인후두부 이상감을 호소하는 환자와 갑상선 병변과의 임상적 연관성

박경호,박영학,황성재,강민곤,박홍진,김민식,조승호,Park Kyoung-Ho,Park Young-Hak,Hwang Sung-Jae,Kang Min-Gon,Park Hong-Jin,Kim Min-Sik,Cho Seung-Ho 대한기관식도과학회 2004 大韓氣管食道科學會誌 Vol.10 No.2

Background and Objectives : Globus pharyngeus is the feeling of a lump or foreign body in the throat. Otolaryngologists are often confronted with this condition, and some author reported that it represents 3 percent of all new clinic referral. The purpose of this study is to estimate the incidence of impalpable thyroid lesion in patients with globes pharyngeus and investigate possible association between globus pharyngeus and thyroid lesions. Material and Method : 146 patients with globus pharyngeus and 30 controls were prospectively examined by high resolution ultrasound. Results: Thyroid abnormalities were present in $75/146(51\%)$ patients with globus pharyngeus and in $7/30(23\%)$ controls. Of the patients with globus, 55 patients had a nodule or nodules, 11 patients had a cyst or cysts, 9 patients had diffuse abnormalities. Solitary nodule ranged from 4mm to 20mm. Conclusion : Impalpable, ultrasound detectable thyroid abnormailities are significantly more common in patients with globus pharyngeus than in controls. The thyroid abnormalities may be the cause of globus symptoms in some patients, and high resolution ultrasound is an important modality in patients presenting with globus.

과거민감도 스펙트럼을 포괄하는 공정 스케줄링 모델

박경호,황호영,이창건,민상렬,Park, Kyeong-Ho,Hwang, Ho-Young,Lee, Chang-Gun,Min, Sangl-Yul 한국정보과학회 2007 정보과학회논문지 : 시스템 및 이론 Vol.34 No.5

기존의 공정 스케줄링 방법들 중 GPS(generalized processor sharing)는 순간적 관점에서의 공정성을 추구하는 반면에, virtual clock은 장기적 관점에서의 공정성을 추구하는 특성을 지닌다. 이 논문에서는 이들의 차이가 과거의 서비스 정보를 추후의 스케줄링에 반영하는 정도에 있음에 주목하고, GPS와 virtual clock을 포괄하는 스펙트럼 형태의 스케줄링 모델을 제시한다. 이 모델에서 각 응용의 자원 획득 권한은 예치권한이라는 값으로 표현되는데, 예치권한은 각 응용별로 미리 정해진 고유한 비율로 계속 증가하며, 서비스를 받으면 소비된다. 소비되지 않고 누적된 예치권한은 과거에 서비스가 이루어지지 않은 정도를 표현하는 값이라고 볼 수 있으며, 이는 응용의 스케줄링 가능성을 높이므로 이후의 서비스 지연시간을 상대적으로 단축하는 효과를 낸다. 예치권한을 주기적으로 감쇄시키면 과거 정보의 반영 정도를 줄일 수 있으며, 이 때 그 감쇄 정도는 과거행태를 반영하는 정도를 의미한다. 과거의 정보를 전혀 반영하지 않을 경우 GPS의 특성을 나타내게 되며, 모두 반영할 경우 virtual clock의 특성을 보이게 된다. 이러한 스펙트럼 상에서는 평균지연시간과 장기적 공정성 사이에 절충 관계가 존재한다. 이 논문에서는 제시된 모델의 특성을 분석하고 실험을 통해 검증한다. GPS(generalized processor sharing) is a fair scheduling scheme that guarantees fair distribution of resources in an instantaneous manner, while virtual clock pursues fairness in the sense of long-term. In this paper, we notice that the degree of memorylessness is the key difference of the two schemes, and propose a unified scheduling model that covers the whole spectrum of history-sensitiveness. In this model, each application's resource right is represented in a value called deposit, which is accumulated at a predefined rate and is consumed for services. The unused deposit, representing non-usage history, gives the application more opportunity to be scheduled, hence relatively enhancing its response time. Decay of the deposit means partial erase of the history and, by adjusting the decaying rate, the degree of history-sensitiveness is controlled. In the spectrum, the memoryless end corresponds GPS and the other end with full history corresponds virtual clock. And there exists a tradeoff between average delay and long-term fairness. We examine the properties of the model by analysis and simulation.

