황석영의 제자 김한수가 쓴 ' 황석영 석방이유서 ' : 황석영을 가두지 말고 우리의 미래를 가두라

김한수 사회평론 1996 사회평론 길 Vol.96 No.11

Streptozotocin 유도 당뇨성 흰쥐의 혈당, 전해질 및 지질대사에 삼백초 추출액이 미치는 영향

김한수,Kim, Han-Soo 한국생명과학회 2006 생명과학회지 Vol.16 No.6

Streptozotocin(STZ 55 mg/kg BW., I.P. injection)으로 유발된 당뇨성 Sprague Dawley계 수컷 흰쥐에 있어서, 삼백초 생리활성물질 추출액(3.5 g% extract)의 섭취에 의한 혈당, 전해질, 혈청 지질개선효과 및 당질대사 이상 등에 관여하는 효소의 활성 변동을 생리생화학적 측면에서 검토하기 위하여 본 실험을 수행하였다. 기본식이만을 급여한 대조군인 Normal군을 비롯한 STZ 당뇨 유발군(NSW군), 당뇨 유발에 삼백초 잎 추출액을 섭취시킨 군(NSSL군) 및 당뇨 유발에 삼백초 뿌리 추출액을 섭취시킨 군(NSSR군)을 5주간 실험 사육하였다. 혈당 농도는 당뇨 유발군에 삼백초 추출액을 급여하므로서 유의적으로 저하됨을 관찰할 수가 있었다. 또한 혈청 총 콜레스테롤, 동맥경화지수, LDL, LDL- 콜레스테롤, 유리 콜레스테롤, 콜레스테롤 에스테르 비, 중성지방 및 인지질 농도 등은 삼백초 추출액을 섭취시킨 군(NSSL군, NSSR군)에서 농도가 유의성 있게 감소되는 것으로 나타났다. 한편, HDL-콜레스테롤 및 총 콜레스테롤에 대한 HDL-콜레스테롤 비 등은 삼백초 추출액 섭취(NSSL군, NSSR군)에 의해서 유의성 있게 증가 되는 것으로 나타났다. 혈청 중의 전해질(Na, K, Cl) 및 creatinine 농도는 STZ으로 당뇨 유발군에 삼백초 추출액을 섭취시킴으로서 유의성 있는 농도 저하 효과를 보였다. 또한, 혈청 중 aminotransferase(AST, ALT), creatine phosphokinase(CPK), lactate dehydrogenase(LDH) 및 alkaline phosphatase(ALP)의 활성은 STZ으로 당뇨 유발 시킨 후 삼백초 추출액을 섭취시킴으로서 저하되는 것으로 나타났다. 한편, 삼백초 잎(NSSL군)과 뿌리(NSSR군) 추출액 섭취에 따른 혈당, 각 종 지질 성분 및 효소 활성치의 두 군 간의 비교는 삼백초 잎이 뿌리 추출액에 비하여 다소 효과적인 차이를 보였으나 유의성 있는 변화는 보이지 않았다. 이상과 같은 결과들을 미루어 볼 때, 삼백초 중의 생리활성물질이 STZ으로 유발된 당뇨성 흰쥐의 혈당 조절 기능이상 및 혈청 지질대사 이상 등에서 오는 각종 질환의 예방 및 개선 작용에 효과가 있을 것으로 생각된다. The purpose of this study was to observe the effects of the feeding physiological activity substance in Saururus chinensis Baill extract on the improvement of the blood glucose, electrolyte (Na, K, CI) concentration and lipid metabolism in the serum of streptozotocin (STZ, 55 mg/kg B.W., I.P. injection)-induced hyperglycemic rats fed the experimental diets for 5 weeks. Concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, triglyceride (TG) and phospholipid (PL) in serum were significantly higher in the hyperglycemic group (group NSW), STZ (I.P.)+Saururus chinensis Baill leaf 3.5 g% extract group (group NSSL) and STZ (I.P.)+Saururus chinensis Baill root 3.5 g% extract group (group NSSR) than those in the control group (group Normal, basal diet+water). But the concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, TG and PL in serum were remarkably lower in the groups NSSL and NSSR than those in the NSW, whereas the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration in the groups NSSL and NSSR were significantly higher than in the group NSW. Electrolyte and creatinine concentrations in serum were significantly lower in the groups NSSL and NSSR than those in the group NSW. The activities of aminotransferase (AST, ALT), creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in serum were remarkably lower in the groups NSSL and NSSR than in the hyperglycemic group NSW. However, no significance was found in the comperative effect of the groups NSSL and NSSR. From the above results, it was suggested that Saururus chinensis Baill was effective in the improvement of the blood glucose, electrolyte, glucide and lipid metabolism in serum of STZ-induced hyperglycemic rats.

