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방사선 손상 Balb/C 마우스 모델에서 누에 체액(Silkworm Hemolymph)의 간조직 보호 효과
남유리,강정애,노종국,최미희,Hayu Tyas Utami,장범수,박상현 한국방사선산업학회 2014 방사선산업학회지 Vol.8 No.1
This study was designed to evaluate the protective effect of silkworm hemolymph againstγ-irradiation induced damage in the liver of mice. Female Balb/C mice (6 weeks old) were exposedto γ-irradiation (6 Gy) and administered orally to silkworm hemolymph (5 ml kg-1 BW) for 7 dayspost-irradiation. The body weight, spleen index, plasma aspartate transaminase (AST), plasmaalanine transaminase (ALT), and liver malondialdehyde (MDA) levels were determined. Comparedwith irradiated control mice, the activity of plasma AST and the level of MDA were significantlydecreased in mice treated silkworm hemolymph. These results show that silkworm hemolymph isfound to have a protective effect against γ-irradiation induced damage in mice.