3- ( 3,4- dichloro phenyl ) -1,1- dimethylurea 이 Mpoxy / Dicyandiamide 계의 경화에 미치는 영향

김형순,김완영,김영자 ( Hyung Soon Kim,Wan Young Kim,Young Ja Kim ) 한국공업화학회 1996 공업화학 Vol.7 No.5

에폭시 수지를 접착제의 base resin으로 이용하기 위해 DGEBA/dicy계의 경화특성을 조사하였다. dicy는 상온에서 저장안정성이 우수하여 일액형 접착제의 경화제로서 유용하다. 그러나 고온에서 경화시 열분해될 우려가 있으므로 경화온도를 낮추기 위해 diuron을 경화촉진제로 사용하였다. Epoxy/dicy계에서 dicy의 사용량이 증가함에 따라 경화반응열이 증가하였으며, 경화 후 수지의 유리전이온도(T_g)도 증가하는 것으로 관찰되었다. Diuron을 경화촉진제로 사용함으로써 약 40℃정도 낮은 온도에서 경화반응이 진행되었으며, 수지의 유리전이온도는 감소되었다. 경화반응의 속도론적 고찰은 Kamal이 제안한 자촉매반응의 모델식으로 해석하였으며, diuron의 경화촉진 효과를 확인할 수 있었다. Cure characteristics of DGEBA(diglycidyl ether of bisphenol A)/ dicy(dicyandiamide) system containing diuron(3-(3,4-dichloro phenyl) -1,1-dimethylurea) as an accelerator was investigated. The system has shelf life of six months because dicy is insoluble in liquid/solid resins at room temperature. It is generally known that dicy is an adequate curing agent for one component adhesive due to its highly latent property. With increasing the amount of added dicy, reaction heat of DGEBA/dicy system increased and degree of conversion was not varied. For DGEBA/dicy /diuron system, cure temperature decreased about 40℃ and cure reaction became fast by the addition of diuron which activates dicy. T_g of the mixed resin decreased with the amount of accelerator, which was interpreated with molecular structure forming loose chain. Cure kinetics of DGEBA/dicy and DGEBA/dicy/diuron system were explained using Kamal`s autocatalytic reaction model. The effect of acceleration was confirmed with that reaction model.

특집:자연모사 그린테크놀로지 - 생체모방 경량 소재 기술

김형순,김영희,김도경,Kim, Hyeong-Sun,Kim, Yeong-Hui,Kim, Do-Gyeong 재료연구소 2011 機械와 材料 Vol.23 No.4

생체모방 경량 나노복합 에코소재기술은 자연계에 존재하는 물질의 구조를 모방하여 저온 저에너지 소모공정을 통하여 고경량 및 고강도를 갖는 나노복합체를 제조하는 친환경 신소재 기술이다. 고효율 저공해 성능에 초점을 맞추어 $CO_2$ 배출 및 지구온난화를 억제하고 웰빙사회에 적합한 차량을 개발하는 것이 현재 전세계 자동차회사들의 주된 관심사이다. 이러한 상황에 생체모방기술은 에너지 환경산업분야의 소재로 응용하는 원천기술로 기대된다. 이 생체모방기술은 자연 친화적 재료를 개발하여 하이브리드/전기 자동차의 내/외장재, 고효율 건축자재, 첨단 항공우주 신소재에도 응용이 가능하다. 최근에 보고된 생체모방 경량 나노 복합 에코소재 기술을 조사하였다.

