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위상피이형성과 위암종에서 FasL의 발현 및 Apoptosis에 관한 연구
박건욱,한상영,이종훈,금동주,노명환,최석렬,김종성,노미숙,Park Gun Uk,Han Sang Young,Lee Jong Hun,Keum Dong Joo,Roh Myung Hwan,Choi Seok Ryeol,Kim Jong Seong,Roh Mee Sook 대한위암학회 2001 대한위암학회지 Vol.1 No.2
Purpose: This study was to observe whether the apoptotic function of tumor-infiltrating lymphocytes (TIL) is induced in human gastric epithelial dysplasia and gastric adenocarcinoma according to the role of FasL expression. Materials and Methods: A total of 56 gastric epithelial dysplasia and gastric adenocarcinoma patients were enrolled in this study: 9 cases of gastric epithelial dysplasia, 18 cases of early gastric carcinomas (EGC) and 29 cases of advanced gastric carcinomas (AGC). Immunohistochemical staining was performed for FasL and CD45, and the terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) method was used to detect cell death in tumor-infiltrating lymphocytes. Results: 1) Positive reactions of FasL to neoplastic cells were $88.9\%$ (8/9) in gastric epithelial dysplasia, $83.3\%$ (15/18) in EGC, and $75.9\%$ (22/29) in AGC. 2) Expression of TIL was decreased in the FasL positive region and was increased in the FasL negative region, and significant expression of TIL was observed in the AGC group (P=0.001). 3) Expression of apoptotic TIL was very similar to the FasL expression, and $100\%$ expression was observed in gastric epithelial dysplasia group. 4) Expression of apoptotic TIL was increased in the FasL positive region and decreased in the FasL negative region, and significant apoptotic expression was observed in the gastric epithelial dysplasia and EGC groups (P=0.0420, P=0.0263, respectively). Conclusion: These results suggest that FasL is a prevalent mediator of immune privilege in epithelial dysplasia and cancer of the stomach.
높은 승압비를 가진 단일 스위치형 소프트 스위칭 부스트 컨버터
박건욱(Kun-wook Park),정두용(Doo-yong Jung),정용채(Yong-chae Jung),원충연(Chung-yuen Won),서광덕(Kwang-duck Seo) 전력전자학회 2009 전력전자학술대회 논문집 Vol.2009 No.1
A dc/dc converter for low voltage such as battery and fuel cell system is required to step up and regulate the low and widely variable voltage. In this paper, we have proposed a soft switching boost converter with high voltage gain using a single switch. Simulatin results obtaind from a 400W are given. Through the theoretical analysis and simulation, operation modes and characteristics of the proposed topology is verified.