심부전의 한약 임상연구에 활용된 한약재에 대한 기구축 DB(K-HERB NETWORK)를 활용한 네트워크 분석

박수빈,김예지,배기상,김철현,윤인애,임정태,추홍민,Subin Park,Ye-ji Kim,Gi-Sang Bae,Cheol-Hyun Kim,Inae Youn,Jungtae Leem,Hongmin Chu 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.3

Objectives: Heart failure is a chronic disease with increasing prevalence rates despite advancements in medical technology. Korean medicine utilizes herbal prescriptions to treat heart failure, but little is known about the specific herbal medicines comprising the network of herbal prescriptions for heart failure. This study proposes a novel methodology that can efficiently develop prescriptions and facilitate experimental research on heart failure by utilizing existing databases. Methods: Herbal medicine prescriptions for heart failure were identified through a PubMed search and compiled into a Google Sheet database. NetMiner 4 was used for network analysis, and the individual networks were classified according to the herbal medicine classification system to identify trends. K-HERB NETWORK was utilized to derive related prescriptions. Results: Network analysis of heart failure prescriptions and herbal medicines using NetMiner 4 produced 16 individual networks. Uhwangcheongsim-won (牛黃淸心元), Gamiondam-tang (加味溫膽湯), Bangpungtongseong-san (防風通聖散), and Bunsimgi-eum (分心氣飮) were identified as prescriptions with high similarity in the entire network. A total of 16 individual networks utilized K-HERB NETWORK to present prescriptions that were most similar to existing prescriptions. The results provide 1) an indication of existing prescriptions with potential for use to treat heart failure and 2) a basis for developing new prescriptions for heart failure treatment. Conclusion: The proposed methodology presents an efficient approach to developing new heart failure prescriptions and facilitating experimental research. This study highlights the potential of network pharmacology methodology and its possible applications in other diseases. Further studies on network pharmacology methodology are recommended.

아동기 외상경험과 성인기 양육태도 및 신경증과의 관계

박수빈,Park, Subin 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The objective of this study was to examine the association between childhood adversity and parenting attitude and neuroticism in adulthood. Methods : Forty nine women were recruited from community and completed Early Trauma Inventory-Short Form (ETI-SF). We compared scores on the Maternal Behavior Research Instrument (MBRI), Neuroticism of NEO Personality Inventory (NEO-PI), and Beck Depression Inventory (BDI) between women with and without childhood adversity. Results : Compared to women without childhood adversity, women with childhood adversity showed more rejecting parenting attitude and higher Depression and Self-Consciousness scores on Neuroticism domain of NEO-PI. Total ETI-SF scores and emotional abuse scores were positively correlated with rejecting attitude scores on the MBRI and BDI scores. Physical abuse scores were positively correlated with rejecting attitude scores. There were positive correlations between rejecting attitude scores on the MBRI, Neuroticism scores on the NEO-PI, and BDI scores. Conclusion : Our results suggest that childhood adversity may have a negative impact on parenting attitude and emotional state in adulthood. For girls who experienced traumatic event, early intervention is needed to prevent the development of neurotic temperament and rejecting parenting in adulthood.

외상 후 스트레스장애 아동의 정신병리와 부모의 우울불안 증상과의 관계

박수빈,김소윤,권오향,배정훈,유희정,Park, Subin,Kim, So Yoon,Kwon, Oh-Hyang,Bae, Jeong-Hoon,Yoo, Hee Jeong 대한불안의학회 2013 대한불안의학회지 Vol.9 No.1

Objectives: The objective of this study is to examine the association between the children's psychopathology and age, intellectual quotient, and parental psychopathology in children with post-traumatic stress disorder (PTSD). Methods: The emotional and behavioral problems of 35 children with PTSD (23 boys, 12 girls, mean age, $10.26{\pm}2.47$ years) were investigated by retrospective chart review. Their parents' anxiety and depression symptoms were also investigated. We examined the correlations between children's psychopathology and their parents' anxiety and depression symptoms, as well as their age and IQ. Results: There were positive correlations between maternal trait anxiety and depression, and children's emotional problems. State and trait anxiety of children with PTSD were positively correlated with age, and attention-deficit hyperactivity disorder symptoms were negatively correlated with age. Conclusion: Our results suggest that psychiatric manifestation of children who experienced trauma could differ according to the development stage, and the treatment of children with PTSD should involve parental education about the effect of maternal emotional states on children.