조위승청탕(調胃升淸湯) 전탕액(煎湯液)이 XO/HX에 의해 손상(損傷)된 배양(培養) 해마신경세포(海馬神經細胞)에 미치는 효과(效果)

김형순,김경요,고기덕,김일환,송승연,Kim, Hyoung-Soon,Kim, Kyung-Yo,Go, Gi-Deok,Kim, Il-Hwan,Song, Seung-Yun 사상체질의학회 2002 사상체질의학회지 Vol.14 No.1

Jowiseungcheongtang(JST) has been in Sasang constitution medicine for many years as a therapeutic agent for cerebral disease. But the effect of Jowiseungcheongtang(JST) on neurotoxicity is not known. The purpose of this study was to determine the effects of Jowiseungcheongtang(JST) on the hippocampal cell injured by Xanthine Oxidase/Hypoxanthine. The results were as follows: 1. XO/HX decreased the survival rate of the cultured hippocampal cells on NR assay and MTT assay. 2. JST water extract have efficacy of decreasing a amount of lipid peroxidation increased by XO/HX in cultured hippocampal cells. 3. JST water extract have efficacy of increasing DNA synthesis decreased by XO/HX in cultured hippocampal cells. From the above results, It is concluded that JST has marked efficacy in preventing cultured hippocampal cells from the damages by XO/HX.

21세기 블루오션, 한의학의료관광활성화를 위한 탐색적 연구

김형순,주종천,Kim, Hyoung-Soon,Joo, Jong-Cheon 사상체질의학회 2009 사상체질의학회지 Vol.21 No.2

1. Objective : This study aims to evaluate the medical tourism structures in countries with prosperous medical tourism industry such as Thailand, Malaysia, Singapore and India in order ro propose optimal strategies that can promote the medical tourism in Korea. 2. Methods : All pertinent literature concerning medical tourism directly and indirectly were assessed, and reviews of medical tourism strategies found in various countries were evaluated. 3. Results : Evaluation of related literature reveals that medical tourism is a recent burgeoning industry that has grown In market size considerably in the last five to ten years. Also, it shows that oriental medicine is a highly likely candidate amidst the various medical fields for attraction foreign patients. 4. Conclusion : The Korean government should support and install appropriate legal and administrative bodies in order to attract medical tourists; Korea-specific medical tourism programs (ie. traditional Korean medicine package tours) should be developed in order to attract medical tourists from the western world and the middle-east. In addition, low-price policy of medical tourism is not a proper strategies for the competition against advanced medical tourism destinations such as Thailand, Malaysia, Singapore and India. Differentiated medical tourism package such as oriental medical tourism program rather than provision of low-price policy seems to be more effective strategy for the medical tourism in Korea. Future studies on strategies for promoting medical tourism should focus on how foreigners recognize traditional Korean medicine, what diagnostic approach might be appealing to them and how the legal system concerning the medical procedures may be altered and modified.

외국인이 인식하는 한의학 의료관광의 가능성 및 사상체질진단 경제적 가치평가

김형순,이희승,차병헌,주종천,Kim, Hyoung-Soon,Lee, Hee-Seung,Cha, Byung-Hun,Joo, Jong-Cheon 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Objectives : This study aimed to provide practical insights on the development of traditional Korean medical tourism and maximize the satisfaction of foreign patients. The main objectives of this study were also to evaluate Sasang Constitutional Medicine(S.C.M.) diagnosis cost from foreigners' perspectives. 2. Methods : For this study, the data were collected from tourists to Korea between January 3, 2010 to February 20, 2010. The sample used in this study was mainly composed of Japanese, Chines and US/Canada, because they are the major national visitor origin group to Korea. The primary data were collected by questionnaire survey using a standardized instrument with a convenience sampling procedure, and efforts of the interviews involved an on-site, self-administrated questionnaire to those sitting or visiting tourist attractions. The total size of the sample was 276 of which 275 showed no missing value against the factors needed for final analysis and were for analysis as an effective sample. SPSS 13.0 for window was used to analyze the collected data on which descriptive statistics and the Limited Dependent(LIMDEP) 8.0 program was used in estimating the willingness-to-pay(WTP) for traditional Korean medical tourism through the Contingent Valuation Method(CVM). A dichotomous choice question form of a CVM was applied to estimating the value. 3. Results and Conclusion: 1. There was significant statistical relationship between attributes when considering medical tourism destination and socio-demographic profiles such as age group, nationality, educational level and occupation. 2. In the level of recognition on Korean medicine, north Americans showed low level of recognition compared to other nationalities. In addition, in terms of age group, 20's and 30's showed low level of recognition on Korean medicine, 3. In relation to the level of interest on Korean medicine, Japanese respondents had higher interesting level on Korean medicine. Also singles had higher level of interest. 4. Regarding preferred Korean medical treatment program, there found significant statistical relationship between Korean medical treatment program and socio-demographic characteristics. 5. The estimating result of the logit model showed that the variables affecting the WTP for Sasang Constitutional medicine diagnosis were offered price and potential ability of medical tourism destination. 6. In relation to WTP for Sasang Constitutional medicine diagnosis, Japanese respondents showed a WTP of USD 62.69 and Chinese respondents showed USD 57.09. On the other hands, respondents from north America and other countries showed a WTP of USD 65.50. In conclusion, from this study, the results found that the opportunities in tradition Korean medical tourism are immense and the possible rewards are numerous. It is time to continue to promote 'Sasang Constitutional medicine' and make the Korean medical tourism programs considering on nationalities, age group, gender and WTP.

