http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
뇨중 Urinary Dipeptidase 의 근원에 대한 고찰
박행순,김도하,박성광,강성귀,Marlyn Burks,James M . Mullins,Benedict J . Campbell ( Haeng Soon Park,Doh Ha Kim,Sung Kwang Park,Sung Kyew Kang,Marlyn Burks,James M . Mullins,Benedict J . Campbell ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.4
Urinary dipeptidase, an enzyme with β-lactamase activity, was purified from the urine of healthy individuals. The purified enzyme was monophoretic when examined in polyacrylamide gel electrophoresis at pH 8.3, and its molecular mass estimated by HPLC was 227,000 daltons. It catalyzed the hydrolysis of the β-lactam antibiotic, N-formimidoyl-thienamycin (imipenem) with K_m=15.8 mM and V_(max)= 55 μ㏖/min/㎎. Lineweaver-Burk analysis of urinary dipeptidase-catalyzed hydrclysis of imipenem in the presence of cilastatin (Z-S-[6-carboxy-6-{ [2,2-dimethyl-(S)-cyclopropyl carboxy]-amino}-5-hexenyl]-L-cysteine) demonstrated reversible, competitive inhibition. The K_i for the competitive inhibitor, cilastatin, was 6 M. Renal dipeptidase was solubilized with n-butanol from membranes prepared from the kidneys of renal stone patients and purified. The two enzymes showed many properties in common including molecular mass, substrate specificity, kinetic parameters, inhibition by cilastatin, pH optima, electrophoretic mobility, and immunological cross-reactivity. Disintegration of kidney tubules and release of peptidase activity into the urine of rabbits treated with sublethal levels of the nephrotoxic agent, cephaloridine, suggest that the urinary dipeptidase originates from the proximal tubules of mammalian kidneys.
척출 냉혈동물 심방의 Alpha-Adrenoceptors에 관한 연구(I) 개구리 심방의 clonidine, oxymetazoline 및 phenylephrine에 대한 반응
최수형(Soo Hyung Choi),박행순(Haeng Soon Park),신동호(Dong Ho Shin) 대한약학회 1988 약학회지 Vol.32 No.2
Effects of the selective alpha-adrenoceptor agonists, clonidine, oxymetazoline and phenylephrine, on heart rate and contractile force were investigated in the isolated frog atria and it was attempted to examine the influence of adrenoceptor antagonist upon those. Clonidine produced dose-dependent negative chronotropic and positive inotropic effects. The negative chronotropic effect was significantly attenuated in the presence of prazosin and yohimbine but not propranolol. The positive inotropic effect was significantly attenuated by prazosin, yohimbine and propranolol. Oxymetazoline produced dose-dependent negative chronotropic and inotropic effects. The negative chronotropic effect was significantly attenuated in the presence of prazosin, which was partially augmented by yohimbine but was not affected by propranolol. The negative inotropic effect was not affected by propranolol but it was partially augmented by yohimbine and was partially attenuated by prazosin. Phenylephrine produced dose-dependent positive chronotropic and inotropic effects. The positive chronotropic and inotropic effect were significantly attenuated in the presence of propranolol but were not affected by prazosin and yohimbine. These results suggest that the negative chronotropic effect by clonidine and oxymetazoline is mediated by alpha-adrenoceptors, the positive chronotropic and inotropic effects by phenylephrine are mediated by beta-adrenoceptors, and alpha-adrenoceptors mediated the inhibitory chronotropic responses exists in the isolated frog atria.
에어탈 정 ( 아세클로페낙 100mg ) 에 대한 세니탈 정의 생물학적 동등성
김수진(Soo Jin Kim),오인준(In Joon Oh),박행순(Haeng Soon Park),서세민(Se Min Seo),서순팔(Soon Pal Suh),이용복(Yong Sok Lee) 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.4
Bioequivalence of two aceclofenac tablets, the Airtal^(TM) (Daewoong Pharmaceutical Co., Ltd.) and the Senital^(TM) (Hana Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20∼29 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100 ㎎ of aceclofenac was orally administered, blood was taken at predetermined time intervals and the concentration of aceclofenac in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_t) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_t between two tablets were 3.69%, 2.44% and 0.51%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_t were 87.85%, 98.70% and more than 99%, respectively. Detectable differences (Δ) and confidence intervals were all less than ±20%. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Senital^(TM) tablet is bioequivalent to Airtal^(TM) tablet.
신장의 근위세뇨관에서 Renal Dipeptidase(RDPase)의 유도에 관한 키토산의 효과
김영호(Young Ho Kim),윤현중(Hyun Joong Yoon),박행순(Haeng Soon Park),이명렬(Myung Yul Lee),김종세(Jong Se Kim) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.7
기능성 식품 소재로서 이미 많이 알려진 키토산이 신장과 관련하여 식품이나 의료용 소재로서 활용이 가능한 지를 알아보기 위하여 신장 기능과 민감하게 관련이 있는 효소인 RDPase, Udpase의 활성을 체내ㆍ체외 실험을 통하여 관찰하였다. 체외 실험에서 글리세롤에 의해 유도된 RDPase의 유리ㆍ활성 감소를 다시 회복시키는 것을 관찰하였다. 체내 실험에서 글리세롤 투여에 의하여 손상된 신장의 근위세뇨관에서 급격히 증가한 RDPase의 활성을 키토산이 확실하게 감소시키는 것을 관찰할 수 있었다. 키토산을 공급한 쥐의 소변에서의 Udpase의 활성이 증가하는 것을 관찰하였다. The purpose of this study was to evaluate the effects of chitosan, which is deacetylated derivative of chitin, on the renal function. Renal dipeptidase (RDPase, membrane dipeptidase, dehydropeptidase 1, EC 3.4.13.19) is glycosyl phosphatidyl-inositol (GPI)-anchored ectoenzyme of renal proximal tubular microvilli and was related with renal disease including acute renal failure, pyelitis and nephritis. The released RDPase and Udpase activities were assayed by modified fluorometric method. In vitro experimental groups were consisted of group 1, the concentration ranges of 0, 0.01, 0.05 and 0.1% chitosan only, group 2, the concentration ranges of 1, 2 and 4 mM glycerol only, and group 3, the concentration ranges of 0, 0.01, 0.05 and 0.1% chitosan in the presence of glycerol (4 mM). In vivo experimental groups were consisted of group 1 in which rats were treated with glycerol for the purpose of glycerol-induced renal damage, and group 2 in which rats were treated with chitosan plus glycerol. The RDPase release of 0.01, 0.05, and 0.1% chitosan groups were increased in the concentration dependent manner. The RDPase release of 1, 2, and 4 mM glycerol groups were decreased in the concentration dependent manner. Chitosan in the presence of glycerol restored the released RDPase activity in the proximal tubules. In vivo, chitosan inhibited the decrease of RDPase release by glycerol in the kidney and blocked the decrease of Udpase activity by glycerol in urine. These results indicated that chitosan was possible as a functional food to control renal function and its diseases.