도시거주 결혼이민여성의 정신건강 현황과 영향 요인

박수빈,용효중,홍진표,Park, Subin,Yong, Hyo Joong,Hong, Jin Pyo 대한불안의학회 2015 대한불안의학회지 Vol.11 No.1

Objective : The objective of this study was to examine the mental health status and its correlates of the marriage-migrant women in Seoul, Korea. Methods : One hundred and seventy marriage-migrant women and one hundred and sixteen married Korean women were recruited from community to complete Symptom Check List-90-Revision (SCL-90-R). Marriage-migrant women were also asked for their socio-demographic factors, acculturative stress, family-relationship stress, and social support. The scores on the SCL-90-R were compared between marriage-migrant women and married Korean women, and the correlates of marriage-migrant women's mental health were investigated. Results : Compared to married Korean women, marriage-migrant women showed lower levels of mental health problems including somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, paranoid ideation, and psychoticism. Longer length of residence in Korea, lower family income, social support, higher acculturation stress, and family relationship stress were all associated with mental health problems of marriage-migrant women Results : Our results suggest that mental health of marriage-migrant women is not necessarily bad, and several factors may affect their mental health. However, further studies are required in a larger representative sample to confirm the study findings.

신호정보(SIGINT) 위성의 특징과 개발 현황

박수빈(Subin Park),권오준(Ohjun Kwon),김주황(Juhwang Kim),엄재령(Jae-Lyung, Um),이준호(Junho Lee),장종진(Jong-Jin Jang) 한국항공우주학회 2022 한국항공우주학회 학술발표회 논문집 Vol.2022 No.11

주행 및 교통 시뮬레이션을 이용한 공격운전이 교통류에 미치는 영향 분석

박수빈(PARK, Subin),김윤종(KIM, Yunjong),오철(OH, Cheol),최새로나(CHOI, Saerona) 대한교통학회 2018 대한교통학회지 Vol.36 No.3

공격운전은 주변차량 운전자를 위협하며 주행하기 때문에 교통사고 발생 개연성이 높다. 따라서 공격운전의 법제도 마련, 검지, 관리방안 등 대책이 필요하다. 본 연구의 목적은 공격운전의 주행행태가 교통류에 미치는 영향을 분석하였다. Multi-agent 주행 시뮬레이션과 교통류 시뮬레이션 VISSIM을 이용하여 공격운전의 거동을 구현하였다. 교통류 시뮬레이션과 상충분석을 이용하여 공격운전이 교통운영효율성 및 교통안전성 측면에서 교통류에 미치는 영향을 분석하였다. 분석 시나리오는 다양한 교통상황과 공격운전차량 비율을 고려하여 설정하였다. 상충분석 결과 일반적으로 공격운전 주행행태는 교통안전성을 감소시키는 것으로 나타났다. 교통운영효율성 분석결과 흥미로운 점은 서비스 수준 A, B, C 경우 공격운전차량 비율이 증가할수록 평균주행속도가 증가하였다. 이와 반대로 서비스 수준 D와 E인 경우 공격운전차량 비율이 증가할수록 평균주행속도가 감소하였다. 본 연구 결과는 공격운전을 줄이기 위한 교통안전정책 마련 시 기초자료로서 효과적으로 활용될 수 있을 것으로 기대된다. Aggressive driving leads to a greater crash potential because it threatens surrounding vehicles. This study conducted traffic simulation experiments using driving behavior data obtained from multi-agent driving simulations. VISSIM traffic simulator and surrogate safety assessment model (SSAM) were used to identify the impacts of aggressive driving on traffic stream in terms of safety and operational efficiency. Market penetration rates (MPR) of aggressive driving vehicle, coupled with various traffic conditions, were taken into consideration in analyzing the impacts. As expected, it was identified that aggressive driving vehicles tended to deteriorate the traffic safety performance. From the perspective of operational efficiency, interesting results were observable. Under level of service (LOS) A, B, and C, it was observed that the average travel speed increased with greater MPRs. Conversely, the average travel speed decreased with under LOS D and E conditions. The outcome of this study would be effectively used for developing safety-related policies for reducing aggressive driving behavior.

HTML 웹 문서 무결성 검증 시스템

박수빈(Subin Park),조동섭(Dongsub Cho) 한국멀티미디어학회 2008 한국멀티미디어학회 학술발표논문집 Vol.2008 No.2

인터넷의 발전과 함께 다양한 응용 서비스들은 사용자들의 편의성과 정보의 접근성을 향상시키고 있다. 그러나 고도의 정보통신망 구축은 네트워크 침입의 위험을 증대시켰고 그에 따라 안정성 있는 인터넷 환경의 구축이 요구되고 있다. 웹에 대한 의존도가 커져감에 따라 정보의 고도화로부터 야기된 역기능이 사회적 문제로 지적되고 있으며 웹 페이지 변조 공격과 같이 웹의 취약점을 공략한 해킹 사건들이 많이 일어나고 있다. 이에 본 논문에서는 웹 페이지 변조 시 무결성을 검증할 수 있는 시스템을 개발하고자 한다. 이에 사용자는 ‘올바른 전송’을 확인함으로써 웹 페이지의 신뢰성을 증대시킬 수 있다.