단결정 알루미나의 균열첨단에서 전위거동

김형순,Kim, Hyeong-Sun,Robers, S.G 한국재료학회 1994 한국재료학회지 Vol.4 No.5

취성재료의 균열첨단에서 전위의 이동에 대한 거동을 이해하기 위하여 단결정의 알루미나에 대한 취성-연성 전이(BDT)에 대한 한 연구가 진행되었다. 여러 온도에서, 예비균열된 시편으로 4점 굽힘시험을 이용하여 임계응력확대계수와 항복강도가 측정되었다. 그 결과로, BDT온도는 변형속도와 시편 방향에 따라 달랐다.:(1120)파단면에 대하여 $4.2 \times 10^{-6}$와 $4.2 \times 10^{-7}s^{-1}$에서 BDT온도는 각각$1034^{\circ}C$, $1150^{\circ}C$이었다. 또한 4점굽힘 시험을 이용하여 연성영역에서 균열첨단으로 부터 방출된 전위의 이동거리과 방향은 에칭 피트법에 의해서 측정되었다. 이중 에칭법을 이용하여 즉정된 사파이어에서 전위의 이동속도는 모델링 연구에 응용되었다. A work on the brittle to ductile transition (BDT) in single crystal alumina has been performed to understand and assess the dynamics of dislocation mobility around crack tip of brittle material. The critical stress intensity factor and yield strengths were obtained from bending test using precracked specimens at elevated temperatures. It was found that the BDT temperature was dependent on strain rate and orientation of specimen : for (1120) fracture surface, $1034^{\circ}C$, $1150^{\circ}C$ for $4.2 \times 10^{-6}$, $4.2 \times 10^{-7}s^{-1}$ respectively. Under a 4 point bending test, the moving distance of dislocation generated near crack front in ductile range is determined by an etch pits method. The velocity of dislocation in sapphire obtained from the double etching method was applied to modelling study.

KOVA News-‘INKE 2002’는 한민족 네트워크 실현의 출발점

김형순,Kim, Hyeong-Sun 벤처기업협회 2002 벤처다이제스트 Vol.2 No.-

열다한소탕(熱多寒少湯)이 저산소성(低酸素性) 대뇌신경세포(大腦神經細胞) 손상에 미치는 영향(影響)

김형순,배영춘,이상민,김경요,원경숙,심규헌,박수정,Kim, Hyoung-Soon,Bae, Young-Chun,Lee, Sang-Min,Kim, Kyung-Yo,Won, Kyoung-Sook,Sihm, Gyue-Hearn,Park, Su-Jeong 사상체질의학회 2003 사상체질의학회지 Vol.15 No.1

