this study is to evaluate the cosmetic outcome of volume displacement surgery and patients’ satisfaction in Korean women with relatively small breast size. Methods: This is a retrospective study of 173 patients who had volume displacement of OPS between January 2008 and December 2013. Cosmetic outcome was evaluated by patients’ questionnaire and a doctor. The patients’ satisfaction was assessed by a questionnaire divided into four categories; cosmetic satisfaction, satisfaction on operative method, femininity, and side effects. Relationship between removed specimen volume and patients’ satisfaction was also analyzed. Results: About 90% of patients answered above the fair in cosmetic items and operative methods, only less than 5% of all patients reported of severe complications such as cramps or limitations of exercise. The patients’ cosmetic satisfaction score were significantly inversely related with removed specimen volume and doctor’s cosmetic assessment was also accordance with this result (P<0.05). Most patients preferred good contour over short scar regardless of age and marital status (good contour 54% vs. short scar 21%). Conclusion: Volume displacement of OPS brings both the best possible cosmetic outcome and high patient satisfaction for Korean women with a small size of breast in breast cancer surgery. It is highly suggestive that Korean women considers good contour more than the size of scar; therefore, volume displacement of OPS is a recommendable means of breast cancer surgery for Korean women.