주의력결핍 과잉행동장애 아동에서 α-2A 아드레날린 수용체 유전자의 MspI 유전자 다형성에 따른 메칠페니데이트 치료 전후 뇌관류 비교

박수빈(Subin Park),배정훈(Jeong-Hoon Bae),김재원(Jae-Won Kim),양영희(Young-Hui Yang),오승민(Seungmin Oh),홍순범(Soon-Beom Hong),박민현(Min-Heyon Park),김붕년(Boong-Nyun Kim),신민섭(Min-Sup Shin),유희정(Hee-Jeong Yoo),조수철(Soo-Churl 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.1

Objectives:Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods:Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results:No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion:Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.

인공지능 기반 실시간 교통신호 제어를 통한 운전자 만족도 향상에 관한 연구

박수빈(Subin Park),박주한(Juhan Park ),박성우(Sungwoo Park),배재현(Jaehyun Bae),이기동(Ki-Dong Lee) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.12

고전 다시쓰기를 통해 본 역사의식과 이상향 비교 연구 - 이광수(1923)와 채만식(1946)의 『허생전』을 중심으로

박수빈(Park Subin) 한국비평문학회 2020 批評文學 Vol.- No.78

본 논문은 ‘친일문학’을 통해 본 이광수와 채만식의 흥미로운 관계성에서 출발한다. 그들은 각기 다른 시기 자신들의 역사의식과 현실비판의식, 이상향을 고스란히 담은 고전, 『허생전』을 썼다. 여기에서는 일제강점기와 해방기 두 작가의 시대감각과 현실인식의 내부를 효과적으로 파악하고자 ‘인물-영웅모델’과 ‘이상향-새나라’의 형상화에 주목하여 두 작품을 비교분석한다. 이광수가 허생원의 ‘비범함’을 드러내는 데 서술의 목적을 두었다면, 채만식은 그의 ‘인간미’와 애민정신을 강조한다. 이광수의『허생전』이 모든 사람들로부터 무시당하던 초라한 한 선비가 순전히 자신의 비범한 지략(智略) 하나로 돈도 권력도 손쉽게 손에 넣는 통쾌한 ‘영웅적 모험담’이라면, 채만식의『허생전』은 조선의 역사와 운명을 걱정하는 한 선비가 자신의 사상과 능력을 시험하기 위해 끊임없이 백성을 구하는 ‘과정의 서사’라 할 수 있다. 그래서 이광수의 ‘허생원’이 자신을 업신여기던 사람들에게 능력을 보여주고 마침내 왕까지도 감탄하게 하는 비범한 인물로 그려진다면, 채만식의 ‘허생원’은 아직 그 여정이 채 끝나지 않은 길 위의 인물로 남는다. 두 작품 속 허생원은 각각 일제강점기 이광수가 염원하던 지도자상, 해방기 채만식의 고민을 고스란히 담고 있는 존재라는 점에서 의의가 있다. 또한 일제말기 이광수를 모방함으로써 자신의 친일세계를 구축했던 채만식이 ‘역사’와 ‘고전 다시쓰기’를 통해 해방기를 가능성의 시공간으로 만들어보고자 했다는 점에서『허생전』은 채만식 해방기 작품 세계에서 중요한 의미를 갖게 된다. This paper starts from the interesting relationship between Lee Kwangsoo and Chae mansik through ‘pro-Japanese literature’. Each of them wrote 〈Heosaengjeon〉 containing historical awareness, criticism on reality, a classic containing Utopia of their own lives. Two works were compared and analyzed to effectively grasp the period senses and the reality perception of Japanese colonial era and period of liberation by focusing on the image of the "character-hero model" and ‘Utopia –new country’. Lee Kwangsoo focused on writing to reveal extraordinariness of ‘Heo Saengwon’, while Chae Mansik ‘humanity’ and ‘love for the people’. So, Lee Kwang-soo"s 〈Heosaengjeon〉is ‘Hero Adventure Story’, in which a humble classical scholar ignored by all people easily put money and power into his hands with his extraordinary resource while, Chae Mansik"s 〈Heosaengjeon〉 is ‘Process Story’, in which a classical scholar worrying about history and destiny of Choseon constantly saves the people to test her own thoughts and abilities. So, Lee Kwang-soo"s Heo Saeng-won is depicted as extraordinary person who shows his ability to everyone ignoring him and finally even a king admires him, while Chae Man-sik"s ‘Heo Saengwon’ remains a character on the road that is not over yet. Heo Saengwon of the two works contains a person who Lee Kwangsoo longs for in Japanese colonial era and a person who Chae Mansik worries about in period of liberation respectively, which is very important in that Chae Mansik who built his own pro-Japanese world by imitating Lee Kwangsoo at the end of the Japanese Colonial Period wanted to make period of liberation a possible time space through ‘history’ and ‘rewriting classics’.