To elucidate the neuroprotective effect of Yeoldahanso-tang(YHT) on nerve cells damaged by hypoxia, the cytotoxic effects of exposure to hypoxia were determined by XTT(SODIUM3,3'-{I-[(PHENYLAMINO) CARBONYL]-3,4-TETRAZOLIUM}- BIS (4-METHOXY-6-NITRO) BENZENE SULFONIC ACID HYDRATE), NR(Neutral red), MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and SRB(Sulforhodamin B) asssay. The activity of catalase and SOD(Superoxide dismutase) was measured by spectrophometry, and $TNF-{\alpha}$(Tumor cell necrosis $fector-{\alpha}$) and PKC(Protein kinase C) activity was measured after exposure to hypoxia and treatment of YHTWE. Also the neuroprotective effect of YHTWE was researched for the elucidatioion of neuroprotective mechanism. The results were as follows; 1. Hypoxia decreased cell viability measured by XTT, NR assay when cultured cerebral neurons were exposed to 95% N2/5% CO2 for $2{\sim}26$ minutes in these cultures and YHTWE inhibited the decrease of cell viability. 2. H2O2 treatment decreased cell viability measured by MTT, and SRB assay when cultured cerebral neurons were exposed to 1-80 ${\mu}M$ for 6 hours, but YHTWE inhibited the decrease of cell viability. 3. Hypoxia decreased catalase and SOD activity, and also $TNF-{\alpha}$ and PKC activity in these cultured cerebral neurons, but YHTWE inhibited the decrease of the catalase and SOD activity in these cultures. 4. Hypoxia triggered the apoptosis via caspase activation and internucleosomal DNA fragmentation. Also hypoxia stimulate the release of cytochrome c forom mitochondria. YHTWE inhibited the apoptosis via caspase activation induced by hypoxia. From these results, it can be suggested that brain ischemia model induced hypoxia showed neurotoxicity on cultured mouse cerebral neurons, and the YHTWE has the neuroprotective effect in blocking the neurotoxicity induced by hypoxia in cultured mouse cerebral neurons.

십이미관중탕(十二味寬中湯)과 오수유부자리중탕(吳茱萸附子理中湯)의 간손상(肝損傷) 보호작용(保護作用)에 대한 연구

김형순,배영춘,이상민,김경요,원경숙,이경성,Kim, Hyoung-Soon,Bae, Young-Chun,Lee, Sang-Min,Kim, Kyung-Yo,Won, Kyung-Sook,Lee, Kyung-Seong 사상체질의학회 2003 사상체질의학회지 Vol.15 No.1

Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) has been developed as prescriptions for the Soyeumin constitution. The hepatoprotective effect of the water extract of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) was investigated against carbon tetrachloride (CCl4)-induced hepatic damage. A single intra-peritoneal injection of CCl4 produced liver damage in rats as manifested by the significant rise of aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP) in serum as compared to those of untreated normal group. Pretreatments of rats with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) 500 mg/kg for 7 days) were significantly reduced AST, ALT, and ALP levels compared with CCl4-treated control group. Treatment of rats with CCl4 led to significantly increase in lipid peroxidation and significantly decrease in cytochrome P450 and P450 reductase. The oral administration of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract significantly inhibited the accumulation of microsomal thiobarbituric acid reactive substance (TBARS) and increased the cytochrome P450 and P450 reductase activity. All these biochemical alterations resulting from CCl4 administration were inhibited by the pretreatment with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SG1) extract. These results suggest that Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract can be useful as a hepatoprotective agent. And the effect of NO modulation by NO synthesis or precursors, and Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang (SGT) water extract was researched on chronic liver damage induced by CCl4 administration. It was observed that endogenous NO protected the liver from lipid peroxidation, fibrosis, and damage. Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract showed the hepatoprotective effect on the chronic liver cirrhosis model and relationship with NO modulation.

