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남윤성,정창진,김남근,윤태기,차광렬,Nam, Yoon-Sung,Jeong, Chang-Jin,Kim, Nam-Keun,Yoon, Tae-Ki,Cha, Kwang-Yul 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.3
Objective : To analyze the clinical characteristics of obese infertile women. Material and Method: Height, weight, body mass index, menstrual pattern, glucose, insulin, glucose/insulin ratio, dehydroepiandrosterone sulfate (DHEA-S), testosterone, free testosterone and plasminogen activator inhibitor (PAI-1) of 15 obese infertile women were tested. Results: Of 15 obese infertile women, the number of diabetes mellitus, hyperinsulinemia, and insulin resistance was 2 (13%), 2 (13%), 2 (13%), respectively. The incidence of increased DHEA-S, testosterone, and free testosterone was 7 (47%), 1 (7%), 6 (40%), respectively. Notably, all patients showed increased PAI-1. Conclusions: Obesity is associated with infertility as well as many kinds of health problems. Obesity is closely related to insulin resistance and it also causes hyperandrogenism. Increased PAI-1 is one of the important causes of thrombophilia. Consequently, in the workup of obese infertile patient, many aspects of health problems should be considered.
Bromocriptine 질투여로 치료된 프로락틴과다증 1례
남윤성,이우식,박찬,윤태기,차광열,Nam, Yoon-Sung,Lee, Woo-Sik,Park, Chan,Yoon, Tae-Ki,Cha, Kwang-Yul 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3
Objective: To report the efficacy of vaginally administered bromocriptine. Material and Method: Case report. Results: The prolactin level was significantly decreased after the administration of bromocriptine vaginally. Conclusions: The vaginal administration of bromocriptine can be an alternative to oral administration in patients with hyperprolactinemia who show severe side effects.
Homocysteine 과다증과 관련된 반복 자연유산에서 Methylenetetrahydrofolate Reductase돌연변이에 대한 분석
남윤성,최종순,하권수,이지원,오도연,Nam, Yoon-Sung,Choi, Jong-Soon,Ha, Kwon-Soo,Lee, Zee-Won,Oh, Do-Yeon 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3
Objective: To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in recurrent spontaneous abortion associated with hyperhomocysteinemia. Material and Method: The blood sample of habitual aborter with high fasting homocysteine level was tested by PCR - RFLP method. Results: The patient was found to be a homozygosity for MTHFR gene mutation that was confirmed by the finding which is consistent with the mutation at the nucleotide 677 C to T, corresponding to Ala to Val. Conclusions: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the MTHFR mutation should be examined in the workup of recurrent spontaneous abortion showing hyperhomocysteinemia.
남윤성,김남근,이수만,강명서,오도연,차광렬,Nam, Yoon-Sung,Kim, Nam-Keun,Lee, Su-Man,Kang, Myung-Seo,Oh, Do-Yeon,Cha, Kwang-Yul 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.3
Objective : To evaluate factor XII deficiency in patients with recurrent spontaneous abortion and its relation to aPTT. Material and Method: Factor XII was analyzed by clotting method. Results: Of 70 patients with recurrent spontaneous abortion, there were 35 cases of factor XII deficiency. Among them, there were only 3 cases of prolonged aPTT. Conclusions: It is still unclear whether factor XII deficiency is related to recurrent spontaneous abortion. Molecular approaches should be used to understand further the causal relationship. But based on this result, in the workup of patients with recurrent spontaneous abortion, factor XII should be included. aPTT is not likely to represent the abnormality of factor XII.
착상전 유전진단을 이용하여 성공적으로 분만한 반복자연유산 1례
남윤성,이숙환,엄기붕,이은정,정형민,차광열,Nam, Yoon-Sung,Lee, Sook-Hwan,Oum, Ki-Bung,Lee, Eun-Jung,Chung, Hyung-Min,Cha, Kwang-Yul 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.3
Objective: To report the successful delivery in a patient of recurrent spontaneous abortion caused by chromosomal abnormality. Material and Method: Case report. Results: Twelve oocytes were obtained by in vitro fertilization. Of eleven oocytes fertilized, two embryos turned out to be normal by using fluorescent in situ hybridization on blastomere biopsy. The patient succeeded in pregnancy and the result of amniocentesis was found to be normal. She delivered the healthy female baby by cesarean section. Conclusions: The successful delivery is possible in recurrent spontaneous abortion related with reciprocal translocation by using preimplantation genetic diagnosis.
