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나선형 CT와 16 Slice MDCT의 Brain과 Abdome 검사 시 산란선에 관한 연구
윤재혁(Jae hyeok Yun),류병규(Byeong gyu Ryu),이관원(Gwang won Lee),김동수(Dong su Kim),장양선(Yang seon Jang),구양수(Yang su Ku) 대한CT영상기술학회 2008 대한CT영상기술학회지 Vol.10 No.1
Purpose The present study purposed to measure the degree of scattered ray of radiation in spiral CT and 16-Slice MDCT of brain and abdomen using Rando phantom and to examine the change in non-patients’ exposure to scattered ray according to distance between the central beam and the patient and the reduction of exposure according to the thickness of a protection outfit for shielding from radiation. Materials and methods We measured the change of scattered ray on non-patients according to distance between the brain beam of CT and the patient and the change of scattered ray according to the thickness of an apron for shielding from scattered ray, assuming a critically ill patient and an infant on Somatom Plus 4 and MDCT table at the present hospital using Rando phantom under the same setting of cerebral and abdominal CT scan parameters. In order to reduce errors in measurements, each factor was measured three times and the mean value was obtained. The height of the survey meter probe was 111.5cm, which is ordinary adults’ iliac crest level. Results A. In the result of brain test with Plus 4, the reduction rate of scattered ray at a distance of 50cm according to distance from the central beam without an apron (15.5mR) and with an apron on: 1. When Pb equivalent was 2.5mm, the reduction rate of scattered ray was 91.55% at 50cm, 94.82% at 100cm, 98.64% at 150cm, and 99.38% at 200cm. 2. When Pb equivalent was 5.0mm, the reduction rate of scattered ray was 98.50% at 50cm, 99.26% at 100cm, 99.58% at 150cm, and 99.70% at 200cm. 3. When Pb equivalent was 7.5mm, the reduction rate of scattered ray was 98.87% at 50cm, 99.37% at 100cm, 99.79% at 150cm, and 99.80% at 200cm. B. In the result of brain test with 16-Slice MDCT, the reduction rate of scattered ray at a distance of 50cm according to distance from the central beam without an apron (16.47mR) and with an apron on: 1. When Pb equivalent was 2.5mm, the reduction rate of scattered ray was 95.40% at 50cm, 97.69% at 100cm, 98.84% at 150cm, and 99.33% at 200cm. 2. When Pb equivalent was 5.0mm, the reduction rate of scattered ray was 98.54% at 50cm, 99.18% at 100cm, 98.54% at 150cm, and 99.66% at 200cm. 3. When Pb equivalent was 7.5mm, the reduction rate of scattered ray was 98.10% at 50cm, 99.55% at 100cm, 99.86% at 150cm, and 99.78% at 200cm. C. In the result of abdomen test with Plus 4, the reduction rate of scattered ray at a distance of 50cm according to distance from the central beam without an apron (61.47mR) and with an apron on: 1. When Pb equivalent was 2.5mm, the reduction rate of scattered ray was 91.52% at 50cm, 97.15% at 100cm, 98.74% at 150cm, and 99.40% at 200cm. 2. When Pb equivalent was 5.0mm, the reduction rate of scattered ray was 98.48% at 50cm, 99.19% at 100cm, 99.60% at 150cm, and 99.72% at 200cm. 3. When Pb equivalent was 7.5mm, the reduction rate of scattered ray was 98.81% at 50cm, 99.49% at 100cm, 99.71% at 150cm, and 99.82% at 200cm. D. In the result of abdomen test with 16-Slice MDCT, the reduction rate of scattered ray at a distance of 50cm according to distance from the central beam without an apron (79.47mR) and