초고층빌딩 개산견적 코스트 모델 및 시스템 개발

김한수,김영석,권순욱,조은석,Kim, Han-Su,Kim, Yeong-Seok,Gwon, Sun-Uk,Jo, Eun-Seok 한국건설관리학회 2013 한국건설관리학회 논문집 Vol.14 No.4

제2분과 : 식물변화 및 관리 ; 경관생태학적 개별비오톱 평가 방법 연구

김한수,오충현 한국환경생태학회 2012 한국환경생태학회 학술대회지 Vol.2012 No.1

초고층건물 기본설계를 위한 모델링 기법 ( A Modeling Technique for Structural Schematic Design of Tall Buildings )

김한수,정종현,조석희 대한건축학회 2001 大韓建築學會論文集 : 構造系 Vol.17 No.8

인후두역류질환의 실험실 검사의 재평가

김한수,Kim, Han-Su 대한후두음성언어의학회 2007 대한후두음성언어의학회지 Vol.18 No.2

Laryngopharyngeal reflux disease (LPRD) is the result of retrograde flow of gastric contents to the laryngopharynx. Laryngoscopic findings and special questionnaires are first step of diagnosis of LPRD. Empiric trials of Proton pump inhibitor' test (PPI test) is recommended as treatment and diagnosis. However confirmation of reflux is then recommended primarily in patients with persistent symptoms despite acid-suppressive therapy. The 24 hour ambulatory double pH monitoring has been a gold standard method in diagnosis of LPRD even though it has some limitation. The combined multichannel intraluminal impedance and pH monitoring is a new-rising test tool. It can detect acid/non-acid, liquid/gaseous reflux and clearance of refluxate. The water siphon test is also used for diagnosis of LPRD.

A LONG-TERM FIELD TEST OF A LARGE VOLUME IONIZATION CHAMBER BASED AREA RADIATION MONITORING SYSTEM DEVELOPED AT KAERI

김한수,김용균,진현호,하장호,김정복,박세환 대한방사선방어학회 2009 방사선방어학회지 Vol.34 No.2

An Area Radiation Monitoring System (ARMS) ionization chamber, which had an 11.8 L active volume, was fabricated and performance-tested at KAERI. Low leakage currents, linearities at low and high dose rates were achieved from performance tests. The correlation coefficients between the ionization currents and the dose rates are 1 at high dose rate and 0.99 at low dose rate. In this study, an integration-type ARMS ionization chamber was tested over a year for an evaluation of its long-term stability at a radioisotope (RI) repository of the Young-gwang nuclear power plant. The standard deviation of dose rate of 1 day data and over a 100-days mean value were 6.2 μR/h and 2.9 μR/h, respectively. The fabricated ARMS ionization chamber showed stable performance from the results of the long-term tests. Design and performance characteristics of the fabricated ionization chamber for the ARMS from performance-tests are also addressed.

피부화상에 의한 피부 및 간의 조직학적 변화에 관한 연구

김한수,김상수,김용권,Kim, Han-Soo,Kim, Sang-Soo,Kim, Yong-Kwon 대한물리치료과학회 2001 대한물리치료과학회지 Vol.8 No.1

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald bum, biochemical assay and morphological changes in skin tissue, serum and liver tissue were examined. The effects of bum injury on the levels of glutathione, lipid peroxide and on the activities of oxygen free radical generating and scavenging enzymes have been determined in association with observing of histologic and ultrastructural changes, measuring the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. The activity of xanthine oxidase, an enzyme of oxygen free radical generating system. was elevated (p<0.01) in serum, but not in skin and in liver tissue. Futhermore, thermal injury decreased not only the protein concentration in plasma but also the number of leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

