일 지역사회거주 치매의심 노인에서 Apolipoprotein E ${\varepsilon}4$와 인지기능 간의 연관성

문석우,서정석,남범우,최진영,이창훈,박경운,김기웅,Moon, Seok Woo,Seo, Jeong Seok,Nam, Beom Woo,Choi, Jin Young,Lee, Chang Hoon,Park, Kyoung Un,Kim, Ki Woong 대한생물정신의학회 2008 생물정신의학 Vol.15 No.1

Objectives : It was the aim of the present paper to examine the impact of the apolipoprotein E(APOE) ${\varepsilon}4$ on cognitive performance in community-dwelling elderly samples with 'questionable dementia'. Methods : Total 295 samples who were diagnosed with 'questionable dementia' in the recent year and completed the Korean version of the Consortium Establish a Registry for Alzheimer's Disease(CERAD-K) neuropsychological assessment protocol, were recruited. The CDR test established score of 0.5. Genomic DNA was extracted from the venous blood and APOE genotyping was done in this group. Their cognitive performance was compared by the occurrence of the APOE ${\varepsilon}4$ allele. Results : The impact of ${\varepsilon}4$ allele was significant in the Word List Recall Test(WLRT, F=4.511, df=1, p=0.035). The 'young-old' group aged 75 years and under had a significantly lower performance on the Word List Recall Test(WLRT, F=5.090, df=1, p=0.015), but the 'old-old' group over 75 years of age had not significantly different performance on the all the item of tests in ${\varepsilon}4$+ allele group. Conclusion : The conclusion to be drawn here is that community-dwelling elderly samples with ${\varepsilon}4$ allele in 'questionable dementia' had a significantly lower performance on the Word List Recall Test in the CERAD-K neuropsychological test batteries and the effect was prominent in the 'young-old' age group.

신경회로망을 이용한 PID 제어기의 이득조정

문석우(Seok-Woo Moon),이종호(Chong Ho Lee) 대한전기학회 1992 대한전기학회 학술대회 논문집 Vol.1992 No.7

가족력 있는 전측두엽치매 1예

문석우(Seok Woo Moon),함웅(Woong Hahm),이규항(Kyu Hang Lee) 대한노인정신의학회 2003 노인정신의학 Vol.7 No.2

The average age of frontotemporal dementia onset is much younger than that of the Alzheimer's disease. Behavioral disturbances occur at the early stage of frontotemporal dementia, and social dysfunction and personality deterioration may ensue. For this reason, it may be misdiagnosed as other psychiatric disorders. Therefore, more careful observation and concern is required for proper diagnosis. This report is about the case of a patient who had been misdiagnosed of disorders like schizotypal personality disorder, schizophrenia, obsessive compulsive disorder etc., and therefore have been treated for those. We reviewed this case based on the data of neuropsychiatric history, family history, neuropsychological test, brain MRI, and SPECT, and considered this case as frontotemporal dementia with family history. This is the first frontotemporal dementia case with family history in Korea, so hereafter we may discover the gene locus associated with this case. This study can be very useful for the following frontotemporal dementia studies in Korea.

조기발병 경도인지장애에서 해마 부분체의 구조적 변화

문석우(Seok Woo Moon),유도연(Do Yen Yoo) 대한생물치료정신의학회 2021 생물치료정신의학 Vol.27 No.1

Objectives:The aim of this study was to examine the structural change in the hippocampal subfields in early-onset (EO) mild cognitive impairment (MCI) patients associated with the APOE ε4 carrier state. Methods:This study had 50 subjects aged 55-63 years, all of whom were diagnosed with amnestic MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K). The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer’s disease (AD) converted (ADconv) groups 2 years later. The volumes of hippocampal subfields were measured for all the subjects. The calculations were based on the change of the volumes between the 2-year-interval brain Magnetic resonance image (MRI) scans between MCIcont and ADconv groups according to the Apolipoprotein ε4 (APOE ε4) carrier state. Results:There was a significant correlation between APOE ε4 allele and structural changes in several hippocampal subfields. The volume reduction in cornus ammonis 1 (CA1) field and subiculum, especially in the APOE ε4 carriers. The significance was more prominent in ADconv group. Conclusion:These results suggest that the possession of APOE ε4 allele may lead to significantly greater predilection for the structural changes in hippocampal subfields, showing significant changes, especially in the ADconv patients compared with MCIcont patients.

