대장 종양조직의 Ornithine Decarboxylase 활성도

김중영(Joong Young Kim),유효민(Hyo Min Ryu),박효진(Hyo Jin Park),김원호(Won Ho Kim),박인서(In Suh Park),함기백(Ki Baik Hahm),김진홍(Jin Hong Kim),이상인(Sang In Lee),이경식(Kyong Sik Lee) 대한내과학회 1996 대한내과학회지 Vol.50 No.1

N/A immediately in liquid nitrogen, stored at -70℃, and were analyzed for ODC activity within two weeks. ODC activity was assayed by a raiometric technique in which the amount of 14CO2 liberated from L-[1-14C] ornithine was measured according to the method by Fujimoto. Radioactivity of the 14CO2 trapped in the filter paper was measured in an aqueous miscible scintillant. Results: 1) Mean ODC activity(pmol CO2/hr/mg protein) of cancer, polyp and adjacent normal mucosa were 18.31, 8.05, 9.63, respectively. There was a significant difference in mean ODC activity in cancer tissue compared with polyp and adjacent normal mucosa. 2) There was no significant difference in mean ODC activity according to the size, age, morphology, differentiation and stage of cancer. But there was a statistical difference in mean ODC activity according to sex and tumor location. Mean ODC activity of males with cancer and of those with colon cancer was significantly higher than that of females with cancer and of those with rectal cancer. 3) Mean ODC activity fo cancer coexistent with adenoma was significantly higher than that of cancer with no coexisting adenoma. 4) In adjacent normal mucosa of cancer and polyp, mean ODC activity were 9.63, 6.45, respectively. There was no statistical difference in mean ODC activity between the two groups. 5) Mean ODC activity in adenomatous polyps and non-adenomatous polyps were 8.94, 7.03, respectively. Conclusion: 1he ODC activity in cancer tissue of large bowel was markedly increased compared with polyp and normal appearing colonic mucosa. But ODC activity was not correlated with invasion and differentiation of colorectal cancer. These results suggest that the elevation of ODC is correlated with cell proliferation status of colorectal cancer and reflects changes in the large bowel epithelium toward phenotypic neoplastic expression. Also, the mucosa of colorectal cancer with coexisting adenoma was shown to demonstrate a marked increase in mean ODC activity than that of colorectal cancer without adenoma. But the mucosal proliferation status of polyp was not higher than that of normal mucosa adjacent to polyp and ODC activity had no correlation to the pathologic characteristics of polyps. A broad and larger scale study on ODC activity of colorectal polyps is necessary to help predict cell proliferation of tumor

저혈당증을 동반한 간의 혈관주위세포종

최흥재(Heung Jai Choi),한광협(Kwang Hyub Han),김원호(Won Ho Kim),박찬일(Chan Il Park),노성훈(Sung Hoon Noh),김중영(Joong Young Kim),이승우(Seoung Woo Lee),성순희(Soon Hee Sung) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1

Hemangiopericytoma, which was first described in 1942 by Stout and Murrary, is a rare soft tissue sarcoma of vascular origin and is comprised of pericytes. Although this neoplasm may occur anywhere in the body, it very rarely occurs in the liver, especially in association with hypoglycemia. Hemangiopericytoma associated with hypoglycemia was rerted by several authors but has not been reported yet in Korea. We herein report a case of hemangiopericytoma of the liver associated with hypoglycemia in a 31-year-old female. She had frequent hypoglycemic episodes in spite of intravenous infusion of high glucose solution. Huge hypervascular tumor was disclosed by abdominal ultrasono- graphy, aMominal CT scan, Doppler ultrasonography and aortography. Hypoglycemia was disappeared after operation.

낭종내 Minocyclin chloride 1회 주입으로 치료된 거대 간낭종

강진경(Jin Kyung Kang),박인서(In Suh Park),문영명(Young Myung Moon),임대순(Dae Soon Yim),김중영(Joong Young Kim),함기백(Ki Baik Hahm),라선영(Sun Young Ra),최흥재(kHeung Jai Choi) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2

Hepatic cysts are often encountered on ahdominal ultrasonography or computed tomography and are usually asymptomatic. However, huge cyst bothers the patients either by compression or complicaticns such as intracystic infections or hemorrhage!. Various modalitles of treatments such as alcohol instillation or other sclerosing agents instillation have been reported. However, two or more sessions of treatment are usually required to ablate cyst We report, here, one-shot instillation of minocyclin chloride to treat a large hepatic cyst causing compression symptom with improvement.

