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간동맥을 통한 LAK 세포의 주입과 Interleukin-2 정맥주입을 이용한 간암환자의 치료
이경식,김병로,최승훈 ( Kyong Sik Lee,Byong Ro Kim,Seung Hoon Choi ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.4
We have examined the effect of intraarterial infusion of LAK cells through the hepatic artery and intravenous Interleukin-2 in humans with hepatoma unresponsive to other treatments. There were ten primary hepatomas and three metastatic hepatomas. Two patients out of six intraarterial infusion of LAK cella survived more than two years. And two out of seven intravenous infusion of LAK cells survived more than two years. Cellular cytotoxicity was measured by four hour Chromium release assay. This study showed that intraarterial infusion of LAK cells augmented LAK activity more prominent than intravenous infusion of LAK cells. It covld be speculated that intraarterial infusion of LAK cells in the patients with hatoma potentiated immunological response of the host by rendering a large number of LAK cells to the tumor.
이경식(Kyong Sik Lee),김충배(Choong Bai Kim),이경포(Kyung Po Lee),이상훈(Sang Hoon Lee) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
Intussusception in adults is relatively rare and usually occurs secondary to tumors or other underlying causes. It appears that the incidence of associated malignancy is increasing compare to the past. The characteristics of adult intussusception is multiple attacks of partial intestinal obstruction and its chronic course. However, preoperative diagnosis is often difficult due to its vague and variable clinical picutres. The treatment principle is operative intervention to its causative lesion. During the past 20 years, from Jan. 1967 to Aug. 1987, 38 adult patients had documented adult intussusception at Yonsei Medical Center; 24 instances of intussusception originating in the small intestine and 14 instances originating in the colon. The etiologic factors were found in 27 cases (71%). Of the 14 colon intussusception, 3 cases were associated with malignancy and 6 out of 24 small bowel intussusception were result from the malignancy. The most common malignancy found was malignant lymphoma. Surgical intervention was carried out in all of these 38 cases; 26 cases underwent surgical resection and remainder was reduced manually after surgical exploration.