내부회계관리제도 검토의견의 정보효과

김한수 한국기업경영학회 2012 기업경영연구 Vol.19 No.3

A series of accounting sandals in U.S. led to enactment of the Sarbanes-Oxley (SOX) Act in 2002 to restore public confidence in the quality of audited financial statements. Especially in the section 404 of SOX, it emphasizes the importance of internal control in order to produce reliable financial statements. This SOX affected Korea’s accounting system and resulted in passing the new accounting legislation in April 2004. One of the acts in the new accounting system is the internal control over the financial reporting system, which is similar to section 404 of SOX. According to the new legislation, managers are responsible for the efficiency and effectiveness of their inter control accounting system. Auditor evaluated manager’s assessment of internal accounting control system of their internal control accounting system and submit reports based on their findings. Some of the company managers are doubting whether new legislation is really needed in Korean financial environment. Preceding researches analyzed data from that of accounting information providers. I wondered about market participant’s point of view. This study investigates empirically for the information contents by analyzing market reactions on the review opinions about internal accounting control system over financial report. This study analyzed the relationship between CAR and review opinions when the review opinions were announced publicly by sampling 192 listed companies which of review opinions were not unqualified from 2006 to 2008. I predicted a negative coefficient for CAR and internal control weakness. The empirical findings are as bellow. First, in the case of companies which announced their weak points of internal accounting controls, negative market reactions has been shown in the stock market, in particular KOSDAQ market. Second, it was reported that when the review opinions were qualified, market reacted differently according to the reason of review opinions. That is, market reacted more negatively to the adverse opinion rather than the other significant weaknesses. Contributions of this study which are also differences with preceding studies are as follows. First, preceding researches related to audit opinions on audit reports used general shareholders meeting day or a week prior to the meeting day as the standard. This study, however, used the day when audit reports were announced publicly as the standard. Second, this is the first study which analyzes investor’s direct reactions domestically. It is a unique study which analyzed data from a market participant’s point of view compared to preceding researches which analyzed data from that of accounting information providers. Third, it is the first study which indicates empirical evidences for whether market reacts differently according to the reasons for qualifications. On the other hand, this study has the following limitations. First, this study could on control some facts which might affect market reactions such as nod grades and outcomes of lawsuits. Second, the number of samples which reported their weakness points is comparatively small since this study has been conducted from 2006 to 2008. Therefor, if one were to extend the period of study, other meaningful findings could be achieved after experiences of operating internal accounting control system over report have been accumulated. ‘주식회사의 외부감사에관한법률’에 따라 상장기업은 2004년 4월 1일 이후 개시하는 사업연도부터 내부회계관리제도를 구축․운영하고 있으며, 외부감사인은 내부회계관리제도에 대한 검토보고서를 공시하도록 규정하고 있다. 본 연구에서는 내부회계관리제도 검토보고서 공시시점에서 의견종류에 따른 시장반응을 살펴봄으로써 검토의견의 정보효과를 검증하였다. 이를 위해 2006년부터 2008년까지 거래소에 상장된 금융업에 속하지 않은 12월 결산법인을 대상으로 분석하였다. 분석결과는 다음과 같다. 첫째, 코스닥시장에 상장된 기업 중 내부통제의 취약점이 지적된 기업은 그렇지 않은 기업에 비해 의견공시시점의 시장반응은 부정적인 것으로 나타났다. 둘째, 정보이용자는 코스닥시장에 상장된 기업 중 중요한 범위제한으로 인해 내부회계관리제도 검토의견이 거절되었을 때 중요한 취약점으로 지적된 경우보다 더 부정적으로 인식하는 것으로 나타났다. 본 연구의 공헌점은 다음과 같다. 첫째, 기존 감사보고서상 감사의견 등과 관련된 선행연구에서는 사건일로 대부분 주주총회일을 사용하거나 단순히 주주총회 7일 전을 사건일로 보았다. 그러나 본 연구에서는 증권거래소에 감사보고서가 최초로 접수된 일자를 사건일로 보아 정확한 공시시점을 포착하였다. 둘째, 회계정보 공급자 입장에서 수행되었던 기존의 선행연구와는 달리 회계정보의 수요자인 정보이용자 관점에서 검토의견의 정보효과를 살펴보았다

연속유입 간헐포기공정 모델 파라미터의 민감도 분석

김한수,전석준 대한상하수도학회 2003 상하수도학회지 Vol.17 No.5

Intermittent aeration system with continuous inflow (IASWCI) model was established based on the mass balances in the aerobic and anoxic phases. This model contains 14 parameters and is composed of 7 state variables in each phase. The important parameters can be identified by parameter sensitivity analysis. Sensitivity analysis was accomplished by varying the numerical value of the parameters in the IASWCI model and determining the resulting impact in the predicted response. It has shown that μ_(max,H) (maximum specific growth rate of heterotrophs) of IASWCI was the most sensitive one in the COD removal process while i_(xB) (ratio of nitrogen to organic in microorganism) was the most sensitive one in nitrification process and Y_(H) (yield coefficient of heterotrophs) was the most sensitive one in denitrification process. Based on the senitivity analysis and calibration process of IASWCI model, mathematical model simulation was accomplished by using the model with another input data set. As the results of the model simulation, it is possible to predict behaviors of organic and nitrogen in case that the model is applied to a full-scale wastewater treatment plant.