간의 국소적 지방 침윤 1예

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),정재복(Jae Bock Chung),한광협(Kwang Hyub Han),김원호(Won Ho Kim),박찬일(Chan Il Park),유형식(Hyung Sik Yoo),김중영(Joong Young Kim),한은경(Eun Kyung Han) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2

N/A Focal fatty infiltration of the liver, a poorly characterized entity, was discovered incidentally at postmortem examination in the past, After both ultrasound and computed tomography (CT) have been extensively used over the past few years for imaging the hepatic parenchyma, it was possible to demonstrate focal fatty infiltration of the liver. Focal fatty infiltration of the liver may simulate mass lesions, so it is important to distinguish from space occupying lesions of the liver. Recently we encountered a case of focal fatty infiltration of the liver, which mimicked a liver tumor. It was detected by ultrasound and we performed abdominal CT, RBC liver scan, angiography and ultrasound guided needle biopsy. The diagnosis of focal fatty infiltration of the liver was established histologically.

급성 심근염 및 방실전도차단이 동반된 한국형 출혈열 1예

김응,홍천수,김준명,이이형,김중영 대한감염학회 1987 감염 Vol.19 No.2

There are many complications of Korean Hemorrhagic Fever such as hypertension, infection, anemia, hemorrhage, respiratory and neurologic complications, and few are reported on cardiovascular complication. We experienced one case of Korean Hemorrhagic Fever associated with acute myocarditis and second degree heart block recently.

유전자 알고리즘을 이용한 하이브리드 퍼지 제어기

오성권,김중영,이대근 圓光大學校大學院 2000 論文集 Vol.24 No.-

본 논문은 최적 자동동조 알고리즘으로 동조한 하이브리드 퍼지 제어기를 제안한다. 기존 PID제어기는 정상상태 오차를 개선하고 제어감도를 향상시키지만 제어환경이나 변수 변화에 매우 민감하여 비선형 시스템, 동적 시스템, 고차 시스템 및 수학적 모델 선정이 어려운 시스템에서는 효과적이지 못하는 단점을 가지고 있다.[13] 이에 반해 퍼지 제어기는 인간의 지식과 경험을 이용하는 지적제어 방식으로 IF-THEN 형식의 제어규칙으로부터 제어 입력을 결정하는 병렬형 제어이다. 이에 본 논문에서는 첫째, PID 제어기와 퍼지 제어기의 장점을 하중계수(α)를 이용하여 결합한 하이브리드 퍼지 제어기를 제안한다.[8] 둘째, 유전자 알고리즘을 이용하여 제어파라미터를 자동으로 동조하여 하이브리드 퍼지 제어기의 성능을 개선한다.[1] 나아가 제안한 하이브리드 퍼지 제어기를 로켓이나 로봇 자세제어의 기본이 되는, 대표적 비선형 시스템인 도립진자 시스템에 적용하여 안정화 제어를 수행하며 제안된 하이브리드 제어기의 평가와 우수성을 입증하고자 한다. In this paper , we propose the hybrid fuzzy controller(HFC) and the hybrid auto-tuning algorithm. The proposed HFC combined a PID controller with a fuzzy controller concurrently produces the better output performance such as sensitivity improvement in steady state and robustness in transient state than any other controller. In addition, a optimal auto-tuning algorithm, genetic algorithm automatically generates weighting factor, scaling factors and PID control gains and optimizes the output of HFC. As an typical example of non-linear system in control theory, an inverted pendulum will be controlled by the suggested HFC and illustrated the performance and applicability of this proposed method by simulation.

원발성 뇌 임파종으로 오인된 과립구성 육종 1 예

이선주,이영식,김규래,윤정훈,한지숙,최인준,고윤웅,김중영 대한내과학회 1988 대한내과학회지 Vol.35 No.3

Granulocytic sarcoma is a localized tumor mass com- posed of immature cells of the granulocytic aeries, which is usually associated with myelogenous leukemia and may occur anywhere in the body. Hawever, intra-cranial involvement of the central nervous system by granulocytic sarcoma is rare. In addition, it is subject to be misdiagnosed as lymphoma. A case is presented of a 23-year-old woman with a granulocytic sarcoma of the brain suffering from loss of consciousness and headache. She was initially diagnosed as having a primary lymphoma of the brain 2 months before admission, when the peripheral blood findings were not remarkable. On admission, the peripheral blood and bone marrow findings were compatible with acute myeloid leukemia (FAB M2). Review of the pathologic slides and histochemical studies of the intra- cranial mass revealed a granulocytic sarcoma accompanied by starry-sky appearance.