http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
부천지역 만삭 임신부의 프탈레이트 노출 정도 측정: 예비 실험연구
김태희 ( Tae Hee Kim ),홍연표 ( Yeon Pyo Hong ),이해혁 ( Hae Hyeog Lee ),정수호 ( Soo Ho Chung ),양윤정 ( Yun Jung Yang ),김상연 ( Sang Yon Kim ),고영림 ( Young Lim Kho ),김준모 ( Jun Mo Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.3
목적: 프탈레이트는 프탈산 plasticizers로 사용되는 esters의 한 종류로 국외에서는 많은 연구를 통해 프탈레이트의 노출에 대하여 기술하고 있으나, 우리나라에서는 이와 관련된 연구가 부족한 실정이다. 이에 우리는 만삭 임신부의 소변에서 프탈산의 노출을 평가하였다. 연구방법: 2009년 8월부터 2010년 4월까지 32명의 만삭 분만한 임신부를 대상으로 하였으며, 기관윤리위원회(Institutional Review Board)를 통과하였고, 환경과 식습관에 대하여 질문서와 산과력 및 과거력을 조사하였다. 프탈레이트의 노출을 평가하기 위해서 10가지 phthalate metabolites (mono-methyl phthalate [MMP], mono-ethyl phthalate [MEP], mono-n-butyl phthalate [MnBP], mono benzyl phthalate [MBzP], mono-(2-ethylhexyl) phthalate [MEHP], mono-[2-ethyl-5-hydroxyhexyl] phthalate [MEHHP], mono-(2-ethyl-5-oxohexyl) phthalate [MEOHP], mono-isobutyl phthalate [MiBP], mono-(2-ethyl-5-carboxypentyl) phthalate [5cx-MEPP], and mono-(2- carboxymethylhexyl) phthalate [2cx-MMHP])를 분만 전 24시간 내에 임신부의 소변에서 측정했다. 이들 자료는 예비 실험연구이다. 결과: 임신부들의 평균 나이는 31.1±3.2세, 평균 주수는 38.4±1.3주였다. Creatinine-corrected concentration (geometric mean; μg/g Cr)는 1.754 (MMP), 3.443 (MEP), 3.839 (MnBP), 2.721 (MBzP), 2.437 (MEHP), 4.042 (MEHHP), 3.504 (MEOHP), 2.805 (MiBP), 3.765 (5cx-MEPP), 3.775 (2cx-MMHP)를 나타내었다. 결론: 우리의 데이터는 분만 전 임신부의 소변에서 측정한 프탈레이트의 예비 연구자료로서 본 자료를 토대로 앞으로 다 기관연구 연구에 도움이 될 것으로 보인다. Objective: Phthalates are a group of phthalic acid esters and these are used as plasticizers. Several studies have described phthalate exposure in other countries, but there are no such reports from Korea. We assessed exposure to phthalic acid in the urine of full term pregnant women. Methods: There were 32 full term deliveries in our hospital from August, 2009 to April, 2010. We received approval from the Institutional Review Board at our hospital and written informed concept from all the patients. We review the obstetrics history, the history of medical illness and other problems. To assess exposure to different phthalates, we measured the concentrations of nine phthalate metabolites in the spot urine samples collected 24 hours before delivery. The urinary concentrations of 10 phthalate ester metabolites (mono-methyl phthalate [MMP], mono-ethyl phthalate [MEP], mono-n-butyl phthalate [MnBP], mono benzyl phthalate [MBzP], mono-[2-ethylhexyl] phthalate [MEHP], mono-[2-ethyl-5-hydroxyhexyl] phthalate [MEHHP], mono-[2-ethyl-5-oxohexyl] phthalate [MEOHP], mono-isobutyl phthalate [MiBP], mono-[2-ethyl-5-carboxypentyl] phthalate [5cx-MEPP], and mono-[2-carboxymethylhexyl] phthalate [2cx-MMHP]) were analyzed in the spot urine samples collected from the pregnant women. The data is being used as a pilot study for a large multicenter study. Results: The mean age was 31.1±3.2 years. The mean gestational age was 38.4±1.3 weeks. The creatinine-corrected concentration (geometric mean: μg/g Cr) was 1.754 (MMP), 3.443 (MEP), 3.839 (MnBP), 2.721 (MBzP), 2.437 (MEHP), 4.042 (MEHHP), 3.504 (MEOHP), 2.805 (MiBP), 3.765 (5cx-MEPP), and 3.775 (2cx-MMHP). Conclusion: Our data reflects a preliminary description of pregnant women`s exposure, before delivery, to phthalates. So, a prospective multicenter study is needed to evaluate phthalate exposure based on our data.
