http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
포스터 발표 : 위 ; 장형화생 아형에 따른 cyclooxygenase-2(COX-2)의 발현
민상운 ( Sang Woon Min ),윤경원 ( Kyong Won Yoon ),조성범 ( Seong Beom Cho ),박창환 ( Chang Hwan Park ),이완식 ( Wan Sik Lee ),주영은 ( Young Eun Joo ),김현수 ( Hyun Soo Kim ),최성규 ( Sung Kyu Choi ),유종선 ( Jong Sun Rew ),김세 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 위점막의 장형화생은 조직학적, 점액 및 효소 조직화학적 특성에 따라 여러 가지 아형으로 분류되며 제 3형, 즉 sulfomucin을 가진 불완전형 장형화생의 아형이 장형위암종과 관련이 있다고 보고되고 있다. 위암종을 포함한 여러 암종에서 COX-2의 발현의 증가가 보고되고 있으며, apoptosis 억제, 혈관생성 증가 등의 기전에 의해 종양의 발생 및 진행에 영향을 미치는 것으로 알려져 있다. 이에 본 연자들은 장형화생 단계에서 미치는 COX
위암 및 전구병변에서 Cyclooxygenase-2와 p53의 발현
민상운 ( Sang Woon Min ),손영해 ( Young Hae Shon ),박창환 ( Chang Hwan Park ),이완식 ( Wan Sik Lee ),주영은 ( Young Eun Joo ),최성규 ( Sung Kyu Choi ),유종선 ( Jong Sun Rew ),박창수 ( Chang Soo Park ),김세종 ( Sei Jong Kim ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.4
Background/Aims: The mechanism that controls cyclooxygenase-2 (COX-2) expression is not clear yet. Recently, it is reported that COX-2 expression is significantly high in the presence of mutated p53 genes. Thus, we investigated the expression of COX-2 and p53 in each stage of chronic gastritis, intestinal metaplasia, dysplasia, and gastric cancer, and studied their correlations. Methods: The expressions of COX-2 and p53 in 128 local lesions were assessed immunohistochemically by using Micro-Probe System in a total of 101 patients. There were 23 chronic gastritis, 50 intestinal metaplasia, 34 dysplasia, and 21 intestinal type of gastric cancer. Results: The expression of COX-2 was increased in 30.4% (7/23) of chronic gastritis, 68% (34/50) of intestinal metaplasia, 82.3% (28/34) of dysplasia, and 85.7% (18/21) of intestinal type gastric cancer. The expression of COX-2 was significantly increased as the disease progressed into gastric cancer (p<0.001). On the other hard, p53 was expressed positively in 38% (8/21) of gastric cancer, and 5.9% (2/34) of dysplasia. Although the difference was not statistically significant, expression of COX-2 seemed to be increased in gastric cancer with positive p53. Conclusions: COX-2, one of the major factors involved in the gastric carcinogenesis, may be involved in the early stage. Additionally, co-expression of COX-2 and p53 may have a role in promoting gastric carcinogenesis. (Korean J Gastroenterol 2003;41:268-276)
장형화생 아형에 따른 inducible nitric oxide synthase (iNOS)의 발현
백강우 ( Kang Woo Paik ),민상운 ( Sang Woon Min ),손영해 ( Young Hae Sohn ),박창환 ( Chang Hwan Park ),이완식 ( Wan Sik Lee ),주영은 ( Young Eun Joo ),최성규 ( Sung Kyu Choi ),유종선 ( Jong Sun Rew ),박창수 ( Chang Soo Park ),김 대한내과학회 2003 대한내과학회지 Vol.64 No.2
목적: 제3형 장형화생, 즉 sulphomucin을 가진 불완전형 장형화생의 아형은 장형위암종과 관련이 있다고 보고 되고 있다. NOS에 의해 생성되는 NO는 종양발생에 관여하는 nitrosamine 생성, DNA 손상, 만성 염증과 관련된 조직손상의 매개체로 작용하여 종양발생에 중요한 역할을 할 것으로 추측되고 있고, 위암종을 포함한 여러 종류의 암에서 NOS의 발현의 증가가 보고 되고 있다. 이에 본 연구에서는 장형화생 단계에서 미치는 NO의 영향을 Background: Intestinal metaplasia (IM) type 3 has been suggested to be associated with gastric cancer of intestinal type. Excess nitric oxide (NO) has been reported to be associated with pathogenesis of various diseases, including gastric cancer. This stu
과민성 대장 증후군 환자에서 대장 비만세포에 관한 연구
