돈 몰리는 인천 부동산 시장

박준형,Park, Jun-Hyeong 한국주택협회 2007 주택과 사람들 Vol.211 No.-

CollectiveAccess를 활용한 지역예술단체 디지털 아트 아카이브 구축 - J미술협회를 중심으로 -

박준형,박지원,한희영,정지나,김용,Park, Jun-Hyeong,Park, Ji-Won,Han, Hui-Lyeong,Jeong, Ji-Na,Kim, Yong 한국도서관정보학회 2017 한국도서관정보학회지 Vol.48 No.3

지역예술단체는 공연, 전시, 공모전, 축제 등 지역 내 다양한 행사를 주관하고 지역예술가의 정보 공유의 장, 신진예술가 발굴 및 지원 등 지역의 문화예술활동을 주도하며 오랫동안 지역 사회의 예술문화 발전에 큰 공헌을 하고 있다. 지역예술단체 기록은 과거와 현재의 지역문화예술의 수준과 가치를 보여주는 역사적인 의미를 지닌 기록이기 때문에 체계적인 관리가 필요하다. 또한 다양한 프로젝트를 진행하면서 생산된 지역예술단체의 기록은 이용자의 관심과 요구가 높기 때문에 이를 효과적으로 보여줄 수 있는 전시 서비스가 필요하다. 이에 본 연구는 공개소프트웨어인 CollectiveAccess를 기반으로 지역예술단체 디지털 아트 아카이브를 구축하여 지역예술단체 기록을 체계적으로 관리하며 전시 서비스할 수 있는 방안을 제시하고자 한다. Local Arts Organization has performed various events in the provinces such as performances, exhibitions, competitions, and festivals, has been a place where local artists share information of arts, and has contributed greately to the development of art culture in the provinces for a long time. Records of Local Arts Organization are historical records showing the level and value of past and present local cultural arts, so systematic management and preservation is necessary. Also, since the records of Local Arts Organization are high in interest and demand of users, exhibition services are needed to show them effectively. Therefore, this study shows how to construct a Local Arts Organization based on CollectiveAccess, which is open software, to manage Local Arts Organization and provide exhibition services.

유전학을 이용한 사상의학 임상연구 동향 분석

박준형,박지은,이슬,이용재,이정윤,Park, Junhyung,Park, Jieun,Lee, Seul,Lee, Yong-jae,Lee, Jeongyun 사상체질의학회 2021 사상체질의학회지 Vol.33 No.3

Objectives The aim of this study was to review the current clinical Sasang constitutions studies by using genetics and to provide basic data for developing in a better direction of research. Methods Research articles on genetics of the clinical Sasang constitutions studies were extracted from six databases. The articles were classified were published year, published journals, and the types of studies. Subjects of research and experimental methods for the genetic research were summarized. Results A total of 43 selected research articles were published from 1996 to 2020 and more than half of them were published in Journal of Sasang Constitutional Medicine and Journal of Korean Oriental Medicine. There were three main types of researches. The three types of researches were for investigating a genetic indicator for classification of Sasang constitutional type, confirming a relationship between pathological gene and Sasang constitutional type, and checking a hereditary of Sasang constitutional type. But these studies did not yield clear results illustrating a relationship between Genetics and Sasang Constitutional Medicine. Discussion In this study, the necessity of the follow up studies to demonstrate a relationship between Genetics and Sasang Constitutional Medicine was confirmed.

Solid Dispersion as a Strategy to Improve Drug Bioavailability

박준형,전명관,조훈,최후균,Park, Jun-Hyung,Chun, Myung-Kwan,Cho, Hoon,Choi, Hoo-Kyun The Korean Society for Biotechnology and Bioengine 2011 KSBB Journal Vol.15 No.6

