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신욱진,이상규,황정하,박종찬,조용희,노은지,송연화,서행란,최강열 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Although the development of drugs that control Ras is an emerging topic in cancer therapy, no clinically applicable drug is currently available. We have previously utilized knowledge of the Wnt/β-catenin signaling-dependent mechanism of Ras protein stability regulation to identify small molecules that inhibit the proliferation and transformation of various colorectal cancer (CRC) cells via degradation of both β-catenin and Ras. Due to the absence of Ras degradation in cells expressing a nondegradable mutant form of β-catenin and the need to determine an alternative mechanism of Ras degradation, we designed a cell-based system to screen compounds that degrade Ras independent of the Wnt/β-catenin signaling pathway. A cell-based high-content screening (HCS) system that monitors the levels of EGFP-K-RasG12V was established using HCT-116 cells harboring a nondegradable mutant CTNNB1 (ΔS45). Through HCS of a chemical library composed of 10,000 compounds and subsequent characterization of hits, we identified several compounds that degrade Ras without affecting the β-catenin levels. KY7749, one of the most effective compounds, inhibited the proliferation and transformation of CRC cells, especially KRAS-mutant cells that are resistant to the EGFR monoclonal antibody cetuximab. Small molecules that degrade Ras independent of β-catenin may able to be used in treatments for cancers caused by aberrant EGFR and Ras.
The Effects of Recombinant Synucleins and Insulin-like Growth Factor 1 on Cancer Cell Migration
신욱진,김종선 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.2
The synuclein family consists of three distinct genes, α-synuclein, β-synuclein, and γ-synuclein. The α-synuclein and β-synuclein are predominately expressed in brain and especially α-synuclein is related with Parkinson's disease,Alzheimer's disease, and dementia with Lewy bodies. The γ-synuclein was first identified as breast cancer specific gene 1. It is expressed in the peripheral nervous system and also detected in breast and ovarian cancers. The γ-synuclein is also known to mediate metastasis of breast and ovarian cancer cells. Insulin-like growth factor 1 (IGF-I) is one of the growth factors that plays an important role in cell proliferation and migration in cancer cells, as well as in normal cells. In this study, we investigated the migrations of SKOV-3, MDAMB-231, and HeLa cells by the recombinant synuclein proteins (α-, β-, and γ-synucleins) and IGF-I and the molecular mechanism. Furthermore, we investigated the membrane ruffle formation of SKOV-3 cells by recombinant synuclein proteins and IGF-I. As a result, synucleins and IGF-I were found to induce cancer cell migrations. Simultaneous synucleins and IGF-I treatment on the cancer cells induced more migrations than the individual synuclein or IGF-I treatments. The synucleins or IGF-I treatments increased the expressions of membrane-type1 matrix metalloproteinase (MT1-MMP) and cluster of differentiation 44 (CD44). Moreover,simultaneous synucleins and IGF-I treatments further increased the expressions of MT1-MMP and CD44. The synucleins and IGF-I promoted the conformational change of actin filaments, and then this led to the membrane ruffle formation.
신욱진,조남규 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.3
This paper proposed a error compensation methodology for three-DOF translational parallel manipulator. The proposed method used CMM (coordinate measuring machine) as metrology equipment to measure the position of end-effector. To identify the transform relationships between the coordinate system of the parallel manipulator and the CMM coordinate system, a new coordinate referencing (or coordinate system identification) technique is presented. By using this technique, accurate coordinate transformation relationships are efficiently established. According to these coordinate transformation relationships, an equation to calculate the compensating error components at any arbitrary position of the end-effector is derived. In this paper, monte Carlo simulation method is applied to simulate the compensation process. Through the simulation results, the proposed error compensation method proves its effectiveness and feasibility.
신욱진(Shin Wook-Jin),이혁(Lee Hyuk),정제창(Jeong Jechang) 한국방송·미디어공학회 2010 한국방송공학회 학술발표대회 논문집 Vol.2010 No.11
현대 사회에서 영상 콘텐츠 (contents)의 사용량이 급증함에 따라 영상압축 기술은 이동통신이나 DMB 등의 시스템에 필수적인 기술이 되었으며 이에 따라 MPEG-x와 H.26x 등 국제적인 표준들이 존재한다. 전역 탐색 알고리듬은 주어진 검색 범위(search range) 내에서 모든 후보들의 변위의 에러 기준에 따라 최솟값을 이용해 위치를 검색하는 알고리듬이다. 그러나 전역 탐색 알고리듬은 각 화소에 대해 엄청난 양의 계산 로드를 가지며 이로 인해 심각한 문제를 발생시키는 단점이 있다. 1비트 변환 (one-bit transform) 을 이용한 고속 움직임 추정 알고리듬은 참조 프레임과 현재 프레임을 1비트, 즉 0 또는 1만 갖는 값으로 변환하는데, 이에는 exclusive-OR 연산을 통해 블록 매칭 에러 (block matching error)를 계산하는 과정과 변환하는 과정이 포함된다. 본 논문에서는 다양한 커널 (kernel)들을 이용한 1비트 변환과 움직임 추정에 대해 다루었으며, 기존에 있었던 1비트 변환에 이용된 커널과는 다른 다양한 커널을 이용한 움직임 추정 결과들을 비교해봄으로써 화질열화를 최소로 하는 커널을 찾는 것에 대해 연구했다.