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바이오칩을 이용한 Protein Kinase C의 활성에 대한헤스페리딘의 저해 효과
강정애,노종국,최미희,정영진,박상현 한국방사선산업학회 2011 방사선산업학회지 Vol.5 No.1
Protein kinases are the most important drug targets for the treatment of numerousdiseases. The involvement of protein kinase C (PKC) in many biological processes such as development,memory, cell differentiation, and proliferation has been demonstrated. PKC is recognizedas an important player in carcinogenesis. Thus, a variety of PKC inhibitors have been investigated. Among them, flavonoids have been demonstrated to affect the activity of many mammalianin vitro enzyme systems. The recent investigation was performed to evaluate the inhibitory effectsof hesperidin, which is a flavonoid, on the proliferation and carcinogenesis of many cancers. Inthis study, an efficient kinase assay based on a biochip using radio-phosphorylation was establishedand performed for an examination of the inhibitory effects of hesperidin on PKC activity atdifferent concentrations of 50, 200, 500 nM. It was found that hesperidin shows inhibitory potencyon PKC, and that the biochip can be used to rapidly screen kinase inhibitors resulting in the therapeuticagents.
손민주,노종국,이주상,장범수,박상현 한국방사선산업학회 2012 방사선산업학회지 Vol.6 No.2
Gold nanoparticles (GNPs) have led to the development of a new field in the diagnosisand treatment of diseases such as cancer. An efficient synthesis of gold nanoparticles within therange of 8~57 nm was established by γ-ray irradiation. The good point of a radiation-basedmethod is the production of gold nanoparticles with a higher concentration and narrower sizedistribution compared with conventional methods. The size of gold nanoparticles was controlledusing two methods. : (i) varying the γ-ray irradiation dose of 10 to 25 kGy and (ii) varying the concentrationof HAuCl4 solution from 4 to 40 mM. In addition, the GNPs were radiolabeled using[125I]NaI in a simple and fast manner with high yields. The produced gold nanoparticles were characterizedusing a transmission electron microscopy (TEM), a UV-visible spectrophotometer, anda radio-TLC imaging scanner. From these results, these radiolabeled GNPs can be applicable fora radioisotope tag of biomolecules.
ICR 마우스에서 감마선 조사로 유도된 조혈조직 손상 모델 확립
강정애,노종국,장범수,정영진,박상현 한국방사선산업학회 2013 방사선산업학회지 Vol.7 No.1
Ionizing radiation causes the massive generation of reactive oxygen species, resultingin cellular and tissue damage. The present study was performed to evaluate γ-irradiation inducedcellular damage in ICR mice. The mice were divided into four groups with ten mice in each group. Group 1 served as an unexposed control group. Groups 2, 3, and 4 were exposed to 3, 5, and 7Gyof γ-radiation, respectively. Five mice per group were sacrificed 1 and 7 days after γ-radiation. Exposure to γ-irradiation resulted in hematopoietic damage in a dose-dependent manner whencompared with the unexposed control group, which featured a significantly decreased spleen index. However, the exposed mice showed no significant differences in their serum AST, ALT and in thehistopathological change of their liver. These results suggest that γ-irradiation is a good tool to preparea hematopoietic damage model. This animal model can be employed to study the hematopoieticefficacy of biologically active compounds.
방사선 손상 Balb/C 마우스 모델에서 누에 체액(Silkworm Hemolymph)의 간조직 보호 효과
남유리,강정애,노종국,최미희,Hayu Tyas Utami,장범수,박상현 한국방사선산업학회 2014 방사선산업학회지 Vol.8 No.1
This study was designed to evaluate the protective effect of silkworm hemolymph againstγ-irradiation induced damage in the liver of mice. Female Balb/C mice (6 weeks old) were exposedto γ-irradiation (6 Gy) and administered orally to silkworm hemolymph (5 ml kg-1 BW) for 7 dayspost-irradiation. The body weight, spleen index, plasma aspartate transaminase (AST), plasmaalanine transaminase (ALT), and liver malondialdehyde (MDA) levels were determined. Comparedwith irradiated control mice, the activity of plasma AST and the level of MDA were significantlydecreased in mice treated silkworm hemolymph. These results show that silkworm hemolymph isfound to have a protective effect against γ-irradiation induced damage in mice.
감마선 조사로 유도된 세포 손상 마우스에서 루틴 투여 후의 방사선 방호 효과
강정애(Jung Ae Kang),윤선혜(Seon Hye Yoon),노종국(Jong Kook Rho),최대성(Dae Seong Choi),장범수(Beom-Su Jang),박상현(Sang Hyun Park) 한국식품과학회 2015 한국식품과학회지 Vol.47 No.3
본 연구는 BALB/c 마우스에서 감마선 조사 후 루틴을 7일 동안 경구투여하여 감마선 조사로 인한 조혈계 및 간세포 손상에 대한 방사선 회복 효과를 검토하였다. 루틴의 투여는 감마선 조사군에 비해 조혈 면역계 손상을 억제하여 보호하였으며, 증가된 간독성 지표 효소도 유의적으로 감소하여 간세포 손상에 대한 보호효과를 확인하였다. 방사선 조사에 의해 체내에서 생성된 자유 라디칼은 생체물질과 결합하여 지질과산화를 일으키고 산화적 스트레스를 유도하여 조직을 손상시킨다. 루틴을 투여한 군은 감마선 조사군에 비해 지질과산화가 유의적으로 낮게 나타나 방사선에 의한 장해를 감소시킨 것으로 사료된다. 루틴을 투여한 군의 항산화 효소의 활성은 감마선 조사군에 비해 유의적으로 증가하여 생체 내에 항산화 활성을 회복시켰다. 이 상의 결과를 통해 방사선 조사 후에 루틴의 투여는 방사선에 의한 조혈계 및 간세포 손상에 대해 회복 효과가 있어 방사선 보호제로 유용하게 사용될 수 있다. This study aimed to investigate the therapeutic effect of rutin against whole-body γ-irradiation in BALB/c mice. BALB/c mice were randomly divided into four groups and exposed to 6 Gy γ-irradiation. One hour later, mice were orally administered rutin (50 and 100 ㎎/㎏) for seven consecutive days. γ-Irradiation (6 Gy) resulted in cellular damage as manifested by elevated levels of plasma hepatic marker enzymes and lipid peroxidation in liver tissue, accompanied with decreased spleen and thymus indices, and white blood cell count. In addition, γ-irradiation significantly decreased the levels of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and catalase. Rutin treatment significantly protected against γ-irradiation-induced cellular damage, which was evident by the improvement in the status of most of the investigated parameters. Therefore, rutin has beneficial effects against radiation-induced damage.