중등도 이하 소아 근시에서 안경과 각막굴절교정렌즈 착용이 안축장 성장에 미치는 영향 비교
김태희(Tae Hee Kim),김명훈(Myung Hun Kim),곽주영(Joo Young Kwag),최진석(Jin Seok Choi),박규홍(Kyu Hong Pak),이경욱(Kyeongwook Lee),박태성(Taeseong Park),정성근(Sung Kun Chung),현주(Joo Hyun) 대한안과학회 2018 대한안과학회지 Vol.59 No.11
목적: 중등도 이하 소아 근시에서 안경과 각막굴절교정렌즈(orthokeratology lens, OK) 착용이 안축장 성장에 미치는 영향 및 관련인자를 알아보고자 하였다. 대상과 방법: 2013년부터 2015년까지 내원한 6세에서 13세 사이 -4.50디옵터 이하의 구면렌즈대응치를 가진 소아 100명을 대상으로 후향적으로 OK군(75안)과 안경군(64안) 간에 안축장 변화와 안축장과 관계된 인자들을 분석하였다. 결과: 안축장 변화는 1년째에 OK군이 0.24 ± 0.29 mm의 증가를, 안경군이 0.42 ± 0.20 mm의 증가를 보였으며, OK군에서 안경군에 비해 유의하게 안축장 성장이 억제되는 양상을 보였다(Mann-Whitney U test, p<0.05). OK군에서 처음 착용한 나이만이 안축장 변화와 음의 상관관계가 있는 것으로 나타났다(Pearson’s correlation, r=-0.481, p<0.05). 안경군에서는 처음 착용한 나이가 안축장 변화와 음의 상관관계(Pearson’s correlation, r=-0.462, p<0.05)를, 그 외에 현성굴절검사의 초기 구면렌즈대응치 및 초기 구면렌즈값, 난시값은 안축장 변화와 양의 상관관계를 보였다. 안축장 변화를 비교해 보았을 때 OK를 착용한 경우 6세 이상 9세 미만군(28안)에비해 9세 이상 13세 이하군(47안)에서 유의하게 안축장 성장이 더 억제되는 양상을 보였다(Mann-Whitney U test, p<0.05). 결론: OK 착용은 안경 착용에 비해 효과적으로 안축장의 성장을 억제할 수 있으며, 9세 이상 13세 이하의 소아에서도 효과적인 안축장 성장 억제가 가능하다. Purpose: To assess the effect on axial elongation and associated factors between spectacles and of orthokeratology lens (OK) wearing in children with mild to moderate myopia. Methods: A total of one hundred subjects, ranging in age from 6 to 13 years, and with mild to moderate myopia no more than -4.50 diopters in spherical equivalent, visited our clinic from 2013 to 2015. The OK group (75 eyes) and the spectacles group (64 eyes) were compared and analyzed on the axial elongation and associated factors. Results: In the OK group, axial length was elongated in 1 year period with a mean increase of 0.24 ± 0.29 mm. In spectacles group, axial length was elongated in 1 year period with a mean increase of 0.42 ± 0.20 mm. The statistically significant suppression of axial elongation was observed in OK group compared to the spectacles group (Mann-Whitney U test, p < 0.05). For OK group, the age of starting OK (Pearson’s correlation, r = -0.481, p < 0.05) was the only influencing factor on axial elongation, which had negative correlation with axial elongation. In spectacles group, the age of starting spectacles had negative correlation with axial elongation (Pearson’s correlation, r = -0.462, p < 0.05) and baseline spherical equivalent, spherical diopter, cylindrical diopter from manifest refraction had positive correlation with axial elongation. Comparison of axial elongation in orthokeratology lens group and spectacles group by age groups (6 to 9 years [28 eyes], 9 to 13 years [47 eyes]), 9 to 13 years of orthokeratology lens group had the stronger suppression of axial elongation (Mann-Whitney U test, p < 0.05). Conclusions: The OK effectively suppresses axial elongation compared to the spectacles. Although the patients are in age from 9 to 13 years, the axial elongation was effectively suppressed.