with an apron on: 1. When Pb equivalent was 2.5mm, the reduction rate of scattered ray was 96.56% at 50cm, 98.64% at 100cm, 99.34% at 150cm, and 99.69% at 200cm. 2. When Pb equivalent was 5.0mm, the reduction rate of scattered ray was 98.96% at 50cm, 99.45% at 100cm, 99.72% at 150cm, and 99.85% at 200cm. 3. When Pb equivalent was 7.5mm, the reduction rate of scattered ray was 99.56% at 50cm, 99.75% at 100cm, 99.86% at 150cm, and 99.94% at 200cm. Conclusion According to the results of this study, scattered ray decreased with the increase of distance. The scattered ray shielding effect was highest when the Pb equivalent of the radiation shielding outfit was 7.5mm. However, the reduction rate of scattered ray with a radiation shielding outfit at thickness of 5.0mm was higher (+4% on the average) than that with an outfit a
형질전환동물세포주에서 벤조피렌의 변이유발성에 대한 천연물질의 항 돌연변이 효과
엄미옥,한의식,손수정,김종원,류병규,변은경,강일현,강혁준,길광섭,오혜영 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
인간에게 고퉁을 주고 있는 질병중 많은 부분이 돌연한이로 인한 특정 유전자의 손상과 손상된 윤전자의 발현과 관련되어 있음이 밝혀져 왔다. 특히 암은 대표적인 유전자 돌연변이의 결과로 생기는 빌병으로서, 많은 암 유발 용힌중 화학물질에 의한 돌연변이 유발작용이 발암성과 관련하여 많은 관심의 대상이 되고 잇다. 따라서 본 연구에서는 외부DNA를 자신의 genome내게 삽입시킨 형질전환동물로부터 제조된 세포주를 이용하여 유전자 돌연변이를 검출할 수 있는 최신 유전독성 연구기댄을 확립하고자 하였다. 시험법을 확립하기 위하여 f3c f gene을 target으로 하는 Big Blue· Transgenic Mouse Embryonic Cell을 사용하였으며,시험법의 타당성 및 재현성여분를 확인하기 위하여 음성대조물질로는 1% DMSO, 양성대조물질로는 100rg/mf MNU(rnethrlnitrosourea)를 이웅하여 시험한 결과 mutant frequency(MF)는 각각 0.55±0.39Nle-', 4.26±1.51×10-'으로 나타나 재현성을 확인하였다. 또한 이 시험법의 유용성을 높이기 위하여 B[alP (benzo(alpyrene)를 양성대조물질로 in oifro대사환성화계에서 시험한 결과, 처리농도 20, 40, 60rgjm1에 대하여 Mf값이 9.1츠겪.14×10-", 14.3츠깆.86×10-', 20.St3.78×10-"로서 농도의존성을 보였다. 또한 식품을 비롯한 각종 천연물에는 돌연변이원 물질의 활성을 억제 또는 경감시키는 작용이 많이 보고되고 있어 갈조류의 일종으로서 강력한 항산화효과를 나타내는 것으로 알려진 료」ooi3 rfofonif☞ra(속칭 :곰피)를 사옹하여 꽉립된 시험법으로 항돌연변이 효과를 점색하고자 하였다. 양성대조물질로 사용한 MNU에 대하여 곰릭의 메탄을 추출물을 병용투여하여 항돌연변이 효자를 시험하였다. 100rg/mf MNU와 곰피 25.6, 51.2, 100.3#9/mf을 병용처리한 결과 MF가 각각 67, 79, 74% 감소하여, 형질전환동물세포주께서 공피 추출물치 돌연변이 억제 효과를 관찰하였 다. 그러나 암 예방제 개발의 기초자료로 활용하기 위해서는 돌연변이된 염기 서열을 분석하여 변이의 종류와 특성을 확인하여 그 작용기전을 밝히는 추가연구가 수챙되어야 할 것으로 사료된다. Transgenic animal cell with a A shuttle vector containing a fac ftarget gene is useful as a short-term in oifro mutagenesis assay. The gene is recovered from the cells treated by exposiog mousegenomic DNA to in oifro packaging extracts and plating the rescued phage on agar plates containing S-brorno-4-chloro-3-indolyl fD-galactopyranoside (X-gal). Phage with mutations in the f3c f gene formblue plaques, whereas phage with a nonrnutated fac J form colorless plaques, so mutant is defected easily.In order to estabilish this new transgenic technology, we studied mutagenicity of the direct-ectingalkylating agent N-methyl-N-nitrosourea (MNU ) and indirect mutagen benzora]pyrene in the BigBlue" transgenic mouse emf)ryonic cell line. Treatment of the cells with MNY or benzo[alpyrene causedinduction of mutations over 1% DMSO negative control and we conformed the reproducibility of thetransgenic mutagenicity assay. Also, dose-dependent response has been ohserved in benzo[a]pfrene-treatment cells. Sdrfonia afofonif☞ra, an edible brown algae, haying a strong antioBidizing activity, wasevaluated its antimutagenic effect by performing this assay, the methanol extract of Sffonia sfofonifrrashowed rfuction of mutation frequencies in MNU-treated transgenic mouse cells.