체홉과 현대 러시아 농촌소설

문석우(Seok Woo Moon) 한국러시아문학회 2001 러시아어문학 연구논집 Vol.10 No.-

N/A

우울증과 인지손상

문석우 ( Seok Woo Moon ) 한국정신병리진단분류학회 2008 精神病理學 Vol.17 No.1

The word pseudodementia implies that the depression is primary and that the poor cognitive impairment is a concomitant aspect of the primary condition and the cognitive affective disorder implies that the cognitive disorder is primary and that the affective symptom is secondary. Some elderly patients with depression appear irreversibly demented but fully recover cognitively with successful treatment of the depression. Several studies demonstrate that approximately the half of individuals who present with both depression and cognitive impairment is cognitively intact on long-term follow-up and that the other half develops a permanent cognitive disorder. I review evidence that supports the existence of the entity, depression induced cognitive impairment (DICI).

기억과 회상에 나타난 체홉의 창작과 예술문제

문석우(Moon Seok Woo) 한국노어노문학회 2012 노어노문학 Vol.24 No.1

이 글은 전통적인 창작원리 속에서 기억이나 회상이라는 현상을 러시아문학은 어떻게 발전시켜왔으며, 또 그런 문학전통을 이어받은 작가 체홉은 자신의 창작과정에서 기억의 현상을 어떻게 예술적으로 사용했는지를 살펴보려는데 목적이 있다. 제 2장에서는 19세시 러시아문학에서 기억의 문제와 체홉, 제 3장에서는 체홉의 작품에서 기억현상과 내면세계의 묘사를 다루었다. 연구결과로는 체홉 작품에서 기억은 시-공간에 자리 잡은 서술 구조의 요소로서 인물의 구성 성분으로 여겨지며, 한편으로는 그의 창작 전체의 주제론적인 바탕을 이루고 있음을 알 수 있었다. 기억의 현상, 특히 회상은 체홉 작품에서 예술구조상 중요하고 다기능적인 요소로 작용하며, 작가의 세계관과 창작과정에서 중요한 구성 요소라는 생각을 갖게 만든다. 체홉이 창작활동에서 기억의 주제를 이용한 이유는 예술상의 필요성 때문이었다. 자신만의 심리적인 문체를 만들어야 할 필요성과 자기 작품이 보여주는 장르적 특성이 심리주의의 특별한 형식과 주제를 구성하는 특별한 방법을 요구하기도 했기 때문이다. 체홉의 심리주의 기법은 인간의 정신세계에 대한 작가의 지속적인 관심이기도 했다. 체홉이 작품을 구성하는데 사용한 여러 기억 현상은 형태를 강화할 때 특별한 방법이었으며 묘사와 심리, 그리고 주제구성을 간결하게 만드는 방법이었다. 회상, 그리고 특히 회상이 발생하는 무의식적인 성격이 보여주는 심리적인 과정의 메커니즘, 상상과 꿈의 메커니즘과 병적인 상태를 발생시키는 메커니즘을 사용한 덕택에 체홉은 인물의 내면세계나 의식의 변형으로 이루어진 작품에서 시학적으로 심리적으로 작품을 압축하여 간결하게 만들 수 있었다고 생각한다. This paper observes how Russian literature developed such phenomena as memory and recollection according to traditional writing principles and how Chekhov, as the write who followed such literary traditions, used in artistic manner the phenomenon of memory in his writing. In chapter 2 we deal with significance of memory in literature, and the object of study is Chekhov’s phenomenon of memory in Russian literary tradition, in chapter 3 we observe phenomenon of memory and description of the inner world in Chekhov’s works. As a result of study, we learn that in Chekhov’s works memory as an element of narration structure that takes place in time and space is considered as a constitute component of a character and in the meantime has become a thematic foundation of his whole writing. Phenomenon of memory and especially recollection are essential and multifunctional artistic elements of Chekhov’s works and one comes to conclusion that they are an important constitute elements of the writer’s worldview and creative work. Besides, another reason for Chekhov to use a theme of memory is the artistic necessity. A need for creating his own psychological literary style and genre specifics of his works demanded a particular method of composing particular form and theme of psychologism. Chekhov’s psychological technique was also explained by his continuous interest in human’s mental world. Various phenomena of memory that Chekhov used while composing his works were a special method of strengthening the form and ways of making concise description, psychology and theme construction. One comes to think that as a benefit of using recollection and especially mechanism of psychological process that shoes the unconscious nature of recollection’s development, as well as using mechanisms of imagination and dream and mechanisms that produce abnormal conditions, Chekhov in his works, that are composed of transformation of character’s inner world or consciousness, was able to enrich his works poetically and psychologically and make them more concise.