Solid dispersion is one of well-established pharmaceutical techniques to improve the dissolution and consequent bioavailability of poorly water soluble drugs. It is defined as a dispersion of drug in an inert carrier matrix. Solid dispersions can be classified into three generations according to the carrier used in the system. First and second generations consist of crystalline and amorphous substances, respectively. Third generation carriers are surfactant, mixture of polymer and surfactants, and mixture of polymers. Solid dispersions can be generallyprepared by melting method and solvent method. While melting method requires high temperature to melt carrier and dissolve drug, solvent method utilizes solvent to dissolve the components. The improvement in dissolution through solid dispersions is attributed to reduction in drug particle size, improvement in wettability, and/or formation of amorphous state. The primary characteristics of solid dispersions, the presenceof drug in amorphous state, could be determined by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and fourier-transformed infrared spectroscopy (FTIR). In spite of the significant improvement in dissolution by solid dispersion technique, some drawbacks have limited the commercial application of solid dispersions. Thus, further studies should be conducted in a direction to improve the congeniality to commercialization.

자동합성장치를 이용한 [$^{18}F$]Fallypride의 합성

박준형,문병석,이홍진,이효준,이인원,이병철,김상은,Park, Jun-Hyung,Moon, Byung-Seok,Lee, Hong-Jin,Lee, Hyo-Jun,Lee, In-Won,Lee, Byung-Chul,Kim, Sang-Eun 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.2

$[^{18}F]$Fallypride는 뇌의 도파민(dopamine) $D_2/D_3$ 수용체 (receptor)에 특이적으로 결합하는 길항제(antagonist)로 대뇌피질의 도파민 기능을 규명하기 위하여 많이 사용되어지는 방사성의약품이다. 그동안 발표되어진 자동 합성화 장치를 이용한 [$^{18}F$]Fallypride 합성은 20~30%의 낮은 합성 수율과 33~63 GBq/mmol의 낮은 비방사능이 보고되어졌고, 또, 상대적으로 긴 표지시간과 높은 농도의 base를 사용하기 때문에 다양한 부산물이 생성되어 정제의 어려움이 있어 임상에 사용되기에 한계가 많았었다. 본 연구에서는 다목적 F-18 합성장치인 GE TracerLab $FX_{FN}$ 모듈을 사용하여 base 농도를 최소화할 수 있는 연구를 수행하였고, [$^{18}F$]fallypride 합성에 적용하여 높은 합성수율과 비방사능(specific activity) 및 방사화학적 순도(radiochemical purity)를 합성하는 최적의 조건을 찾을 수 있었다. 이를 바탕으로 $66{\pm}1.4%$ (decay-corrected, n=28)의 높은 합성수율과 HPLC 분리, SPE 정제시간을 포함하여 총 $51{\pm}1.2$분에 빠르게 합성할 수 있었다. 합성 후, 품질관리 테스를 해 본 결과, 방사 화학적 순도는 95%이상, 비방사능은 166~470 $GBq/{\mu}mol$이었다. 본 연구에서 사용된 합성법은 [$^{18}F$]Fallypride를 이용한 dopamine $D_2/D_3$ 연구의 임상적 사용에 도움이 될 것이며, 낮은 농도의 base를 사용한 이 F-18 추출방법은 base에 민감한 전구체의 자동합성 생산에 유용할 것으로 사료된다. Purpose: $[^{18}F]$Fallypride plays an effective radiotracer for the study of dopamine $D_2/D_3$ receptor occupancy, neuropsychiatric disorders and aging in humans. This tracer has the potential for clinical use, but automated labeling efficiency showed low radiochemical yields about 5~20% with relatively long labelling time of fluorine-18. In present study, we describe an improved automatic synthesis of [$^{18}F$]Fallypride using different base concentration for routine clinical use. Materials and Methods: Fully automated synthetic process of [$^{18}F$]Fallypride was perform using the TracerLab $FX_{FN}$ synthesizer under various labeling conditions and tosyl-fallypride was used as a precursor. [$^{18}F$]Fluoride was extracted with various concentration of $K_{2.2.2.}/K_2CO_3$ from $^{18}O$-enriched water trapped on the ion exchange cartridge. After azeotropic drying, the labeling reaction proceeded in $CH_3CN$ at $100^{\circ}C$ for 10 or 30 min. The reaction mixture was purified by reverse phase HPLC and collected organic solution was exchanged by tc-18 Sep-Pak for the clinically available solution. Results: The optimal labeling condition of [$^{18}F$]Fallypride in the automatic production was that 2 mg of tosyl-fallypride in acetonitrile (1 mL) was incubated at $100^{\circ}C$ for 10 min with $K_{2.2.2.}/K_2CO_3$ (11/0.8 mg). [$^{18}F$]Fallypride was obtained with high radiochemical yield about $66{\pm}1.4%$ (decay-corrected, n=28) within $51{\pm}1.2$ min including HPLC purification and solid-phase purification for the final formulation. Conclusion: [$^{18}F$]Fallypride was prepared with a significantly improved radiochemical yield with high specific activity and shorten synthetic time. In addition, this automated procedure provides the high reproducibility with no synthesis failures (n=28).

