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김창욱,조성원,이충웅,Kim, Chang-Wook,Cho, Seong-Won,Lee, Choong-Woong 대한전자공학회 1994 전자공학회논문지-B Vol.b31 No.11
This paper deals with fast competitive learning using classified learning rates. The basic idea of the proposed method is to assign a classified learning rate to each weight vector. The weight vector associated with an output node is updated using its own learning rate. Each learning rate is changed only when its corresponding output node wins the competition, and the learning rates of the losing nodes are not changed. The experimental results obtained with image vector quantization show that the proposed method learns more rapidly and yields better quality that conventional competitive learning. 본 논문은 분류된 학습률을 이용한 고속 경쟁 학습에 대한 연구이다. 이연구의 기본 개념은 각 출력 노우드의 연결강도 벡터에 분류된 학습률을 할당하는 것이다. 출력 노우드의 각 연결강도 벡터는 자기 자신의 학습률에 의하여 갱신된다. 각 학습률은 관련되는 출력 노우드가 경쟁에서 승리할 때에만 변화되며, 승리하지 못한 노우드들의 학습률은 변화되지 않는다. 영상 벡터 양자화에 대하여 실험한 결과는 제안한 방법이 기존 경쟁 학습 방법에 비하여 더 빠르게 학습되고 더 좋은 화질을 갖게 됨을 보였다.
김창욱,신문석,김병천,이규석,송준영 ( Chang Wook Kim,Moon Seok Shin,Byung Chun Kim,Kyu Suk Lee,Jun Young Song ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
Epidermodysplasia verruciformis(EV) is a rare, sometimes familial disorder characterized by chronic infection with EV-specific HPV types. It manifests itself as numerous flat warts, red and brownish macules, and pityrias:s versicolor-like lesions. Immunodeficient staies such as AIDS renal transplantation, Hodgkins dis ase, and systemic lupus erythematosus, have been associated with EV. We report a case of a 42-year old female with EV, with lesions on the chest, shoulders, and back, For about the past 2, years, she had been treated with prednisolone for systemic lupus erythematosus. Histopathological findings revealed loose basket-weave-like hyperkeratosis and there were clear large cells arranged in nests in the granular and spinous layers. Their nuclei were shrunken and pyknotic, and the clear cytoplasm was dotted with dispersed keratohyaline granules of different sizes anr shapes. Electron microscopic findings showed aggregates of many viral particles in the nuclei of displastic epidermal keratinocytes. Pan papilloma virus monoclonal Antibody positive nuclei were;hown by immunoperoxidase staining. She has been treated with CO, laser and Tretinoin(0.1% ) oin ment. The patient is being monitored for any signs of recurrence for a period of 5months (Korean J Dermatol 1997;35(6): 1203-1207)
자외선 B 조사에 따른 HaCaT 각질형성세포주 및 편평상피세포암 세포주에서 Anti-proliferative Genes의 발현 양상 비교
김창욱 ( Chang Wook Kim ),조재위 ( Jae We Cho ),이규석 ( Kyu Suk Lee ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.11
Background: Impairment of the DNA repair system after UVB irradiation is the key factor in transformation of normal keratinocytes to squamous cancer cells (SCC). Among anti-proliferative genes (APRO), BTG1, BTG2, and TOB genes are involved in the repairing of DNA damage and, BTG3 and TOB 2 are involved in differentiation and cell cycle arrest in human cells, respectively. However, the expressions of APRO genes in SCC and human keratinocytes after UVB irradiation are largely unknown. Objective: The purpose of this study was to investigate the expression levels of APRO genes in UVB-irradiated HaCaT keratinocyte lines and SCC cell lines. Methods: Cells were irradiated with UVB at various doses (0, 100, 200, 300 mJ/㎠), then total RNA was extracted from the cells. The expression of genes were confirmed by RT-PCR analysis using specific primers. The results were obtained from two independent experiments. Results: The expression of BTG1, BTG2, and TOB2, but not BTG3 and TOB, were markedly increased in UVB-irradiated HaCaT cells, compared to UVB-irradiated SCC. To confirm the expression levels of BTG1, BTG2, and TOB2 genes correlated with extent of DNA damage or susceptibility to cell death by UVB, we carried out staining of surviving UVB-irradiated HaCaT and SCC cell lines. Interestingly, it was found that the number of surviving HaCaT colonies was higher than SCC cell lines. Conclusion: The number of surviving colonies, as well as the expression of BTG1, BTG2, and TOB2 after UVB irradiation were higher in HaCaT cells than the SCC cell lines, suggesting that the gene expression of BTG1, BTG2, and TOB2 in HaCaT cells might be involved in reducing the death of UVB-irradiated cells by repairing DNA damage. (Korean J Dermatol 2006;44(11):1317~1324)