박창환 ( Chang Hwan Park ),나호영 ( Ho Young Na ),민상운 ( Sang Woon Min ),이완식 ( Wan Sik Lee ),주영은 ( Young Eun Joo ),김현수 ( Hyun Soo Kim ),최성규 ( Sung Kyu Choi ),유종선 ( Jong Sun Rew ),김세종 ( Sei Jong Kim ),이민철 ( M 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<Background> The visceral sensory hypersensitvity is most important in the pathophysiology of the irritable bowel syndrome(IBS). But the mechanisms responsible for visceral hypersensitivity are unclear. These exaggerated responses may be due to increased
포스터 전시 : 위장관 ; 위암종에서 신생혈관형성에 대한 혈관내피성장인자와 p53의 역할
주영은 ( Young Eun Joo ),손영해 ( Young Hae Sohn ),윤경원 ( Kyong Won Yoon ),박근수 ( Geun Soo Park ),민상운 ( Sang Woon Min ),이완식 ( Wan Sik Lee ),박창환 ( Chang Hwan Park ),김현수 ( Hyun Soo Kim ),최성규 ( Sung Kyu Choi ),유 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈Objectives〉 Angiogenesis is of crucial importance for tumor growth and development of metastases. VEGF. The purpose of our study was to evaluate the prognostic from established clinicopathological parameters in gastric cancer. 〈Methods〉 In this study, we
궤양성 대장염 환자에서 혈청 Interleukin-10과 Interleukin-12 측정에 의한 Th1/Th2 반응의 평가
최성규,김태연,김현수,주영은,김세종,유종선,서강석,민상운,유상두 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1
Background/Aims: Previous studies showed that ulcerative colitis (UC) was a T-helper 2 (Th2) response dominant disease while Crohn's disease was a T-helper 1 (Th1) response dominant disease. In this study, we evaluated the Th1 and Th2 reponses by measuring the serum levels of interleukin (IL)-10 and IL-12 in patients with UC and normal controls. Methods: Serum concentrations of IL-10 and IL-12 were measured using an enzyme linked immunosorbent assay in 24 patients (15 with mild to moderatie disease, 9 with severe disease) with UC and 11 healthy controls. Results: The serum concentrations of IL-10 in patients with UC were significantly higher than those of controls (P$lt;0.05), while the concentrations of IL-12 in the patients were significantly lower than those of controls (P$lt;0.05). Additionally, the serum concentrations of IL-10 and IL-12 were not closely related to the severity of the disease. Conclusions: The above results suggest that UC may be resulted from dysregulation of Th1 and Th2 immune response. However, there was no definite correlation between the severity of disease and the level of IL-10 or IL-12.
최성규,이수정,김현수,김남진,김세종,유종선,나호영,민상운 대한내과학회 2000 대한내과학회지 Vol.59 No.1
Primary squamous cell carcinoma of the liver is very rare. It has previously been reported to arise from the lining of developmental hepatic cyst or in hepatic teratoma. Also, there are published reports of the occurrence of such a tumor in association with intrahepatic cholesterol stones, hypercalcemia in a cirrhotic liver, and clonorchiasis. The previous reports showed male predominance. The prognosis of this tumor is extremely grave, and no case has survived more than one year. A 73-year-old woman was found to have a primary squamous cell carcinoma of the liver. The tumor, which measured 11×7 cm and located in the left hepatic lobe, was diagnosed by percutanous biopsy. No evidence of other primary foci was demonstrated in systemic workup. Left hepatectomy was done. In computed scan on 4 months after operation, tumor seedings were revealed on right hepatic lobe, omentum and several lymph nodes. She died on 6 months after operation.(Korean J Med 59:100-103, 2000)