급성 유기인제 중독중에서 호흡부전에 대한 임상적 고찰

류형국(Hyung Kug Ryu),한형원(Hyung Won Han),조희영(Hee Young Cho),김인환(In Hwan Kim),이일세(Il Se Lee),이경민(Kyung Min Lee) 대한내과학회 1993 대한내과학회지 Vol.45 No.4

Background: Respiratory failure being the most common cause of death in acute organophosphorus poisoning has been known to develop due to acute cholinergic effect, but it may persist after disappearance of acute cholinergic symptoms and may also develop after acute cholinergic period. Atropine and PAM have been used as an antidote in the treatment of acute organophos-phorus poisoning, but it has been recognized that they could not prevent the development of respiratory failure that occurs after acute cholinergic period. Method: 94 patients with acute organophosphorus poisoning have been studied retrospectively by the authors at the Pohang Sunlin Presbyterian Hospital from Jan 1988 to Dec 1992. Of this number, 19 patients with respiratory failure were evaluated. Results: 1) Among the exposed organophosphates in 19 patients with respiratory failure, fenthion was the most common in 5 cases, dichlorvos in 3 cases, demeton in 2 cases, phenthoate and edifenphos each in l case and unknown agents in 7 cases. 2) Mean time to onset of the respiratory failure was 22.2±20.1 hours (range from 1 to 77 hours) and mean time to recovery of the respiratory function in 7 cases who received respiratory support for protracted period was 9 days (range from 5 to 16 days). 3) Serum cholinesterase activity on arrival had no significant difference between patients with and without respiratory failure (22.5% vs 34.4 % of normal subjects). 4) Mean dose of PAM administered within first 24 hours had no significant difference between patients with and without respiratory failure (1.35±1.01g vs l.02±1.21 g), Mean dose of atropine administered within first 24 hours was significantly higher in patients with than patients without respiratory failure (48.75±37.58 mg vs 22.71±29.45 mg). 5) 12 patients among a total of 94 patients expired, so that the mortality rate was 12.8%. Among the expired eases, 6 patients discontinued treatment due to economic problems and only 6 patients died in hospital during the treatment. Conclusion: These results suggest that respiratory failure in acute organophosphorus poisoning may develop without any cholinergic symptoms and has no correlation with serum cholinesterase activity. Atropine and PAM could not prevent the development of respiratory depression, so that establishment of airway and respiratory support should be done in all cases of respiratory failure.

Propylthlouracil에 의한 간염 3예

한형원,류형국,김인화,이일세,신영호,신현수,이경민 大韓消化器病學會 1995 大韓消化器病學會誌 Vol.27 No.1

작약(芍藥) 재배년수(載培年數)와 지상부(地上部) 고사시기(枯死時期)에 따른 수량(收量)과 Paeoniflorin 함량 변화(變化)

박소득,김기재,김재철,김세종,류정기,김형국 韓國藥用作物學會 2000 한국약용작물학회지 Vol.8 No.2

작약 정식후 1년생은 일반관리법으로 재배하고 2년생부터 3년생 및 4년생까지 1년에 4회씩 지상부 병해에 적용약제를 살포하여 정상생육한 작약과 6, 7, 8, 9월 하순에 2년 및 3년동안 연속 고사한 작약을 10월 상순에 수확하여 수량과 paeoniflorin 함량을 조사하여 다음과 같은 결과를 얻었다. 경장, 경직경 및 주당 줄기수는 고사시기가 빠를수록 정상생육에 비해 감소하는 경향이었다. 주당 화뢰수는 정상생육한 3, 4년생이 각각 11.5개, 16.2개인데 비해 6월 하순 고사구는 각각 5.2개, 4.6개로 현저히 적었고, 측화수도 6월, 7월 하순 고사구가 정상생육에 비해 현저히 감소하였다. 재배년수별 지상부 고사시기에 따른 주근장 및 주근경은 3년생의 경우 정상생육이 각각 44.2cm, 20.7mm 인데 비해 6 월 하순고사구가 각각 38.7cm, 18.2mm 로 가장 많이 감소하였다. 상품성이 우수한 뿌리 굵기 10mm 이상의 뿌리수는 3, 4년 정상생육한 작약이 26.0개, 40.0개인데 비해 고사시기가 빠를수록 점차 감소하여 2, 3 년 연속 6월 하순에 고사한 작약은 각각 21.1개 , 33.2개로 가장 적었다. 건근수량은 3년 연속 고사한 4년생 작약에서 6월 하순 고사가 1,007kg/10a로 가장 낮았고, 정상생육구에서는 1,603kg/10a으로 유의적으로 높았다. paeoniflorin 함량은 3년생과 4년생 간에는 차이가 없었고, 고사시기가 빠를수록 증가하여 6월 하순 고사구가 가장 높았다. 뿌리굵기별 paeoniflorin 함량은 뿌리가 굵을수록 감소하였다. Field experiments were conducted to investigate the yield and paeoniflorin content between healthy peony and blight plot of top part with every year during 3 years at June, July, August, September, separately. Stem length and diameter, No. of stem in the blight plot of peony were decreased in early in blight time compared with those in no blight growth. No. of flower buds per plant was 5.2, 4.6 in 3 year- grown and 4year-grown plots at late June blight compared with 11.5, 16.2 in no blight. No. of axillary flower was also similar to as above. Main root length and root diameter was most decreased in the plot of late June blight compared with healthy peony. No. of root more than 10mm of root diameter was small in order of blight time, namely Late June, July, August and September. The root dry yield of 4 year healthy peony was most high in 1,603kg per 10a, but it was lowed in 1,007kg in the plot lasted blight during 3years at late June. Paeoniflorin content was no different between 3year-grown and 4year-grown, but it was high in late June blight plot increased with the early in blight time.