불임환자와 반복자연유산 환자에서 루프스 항응고인자와 항카디오리핀 항체에 대한 연구
남윤성,차광렬,백진영,김남근,강명서,오도연,Nam, Yoon-Sung,Cha, Kwang-Yul,Baek, Jin-Young,Kim, Nam-Keun,Kang, Myung-Seo,Oh, Do-Yeon 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.1
Objective : To report the prevalence of lupus anticoagulants and anticardiolipin antibodies in patients with recurrent spontaneous abortion and infertility. Material and Method: Lupus anticoagulants and anticardiolipin antibodies were analyzed by Diluted Russell's Viper Venom Test (DRVVT) and solid phase enzyme immunoassay, respectively. Results : In 200 patients with infertility, there were 6 cases (3%) with positive lupus anticoagulants or anticardiolipin antibodies. Of these, 3 patients (1.5%) showed positive lupus anticoagulants and anticardiolipin antibodies, respectively. In 120 patients with recurrent spontaneous abortion, there were 13 cases (10.8%) of positive lupus anticoagulants or anticardiolipin antibodies. Of these, one patient (1%) showed lupus anticoagulants and 12 patients (10%) showed anticardiolipin antibodies. But in two groups, there was no cases with positive lupus anticoagulants and anticardiolipin antibodies. Conclusion: Lupus anticoagulants and anticardiolipin antibodies are definite cause of recurrent spontaneous abortion. There has been a speculation that they might be associated with infertility and repeated IVF failures. But it was found that the role of lupus anticoagulants and anticardiolipin antibodies in these cases are not clear.
남윤성,이숙환,이우식,박찬,김종욱,차광열,Nam, Yoon-Sung,Lee, Sook-Hwan,Lee, Woo-Sik,Park, Chan,Kim, Jong-Wook,Cha, Kwang-Yul 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3
Objective: To report the pedigree of Kallmann syndrome inherited in autosomal dominant mode with variable expressivity. Material and Method: Case report. Results: The patient had amenorrhea and anosmia but did not have a sign of absolute hypo gonadotropic hypogonadism. Her father had an anosmia and her two elderly sisters also had an anosmia but delivered babies uneventfully. Her two male siblings did not show any signs of hypogonadotropic hypogonadism. Conclusion: Kallmann syndrome has many different modes of inheritance such as autosomal dominant, autosomal recessive, and X-linked form. So the careful investigation of family pedigree is required.
반복자연유산 환자에서 Homocysteine과 Methylenetetrahydrofolate Reductase 돌연변이의 상관관계에 대한 분석
남윤성,차광렬,김남근,강명서,김세현,오도연,Nam, Yoon-Sung,Cha, Kwang-Yul,Kim, Nam-Keun,Kang, Myung-Seo,Kim, Se-Hyun,Oh, Do-Yeon 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.3
Objective : To analyze the interrelationship between homocysteine and methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. Material and Method: Homocysteine and MTHFR mutation were tested by fluorescent polarizing immunoassay and PCR-RFLP method, respectively. Results: In patients with homocysteine level less than 5 ?mol/L, there was no case of normal group but there were four cases of heterozygosity and one case of homozygosity. In patients with homocysteine level 5$\sim$10 ? mol/L, the number of normal, heterozygosity and homozygosity group were eleven, eighteen and eight, respectively. In patients with homocysteine level $10{\sim}15$ ? mol/L, the number of normal, heterozygosity and homozygosity group were four, one and one, respectively. In patients with homocysteine level more than 15 ? mol/L, there was no case of normal and heterozygosity group but there were two cases of homozygosity. Conclusions: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. And there was a significant relationship between homocysteine and MTHFR mutation.
남윤성,김남근,강명서,오도연,차광열,Nam, Yoon-Sung,Kim, Nam-Keun,Kang, Myung-Seo,Oh, Do-Yeon,Cha, Kwang-Yul 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.2
Objective: To evaluate the abnormality of protein S in patients with recurrent spontaneous abortion due to antiphospholipid syndrome. Material and Method: Antigen and activity of protein S were analyzed by enzyme immunoassay and clotting method, respectively. Results: Of 18 patients with antiphospholipid syndrome, 4 patients were found to have no abnormality of protein S. There were 14 cases of protein S abnormality. Among them, there were 8 cases of type 1, 1 case of type 2, and 5 cases of type 3 protein S deficiency. Conclusion: So in the workup of patients with recurrent spontaneous abortion due to antiphospholipid syndrome, the evaluation for protein S is required.
반복자연유산에서 Methylenetetrahydrofolate Reductase 돌연변이에 대한 분석
남윤성,차광렬,김남근,김선희,임진우,강금덕,강명서,김세현,오도연,Nam, Yoon-Sung,Cha, Kwang-Yul,Kim, Nam-Keun,Kim, Sun-Hee,Lim, Jin-Woo,Kang, Geum-Duk,Kang, Myung-Seo,Kim, Se-Hyun,Oh, Do-Yeun 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.3
Objective: To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. Material and Method: The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method. Results: Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190). Conclusion: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.