보중익기가미길경탕에 의한 A549 인체 폐암세포의 전이 억제

배종훈,신동역,박철,박상은,홍상훈,박동일,최영현 대한암예방학회 2011 Journal of cancer prevention Vol.16 No.3

Bojungikkigamikilkyung-tang (BJIKTP), a traditional korean herbal formulation, has been used for patients suffering from a lung disease in oriental medicine. However, the molecular mechanisms underlying BJIKTP-induced anti-invasiveness and anti-metastasis have not been thoroughly studied. In the present study, we investigated the effects of BJIKTP on the correlation between tightening of tight junctions (TJs)and anti-invasive activity in human lung cancer A549 cells. It was found that low concentrations of BJIKTP were not cytotoxic effects, whereas high concentrations of BJIKTP could inhibit the cell proliferation as determined by MTT assay. Within the concentrations which were not cytotoxic effects,BJIKTP markedly inhibited the cell motility and invasiveness in a dose-dependent manner. The anti-invasive activity of BJIKTP was found to be associated with increased tightness of the TJ, which was demonstrated by an increase in transepithelial electrical resistance (TER). The activities of matrix metalloproteinase (MMP)-2 and -9 in A549 cells were dose-dependently inhibited by treatment with BJIKTP,and this was correlated with a decrease in expression of their mRNA and proteins, and up-regulation of tissue inhibitors of metalloproteinases (TIMPs) expression. Additionally, BJIKTP repressed the levels of the claudin family members, which are major components of TJs that play a key role in control and selectivity of paracellular transport. Furthermore, the levels of E-cadherin, a type I transmembrane glycoprotein,and snail, an epithelial to mesenchymal transitionregulator and zinc finger transcription factor,were markedly inhibited by BJIKTP treatment. Taken together, these findings suggest that TJs and MMPs are critical targets of BJIKTP-induced anti-metastasis in human lung cancer A549 cells. (Cancer Prev Res 16, 238-248, 2011)

The Tragedy of Contract and the Naturalistic Fallacy at the Workplace

배종훈 서울대학교 경영연구소 2020 Seoul Journal of Business Vol.26 No.1

This study concerns business ethics. In particular, this study is a critical review of consequentialist ethics, namely, the tragedy of contract, which underlies managerial practices at the workplace and which equates empirical flourishing with behavioural morality, an instance of the naturalistic fallacy. It shows that the application of consequentialist ethics in the corporate world is fundamentally flawed such that empirical consent, a key element of consequentialism, obtains at the expense of the weaker party to an exchange and that consent-based contracting both precludes the autonomy of the subject and paradoxically invites the influence of the third-part expert. The alternative practice is addressed with respect to the tradition of social contract, which places public ordering over private ordering.

보중익기가미길경탕에 의한 A549 인체 폐암세포의 Apoptosis 유도

배종훈,신동역,박철,최영현,박동일 대한암예방학회 2011 Journal of cancer prevention Vol.16 No.4

Bojungikkigamikilkyung-tang (BJIKTP) is a traditional oriental herbal formulation consisting of crude ingredients extracted from nine herbs. This prescription has been widely used for patients suffering from a lung disease in Oriental medicine. In the present study, it was examined the biochemical mechanisms of apoptosis induced by BJIKTP in human non-small-cell lung cancer (NSCLC) cells. It was found that exposure to BJIKTP was found to result in a concentration-dependent growth inhibition by induction of apoptosis, as evidenced by chromatin chondensation, DNA fragmentation and the accumulation of sub-G1phase, in NSCLC A549 cells, but not in NCI-H460 cells. Apoptosis induction of A549 cells by BJIKTP was connected with a modulation of Bcl-2 and inhibitors of apoptosis (IAP) family members, and up-regulation of death-receptor related members. BJIKTP treatment also induced proteolytic activation of caspase-3, -8 and -9, and degradation of caspase-3 substrate proteins including poly (ADP-ribose)polymerase and phospholipase C γ-1. In addition, BJIKTP-induced apoptosis is associated with the reduction of mitochondrial membrane potential (MMP) and cleavage of Bid proteins. Taken together, the results indicate that BJIKTP may be a potential chemotherapeutic agent for use in the control of human lung cancer and that further studies are needed for the identification of the active compounds. (Cancer Prev Res 16, 358-370, 2011)

The Hazards of Leapfrog: Search Routines for Alliance Partner and Evolution of Organizational Capabilities

배종훈 서울대학교 경영연구소 2012 Seoul Journal of Business Vol.18 No.2

This study presents an evolutionary model of capability development and examines the role of strategic alliance in the evolution of organiza- tional capabilities. In particular, this study begins with the observation that each alliance partner’s capability development co-evolves. This study contributes to the literature on capability development by showing the following: (1) a firm’s strategic alliance is ‘fitness-enhancing’ when its partners’ learning is ‘ineffective’; (2) without making additional efforts (i.e., in-house development), a firm is able to employ strategic alliances and to balance between exploitation and exploration to the extent that its (potential) partners are not effective learners; and (3) a firm is unlikely to balance between exploitation and exploration to the extent that its (potential) partners are effective learners.

