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송윤재,강은호,유범희,Song, Yoon-Jae,Kang, Eun-Ho,Yu, Bum-Hee 대한불안의학회 2008 대한불안의학회지 Vol.4 No.2
Depression and anxiety disorders are common psychiatric illnesses whose etiology remains partially understood. The etiology of depression and anxiety disorders is multi-factorial, and abnormalities in neurotransmitter, neuroendocrine system, and brain activation have been implicated in those conditions. However, the pathophysiology of depression and anxiety disorder is certainly not well understood, and some patients with depression or anxiety disorders do not respond to antidepressant therapy. Recently, immunological factors such as cytokines are known to be closely related to central nervous system as well as depression and anxiety disorders. This review highlights recent progress in understanding the function of cytokines in depression and anxiety disorders.
발달협응장애 동반 유무에 따른 주의력결핍 과잉행동장애 아동들의 임상적 특성
송윤재(Yoon-Jae Song),정유숙(Yoo Sook Joung) 대한소아청소년정신의학회 2011 소아청소년정신의학 Vol.22 No.4
Objectives:This study explored the clinical differences in attention-deficit hyperactivity disorder (ADHD) patients with and without developmental coordination disorder (DCD). Methods:Participants were 49 children and adolescents with ages between 6 and 18 years. These subjects were placed into 2 groups: ADHD without DCD (24) and ADHD with DCD (25). We used several evaluation tools on both groups: the Affective Disorders and Schizophrenia-Present and Lifetime Version- Korean Version (K-SADS-PL), Wechsler Intelligence Scale for Children-III (WISC-IIII), Child Behavior Check List (CBCL), Korean Personality Rating Scale for Children (K-PRC), and Bruininks-Osretsky Test of Motor (BOT-2). Results:Patients with both ADHD and DCD had a lower performance intelligence quotient and more internal and external behavioral symptoms than patients with ADHD but not DCD. It is possible that patients with ADHD and motor coordination problems should be noticed earlier and given intensive treatment.
강은호(Eun-Ho Kang),신우용(Woo-Yong Shin),송윤재(Yoon-Jae Song),유범희(Bum-Hee Yu) 고려인삼학회 2009 Journal of Ginseng Research Vol.33 No.3
본 연구는 신체 증상을 호소하는 정상인들을 대상으로 3주간 홍삼 또는 위약을 투여하였고, 홍삼 복용군에서 위약 복용군에 비해 신체 증상 감소 정도가 더 큼을 보여주었다. Various somatic symptoms are known to be related to stress in a general population. Korean red ginseng has been used as a therapeutic agent for the treatment and prevention of many diseases in Oriental medicine. There exist no data, however, on the effect of Korean red ginseng on somatic symptoms in a general population. In this study, 21 normal subjects were randomly assigned to the Korean-red-ginseng group, and 18 subjects to the placebo group. The subjects took 3 g Korean red ginseng or placebo every day for three weeks. After the three-week treatment, there was a 〈time x group〉 interaction effect of a greater reduction in the Symptom checklist-90-revised (SCL-90-R) somatization score (p=0.04) in the Korean-red-ginseng group. This study suggests that Korean red ginseng is effective for the management of somatic symptoms in a general population.
김은숙,허갑범,이현철,임승길,이은직,송영득,남수연,문윤재,김인재,나상규,김경래 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.3
Backbround: Primary empty sella syndrome(PES) is thought to arise from an incompetent diaphragma allowing progressive herniation of arachnoid membrane with secondary compression and atrophy of the pituitary gland. As a consequence of the improvement and widespread use of neuroradiological techniques, such as computerized tomography(CT) and magnetic resonance imaging(MRI), empty sella is more frequently disclosed. The aim of this study is to assess the associated clinical characteristics and endocrinologic disturbance in empty sella syndrome. Methods: From January 1986 to June 1996, 171 patients with empty sella syndrome have undergone analysis for clinical characteristics and associated disease. Result: In our study, PES was diagnosed in 131 of the 171 patients(77%). Primary empty sella syndrome was frequent in middle aged women(female:male 115:16, mean age: 50.6+12.6 years). The common clinical features were headache(80.2%), obesity(72.5%), and hypertension(27.5%). Most of patients with PES have normal pituitary function(75%). The frequent pituitary dysfunction was hyperprolactinemia in PES(21%). Partial and total emptiness of sella on sella CT or MRI were in 111(84.7%) patients, and in 20(15.4%) patients, respectively. The most common associated disease with empty sella syndrome was pituitary adenoma. Conclusion: PES should be considered as a possible cause in obese middle aged women with unexplained headache. The combined pituitary function test should be considered for evaluation of pituitary dysfunction when clinically suspected. (J Kor Soc Endocrinol 12:386-392, 1997)