누적적 잉여용량 공유를 통한 이질적 다중 서버 시스템의 공정 스케줄링

박경호,황호영,Park, Kyeong-Ho,Hwang, Ho-Young 한국정보처리학회 2007 정보처리학회논문지 A Vol.14 No.7

In this paper, we regard computer systems as heterogeneous multi-server systems and propose a cumulative fair scheduling scheme that pursues long-term fairness. GPS(generalized processor sharing)-based scheduling algorithms, which are usually employed in single-server systems, distribute available capacity in an instantaneous manner. However, applying them to heterogeneous multi-server systems may cause unfairness, since they may not prevent the accumulation of scheduling delays and the extra capacities are distributed in an instantaneous manner. In our scheme, long-term fairness is pursued by proper distribution of extra capacities while guaranteeing reserved capacities. A reference capacity model to determine the ideal progresses of applications is derived from long-term observations, and the scheduler makes the applications gradually follow the ideal progresses while guaranteeing their reserved capacities. A heuristic scheduling algorithm is proposed and the scheme is examined by simulation. 이 논문에서는 컴퓨터 시스템을 이질적 서버들로 구성된 시스템으로 간주하고, 장기적 관점에서 응용들간의 공정성을 추구하는 누적적(累積的) 공정 스케줄링 방법을 제시한다. 기존의 단일 서버 환경에서 주로 사용되는 GPS(generalized processor sharing) 기반의 스케줄링 알고리즘들은 순간적 관점에서 서버의 용량을 분배한다. 그러나 이를 이질적 다중 서버 환경에 적용하는 경우, 스케줄링 순서에 의한 지연시간의 오차가 서버들을 거치면서 누적될 수 있고, 잉여용량이 순간적 관점에서만 배분되기 때문에 장기적 관점에서 불공정성 문제가 발생할 수 있다. 본 논문의 방법에서는 각 응용의 예약용량을 보장하면서 잉여용량의 적절한 배분을 통해 장기적 관점의 공정 서비스를 추구한다. 이를 위해, 각 응용이 이상적으로 진행되기 위해 받아야 할 공정한 서비스 용량을 주기적 관찰을 통해 동적으로 파악하여 참조용량 모델로 삼고, 스케줄러는 응용들이 이 참조용량 모델을 점진적으로 따르도록 한다. 또한 이 모델을 효율적으로 구현하기 위한 휴리스틱 알고리즘을 만들고 실험을 통해 이를 검토한다.

이프리플라본 서방정 제조 및 약동학적 평가

박경호,Park, Kyoung-Ho 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.4

Ipriflavone is non-hormonal antiosteoporotic drug which inhibits bone resorption by reducing recruitment and/or differentiation of osteoclasts, and stimulates proliferation and differentiation of osteoblast, and also enhances calcitonin secretion in the presence of estrogen. Although some kinds of immediately-released preparation of ipriflavone are available in commercial market, in present study, we tried to formulate sustained-release tablet using coating method with hydrophobic and hydrophilic coating materials. In vitro dissolution test was applied to evaluate sustained-release patterns of several test preparations (Test tablet A, B and C) designed using different preparation method or different compositions. From the results of dissolution test, test tablet A which showed suitable dissolution profile was selected as the candidate of new product. Pharmacokinetic evaluation of test drug, ipriflavone sustained-release tablets, was conducted in 6 beagle dogs weighing $11.5{\pm}0.5\;Kg$ compared with $Theobon^{\circledR}$ tablet, immediately-released tablet (Kukjae Pharm. Co.) as reference drug. Two products were randomly administered to 6 beagle dogs, and after 1 week, cross-over study was conducted. From the present study, AUC and $T_{max}$ of test product were significantly different from those of reference product (p<0.05), respectively$(AUC\;:\;3646.28{\pm}472.56\;vs\;3646.28{\pm}472.56\;ng{\cdot}hr/ml,\;T_{max}\;:\;4.33{\pm}1.03\;vs\;1.42{\pm}0.38\;hr)$. But $C_{max}$ was not significantly different between two products (p>0.05) $(\;512.52{\pm}48.18\;vs\;443.97{\pm}140.53\;ng/ml)$. From the results of pharmacokinetic evaluations, it was noted that absorption amount of test product was increased, but absorption rate was delayed and $C_{max}$ of two products were not changed. And it was concluded that redesign of the sustained-release preparation which has a lower content of iprifavone rather than test tablet A must be considered.