고온초전도체 Y₁Ba₂Cu₃O7-δ 박막의 Hall 효과

허재호(J. H. Her),류제천(J. C. Ryu),김형국(H. K. Kim),김장환(J. W. Kim) 한국자기학회 1994 韓國磁氣學會誌 Vol.4 No.1

High Tc superconducting Y₁Ba₂Cu₃O_(7-δ) thin film was grown up for c-axis orientation by epitaxial growth method on LaAlO₃ single crystal substrate. The crystal structures of this thin film were found to be c-axis orientation by X-ray diffraction patterns. Hall effect and resistivity measurements were made by van der Pauw method. Hall resistivity was calculated from the magnetoresistivity by considering thermomagnetic effect. The relation was ρ_H = ρ_stanα_n - QBT Ss/Ks The measured Hall resistivity and the calculated one are in good agreement each other.

신증후군에 합병된 뇌동맥 혈전증

이경민,강문규,조희영,배효근,류형국 대한신장학회 1991 Kidney Research and Clinical Practice Vol.10 No.2

Thrombosis is one of the important complications in nephrotic syndrome. Hypercoagulability is known as the principal contributing factor in the pathophysiologic mechanism, but the precise mechanism is not clear yet. Venous thrombosis is frequently encountered, but arterial thrombosis is a relatively rare complication and has been reported mainly in nephrotic children. We are reporting a adult nephroitic patint who developed thrombosis of posterior cerebral artery. Histology of the kidney showed focal glomerulosclerosis. The patient improved with steroid therapy along with anti-platelet drug.

Propylthiouracil에 의한 감염 3예

한형원(Hyung Won Han),류형국(Hyung Kyg Ryu),김인환(In Hwan Kim),이일세(Il Se Lee),신영호(Young Ho Shin),신현수(Hyeon Soo Shin),이경민(Kyung Min Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1

Although propylthiouracilis widely used for the treatment of hyperthyroidism, reports on hepatic injury by this drug are few. The clinical and histologic severity of propylthiouracil-induced hepatitis varies from mild to fulminant hepatic failure. Hypersensitivity is known as the principal pathophysiologic mechanism, but the precise mechanism remains obscure. Recently we e.perienced three cases of overt hepatitis induced by propylthiouracil therapy. Histologic e.amination was made in all three cases and revealed the features of subacute hepatic necrosis, centrilobular necrosis and chronic active hepatitis, respectively. All the patients recovered near completely after the discontinuation of propylthiouracil. Propylthiouracil rarely develops hepatic injury, but may induce severe hepatitis. Thus, monitoring of liver function test should be done in all patients who are receiving the drug due to thyrotoxicosis. (Korean J Gastroenterol 1995;27:125-131)

자연기흉에 동반된 재팽창폐부종

조희영(Hee Young Cho),류형국(Hyung Kug Ryu),한형원(Hyung Won Han),배효근(Hyo Keun Bae),박봉기(Bong Kee Park),이경민(Kyung Min Lee) 대한내과학회 1992 대한내과학회지 Vol.43 No.2

Reexpansion edema is a unilateral noncardiogenic pulmonary edema thnt may develop as a complication of reexpansion of collapsed lung. This complication after reexpansion of spontaneous pneumothorax is extremely rare. The possible mechanisms underlying the reexpansion edema are due to multiple factors, increased pulmonary vascular permeability is one of the primary contributing factors. Reexpansion edema is more likely to occur when the duration of collapse is at least three or more days and the extent of pneumthorax is extensive. It is recommended that rapid evacuation of air with application of a large negative intrapleural pressure be avoided. The prognosis of reexpansion edema is relatively good, but occasionally may lead to fatal outcome. We report here a case of reexpansion edema after treatment of spontaneous pneumothorax which presented serious clinical manifestations.

만성 활동성 간염을 동반한 Wilson병

신현수(Hyeon Soo Shin),한형원(Hyung Won Han),류형국(Hyung Kyg Ryu),김인환(In Hwan Kim),이일세(Il Se Lee),신영호(Young Ho Shin),이경민(Kyung Min Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1

Wilsons disease is a rare inherited disease transmitted with an autosomal recessive trait and characterized by the excessive accumulation of copper in the body, principally in the liver and brain, but with involvement of kidneys, eyes, and skeletal system as well. We experienced a patient with Wilsons disease who showed chronic active hepatitis and cbaracteristic copper accumulation in liver parenchyme and abnormal laboratory finding, neurologic symptom, Kayser-Fleischer ring. Low copper diet and chelation of excess copper resulted in improvement of neurologic symptom in a few months. We report a case of Wilsons disease in male patient with review of literature. (Korean J Gastroenterol 1995;27:132-137)