The Boundaries of Brokerage-Based Knowledge Transfer

배종훈 한국인사조직학회 2010 인사조직연구 Vol.18 No.4

This paper analyzes the theoretical boundaries of brokerage-based knowledge transfer, a model based on Burt’s (1992) structural hole theory. To this end, this paper specifies three theoretical assumptions underlying brokerage-based knowledge transfer and examines whether the violations of those assumptions facilitate or hinder brokerage-based knowledge transfer. In doing so, this paper seeks to identify which assumption is fundamental to brokerage-based knowledge transfer. The following are the three basic assumptions concerning brokerage positions: 1) actors hold knowledge different from one another. 2) the cost of having a tie or forming a relationship is nontrivial. 3) there is no information loss when transferring information from one actor to another. To further examine these assumptions, this paper proposes a model for a tolerable level of information loss that leads to brokerage-based information benefits. In particular, this paper derives two different types of brokerage and shows that brokerage with substitution is preferred to brokerage with minimum direct ties as the ratio of networking cost to information value increases. Moreover, this study shows that the tolerable level of information loss that facilitates brokerage-based knowledge transfer is matched with the cost of having a tie and the ex ante value of knowledge held by partners. In this regard, the working of the third basic assumption is contingent upon that of the first and the second basic assumptions. Finally, it shows that the optimal mix of redundant and non-redundant ties depends again on information loss.

雪滿空庭: 사회적 관계와 범주화

배종훈,이승영 한국인사ㆍ조직학회 2015 한국인사ㆍ조직학회 발표논문집 Vol.2015 No.3

시장의 근간을 이루는 경쟁은 생산자간 경제적 차이를 만들어 내는 사회적 과정이다. 승자와 패자의 차이가 그것이다. 성공의 후일담은 풍성하게 가필되고, 실패의 개인사(個人史)는 지속적으로 누락된다. 그러나 승자와 패자를 나누는 기준은 실상 ‘사소한 차이’에 기반할 수 있다. 본 논문은 생산자간 사소한 차이가 지속 가능한 차이로 변용되는 조건, 즉 범주화 과정은 스스로 독립적인 효과를 가지고 있지 않다고 주장한다. 대신, 범주화의 효과성은 시장 참여자들의 사회적 관계의 특성에 종속된다고 주장한다. 이를 위해, Watts & Strogatz (1998)의 작은 세계 네트워크 모델을 원용하여, 앞선 주장을 논증하고자 한다. 구체적인 내용은 다음과 같다. 최초의 관찰자 즉 사건의 일차적 목격자가 선택 편향이 있다면, 사회적 학습을 통하여 사건을 이해하려는 동조자는 사건의 실체와는 무관하게 긍정의 편향 [positivity bias] 혹은 부정의 편향[negativity bias]을 경험하게 된다. 그리고 사회적 관계의 구조에 따라 이러한 범주화 오류의 규모가 결정된다. 특히 긍정 편향은 관계의 밀도가 감소할수록 강화된다. 즉, 부정의 편향이 궁극적으로는 혁신가의 적응적 학습에서 유래한다면, 긍정의 편향은 사회적 관계에서 발현된다. 비유적으로 말하자면, 성공이라는 카테고리는 관계라는 빈 뜰에서 핀 눈꽃 같은 것이다.

The Elements of Learning : Coordination Capacity and Search Scale

배종훈,강성춘 한국인사조직학회 2010 인사조직연구 Vol.18 No.2

Given a firm’s limited coordination capacity, the balance between the initiation of new search and the termination of old search appears critical to its long-term survival. But the current research on technological innovation and organizational learning has exclusively concerned how to initiate a new search and neglected the need for the termination. This study aims to uncovering the balance between the initiation and termination of searches. Using patent applications in the telecommunications equipment industry from 1991 to 1999, this study suggests that the change in a firm’s search scale is related to its human resources capabilities, prior knowledge, and organizational age.

Surplus Partners in Coordination Networks

배종훈,Jooho Lee 한국사회학회 2012 한국사회학회 사회학대회 논문집 Vol.2012 No.12

SOC를 위한 효율적인 IP 재활용 방법론

배종훈 대한전자공학회 2002 전자공학회지 Vol.29 No.1

VLSI 기술의 발전은 보다 많은 양의 로직을 단일 칩에 집적 가능하게 했고, 이는 System-on-a-chip 시대의 도래를 가능하게 했다. System-on-a-chip을 가능하게 하기 위해서는 많은 종류의 IP (Intellectual Property)가 필요하고, 공정 변환을 쉽게 하기 위해서는 합성이 가능한 RTL 설계가 절실히 요구된다. 본 논문은 이러한 요구에 부응하기 위해서 hard macro 형태의 기존의 IP로 부터 합성 가능한 IP를 자동 생성해 주는 ART(Automatic RTL Translation)로 명명된 기법에 관한 것이다. 제안된 ART 기법을 이용하여 80C52 호환의 8-bit MCU(Micro-controller Unit)의 합성 가능한 RTL model을 자동 생성하였고, 개발된 Soft IP를 이용하여 TCP/IP 전용 MCU를 표함해서 다양한 제품들을 개발하였다.

On Regretful Hierarchy

배종훈 서울대학교 경영연구소 2017 Seoul Journal of Business Vol.23 No.1

This study evaluates the implications of regretful choices at the group level and suggests that regretful choices in the market may underlie the formation of hierarchy, i.e., a collectivity, which may not mitigate the hazards of transactions but serve to absorb personal emotions, i.e., regrets associated with market transactions. In so doing, this study seeks to identify the role of personal emotion in the theory of the firm vis-à-vis calculative trust that is arguably granted to the impersonal firm.