당약의 swertiamarin 분석을 위한 추출조건 최적화
김태희 ( Tae Hee Kim ),장설 ( Seol Jang ),이아름 ( Ah Reum Lee ),이아영 ( A Young Lee ),최고야 ( Go Ya Choi ),김호경 ( Ho Kyoung Kim ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.1
Objectives : Iridoid glycoside, swertiamarin is a well known bioactive component found in Swertia japonica Makino (SJ). In this study, we tried to optimize a suitable method which would extract swertiamarin effectively. Methods : Extraction of SJ was carried out by various conditions of time (5 - 60 min), temperature (30 - 70℃), solvent (from non-polar to polar), and ratio of solvnet / sample (10 : 1 - 40 : 1) using ultrasonic extractor. Swertiamarin in SJ extracts was quantified by high performance liquid chromatography - Phtodiode array detector (HPLC-PDA) using C18 column and the analytical procedure was validated by evaluation of specificity, range, linearity, accuracy (recovery), precision (intra- and inter day variability), limit of detection (LOD), and limit of quantification (LOQ). Results : An efficient extraction condition for swertiamarin in SJ was optimized using sonicator extraction (temperature 40℃, solvent 20% methanol, solvent / sample (20 : 1), and time 10 min. Analytical procedure was optimized by HPLC-PDA using isocratic solvent system of acetonitrile and water (9 : 91), and the method was validated in regard to linearity (correlation coefficient, R2 > 0.9999), range (50 - 1000 μg/mL), intra- and inter-precision (RSD < 5.0 %), and recovery (99 -103 %). LOD and LOQ were 0.051 and 0.155 μg/mL, respectively. Conclusion : An optimized method of extraction for swertiamarin in SJ was established through conditions of diverse extraction and the validation result indicated that the method is suited for the determination of swertiamarin in SJ.
대장 직장암에서 D2-40을 이용한 림프계 미세 혈관 밀도와 혈관 내피세포 성장 인자-C의 단백 발현의 의미
김태희(Tae Hee Kim),김용석(Yong Sok Kim),최영철(Young Chol Choi),김범규(Bom Ku Kim),이태진(Tae Jin Lee),박용검(Yong Geum Park) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.5
Purpose: Studying the prognostic factors of distant metastasis is quite important for predicting these patients’ prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors. Methods: 79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate. Results: The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the Tstage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer. Conclusion: The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer.
김태희(Tae Hee Kim),이영남(Young Nam Lee),박홍현(Hong Hyun Park) 한국호텔관광학회 2001 호텔관광연구 Vol.3 No.3
This study investigated importance/performance(I/P) of food service internship program quality and examined the relationships between students` internship job satisfaction, first job choice, and word-of-mouth. Sixteen variables related to internship quality were categorized into three factors: program structure quality, human relation quality, and program policy. Results showed that all three factors were found to be very high on importance but very low in performance, showing significant differences in all variables in VP comparison. Of three factors, quality of program structure needs to be improved most. Overall internship job satisfaction was significantly influenced by all three factors, especially, quality of human relation and program structure were found to be more influential than program policy. Moreover, overall internship job satisfaction was strongly correlated with student`s first job choice and word-of-mouth. Interns who were more satisfied with their internship experience indicated a greater intention to apply for the job at the firms they have worked as an intern, and showed a greater willingness to talk about their internship experience to others. These results suggest that food service operations develop a structured internship program and select an intern supervisor carefully to increase students` internship job satisfaction and boost corporate image on campus, therefore, resulting in attracting more and better qualified students to the operations.