암모니아 용액중(溶液中)에서 바나듐의 용해(溶解)와 침전거동(沈澱擧動)

박경호,김홍인,이진영,Park, Kyung-Ho,Kim, Hong-In,Lee, Jin-Young 한국자원리싸이클링학회 2008 資源 리싸이클링 Vol.17 No.1

암모니아 용액중에서 바나듐(V)의 침출 시 바나듐의 용해와 후공정에서 $NH_4VO_3$로 침전 회수를 위한 조건에 관한 기초연구를 수행하였다. 침출공점에서 바나듐의 용해도를 높이기 위해서는 높은 온도가 필요하며 $(NH_4)_2CO_3$ 20g/L와 $NH_4OH$ 2.5M의 혼합 용액에서 반응온도가 $90^{\circ}C$일 때 용액 중 바나듐 농도가 16.8g/L이다. 한편 용해된 바나듐을 침전물 형태로 회수하기 위해서는 $25^{\circ}C$에서 $NH_4Cl$을 20g/L를 첨가하고 72시간 정치했을 때 용액에 잔류 바나듐의 농도를 0.0268g/L까지 낮출 수 있었으며 이 경우 바나듐의 회수율은 99.8%이었다. This study was carried out to investigate the solubility of vanadium in ammoniacal solution and precipitation of $NH_4VO_3$ as a function of temperature and addition of ammonia salt. Higher solution temperature is required to get high solubility of vanadium and the vanadium concentration of solution was 16.8g/L at $90^{\circ}C$ with the solution of 20 g/L $(NH_4)_2CO_3$ and 2.5M $NH_4OH$. From this solution, vanadium could be precipitated up to 99.8% with adding 20 g/L $NH_4Cl$, 72 hours settling time at $25^{\circ}C$.

강재(鋼材) 토류판 적용사례에 관한 고찰

박경호,Park, Gyeong-Ho 한국건설안전협회 2008 建設 安全技術 Vol.47 No.-

망간단괴 제연 시 금속계 폐자원의 처리

박경호,남철우,김홍인,박진태,Park Kyung-Ho,Nam Chul-Woo,Kim Hong-In,Park Jin-Tae 한국자원리싸이클링학회 2005 資源 리싸이클링 Vol.14 No.4

망간단괴 용융환원 시 철과 니켈을 주로 함유하고 있는 Ni-Cd 폐전지와 코발트 등을 함유한 석유화학 폐촉매를 대상으로 첨가 원료로서의 사용 가능성을 검토하였다. Ni-Cd 폐전지의 경우 망간단괴와의 첨가비에 관계없이 $5\%$ 코크스 첨가 시, 주회수 대상 금속인 니켈을 전량 합금상으로 회수할 수 있었다. 한편 폐촉매의 경우 폐촉매의 첨가비가 증가할수록 많은 환원제가 필요한데 이는 폐촉매 중의 코발트가 산화물 형태로 존재하여 이를 환원하기 위한 환원제가 필요하기 때문이다. 본 방법은 금속계 폐자원을 처리하고 동시에 유가금속을 회수할 수 있는 방법으로 향후 망간단괴 개발의 상용화 시 경제성을 증대시키고 폐자원의 재활용에 기여 할 것이다. Deep-sea Manganese nodules was treated with reduction-smelting process with adding the spent Ni-Cd battery or the cobalt contained spent catalyst for recovery of nickel and cobalt metals. The nickel in the spent Ni-Cd battery could be recovered by adding $5\%$ coke as a reducing agent regardless of the amount of battery added. However, to recover cobalt from the spent catalyst, it is require to add more coke for reduction of cobalt oxide in the catalyst. The treatment of metal wastes with manganese nodules can contribute to lower the cost for the processing of nodules and to facilitate the recycling of metal wastes.