한국에서 투르게네프의 소개와 1910년에서 1930년대 한국문학에 미친 영향

문석우(Seok Woo Moon) 세계문학비교학회 ( 구 한국세계문학비교학회 ) 1997 世界文學比較硏究 Vol.1 No.-

체홉과 사할린 여행 : 그 문학적 의미

문석우(Moon Suk Woo) 한국노어노문학회 2010 노어노문학 Vol.22 No.3

본 논문은 작가 체홉의 사할린여행 계획과 준비과정을 살펴보고, 사할린여행을 전후로 작가에게 일어난 변화와 작품경향, 그리고 이 여행이 가져다 준 문학적 의미를 고찰하려고 한다. 체홉이 갑자기 사할린여행을 결심하게 된 이유를 추론해보고 이에 대한 여러 비평가들의 견해도 소개한다. 그러나 무엇보다 중요한 것은 사할린여행 이후에 나타나는 그의 문학세계의 변화에 초점을 맞추고 작가의 발전단계를 살펴보는 일일 것이다. 일반적으로 많은 작가들이 시도한 여행은 그들의 창작활동에 큰 전환점을 마련해주었거나, 늘 변화와 새로운 것에 목말라 하는 그들에게 신선한 주제와 소재를 제공해주었기 때문이다. 체홉은 무엇을 할 것인가 고민하다 자신의 일깨워진 사회의식에 따라 사할린 섬주민들의 비참한 실상에 민중이 관심을 갖도록 하기 위해, 그리고 창작의 의무를 다하기 위해 1890년 사할린 여행을 감행했다고 생각된다. 그는 비극적인 유형의 섬 주민들의 삶과 운명을 러시아의 운명, 러시아의 역사적, 사회적, 정신적인 비극과 연결 지어 보려했다. 항상 새로운 것을 추구하며 자유로운 창작을 꿈꾸었던 체홉은 사할린여행 이후에 예술 및 정신세계를 확장해가며 진지한 문학세계를 보여주었고, 이전 작품들과 다른 장르를 사용하기 시작했다. 또한 체홉은 여행 이후 똘스또이의 영향을 벗어나기 시작한다. 『6호실』, 『골짜기에서』와 『농부들』』에서 도시의 무자비하고 억압적인 상황과 상업자본주의에 의해 붕괴되어가는 농촌의 현실을 보여주었다. 그리고 다양한 주제로 삶과 도덕, 죽음과 불멸의 문제 등 인생에 대한 깊은 성찰을 보이기 시작했다. 이제 여행 이전의 소극적인 창작태도에서 여행 이후에는 적극적인 태도로 변하며 자신의 사상을 본격적으로 표출하기 시작한 것이다. 체홉이 1890년대에 다양한 작품과 여러 장르의 발전을 보여줄 수 있었던 것은 삶의 전환점이 된 사할린 여행이 큰 역할을 했다. 체홉은 자신의 문학 발전과정을 거치면서 사회의 다양한 갈등을 이해하고 점차 인간들의 삶이 보여주는 비참한 결과에 관심을 보였다. 사할린 여행 이후 더욱 견고해진 그의 세계관과 사회에 대한 인식 때문이었다. 사할린 여행은 그에게 풍부한 인생경험과 창작을 위한 다양한 소재를 제공해 준 전환점이 되었으며, 이후의 작품창작에 큰 영향을 주었다. Chekhov’s travel to Sakhalin was very meaningful to the writer. This study aims to identify what made Chekhov decide to go to Sakhalin and whether the journey was a vacation or an attempt to find a new turning point for his writing. The body of this study identifies the background which influenced the writer’s decision to go to Sakhalin, the rough outline of The Island of Sakhalin: From Travel Notes - documentary literature written by Chekhov throughout his journey, and changes in Chekhov’s writing features after the travel. Chekhov’s motives for Sakhalin journey were the writer’s duty to inform society about the abandoned and isolated society of the island and to obtain the answer to the present question demanded by that generation. As for the influence on literary developmental process, through this travel Chekhov took his courage as a writer who always pursued new things, a free artist who escapes from the boring reality. To examine the change in his writing, a descriptive feature in the The Island of Sakhalin is remarkable. It shows a direct descriptive style to deliver his ideological and philosophical messages along with objective description through an analytical method. Such description is more specified through detailed description, which shows a position of an active narrator who intends to deliver his utterances or messages directly. Through the process of literary maturity, Chekhov came to understand social conflicts further and have more interest in miserable life of the public. He created more abundant social and psychological stories that consolidated the consciousness of the society and view of the world. His travels were a turning point that provides a variety of experiences and materials for creative writing, and had a great influence on his later writing. Chekhov could write various stories and develop many genres because of the travel to Sakhalin which was a turning point of his life.