이제마(李濟馬)의 형상관(形象觀)이해와 안면부(顔面部) 형태의 해석

김형순,최광진,Kim, Hyung-soon,Choi, Kwang-jin 사상체질의학회 1999 사상체질의학회지 Vol.11 No.1

이제마(李濟馬)는 각 체질의 판단을 위해 체형기상(體形氣像)등의 방법을 제시하였으며, 이를 바탕으로 우리는 여러 가지 다양한 방법의 체질판단을 시도할 수 있다. 그러한 이론의 바탕에는 이제마(李濟馬)의 행위결정론적 사고방식이 강하게 뿌리박고 있다. 이는 "성명론(性命論)"의 '두견요둔(頭肩腰臀)', '이목비구(耳目鼻口)', '함억제복'등의 단어들을 볼 때, 기존처럼 형(形)을 상(象)을 반영하는 객체로 인식하는 것이 아니라, 하나의 부분 주체적 개념으로 인식하고 있는 것을 보면 알 수 있다. 이로 보아 이제마(李濟馬)는 인체의 각 부위에 대하여 기존에 가지고 있던 육체적 기능뿐만 아니라 복잡한 성정적(性情的) 기능도 가지고 있다고 본 것이다. 이러한 고찰과 인체의 외형에 대한 직접적 서술이 있는 "장부론(臟腑論)" 등을 종합해 보면 현재 이용하고 있는 체질판단의 체형기상(體形氣像) 부분에 대하여 일정한 이론을 가지고 설명할 수 있다고 생각하여 다음과 같은 가설을 제시하여 보았다. "사단론(四端論"과 "확충론(據充論)"을 볼 때, 사상인(思象人)의 직부대소(職腑大小)는 태음인(太陽人)의 경우 폐(肺) > 비(脾) > 신(腎) > 간(肝)의 순으로, 소양인(少陽人)은 비(脾) > 폐(肺) > 간(肝) > 신(腎)의 순으로, 태음인(太陰人)의 경우 간(肝) > 신(腎) > 비(脾) > 폐(肺), 소음인(少陰人)은 신(腎) > 간(肝) > 폐(肺) > 비(脾)의 순으로 생각할 수 있으며, "직부론(職腑論)"에서 사람의 형(形)이 형성되는 과정 중에 보이는 '신기혈정(神氣血精)'이라는 개념은 형(形)의 생성과 관련이 있음과 아울러 각 직국(職局) 및 애노희락(哀怒喜樂)의 기운과 통한다라고 할 수 있다. 이러한 관점에서 사상인(四象人)을 분류해 보면, 태음인(太陽人)을 신기정혈형(神氣精血型), 소양인(少陽人)을 기신혈정형(氣神血精型), 태음인(太陰人)을 혈정기신형(血精氣神型), 소음인(少陰人)을 정혈신기형(精血神氣型)으로 분류할 수 있을 것이다. 이러한 역량관계에 따라 각 체질의 외형에 대하여 일정한 설명방법을 도입해 보았으며, 이러한 시도를 바탕으로 사상의학의 형상에 대한 논의가 활발해졌으면 하는 바램이다. Lee, Je-ma proposed ways like Chehyungkisang to judge each constitution, so, on the basis of this, we can judge constitution in various ways. Such a theory is based on behavior determinism's way of thinking of Lee, Je-ma. We can know this that form is not recognized as an object reflecting image, but a subjective concept from Tukyonyodun, Yimokbiku(ears, eyes, nose and mouth), Hameokjebok of Sungmyong Theory. Lee, Je-ma thought each part of human body has not only physical function but also complex temperative function. Putting this consideration and Jangbu Theory describing human body directly, together, it can be said that these all have an established theory on Chehyungkisang of constitution judgement. Thus, the following hypotheses are given. From Sadan Theory and Hwakchung Theory, strength of Jangbu of Sasangin is Pe>Bi>Shin>Kan in Taeyangin and Bi>Pe>Kan>Shin in Soyangin and Kan>Shin>Bi>Pe> in Taeumin and Shin>Kan>Pe>Bi in Soumin. The concept of Shinkihyuljung is related with creation of form and spirit of each Jangkuk and Aenoheerak(sorrow, anger, joy, pleasure). From this viewpoint, Sasangin can be classified into; Taeyangin into Shinkijunghyul type, Taeumin into Hyuljungkishin type, Soumin into Junghyuishinki type. Introduced a fixed way to explain of each constitution according to this strength relationship. I hope more lively discussions on Constitutional Medicine will be continued based on this attempt.