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대장암에서 β-catenin 및 p53 단백의 발현양상과 종양의 병리학적특성 간의 상호관계
문길민,박영진,김한성,박성혜,김지일,김기홍,송병주,이명수,김철남,장석효 대한대장항문학회 2002 Annals of Coloproctolgy Vol.18 No.5
Purpose: Both the β-catenin and p53 play a crucial role in the process of colon carcinogenesis. The expression of β-catenin and/or p53 has been reported to be associated with pathologic features of tumor and prognosis of patients. In addition, several recent studies have suggested a close biological association between p53 expression and nuclear β-catenin level. We analyzed the pathologic variables and p53 expression according to the intra-nuclear β-catenin expression in colon cancer to make such assumptions more clear since they are still controversial issues. Methods: The expressions of β-catenin, p53 and Ki-67 protein in colon cancer were determined by immunohistochemical staining. The relationship between these protein expressions and tumor characteristics was statistically analyzed. R esults: The intra-nuclear β-catenin accumulation was not associated with any of the pathological variables including lymph node metastasis and tumor differentiation, but it was correlated with higher level of Ki-67 proliferation index (P=0.006) and negative staining of p53 (P =0.015). Positive p53 staining was significantly associated with lymph node metastasis (P=0.006), lymphatic invasion (P=0.03) and venous invasion (P=0.02). C onclusion: These results support the suggestion that intra-nuclear accumulation of β-catenin may regulate the p53 activity in colorectal cancer. In addition, positive staining of p53 may be used as a valuable prognostic indicator since it was strongly associated with lymph node metastasis, lymphatic and venous invasion.
김지호(Ji Ho Kim),문길민(Kil Min Moon),이정우(Joung Woo Lee),박석일(Park Suk Il),김주호(Ju Ho Kim) 한국자동차공학회 2012 한국자동차공학회 부문종합 학술대회 Vol.2012 No.5
The pulsating pressure prediction technique was developed in the diesel engine fuel supply system with EUI. The back flow from compressed fuel injector to fuel rail makes a sudden rise in pressure pulsation and the fuel lines causes a pressure wave is transmitted as a whole. If there is an excessive rise in pressure caused by repetitive impact is damaging to the precision parts. The excessive rise in pressure caused by repetitive impact may cause damage to precision parts. Recent emission regulations to strengthen key components of the fuel gauge accuracy made the management of fuel pressure pulsation increase. In this analysis, the 1-D simulation model for predicting the peak is built and test results were simulated. A Built model based on factors that affect the pressure pulsation, were reviewed: the pipe stiffness and length of HCI supply parts, the diameter of orifice, the size of fuel pipe directly connected to HCI.
엔진 헤드/블록 열 피로 내구 해석을 위한 비정상 온도 해석 기술
이준석(S. Lee),문길민(K.M. Moon),하응지(E.J. Ha),방인완(I.H. Bang),송경(S. Keung),박재인(J.I. Park) 한국자동차공학회 2008 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
Thermal fatigue, which leads to cracks and possible failure in high loaded engine, is a new challenge in modem engine development. Thus, an accurate thermomechanical fatigue analysis is a key to a successful life prediction of an engine assembly. However, due to many constraints, especially cost effectiveness and develop time reduction, simulation techniques are needed to substitute for thermal fatigue tests. ALCF(Low Cycle Fatigue) analysis is the most qualified simulation method to accurately predict the thermal fatigue. A transient heat transfer method has been developed to give boundary conditions to LCF analysis and also a LCF analysis is performed and validated with test results.
오일갤러리 유동을 고려한 디젤 엔진 피스톤 온도분포 예측
하응지(Eung-Ji Ha),문길민(Kilmin Moon),박재인(Jaein Park) 한국자동차공학회 2007 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
Control of piston temperature has become one of the important factor for a recent high power and high speed diesel engines. The temperature control for diesel engine piston is commonly achieved by piston cooling jet system with oil gallery flow. However, the oil flow and piston cooling characteristics in the oil gallery have not been understood accurately. Therefore, a numerical procedure has been developed to simulate unsteady oil flow in the piston oil gallery and to predict the piston temperature distribution with oil gallery flow. The predicted piston temperature distribution showed good agreement with measured data Parametric studies were performed to evaluate the influence of oil jet velocity, oil jet nozzle area and oil gallery exit area on the piston temperature. It is found that the average heat transfer coefficient of the oil gallery increased proportional to the amount of oil jet flow. The filling ratio of oil flow and the average piston temperature are converged as the oil flow rate increased.
엔진 온도 평가와 열정산을 위한 통합 열전달 해석 기술
김태균(Taegyun Kim),문길민(Kilmin Moon),송경(Kyong Song),박재인(JaeIn Park) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_1
The increase of power density is limited by engine temperature. Engine component temperatures are an important consideration. because it will affect material strength and lubricating performance, therefore, it is of great importance tor engine designers to estimate component temperature in the early stage of engine development. In the present work, the conjugate heat transfer analysis of calculating heat transfer between head/block solid components and coolants was used. to estimate solid component temperature distribution and heat rejection to coolant. In particular. unsteady heat transfer simulation method of Intake/exhaust valve system were developed. The calculation results were presented and compared with experimental results to confirm the validity of this methodology. It is also applied to optimize engine cooling system through thermal balance.
김태균(Taegyun Kim),문길민(Kilmin Moon) 한국자동차공학회 2013 한국자동차공학회 부문종합 학술대회 Vol.2013 No.5
Variable valve actuation has become a very popular feature in today’s engines. With many of these systems being hydraulically actuated, the engine lubrication system requires enhancement to support their function. To expand the system’s operational range with respect to speed and temperature, a traditional solution has been to increase oil pressure by increasing pump displacement. To better optimize the system, a variable displacement vane pump has been adapted to the engine lubrication system. A pivoting outer ring design is employed that is able to vary the pump’s displacement as a function of pump regulating oil pressure which in-turn provides a net reduction in its drive torque. This paper discusses the CFD (Computational Fluid Dynamics) method by developing a dynamic force balanced model for variable displacement vane pump and also the 1-D detailed VDVP model integrating a lubrication circuit to analyze the pump power consumption over driving cycle mode.