펄스전류에 의한 전착된 Zn 전극의 방전 특성에 관한 연구

박준형,김광범 ( J . H . Park,K . B . Kim ) 한국부식방식학회 1998 Corrosion Science and Technology Vol.27 No.1

서울 강북 재정비촉진지구 17곳 확정

박준형,Park, Jun-Hyeong 한국주택협회 2006 주택과 사람들 Vol.199 No.-

서울의 강북 재정비촉진지구가 확정됐다. 그 동안 서울시가 조례로 시행해오던 뉴타운 사업을 건설교통부가 지구로 지정한 것. 지구로 지정된 곳은 앞으로 대량으로 아파트가 공급되고, 층수 제한이 풀리는 등 개발에 가속도가 붙을 것으로 예상된다. 기대감이 커지고 있는 도시 재정비촉신지구를 돌아보고 향후 시장을 전망했다.

폐쇄성 수면 무호흡 환자에서 임시 하악 전방 이동 장치를 이용한 치료결과 분석

박준형,오수석,홍종락,김창수,팽준영,Park, Joon-Hyung,Oh, Suseok,Hong, Jongrak,Kim, Chang-Soo,Paeng, Jun-Young 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.6

Purpose: The aim of this study was to evaluate the effect of temporary mandibular advancement devices (MAD) in obstructive sleep apnea (OSA) patients Methods: 28 patients (male 21, female 7) undergoing temporary mandibular advancement device treatment for OSA were selected from 2011.01. to 2012.02. in the department of Oral & Maxillofacial Surgery at SamsungMedicalCenter. Treatment efficacy was determined by polysomnography (PSG) at baseline & after MAD delivery. The response group was defined as >50% Apnea-Hypopnea Index (AHI) reduction plus post-MAD AHI <10, and the non-response group was defined as <50% AHI reduction. The lateral cephalogram was analysed including SNA, SNB, UL, MPH, PAS, PASU, and PAST using V-ceph$^{TM}$ (Cybermed, USA). Results: The responsers were 23 patients, and non-responsers were 5 patients. The AHI was significantly reduced with temporary MAD ($8.08{\pm}7.93$) compared with baseline ($28.51{\pm}20.56$) in the response group (n=23). No significant difference was observed between pre MAD and post MAD except SNB on cephalometric analysis. Among 11 patients successfully treated with the temporary device, 9 patients said that using permanent device brings better effect too. Conclusion: These results indicate that the Temporary MAD could not be the only effective tools on OSA but also be used to predict patient's reactivity about permanent appliance treatment. Further studies are warranted to evaluate the relations between temporary MAD and permanent MAD.

백만장자의 주거 트렌드, 펜트하우스-View from the Top

박준형,Park, Jun-Hyeong 한국주택협회 2007 주택과 사람들 Vol.212 No.-

영국 제2의 도시 맨체스터를 가다

박준형,Park, Jun-Hyeong 한국주택협회 2006 주택과 사람들 Vol.194 No.-

맨체스터 시티는 영국의 한가운데 위치한 인구 70만의 도시다. 맨체스터 시티 주변에는 맨체스터를 생활권으로 하는 군소 도시들이 형성돼 있는데, 이러한 도시들과 맨체스터 시티를 합쳐 맨체스터(Greater Manchester)라는 광역 행정권을 형성한다. 맨체스터의 인구는 320만 정도로 영국에서 두 번째로 규모가 큰 도시다.