정신분열증 환자에서의 Haloperidol 및 Reduced Haloperidol의 혈장농도와 임상반응과의 상관성

박경호,김무진,이명걸,심창구,이민화,Park, Kyung-Ho,Kim, Mu-Jin,Lee, Myung-Gul,Shim, Chang-Koo,Lee, Min-Hwa 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.3

The relationship between the plasma haloperidol (HP) concentration and clinical response, and the effects of its active metabolite, reduced haloperidol (RH) on clinical response of HP were investigated in schizophrenic patients. In clinical study I, with 17 schizophrenic patients (male 8, fermale 9) who were administered with three different fixed doses of HP (15, 30 and 50 mg/day) for 3 weeks, the concentrations of HP and RH in plasma and blood and clinical response had been checked before and every week during the study. The clinical response was evaluated by the method of brief psychiatric rating scale (BPRS), and relative improvement of clinical response based on baseline BPRS (before drug treatment) was calculated. The concentrations of HP and RH in plasma and blood were assayed by HPLC. In clinical study II, the plasma RH/HP concentration ratios were checked in 11 patients who were administered with high doses of HP, over 60 mg a day, because of the poor clinical response at usual doses of HP. Plasma HP concentration and relative improvement of BPRS at 3 week in schizophrenic patients showed a 'curvilinear' relationship, and the clinical response was improved relatively over 50% based on the baseline BPRS in the range of $5{\sim}57\;ng/ml $ of HP in plasma. Also, the plasma RH concentrations were increased nonlinearly as the plasma HP concentration increased, and in high plasma HP concentration, over 30 ng/mI, clinical response gradually decreased, while the plasma RH/HP concentration ratio increased nonlinearly. Blood partition coefficients of HP and RH were not changed according to daily HP dose and duration of drug therapy. From these results, it is noted that the higher plasma RH/HP concentration ratio, resulted from the accumulation of RH as HP concentration increased, might explain the 'curvilinear' decrease of HP clinical response.

황(黃) 원료(原料)로서 pyrite와 chalcopyrite를 사용(使用)한 matte 상(相)의 제조(製造) 및 침출특성(浸出特性)

박경호,남철우,장종신,안승천,김홍인,Park, Kyung-Ho,Nam, Chul-Woo,Chang, Jong-Sin,Ahan, Sung-Chen,Kim, Hong-In 한국자원리싸이클링학회 2008 資源 리싸이클링 Vol.17 No.1

Artificial mattes were prepared with adding pyrite or chalcopyrite as sulfur sources with Cu-Ni-Co-Fe alloy. The major phases identified by X-ray diffraction pattern were $(FeSi)_9S_8$, $CuFeS_2$, FeS, $Co_4S_3$, $Ni_3S_2$ and $Cu_2S$ for both mattes, and the matte prepared by adding chalcopyrite showed the higher peak of $Cu_2S$ due to high content of copper. Under optimum conditions, more than 95% copper, 90% nickel and 90% cobalt were extracted into leaching solution and sulfur concentration in the mattes did not much affect the leaching efficiency of the metals. The increase of the amount of pyrite or chalcopyrite added decreased pH in leaching solution and increased the concentration of iron ion dissolved in the leaching solution and the amount of residue. Cu-Ni-Co-Fe 함금상에 황의 원료로서 pyrite 또는 chalcopyrite를 첨가하여 매트상을 제조하는 방법에 대하여 검토하였다. 두 매트상 모두 주성분은 $(FeSi)_9S_8$, $CuFeS_2$, FeS, $Co_4S_3$, $Ni_3S_2$ 그리고 $Cu_2S$의 금속황화물 이었으며, chalcopyrite를 첨가한 매트의 경우 구리의 함량이 높아 $Cu_2S$의 피크가 더 높게 나타났다. 제조한 매트상의 침출 결과 모두 구리는 95%이상, 니켈과 코발트는 90% 이상의 침출율을 보였다. Pyrite와 chalcopyrite 첨가량이 증가할수록 침출액의 pH는 낮아지고, 용해되어 있는 철이온의 농도와 잔사량은 증가하였다. 한편 매트 중 황의 함량변화에 따른 유가금속의 침출율은 모든 시료에 대해 크게 변하지 않았으며, 다만 pyrite를 이용하여 제조한 매트의 경우에 Ni과 Co가 황 함량 증가에 따라 다소 증가하는 경향을 나타내었다.

낙동강 살리기 22공구 현장 적용 친환경준설공법 소개

박경호,김정위,이만수,이원재,Park, Gyeong-Ho,Kim, Jeong-Wi,Lee, Man-Su,Lee, Won-Jae 한국수자원학회 2010 물과 미래(한국수자원학회지) Vol.43 No.3