러시아의 혁명적 아방가르드 예술정신

문석우(Moon Seok Woo) 한국슬라브유라시아학회 2001 슬라브학보 Vol.16 No.1

On the 19th century, modern ideas. modern thoughts were reflected not only upon politics but culture and art, and therefore formed the representative currency of the respective periods. If realism concentrates its attention on the subject. 'how do we live?'. Then in the case of modernism, it asks, 'by what way do we have to live?'. However, the two trends in thought have a common point in that reason is respected and a reasonal world view is pointed to in them. (that they respect reason and point to a reasonal world view) And another representative artistic trend was an Avant-garde movement in Europe, which also reflected modern characteristics. The meanings of the word modernism are various, so when we mention in reference to the 20th century's forms of art, especially to the 20th century's literature, it is used very well. During the period from 1910s to '30s, the term, modernism, freed itself from the attitude of having general sympathy with modern things and had a more special relationship with the artistic experimental consciousness. This period went through the disordered state brought about by World War I and the economic panic. However, it was a period of great creation on the cultural dimension. A strange tension against the complex and varied world was centered on the modernist-writers' fundamental awareness. The writers found the situation they were continuously facing confounded reality and realized some of their problems in their writing method. Modernists, when they describing the experiences wearing high complexity, feel that the classical realism method is not appropriate, and therefore come to take many experiments through various methods in every artistic field. All these attempts inevitably tried to find new methods in order to transcend the greatly simplified experience which had been described by classical art. Hence, rather than just unfolding the plain story, juxtaposition was preferable, and irony rather than unified sentiment. The attitude of the writers or artists were seeking through modernism was usually to deny the authority and conventionality, and was a kind of Nihilism against the established culture. But while searching for the more complicated sentiment on reality, modernism seems to lose the balance of logicality, and this problem has been pointed out as a vulnerable point of modernism by numerous critics. On the contrary, the advocates of the point insisted that the successful experimental methods were much more delicate and complicated than the existing classical old ones, and more appropriate for today's reality, and therefore could help in forming the ultimately satisfactory logicality and the principle of order. In conclusion, the Avant-garde spirit's one characteristic must be the precise awareness of various problems in art, or the constant self-consciousness. The evidence can be showed off from the power and variety of criticism which helped the literature of modernism. We should put a significant meaning into the fact that the recent criticism begins to regard that modernism as an endeavor for providing modern experience through a proper manner, or a highly meaningful method of art.