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RISS 인기검색어
- 검색키워드
- 저자 : 신문석 ( Moon-seok Shin ) (검색결과 5 건)
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김창욱,신문석,김병천,이규석,송준영 ( Chang Wook Kim,Moon Seok Shin,Byung Chun Kim,Kyu Suk Lee,Jun Young Song ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
Epidermodysplasia verruciformis(EV) is a rare, sometimes familial disorder characterized by chronic infection with EV-specific HPV types. It manifests itself as numerous flat warts, red and brownish macules, and pityrias:s versicolor-like lesions. Immunodeficient staies such as AIDS renal transplantation, Hodgkins dis ase, and systemic lupus erythematosus, have been associated with EV. We report a case of a 42-year old female with EV, with lesions on the chest, shoulders, and back, For about the past 2, years, she had been treated with prednisolone for systemic lupus erythematosus. Histopathological findings revealed loose basket-weave-like hyperkeratosis and there were clear large cells arranged in nests in the granular and spinous layers. Their nuclei were shrunken and pyknotic, and the clear cytoplasm was dotted with dispersed keratohyaline granules of different sizes anr shapes. Electron microscopic findings showed aggregates of many viral particles in the nuclei of displastic epidermal keratinocytes. Pan papilloma virus monoclonal Antibody positive nuclei were;hown by immunoperoxidase staining. She has been treated with CO, laser and Tretinoin(0.1% ) oin ment. The patient is being monitored for any signs of recurrence for a period of 5months (Korean J Dermatol 1997;35(6): 1203-1207)
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배양된 각질형성세포에서 Interferon - Υ 가 수포성 유천포창 항원 유전자 발현에 미치는 영향
류영욱(Young Wook Ryoo),신문석(Moon Seok Shin),이규석(Kyu Suk Lee) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.3
N/A Background: Interferon- Υ (IFN- Υ) has been shown to regulate epidermal keratinocyte growth and differentiation and can be isolated from subepidermal vesicles in bullous pemphigoid (BP) patients. In general, the IFN- γ effects ate up-regulatory, and the corresponding transcriptional mechanisms have been elucidated in the case of several genes. One of the markers of the mitotic basal cell phenotype is the expression of BP antigens (BFAG), two hemidesmosomal proteins that were initially recognized as autoantigens in BP. Objective: Since down-regulation of BPA gene expression is one of the earliest events during epidermal differentiation and BPAG is served as the target of autoantibodies, in this study, we examined the effect of IFN-γ on the expression of the gene encoding the BPAG1 and 2. Methods and Results : Northern analysis revealed a dose dependent suppression of BPAG expression by IFN-γ in cultured human skin keratinocytes from 3 different donors, and incubation of the cells with IFN-γ in the presence of cycloheximide demonstrated that this effect reqiured ongoing protein synthesis. Transient transfections of cultured keratinocytes with BPAG1 promoter-chloramphenicol acetyltransferase reporter gene plasmids indicated marked suppression of the promoter activity by IFN-γ. Conclusion : This data, which inactivation of transcription of a basal keratinocyte-specific gene(BPAGl) by IFN-γ, pravides new insight into the mechanisms of IFN-γ mediated keratinocyte gene regulation and epidermal differentitation in inflammatory and blistering skin disease. (Korean J Dermatol 2002;40(3): 235~243)
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심상성 루프스에서 Nested-Primer Gene Amplification Assay에 의한 결핵균 DNA의 검출
신문석,전효진,김병천,이규석,김재룡,권호준,송준영 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4
Lupus vulgaris, which is a progressive form of postprimary tuberculosis in patients with a moderate to high degree of immunity and tuberculin sensitivity, is the most common, most serious, and most variable type of cutaneous and mucous membrane tuberculosis. Domonstration of M.tuberculosis directly or in culture in some of these eruptions can be difficult. It is essential to demonstrate the presence of M.tuberculosis in a clinical sample for a definitive diagnosis of tuberculosis. With the discovery of the polymerase chain reaction (PCR), the DNA diagnostic approach for infection has developed in a short period. With the dual purpose of definitive and rapid diagnosis of tuberculosis, this study examined the usefulness of a nested PCR for detection of M. turberculosis. Compared with a single-step PCR, the two-step PCR was able to enhance sensitivity approximately 1,000-fold on the basis of bacterial counts and DNA quantity. We concluded that two-step nested PCR appeared to be the most useful PCR protocol for early and sensitive diagnostic method detecting M.tuberculosis in acid-fast stain negative specimens.
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색소레이저(Pulsed Dye Laser, SPTL-1) 로 치료한 포도주색 혈관종의 임상효과에 관한 연구
김병천,이규석,신문석,송준영,정재봉,권호준 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.3
Port-wine stains(PWSs) are benign congenital vascular malformation that most commonly occur as isolated lesions on the face, neck, and trunk. The major indication for therapy, regardless of age, is psychological burden imposed by the PWSs. The pulsed dye laser(Candela SPTL-1) is a flashlamp excited dye laser, using the principles of selective photothermolysis that selectively targets the abnormal microvasculatures of cutaneous lesion while sparing adjacent structures including the epidermis, emitting at 585mm wavelength, pulse duration of 450㎲ec and 5mm spot size. From the June 1992 to May 1995, at O.P. D., Department of Dermatology, Keimyung University Hospital, 138 patients with portwine stains were analyzed to evaluate the clinical effects by the pulsed dye laser. The results were as follow : 87.9% of adults and 97.4% of children showed excellent or good results. 86.0% of male and 93.8% of female showed excellent or good results. 90.9% of head and neck, 87.5% 0f trunk, and 87.5% of extremity showed excellent or good results. Complication included transient erythema(12.3%), hyperpigmentation(7.9%), oozing(7.2%), infection(4.3%), edema(2.8%), and hypopigmentation(0.7%). There was no posttreatment sclerosis, hypertrophic or atrophic scar.
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